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    Basically alkylated dithiosalicyclic acid amides and their use as medicaments
    3.
    发明授权
    Basically alkylated dithiosalicyclic acid amides and their use as medicaments 失效
    基本上是烷基化二硫代脂环酸酰胺及其作为药物的用途

    公开(公告)号：US4153702A

    公开(公告)日：1979-05-08

    申请号：US853710

    申请日：1977-11-21

    申请人： Ulrich Horlein ,  Horst Boshagen ,  Friedel Seuter

    发明人： Ulrich Horlein ,  Horst Boshagen ,  Friedel Seuter

    IPC分类号： A61K31/40 ,  A61K31/445 ,  A61K31/4468 ,  A61P7/02 ,  C07D207/09 ,  C07D207/14 ,  C07D211/20 ,  C07D211/26 ,  C07D295/12

    CPC分类号： C07D207/09 ,  C07D211/26

    摘要： The invention provides novel antithrombotics diphenyl-disulphide-2,2'-bis-carboxylic acid amides of the general formula ##STR1## in which R.sup.1 represents a hydrogen or halogen atom or an optionally substituted alkyl, alkoxy or aralkoxy group,R.sup.2 represents a hydrogen or halogen atom or an optionally substituted alkyl or alkoxy group, or together with R.sup.1, and adjacent carbon atoms of the benzenoid nucleus, forms an optionally substituted aliphatic or carbocyclic aromatic ring,R.sup.3 represents an optionally substituted alkyl group,A represents a single bond or an optionally substituted alkylene chain andM and n each represents 0 or a number from 1 to 5, m and n together having a value of 2-5, and acid addition salts thereof.Also included in the invention are compositions containing said antithrombotic compounds and methods for using said compounds or compositions for combating thrombo-embolic illness. In addition, the invention includes methods for the preparation of the antithrombotic compounds.

    摘要翻译： 本发明提供了通式为其中R 1表示氢或卤素原子或任选取代的烷基，烷氧基或芳烷氧基的通式（Ⅰ）的新型抗血栓形成二苯基二硫化物-2,2'-双羧酸酰胺，R2 表示氢或卤素原子或任选取代的烷基或烷氧基，或与R 1和苯环的相邻碳原子一起形成任选取代的脂族或碳环芳环，R 3表示任选取代的烷基，A表示 单键或任选取代的亚烷基链，M和N每个表示0或1至5，M和N的数字为2-5，以及酸的添加量。

    Thrombin inhibitory new dihydroxybenzene ether derivatives
    4.
    发明授权
    Thrombin inhibitory new dihydroxybenzene ether derivatives 失效
    凝血酶抑制新二羟基苯醚衍生物

    公开(公告)号：US4590291A

    公开(公告)日：1986-05-20

    申请号：US385355

    申请日：1982-06-07

    申请人： Horst Boshagen ,  Ulrich Horlein ,  Gerd Reinhardt ,  Friedel Seuter ,  Elisabeth Perzborn

    发明人： Horst Boshagen ,  Ulrich Horlein ,  Gerd Reinhardt ,  Friedel Seuter ,  Elisabeth Perzborn

    IPC分类号： C07C69/92 ,  A61K31/085 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  C07C41/00 ,  C07C43/17 ,  C07C43/20 ,  C07C43/225 ,  C07C51/00 ,  C07C59/31 ,  C07C59/64 ,  C07C59/68 ,  C07C59/90 ,  C07C65/24 ,  C07C65/40 ,  C07C67/00 ,  C07C69/736 ,  C07C69/76 ,  C07C313/00 ,  C07C323/20

    CPC分类号： C07C65/24 ,  C07C59/68 ,  C07C59/90 ,  C07C65/40

    摘要： An ether derivative of a dihydroxybenzene of the formula ##STR1## in which R.sup.1 is 1 to 3 identical or different substituents selected from hydrogen, halogen, trifluoromethyl, carboxyl, alkyl, alkoxy, alkylmercapto and carbalkoxy, with in each case 1 to 4 carbon atoms in the alkyl and alkoxy groups, andR.sup.2 and R.sup.3 are different and each is an alkyl or alkenyl chain in which 1 or 2 CH.sub.2 chain members are optionally replaced by O, S, CO or a phenylene group, and/or in which the chain is optionally substituted by 1 to 3 identical or different substituents selected from hydroxyl, halogen, trifluoromethyl, phenyl, carboxyl, alkyl, alkoxy, alkylmercapto, carbalkoxy, and acyl, the phenyl radical in turn optionally being substituted by halogen, trifluoromethyl, carboxyl, alkyl, alkoxy, alkylmercapto or carbaloxy, and the abovementioned alkyl, alkoxy and acyl groups in each case containing 1 to 4 carbon atoms, and in which at least one of the radicals R.sup.2 or R.sup.3 is substituted and/or in at least one of the radicals R.sup.2 or R.sup.3 1 or 2 chain members are replaced by 1 or 2 identical or different radicals selected from O, S, CO and phenylene, is effective in combating cardiac infarcations, angina pectoric, thromboembolic illnesses, in venous and arterial regions and arteriosclerosis.

    摘要翻译： 其中R 1是1至3个相同或不同的选自氢，卤素，三氟甲基，羧基，烷基，烷氧基，烷基巯基和烷氧基的取代基的式“IMAGE”的二羟基苯的醚衍生物，在每种情况下为1至4个碳原子 在烷基和烷氧基中，且R 2和R 3不同，并且各自为烷基或烯基链，其中1或2个CH 2链成员任选被O，S，CO或亚苯基取代，和/或其中链 任选地被1至3个相同或不同的选自羟基，卤素，三氟甲基，苯基，羧基，烷基，烷氧基，烷基巯基，烷氧基和酰基的取代基取代，苯基依次任选被卤素，三氟甲基，羧基，烷基 ，烷氧基，烷基巯基或卡巴氧基，以及上述烷基，烷氧基和酰基，每种情况下含有1至4个碳原子，并且其中至少一个基团R 2或R 3被取代和/或至少一个o 基团R 2或R 3 1或2链成员被选自O，S，CO和亚苯基的1或2个相同或不同的基团取代，有效地对抗静脉和动脉区域的心脏梗塞，心绞痛，血栓栓塞性疾病，以及 动脉硬化。

    Benzomorphanes
    5.
    发明授权
    Benzomorphanes 失效
    苯并吡啶

    公开(公告)号：US3936463A

    公开(公告)日：1976-02-03

    申请号：US421439

    申请日：1973-12-03

    申请人： Otto Behner ,  Ulrich Horlein ,  Friedrich Hoffmeister ,  Hans Werner Schubert

    发明人： Otto Behner ,  Ulrich Horlein ,  Friedrich Hoffmeister ,  Hans Werner Schubert

    IPC分类号： C07D221/26

    CPC分类号： C07D221/26

    摘要： Benzomorphanes of the formula: ##SPC1##WhereinR is cyclopropylmethyl or cyclobutylmethyl;R.sup.1 and R.sup.2 are the same or different and each is lower alkyl;R.sup.3 is hydrogen; a straight, branched or cyclic, saturated, partially unsaturated or unsaturated aliphatic hydrocarbon unsubstituted or substituted by 1 or more substituents selected from the group consisting of lower alkoxy, lower alkoxycarbonyl, lower alkylmercapto, aryloxy, arylmercapto, arylamino, and an acid amide; an unsubstituted or substituted aromatic moiety; an unsubstituted or substituted 5-, 6- or 7-membered heterocyclic ring; lower alkylamino; di(lower alkyl)amino; arylamino; lower alkyl-arylamino; lower alkoxy; urethane; an acid amide; lower alkoxycarbonylamino; or lower alkoxycarbonyl-lower alkylamino; andA is a bivalent, straight- or branched-chain, saturated, partially unsaturated or unsaturated hydrocarbon of 2 to 10 carbon atoms, unsubstituted or substituted by phenyl or by phenyl substituted by at least 1 substituent selected from the group consisting of lower alkyl, lower alkoxy, nitro, amino and halogen,And pharmaceutically acceptable nontoxic salts thereof, are useful as analgesics.

    摘要翻译： 苯并吡啶的配方：