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1.发明申请COMPOSITION FOR TREATING CANCER BY THE CONTROLLED RELEASE OF AN ACTIVE SUBSTANCE 审中-公开通过控制释放活性物质治疗癌症的组合物公开(公告)号：US20130266637A1
公开(公告)日：2013-10-10
申请号：US13878801
申请日：2011-10-11
申请人： Holger Egger , Bastian Budde , Kai Termming , Anna Arbuzova , Andrea Gramatica , Andreas Herrmann , Juergen Liebscher , Nicolai Brodersen
发明人： Holger Egger , Bastian Budde , Kai Termming , Anna Arbuzova , Andrea Gramatica , Andreas Herrmann , Juergen Liebscher , Nicolai Brodersen
IPC分类号： A61K47/22
CPC分类号： A61K47/22 , A61K31/704 , A61K47/543 , A61K47/551 , A61K47/6911 , A61K47/6913
摘要： The invention relates to a novel composition for treating cancer, which allows the active substance to be released in the direct presence of the cells which are to be treated with the active substance. Said composition comprises an active substance carrier which is in the form of a liposome comprising a disulfide group, a cytostatic agent being contained in the active substance carrier. The invention also relates to a method for the locally defined release of a cytostatic agent.
摘要翻译： 本发明涉及一种用于治疗癌症的新型组合物，其允许活性物质在待用活性物质治疗的细胞的直接存在下释放。 所述组合物包含活性物质载体，其为包含二硫键的脂质体形式，细胞生长抑制剂包含在活性物质载体中。 本发明还涉及局部限定性释放细胞生长抑制剂的方法。
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2.发明授权公开(公告)号：US08399236B2
公开(公告)日：2013-03-19
申请号：US12672096
申请日：2008-08-01
申请人： Stefanie Eiden , Axel Eble , Martin Weiss , Daniel Gordon Duff , Olaf Bork , Holger Egger , Bastian Budde , Sascha Plug
发明人： Stefanie Eiden , Axel Eble , Martin Weiss , Daniel Gordon Duff , Olaf Bork , Holger Egger , Bastian Budde , Sascha Plug
IPC分类号： C12N7/00
CPC分类号： A61K35/76 , A61K47/6901 , C07K7/06 , C07K7/08 , C07K14/005 , C07K17/02 , C07K17/14 , C07K2319/01 , C12N7/00 , C12N15/1037 , C12N2795/14122 , Y10T442/2508 , Y10T442/2525
摘要： The present invention concerns a system, comprising bacteriophages and particles comprising active agents, in which a first additional peptide is fused to proteins of the bacteriophage, the first additional peptide adheres to the surface of the particle and furthermore a second additional peptide is fused to proteins of the bacteriophage. The second additional peptide can adhere on substrate surfaces. The present invention furthermore concerns the use of the system for delayed release of active agents and also a method for production of the system. The present invention furthermore concerns a method for the selection of phage species from a combinatorial phage population.
摘要翻译： 本发明涉及包含噬菌体和包含活性剂的颗粒的系统，其中第一附加肽与噬菌体的蛋白质融合，第一附加肽粘附到颗粒的表面，此外，第二附加肽与蛋白质融合 的噬菌体。 第二个额外的肽可以粘附在基底表面上。 本发明还涉及该系统用于活性剂的延迟释放的用途以及该系统的生产方法。 本发明还涉及从组合噬菌体群体中选择噬菌体物种的方法。
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3.发明申请公开(公告)号：US20100285136A1
公开(公告)日：2010-11-11
申请号：US12672096
申请日：2008-08-01
申请人： Stefanie Eiden , Axel Eble , Martin Weiss , Daniel Gordon Duff , Olaf Bork , Holger Egger , Bastian Budde , Sascha Plug
发明人： Stefanie Eiden , Axel Eble , Martin Weiss , Daniel Gordon Duff , Olaf Bork , Holger Egger , Bastian Budde , Sascha Plug
CPC分类号： A61K35/76 , A61K47/6901 , C07K7/06 , C07K7/08 , C07K14/005 , C07K17/02 , C07K17/14 , C07K2319/01 , C12N7/00 , C12N15/1037 , C12N2795/14122 , Y10T442/2508 , Y10T442/2525
摘要： The present invention concerns a system, comprising bacteriophages and particles comprising active agents, in which a first additional peptide is fused to proteins of the bacteriophage, the first additional peptide adheres to the surface of the particle and furthermore a second additional peptide is fused to proteins of the bacteriophage. The second additional peptide can adhere on substrate surfaces. The present invention furthermore concerns the use of the system for delayed release of active agents and also a method for production of the system. The present invention furthermore concerns a method for the selection of phage species from a combinatorial phage population.
摘要翻译： 本发明涉及包含噬菌体和包含活性剂的颗粒的系统，其中第一附加肽与噬菌体的蛋白质融合，第一附加肽粘附到颗粒的表面，此外，第二附加肽与蛋白质融合 的噬菌体。 第二个额外的肽可以粘附在基底表面上。 本发明还涉及该系统用于活性剂的延迟释放的用途以及该系统的生产方法。 本发明还涉及从组合噬菌体群体中选择噬菌体物种的方法。
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公开(公告)号：US20100279894A1
公开(公告)日：2010-11-04
申请号：US12739015
申请日：2008-11-20
申请人： Stefanie Eiden , Axel Eble , Bastian Budde , Sascha Plug , Peter Krüger
发明人： Stefanie Eiden , Axel Eble , Bastian Budde , Sascha Plug , Peter Krüger
CPC分类号： C12N15/1037 , C07K14/005 , C07K2319/00 , C09D5/002 , C12N2795/00022
摘要： The present invention relates to a composition comprising bacteriophages and coating material for surfaces, characterized in that a first additional peptide is fused on proteins of the bacteriophage and furthermore a second additional peptide is fused on proteins of the bacteriophage. In addition, the present invention relates to a surface that has been coated with the composition and the use of the composition for coating surfaces.
摘要翻译： 本发明涉及一种包含噬菌体和表面涂层材料的组合物，其特征在于，将第一另外的肽融合在噬菌体的蛋白质上，此外，第二另外的肽融合在噬菌体的蛋白质上。 此外，本发明涉及已经涂覆有组合物的表面和用于涂布表面的组合物的用途。
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5.发明申请METHOD FOR PREPARING HIGH-THROUGHPUT SEQUENCEABLE DNA FROM INDIVIDUAL PLAQUES OF PHAGES PRESENTING PEPTIDES 审中-公开用于制备高渗透可序列DNA的方法从提供肽的化学品的个体化公开(公告)号：US20110257045A1
公开(公告)日：2011-10-20
申请号：US13126517
申请日：2009-10-21
申请人： Bastian Budde , Amber Riblett , Sascha Plug , Jürgen Benting
发明人： Bastian Budde , Amber Riblett , Sascha Plug , Jürgen Benting
IPC分类号： C40B50/06
CPC分类号： C12N15/1037 , C12N15/1003 , C12Q1/6806 , C12Q2523/301
摘要： The present invention relates to a process for isolating DNA from individual plaques of peptide-presenting bacteriophages in a high-throughput capacity PCR, wherein the PCR products obtained are sequenceable and a specimen of each phage studied is retained in a replicable state. The PCR is successful despite the presence of inhibitory constituents from the growth medium or the host bacteria.
摘要翻译： 本发明涉及在高通量能力PCR中分离来自肽呈递噬菌体的个体噬菌斑的DNA的方法，其中获得的PCR产物是可顺序的，并且每个噬菌体的样品被保留在可复制状态。 尽管存在来自生长培养基或宿主细菌的抑制成分，PCR仍是成功的。
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