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1.发明授权Process of fabrication IC chip package from an IC chip carrier substrate and a leadframe and the IC chip package fabricated thereby 失效从IC芯片载体基板和引线框架制造IC芯片封装的工艺和由此制造的IC芯片封装
公开(公告)号：US5403785A
公开(公告)日：1995-04-04
申请号：US63059
申请日：1993-05-19
申请人： Hitoshi Arai , Syuichi Furuichi , Toshiyuki Yamaguchi , Takeshi Kanou , Tooru Higuchi , Muneo Yamada , Toshimasa Kitagawa , Takashi Sugimoto
发明人： Hitoshi Arai , Syuichi Furuichi , Toshiyuki Yamaguchi , Takeshi Kanou , Tooru Higuchi , Muneo Yamada , Toshimasa Kitagawa , Takashi Sugimoto
IPC分类号： H01L21/607 , H01L23/495 , H05K3/32 , H05K3/40 , H01L21/60
CPC分类号： H01L24/86 , H01L23/49506 , H01L23/49531 , H01L23/49541 , H01L23/49548 , H01L2224/48091 , H01L2224/48247 , H01L2224/73265 , H01L24/48 , H01L2924/00014 , H01L2924/01006 , H01L2924/01013 , H01L2924/01029 , H01L2924/01033 , H01L2924/01047 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/15787 , H01L2924/181 , H05K3/328 , H05K3/403 , Y10T29/49121
摘要： An IC chip package is fabricated from a substrate carrying an IC chip and formed with a conductive pattern of conductors for electrical connection to the IC chip, and a leadframe having a plurality of connector leads with inner and outer lead sites for electrical connection with associated ones of the conductors and with an external circuit, respectively. Fabrication of the IC chip package is made through the steps of placing the inner lead sites into intimate contact on distal ends of the corresponding conductors, and applying ultrasonic vibrations to contacting surfaces between the inner lead sites and the conductors so as to effect diffusion bonding therebetween. For applying the ultrasonic vibrations, a horn is pressed against the inner lead sites of the connector leads in such a manner as to leave indents in the inner lead sites which act to anchor an encapsulating plastic at the time of encapsulating the IC chip, the substrate, and most of the leadframe, for obtaining tight grip between the encapsulating plastic and the connector leads. At least one of the inner lead site and the distal end of the corresponding conductor may be provided with a suitable plating or bump for facilitating the diffusion bonding.
摘要翻译： IC芯片封装由承载IC芯片的基板制成，并形成有用于与IC芯片电连接的导体图案，以及具有多个连接器引线的引线框架，其具有用于与相关联的电连接的内部和外部引线位置 的导体和外部电路。 通过将内部引线部位紧密接触在相应导体的远端上并对内部引线部位和导体之间的接触表面施加超声波振动以便在其间进行扩散接合的步骤来制造IC芯片封装 。 为了施加超声波振动，喇叭以这样的方式被压靠在连接器引线的内部引线部位上，以便在封装IC芯片时衬底内部引线位置留下凹槽，该内部引线位置用于锚固封装塑料，衬底 和大多数引线框架，用于在封装塑料和连接器引线之间获得紧密的握持。 相应导体的内引线部分和远端中的至少一个可以设置有用于促进扩散接合的合适的电镀或凸块。
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公开(公告)号：US08486462B2
公开(公告)日：2013-07-16
申请号：US12180241
申请日：2008-07-25
申请人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
发明人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
IPC分类号： A61K36/886 , A61K36/00
CPC分类号： C07J17/005 , A23L33/105 , A61K36/886 , A61K36/896
摘要： 3-O-β-D-Glucopyranosyl-4-methylergost-7-en-3-ol or a composition containing 0.001% by mass or more of the aforementioned compound, which is an extract of a plant of the family Liliaceae containing the compound or a fraction thereof, is used as an active ingredient of a hyperglycemia improving agent.
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公开(公告)号：US07754704B2
公开(公告)日：2010-07-13
申请号：US10572099
申请日：2005-03-30
申请人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
发明人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
IPC分类号： A61K31/56
CPC分类号： A61K36/886 , A23L33/11 , A61K31/575 , C07J9/00
摘要： A compound having a hyperglycemia improving effect and a hemoglobin A1c lowering action such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol is used as an active ingredient of a drug or food or drink for improving hyperglycemia.
摘要翻译： 具有高血糖症改善作用和血红蛋白A1c降低作用的化合物，例如4-甲基胆固醇-7-烯-3-醇，4-甲基麦角-7-烯-3-醇和4-甲基西泮-7-烯-3-醇 用作药物或食物或饮料的活性成分，用于改善高血糖症。
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4.发明申请Glycoside Having 4-Methylergost-7-En-3-Ol Skeleton and Hyperglycemia Improving Agent 有权具有4-甲基麦角甾-7-烯-3-O骨架和高血糖症改善剂的糖苷公开(公告)号：US20080044500A1
公开(公告)日：2008-02-21
申请号：US10564464
申请日：2005-03-30
申请人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
发明人： Ryuuichi Higuchi , Masanori Inagaki , Hirotoshi Hayasawa , Muneo Yamada , Miyuki Tanaka , Eriko Misawa , Noriko Wakimoto , Yousuke Itou
IPC分类号： A61K36/886 , A61K31/704 , A61P3/10 , C07J17/00
CPC分类号： C07J17/005 , A23L33/105 , A61K36/886 , A61K36/896
摘要： 3-O-β-D-Glucopyranosyl-4-methylergost-7-en-3-ol or a composition containing 0.001% by mass or more of the aforementioned compound, which is an extract of a plant of the family Liliaceae containing the compound or a fraction thereof, is used as an active ingredient of a hyperglycemia improving agent.
摘要翻译： 3-O-β-D-吡喃葡萄糖基-4-甲基麦角-7-烯-3-醇或含有0.001质量％以上上述化合物的组合物，其为含有化合物的百合科植物的提取物 或其一部分用作高血糖改善剂的活性成分。
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公开(公告)号：US07217524B2
公开(公告)日：2007-05-15
申请号：US11409216
申请日：2006-04-21
摘要： Aplasia of the corpus callosum or aspermatogenesis is diagnosed by investigating existence or expression of the BT-IgSF gene with use of a primer for PCR or probe for hybridization comprising a DNA coding for a novel cell adhesion molecule (BT-IgSF) defined in the following (A) or (B) or a partial sequence thereof: (A) a protein comprising the amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2; (B) a protein comprising an amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2 including substitution, deletion, insertion or addition of one or several amino acids and having a function as a cell adhesion molecule.
摘要翻译： 通过使用PCR引物或用于杂交的探针研究BT-IgSF基因的存在或表达来诊断胼the体或异常生殖的发生，包括编码下述定义的新型细胞粘附分子（BT-IgSF）的DNA （A）或（B）或其部分序列：（A）包含SEQ ID NO：2的氨基酸编号1至409的氨基酸序列的蛋白质; （B）包含SEQ ID NO：2的氨基酸编号1至409的氨基酸序列的蛋白质，包括一个或几个氨基酸的取代，缺失，插入或添加并具有作为细胞粘附分子的功能。
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公开(公告)号：US20060178337A1
公开(公告)日：2006-08-10
申请号：US11409216
申请日：2006-04-21
IPC分类号： A61K48/00 , C07K14/705 , C07H21/04 , C12P21/06
摘要： Aplasia of the corpus callosum or aspermatogenesis is diagnosed by investigating existence or expression of the BT-IgSF gene with use of a primer for PCR or probe for hybridization comprising a DNA coding for a novel cell adhesion molecule (BT-IgSF) defined in the following (A) or (B) or a partial sequence thereof: (A) a protein comprising the amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2; (B) a protein comprising an amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2 including substitution, deletion, insertion or addition of one or several amino acids and having a function as a cell adhesion molecule.
摘要翻译： 通过使用PCR引物或用于杂交的探针研究BT-IgSF基因的存在或表达来诊断胼the体或异常生殖的发生，包括编码下述定义的新型细胞粘附分子（BT-IgSF）的DNA （A）或（B）或其部分序列：（A）包含SEQ ID NO：2的氨基酸编号1至409的氨基酸序列的蛋白质; （B）包含SEQ ID NO：2的氨基酸编号1至409的氨基酸序列的蛋白质，包括一个或几个氨基酸的取代，缺失，插入或添加并具有作为细胞粘附分子的功能。
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公开(公告)号：US5288487A
公开(公告)日：1994-02-22
申请号：US789431
申请日：1991-11-06
申请人： Takuji Kawashima , Nobuya Yanai , Muneo Yamada , Hajime Yokota , Kunio Ujiie , Katsuo Yoshida , Shinya Suzu , Fumimaro Takaku , Kazuo Motoyoshi , Nobuhiro Yamada
发明人： Takuji Kawashima , Nobuya Yanai , Muneo Yamada , Hajime Yokota , Kunio Ujiie , Katsuo Yoshida , Shinya Suzu , Fumimaro Takaku , Kazuo Motoyoshi , Nobuhiro Yamada
CPC分类号： A61K47/42 , A61K38/193 , A61K47/26
摘要： Human M-CSF preparations and recombinant human M-CSF preparations against myelodysplastic syndrome, malignant tumor and hyperlipemia and auxiliary therapeutic preparations to be dosed along with platinum-complex anticancer preparations.
摘要翻译： 人M-CSF制剂和针对骨髓增生异常综合征，恶性肿瘤和高脂血症的重组人M-CSF制剂和与铂复合物抗癌制剂一起给药的辅助治疗制剂。
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8.发明授权Method for promoting secretion of glucagon-like peptide-1 by administering κ-casein 有权通过施用胃蛋白酶来促进胰高血糖素样肽-1的分泌的方法公开(公告)号：US08367608B2
公开(公告)日：2013-02-05
申请号：US13313724
申请日：2011-12-07
申请人： Yousuke Itoh , Kouji Nomaguchi , Muneo Yamada
发明人： Yousuke Itoh , Kouji Nomaguchi , Muneo Yamada
CPC分类号： A61K38/012 , A23J1/202 , A23L2/52 , A23L33/19 , A23V2002/00 , A61K38/17 , A61K38/26 , A23V2200/328 , A23V2250/54246
摘要： The invention relates to a GLP-1 secretagogue and an inhibitor of postprandial rise in blood glucose, containing κ-casein as an active ingredient, and a food or drink for promoting GLP-1 secretion and an inhibitory food or drink of postprandial rise in blood glucose, containing a milk-derived casein protein wherein κ-casein accounts for 60% by mass or more of the milk-derived casein.
摘要翻译： 本发明涉及GLP-1促分泌素和餐后血糖升高抑制剂，其含有酪蛋白作为活性成分，以及用于促进GLP-1分泌的食物或饮料和餐后升高的抑制性食物或饮料 含有乳衍生酪蛋白的血糖，其中，酪蛋白占乳源酪蛋白的60质量％以上。
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公开(公告)号：US20120294913A1
公开(公告)日：2012-11-22
申请号：US13514150
申请日：2010-11-11
申请人： Yuzo Asano , Kouji Nomaguchi , Muneo Yamada , Miyuki Tanaka
发明人： Yuzo Asano , Kouji Nomaguchi , Muneo Yamada , Miyuki Tanaka
CPC分类号： A23L2/52 , A23K10/30 , A23K20/10 , A23L19/01 , A23L33/105 , A61K8/022 , A61K8/97 , A61K36/886 , A61Q19/00
摘要： A technique for efficiently performing pulverization of a dried aloe gel using an air flow type mill is provided. 1) A dried aloe gel is treated by supercritical extraction, an extract is removed from the dried aloe gel to obtain an extraction residue, and then 2) the extraction residue is pulverized with an air flow type mill to produce an aloe powder.
摘要翻译： 提供了使用气流式粉碎机有效地进行干燥的芦荟凝胶粉碎的技术。 1）通过超临界萃取处理干芦荟凝胶，从干燥的芦荟凝胶中除去提取物，得到提取残渣，然后用空气流式研磨机粉碎提取残渣，制成芦荟粉末。
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公开(公告)号：US08101594B2
公开(公告)日：2012-01-24
申请号：US11576652
申请日：2006-02-28
申请人： Miyuki Tanaka , Eriko Misawa , Noriko Habara , Muneo Yamada
发明人： Miyuki Tanaka , Eriko Misawa , Noriko Habara , Muneo Yamada
IPC分类号： A01N43/00
CPC分类号： A23L2/52 , A23L33/11 , A61K31/56 , A61K31/575 , A61K36/886 , A61K36/896
摘要： Compounds such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol which have an activity for improving pancreatic function are used as an active ingredient of a pancreas function improving drug and food or drink.
摘要翻译： 使用具有改善胰腺功能的活性的化合物如4-甲基胆甾-7-烯-3-醇，4-甲基麦芽糖-7-烯-3-醇和4-甲基孕甾-7-烯-3-醇用作 胰腺功能的活性成分改善药物和食物或饮料。
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