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公开(公告)号：US20080187922A1
公开(公告)日：2008-08-07
申请号：US11871932
申请日：2007-10-12
申请人： Honghai Wang , Lu Zhang , Qingzhong Wang , Jun Yue , Min Zhang , Ying Xu , Bingdong Zhu , Jiuling Wang , Yaqing Qie
发明人： Honghai Wang , Lu Zhang , Qingzhong Wang , Jun Yue , Min Zhang , Ying Xu , Bingdong Zhu , Jiuling Wang , Yaqing Qie
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/18 , C12Q2600/156 , G01N33/5695 , G01N2333/35 , G01N2500/00
摘要： The present invention belongs to the field of molecular biology. Specially, the invention relates to the screenings of a new drug target, a vaccine antigen and a test target of anti-tuberculosis treatment. Specially, based on the differential proteome technology and by the techniques of gene sequencing, in vitro protein expression, immunological detection and gene recombination, the invention primarily certifies that the up-regulated expression of Protein Rv2629 and the mutation of Gene 191A/C of Mycobacterium tuberculosis are related to the Rifampicin (RFP) drug-resistance, which provides useful information for the drug-resistance detection of Mycobacterium tuberculosis, the novel drug design and the vaccine development. Firstly, the drug-resistant strains are cultured and the proteins from drug resistance strains and sensitive strains are isolated respectively. Secondly, the proteins from the drug resistance strains and the sensitive strains are compared to determine the differential protein sites, such that the drug-resistant proteins are identified by means of Mass Spectrometry. Next, the up-regulated expression of Protein Rv2629 and the mutation of gene are correlated to the drug-resistance of Mycobacterium tuberculosis by means of gene sequencing technique. Finally, after the gene cloning, the in vitro expression and purification of the protein, the wild-type and mutant-type recombinant protein of Rv2629 are obtained. The polyclonal antibody is prepared, and the protein subcellular localization is carried out. The Minimum Inhibitory Concentrations (MICs) of the strains containing different plasmids obtained by the transformation of recombinant shuttle plasmids are also measured. The gene encoding the protein Rv2629 in the genome of Mycobacterium tuberculosis is isolated and is up-regulation expressed in a Rifampicin (RFP)-resistant strains. And the A/C gene mutation at nucleotide 191 which is related to drug-resistance is detected. The relationship between the mutation and the Rifampicin (RFP)-resistance is primarily certified by molecular biology technique and the in vitro experiments. This invention provides methods used to accurately isolate and identify the drug-resistance protein of Mycobacterium tuberculosis. The A/C mutation of Rv2629 at nucleotide 191 related to the drug-resistance of Mycobacterium tuberculosis is isolated, which shows new approach for the further study of Mycobacterium tuberculosis drug-resistant mechanism, the rapid detection of clinical drug-resistance strains, as well as the developments of new drug targets and vaccines.
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公开(公告)号：US20140100127A1
公开(公告)日：2014-04-10
申请号：US14008250
申请日：2012-03-30
申请人： Mujun Zhao , Feng Wang , Zhen Xing , Liang Da , Ying Xu , Zaiping Li
发明人： Mujun Zhao , Feng Wang , Zhen Xing , Liang Da , Ying Xu , Zaiping Li
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C07K16/40 , C12Q2600/112 , C12Q2600/158 , G01N33/57438 , G01N2333/80
摘要： A marker for the detection of liver cancer and application of the marker thereof. The application includes use of cytochrome p450 family 17 subfamily A polypeptide 1 (CYP17A1 protein) in the preparation of diagnostic reagents or kits for the detection of liver cancer kit. Studies have shown that CYP17A1 expression levels are higher in liver cancer tissues than in the adjacent healthy tissues, and the amount of CYP17A1 in sera of liver patients is significantly higher than that of healthy human population. Therefore, CYP17A1 can be used as a marker for the diagnosis of liver cancer (especially serological diagnosis).
摘要翻译： 用于检测肝癌的标志物及其标记物的应用。 该应用包括使用细胞色素p450家族17亚科A多肽1（CYP17A1蛋白）制备用于检测肝癌试剂盒的诊断试剂或试剂盒。 研究表明，肝癌组织中CYP17A1的表达水平高于相邻健康组织，肝脏患者血清中CYP17A1的含量明显高于健康人群。 因此，CYP17A1可作为肝癌诊断的标志物（特别是血清学诊断）。
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公开(公告)号：US08685901B2
公开(公告)日：2014-04-01
申请号：US11669060
申请日：2007-01-30
申请人： Ying Xu , B. R. Reddy , Rickey Morgan , Lance Brothers
发明人： Ying Xu , B. R. Reddy , Rickey Morgan , Lance Brothers
CPC分类号： C09K8/467 , C04B28/06 , C04B2103/10 , Y02W30/92 , C04B18/08 , C04B22/085 , C04B22/124 , C04B22/16 , C04B24/06 , C04B2103/0006 , C04B2103/001
摘要： A method of servicing a wellbore in contact with a subterranean formation, comprising placing into a wellbore a composition comprising a calcium aluminate cement and a polyvalent cation-containing compound, and allowing the composition to set. A method of increasing the thickening time of a calcium aluminate cement comprising contacting the calcium aluminate cement with a polyvalent cation-containing compound. A method of adjusting the thickening time of a calcium aluminate cement comprising contacting the calcium aluminate cement with a polyvalent cation-containing compound and at least one other set modifier.
摘要翻译： 一种维护与地层接触的井筒的方法，包括将包含铝酸钙水泥和多价阳离子的化合物的组合物放入井筒中，并使组合物凝固。 一种增加铝酸钙水泥的增稠时间的方法，包括使铝酸钙水泥与多价阳离子化合物接触。 一种调节铝酸钙胶泥的增稠时间的方法，其包括使铝酸钙水泥与含有多价阳离子的化合物和至少一种其它组合改性剂接触。
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公开(公告)号：US20140044810A1
公开(公告)日：2014-02-13
申请号：US14112491
申请日：2012-04-17
申请人： Peiyuan Qian , Xiangzhong Huang , Ying Xu , Yu Zhang , Yue Him Wong , Yan Yin , Zhuang Han
发明人： Peiyuan Qian , Xiangzhong Huang , Ying Xu , Yu Zhang , Yue Him Wong , Yan Yin , Zhuang Han
CPC分类号： A01N43/40 , A01N43/30 , A01N65/08 , A61K36/00 , B08B17/02 , B08B17/04 , C07D317/60 , C09D5/1625 , C09D5/165
摘要： Use of amide compounds represented by formula (I), for preventing or reducing settlement and/or fouling of marine fouling organisms on a surface of a submerged object is provided, wherein “-A-” has a formula -(CnH2(n−m))- which is either unsubstituted or substituted by one or more C1 to C4 alkyls, and wherein the formula -(CnH2(n−m))- represents a divalent alkyl, or a divalent alkenyl having one or more double bonds, n is 1 to 15, m is 0 to 4, and 2(n−m)=2, and R is selected from piperidinyl, pyrrolidinyl, isobutylamino, piperazinyl or morpholinyl. Amide compounds of formula (I), a category of antifouling compounds, can be either isolated from natural resources or synthesized, which are nontoxic and environmental-friendly.
摘要翻译： 提供了由式（I）表示的酰胺化合物用于防止或减少浸没物体表面上的海洋结垢生物沉降和/或结垢的用途，其中“-A-”具有式 - （C n H 2（nm）） （C n H 2（nm）） - 表示二价烷基或具有一个或多个双键的二价链烯基，n为1至15， m为0〜4，2（nm）= 2，R选自哌啶基，吡咯烷基，异丁基氨基，哌嗪基或吗啉基。 式（I）的酰胺化合物，一类防污化合物，可以从天然资源中分离出来，也可以合成，无毒且环保。
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公开(公告)号：US20120053080A1
公开(公告)日：2012-03-01
申请号：US13255527
申请日：2010-02-19
申请人： Juan Cui , J. David Puett , Seulgi Hong , Ying Xu
发明人： Juan Cui , J. David Puett , Seulgi Hong , Ying Xu
CPC分类号： G01N33/57484
摘要： Methods for detecting cancer as well as methods of diagnosis of cancer by detecting proteins secreted into biological fluids are disclosed The invention was first applied to detecting proteins secreted into serum and urine However, it is understood that the methods have broader application to developing tools and systems for detecting proteins secreted into other biological fluids such as, but not limited to, saliva, spinal fluid, seminal fluid, vaginal fluid, and ocular fluid Reliable detection of proteins secreted into biological fluids provided by embodiments of the methods will enable more timely and accurate detection and diagnosis of cancer.
摘要翻译： 本发明首先应用于检测分泌到血清和尿液中的蛋白质，但是应当理解，该方法在开发工具和系统方面有更广泛的应用 用于检测分泌到其它生物流体中的蛋白质，例如但不限于唾液，脊髓液，精液，阴道液和眼液可以通过该方法的实施方案提供的分泌到生物流体中的蛋白质的可靠检测将能够更及时和准确 检测和诊断癌症。
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公开(公告)号：US20110185944A1
公开(公告)日：2011-08-04
申请号：US13054938
申请日：2009-04-16
申请人： Peiyuan Qian , Ying Xu , Xiaojian Zhou , Hongping He , Nobuhiro Fusetani , Wei-Min Dai
发明人： Peiyuan Qian , Ying Xu , Xiaojian Zhou , Hongping He , Nobuhiro Fusetani , Wei-Min Dai
IPC分类号： C09D5/16 , C07D407/12 , C07D307/58
CPC分类号： C07D307/33 , C09D5/1637
摘要： A novel chemical genus of furan-2-one antifouling compound as non-toxic, environment friendly antifouling agent, a coating material for objects submerged under the water based on the furan-2-one compounds. The substituted furan-2-one antifouling compounds have a furan-2-one ring and an alkyl side chain thereto and are of the formula: where n=6-14, representing the number of carbon atoms in said side chain.
摘要翻译： 呋喃-2-酮防污化合物的新型化学品为无毒，环保型防污剂，基于呋喃-2-酮化合物浸没在水下的物体涂料。 取代的呋喃-2-酮防污化合物具有呋喃-2-酮环和烷基侧链，具有下式：其中n = 6-14，表示所述侧链中的碳原子数。
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公开(公告)号：US07969332B2
公开(公告)日：2011-06-28
申请号：US12685390
申请日：2010-01-11
申请人： Ying Xu , Shaofang Wang
发明人： Ying Xu , Shaofang Wang
IPC分类号： H03M13/25
CPC分类号： H03M13/136 , H03M13/033 , H03M13/13 , H03M13/618 , H03M13/6525
摘要： A method and apparatus for encoding based on a linear block code, and a method and apparatus for generating a linear block code are provided. The method for encoding based on a linear block code includes: generating a linear block code; and encoding an information sequence with an encoding matrix of the linear block code to obtain a bit stream sequence. The linear block codes have a good minimum distance characteristic, so that the error correction performance is improved.
摘要翻译： 提供一种基于线性块码的编码方法和装置，以及用于生成线性块码的方法和装置。 基于线性块码的编码方法包括：生成线性块码; 以及利用所述线性块码的编码矩阵对信息序列进行编码，以获得比特流序列。 线性块代码具有良好的最小距离特性，从而改善了纠错性能。
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公开(公告)号：US20080309276A1
公开(公告)日：2008-12-18
申请号：US11764486
申请日：2007-06-18
申请人： Ying Xu
发明人： Ying Xu
CPC分类号： G05B19/404 , G05B2219/41344 , G05B2219/45166 , G05B2219/50046 , G05B2219/50156
摘要： A rotating stage assembly performs high precision rotational angle and position error correction by continuous sensing and correcting motor stage assembly errors. It performs these corrections, to adjust for motor environmental and operational errors by sensing and correcting using five sensors placed to measure the adjustments of five corresponding actuators, which adjust the entire motor rotating stage and rotary motor assembly relative to a reference frame.
摘要翻译： 旋转台组件通过连续检测和校正电机台组件误差来执行高精度旋转角度和位置误差校正。 它执行这些校正，以通过使用五个传感器进行感测和校正来调整电机环境和操作误差，这五个传感器用于测量五个相应致动器的调整，该五个传感器相对于参考系调整整个电机旋转台和旋转电机组件。
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公开(公告)号：US07348709B2
公开(公告)日：2008-03-25
申请号：US11107008
申请日：2005-04-15
申请人： Ying Xu
发明人： Ying Xu
IPC分类号： H01L41/08
CPC分类号： H02N2/043
摘要： A positioning device for heavy loads is provided. The positioning device includes a frame and a stage disposed or integrally defined within the frame. The stage is dimensioned and configured to be translatable within the frame in at least one axis of motion. At least one dual-parallel flexure connects the stage to the frame.
摘要翻译： 提供了一种用于重载的定位装置。 定位装置包括框架和设置或整体地限定在框架内的台架。 舞台的尺寸和构造可在至少一个运动轴的框架内平移。 至少一个双平行弯曲将舞台连接到框架。
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