公开(公告)号：US06946363B2

公开(公告)日：2005-09-20

申请号：US10302196

申请日：2002-11-22

Applicant: Howard Davidson

Inventor： Howard Davidson

IPC: H01L21/48 ,  H01L21/58 ,  H01L23/36 ,  H01L21/46

CPC classification number: H01L24/83 ,  H01L21/4882 ,  H01L23/36 ,  H01L24/26 ,  H01L2224/8319 ,  H01L2224/8385 ,  H01L2224/83894 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01079 ,  H01L2924/014 ,  H01L2924/07802 ,  H01L2924/14

Abstract: A method for bonding diamond heat distribution structures to integrated circuit packages using optical contacting. In one embodiment, a heat spreader comprising diamond slab has a flat contact surface which is polished to a high degree of smoothness. An integrated circuit's package also has a flat contact surface which is polished to a high degree of smoothness. The contact surfaces of the diamond slab and the package are thoroughly cleaned and are then placed in contact with each other, establishing an optical contact bond between them. In one embodiment, the contact surfaces of the diamond and package which are to be bonded together are first polished, then a layer of an intermediate material such as silicon carbide is deposited on the polished surfaces. The silicon carbide layers on the contact surfaces are cleaned and placed in contact with each other to establish an optical contact bond. If desired, the silicon carbide layers on the contact surfaces may be activated with a substance such as hydrogen fluoride to promote bonding.

Abstract translation: 一种使用光学接触将金刚石散热结构结合到集成电路封装的方法。 在一个实施例中，包括金刚石板的散热器具有平坦的接触表面，其被抛光到高度的平滑度。 集成电路封装还具有平坦的接触表面，其被抛光到高度的平滑度。 金刚石板和封装的接触表面被彻底清洁，然后彼此接触，在它们之间建立光学接触。 在一个实施例中，首先研磨要结合在一起的金刚石和封装的接触表面，然后在抛光表面上沉积诸如碳化硅的中间材料层。 接触表面上的碳化硅层被清洁并且彼此接触以建立光学接触键。 如果需要，接触表面上的碳化硅层可以用诸如氟化氢的物质来活化以促进结合。

公开(公告)号：US06749931B1

公开(公告)日：2004-06-15

申请号：US09708100

申请日：2000-11-01

Applicant: John M. Pinneo ,  Howard Davidson

Inventor： John M. Pinneo ,  Howard Davidson

IPC: B32B326

CPC classification number: C23C16/045 ,  C01B32/25 ,  C23C16/27 ,  Y10T428/249956 ,  Y10T428/249967 ,  Y10T428/24997 ,  Y10T428/249974 ,  Y10T428/249978 ,  Y10T428/249979 ,  Y10T428/24998 ,  Y10T428/24999

Abstract: A diamond foam article comprises diamond deposited material on a substrate having an open contiguous structure that permits the flow of fluids in at least one direction through the material. Methods for forming a diamond foam article comprise providing a foam substrate; preparing the foam substrate for diamond deposition; and depositing diamond material on the foam substrate by one of several diamond deposition methods.

Abstract translation: 金刚石泡沫制品包括在基材上的金刚石沉积材料，其具有允许流体沿至少一个方向流过该材料的开放的连续结构。 用于形成金刚石泡沫制品的方法包括提供泡沫基材; 制备用于金刚石沉积的泡沫基材; 以及通过几种金刚石沉积方法之一将金刚石材料沉积在泡沫基材上。

公开(公告)号：US07003979B1

公开(公告)日：2006-02-28

申请号：US09524216

申请日：2000-03-13

Applicant: Howard Davidson

Inventor： Howard Davidson

IPC: F25B33/00

CPC classification number: F25B35/04

Abstract: A structure and method of manufacture for a sorber, wherein a mass of sorbent contained in a sorber enclosure comprises a plurality of sorbent disks stacked in face-to-face relation. The sorbent disks are formed from a solid sorbent material such as zeolite and contain surface features in at least one face of each disk which, when the disks are stacked, form passageways by which sorbate is distributed throughout the mass of sorbent material. In one embodiment, each sorbent disk is annular in shape and has a plurality of radial grooves which extend from the periphery of the disk to the aperture through the center of the disk. The disks are stacked face-to-face and an inner conductor is inserted through the center apertures of the disks. This assembly is then inserted into a conductive housing and is enclosed by a pair of end plugs or caps which are secured to the housing. A port in one of the end caps allows sorbate to enter and exit the sorber enclosure. The sorber structure forms a coaxial transmission line for electromagnetic waves which are used to desorb sorbate from the sorbent disks. Alternate embodiments may use sorbent disks which employ surface features other than grooves to provide passageways through the sorbent mass. Alternate embodiments may also have configurations which are not cylindrical and/or coaxial.

Abstract translation: 用于吸附器的结构和制造方法，其中包含在吸附器壳体中的吸收剂的质量包括以面对面的关系堆叠的多个吸附剂盘。 吸附剂盘由诸如沸石的固体吸附剂材料形成，并且在每个盘的至少一个表面中包含表面特征，当盘堆叠时，吸附剂盘形成通道，通过该通道，山梨酸盐分布在整个吸附剂材料块中。 在一个实施例中，每个吸附盘是环形的并且具有多个径向槽，其从盘的周边延伸通过盘的中心到孔。 磁盘面对面堆叠，内部导体插入磁盘的中心孔。 然后将该组件插入导电壳体中，并被固定到壳体上的一对端塞或盖封闭。 一个端盖中的一个端口允许山梨酸进入和离开吸附器外壳。 吸附器结构形成用于电磁波的同轴传输线，其用于从吸附剂盘解吸吸浆。 替代实施例可以使用吸附剂盘，其使用凹槽以外的表面特征来提供穿过吸附剂块的通道。 替代实施例也可以具有不是圆柱形和/或同轴的构造。

公开(公告)号：US06718559B1

公开(公告)日：2004-04-13

申请号：US10066347

申请日：2002-01-31

Applicant: Howard Davidson

Inventor： Howard Davidson

IPC: A42B124

CPC classification number: A42B3/227 ,  A42B3/0406 ,  G09F21/02 ,  Y10T24/3424 ,  Y10T24/3683 ,  Y10T24/4555 ,  Y10T24/45775

Abstract: A device is provided for attachment to the existing snap portions on a helmet such as a motorcycle helmet. Design elements are presented on a display member, and in some embodiments the display member extends across several helmet snap portions. One embodiment incorporates helmet accessories, such as visors, while still providing the outward presentation of the design elements on the display member.

Abstract translation: 提供了一种用于附接到诸如摩托车头盔的头盔上的现有卡扣部分的装置。 设计元件呈现在显示构件上，并且在一些实施例中，显示构件延伸跨越多个头盔卡扣部分。 一个实施例包括诸如遮阳板的头盔附件，同时仍然在显示构件上提供设计元素的外部呈现。

公开(公告)号：US06619858B1

公开(公告)日：2003-09-16

申请号：US09575418

申请日：2000-05-20

Applicant: Rick Lytel ,  Howard Davidson ,  Theresa Sze ,  Nyles Nettleton ,  Dawei Huang

Inventor： Rick Lytel ,  Howard Davidson ,  Theresa Sze ,  Nyles Nettleton ,  Dawei Huang

IPC: G02B636

CPC classification number: G02B6/43 ,  G02B6/4249

Abstract: An optical interconnect is provided that optically connects two adjacent printed circuit boards, or electrical component. The optical interconnect includes a floating frame which is flexibly connected to one electrical component. The floating frame includes a plurality of optical guides. The optical guides are connected to the electrical component either electronically or optically. A second frame, coupled to a second electrical component also contains a plurality of optical guides. A mechanical guide assembly positions the first frame and the second frame are optically coupled. The optical guide in the second frame connects to the second electrical component providing a path for a signal from the first electrical component to the second electrical component.

Abstract translation: 提供光学互连以光学连接两个相邻的印刷电路板或电气部件。 光学互连包括浮动框架，该浮动框架柔性地连接到一个电气部件。 浮动框架包括多个光导件。 光导件以电子方式或光学方式连接到电气部件。 耦合到第二电气部件的第二框架还包含多个光导件。 机械引导组件定位第一框架并且第二框架被光耦合。 第二框架中的光导件连接到第二电气部件，从而提供用于从第一电气部件到第二电气部件的信号的路径。

公开(公告)号：US20120321648A1

公开(公告)日：2012-12-20

申请号：US13593443

申请日：2012-08-23

Applicant: John C. Hutton ,  Richard O'Brien ,  Howard Davidson ,  Seija Hackl

Inventor： John C. Hutton ,  Richard O'Brien ,  Howard Davidson ,  Seija Hackl

IPC: A61K39/00 ,  A61P37/06 ,  A61P3/10 ,  C07K14/435 ,  G01N33/53

CPC classification number: G01N33/564 ,  A61K38/28 ,  A61K38/465 ,  A61K38/51 ,  C12N9/16 ,  G01N33/6854 ,  G01N2333/916 ,  G01N2800/042 ,  A61K2300/00

Abstract: A method and compositions for detecting autoimmunity to islet glucose-6-phosphatase related protein (IGRP). Detection of IGRP autoantibodies alone, and in combination with other molecules such as the 65-kDa form of glutamate decarboxylase (GAD65), insulin and insulin granule membrane proteins ICA512 (IA-2) and phogrin (IA2β) auto-antigens, provides an effective and reliable chemical assay for the diagnosis of autoimmune (type 1) diabetes. Additionally, this invention provides therapeutic regimens based on IGRP and related molecules for the amelioration of the diabetic clinical condition. Therefore, IGRP alone or in combination with other autoimmune diabetes associated antigens such as insulin, IA-2 and GAD65, is useful in the prediction (diagnosis), treatment (therapy), and prevention (prophylaxis) of diabetes.

Abstract translation: 用于检测胰岛素葡萄糖-6-磷酸酶相关蛋白（IGRP）的自身免疫的方法和组合物。 检测单独的IGRP自身抗体，与其他分子如65-kDa形式的谷氨酸脱羧酶（GAD65），胰岛素和胰岛素颗粒膜蛋白ICA512（IA-2）和phogrin（IA2＆bgr）自身抗原组合，提供了一种 有效和可靠的化学测定用于诊断自身免疫（1型）糖尿病。 此外，本发明提供了基于IGRP和相关分子用于改善糖尿病临床病症的治疗方案。 因此，IGRP单独或与其他自身免疫性糖尿病相关抗原如胰岛素，IA-2和GAD65组合可用于糖尿病的预测（诊断），治疗（治疗）和预防（预防）。

公开(公告)号：US20120070847A1

公开(公告)日：2012-03-22

申请号：US13128181

申请日：2009-11-05

Applicant: Jan Jensen ,  John Hutton ,  Xiaoling Qu ,  Howard Davidson

Inventor： Jan Jensen ,  John Hutton ,  Xiaoling Qu ,  Howard Davidson

IPC: G01N33/566 ,  C12Q1/02 ,  C07K16/28 ,  C12N5/071 ,  C07H21/04 ,  C07K14/705

CPC classification number: G01N33/56966 ,  C07K14/705 ,  C07K14/70503 ,  C07K16/28 ,  C07K16/2803 ,  C07K2319/30 ,  C12N5/0676 ,  G01N33/5032 ,  G01N33/507 ,  G01N33/6893 ,  G01N2333/705 ,  G01N2800/042

Abstract: The invention is based, in part, on the discovery that a polypeptide, referred to herein as Betacam, is selectively expressed on the surface of pancreatic islet cells, Thus, in one aspect, the invention is directed to compositions comprising Betacam or that can be used to detect Betacam. In another aspect, the invention provides methods of detecting (e.g., non-invasively) pancreatic beta cells from a mammalian cell source. Another aspect of the invention is directed to cellular purification of pancreatic beta cells from a heterogeneous cell source of multiple kinds. In another aspect, the invention provides methods of identifying agents that modulate activity of Betacam-In yet another aspect, the invention provides for improved treatment and diagnosis of diabetes.

Abstract translation: 本发明部分地基于以下发现：本文称为Betacam的多肽在胰岛细胞的表面上选择性表达。因此，一方面，本发明涉及包含Betacam或可以是 用于检测Betacam。 另一方面，本发明提供了从哺乳动物细胞来源检测（例如非侵入性）胰腺β细胞的方法。 本发明的另一方面涉及从多种异质细胞来源的胰腺β细胞的细胞纯化。 另一方面，本发明提供了鉴定调节Betacam-In的活性的试剂的方法。另一方面，本发明提供改善的糖尿病治疗和诊断。

公开(公告)号：US20070203059A1

公开(公告)日：2007-08-30

申请号：US10573280

申请日：2004-09-20

Applicant: John Hutton ,  Richard O'Brien ,  Howard Davidson ,  Seija Hackl

Inventor： John Hutton ,  Richard O'Brien ,  Howard Davidson ,  Seija Hackl

IPC: A61K38/22 ,  G01N33/53

CPC classification number: G01N33/564 ,  A61K38/28 ,  A61K38/465 ,  A61K38/51 ,  C12N9/16 ,  G01N33/6854 ,  G01N2333/916 ,  G01N2800/042 ,  A61K2300/00

Abstract: A method and compositions for detecting autoimmunity to islet glucose-6 phosphatase related protein (IGRP). Detection of IGRP autoantibodies alone, and in combination with other molecules such as the 65-kDa form of glutamate decarboxylase (GAD65), insulin and insulin granule membrane proteins ICA512 (IA-2) and phogrin (IA-2) auto-antigens, provides an effective and reliable chemical assay for the diagnosis of autoimmune (type 1) diabetes. Additionally, this invention provides therapeutic regimens based on IGRP and related molecules for the amelioration of the diabetic clinical condition. Therefore, IGRP alone or in combination with other autoimmune diabetes associated antigens such as insulin, IA-2 and GAD65, is useful in the prediction (diagnosis), treatment (therapy), and prevention (prophylaxis) of diabetes.

Abstract translation: 用于检测胰岛葡萄糖-6-磷酸酶相关蛋白（IGRP）的自身免疫的方法和组合物。 检测单独的IGRP自身抗体，并与其他分子如65-kDa形式的谷氨酸脱羧酶（GAD 65 N），胰岛素和胰岛素颗粒膜蛋白ICA512（IA-2）和phogrin（IA -2）自身抗原，为自身免疫（1型）糖尿病的诊断提供了有效和可靠的化学分析。 此外，本发明提供了基于IGRP和相关分子用于改善糖尿病临床病症的治疗方案。 因此，IGRP单独或与其他自身免疫性糖尿病相关抗原如胰岛素，IA-2和GAD 65组合可用于预测（诊断），治疗（治疗）和预防（预防） 的糖尿病

公开(公告)号：US20100143374A1

公开(公告)日：2010-06-10

申请号：US12521022

申请日：2007-12-28

Applicant: John C. Hutton ,  Janet M. Wenzlau ,  Jan Jensen ,  Howard Davidson

Inventor： John C. Hutton ,  Janet M. Wenzlau ,  Jan Jensen ,  Howard Davidson

IPC: G01N33/566 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C07K19/00 ,  C07K16/46 ,  A61K39/395 ,  A61K38/17 ,  A61P3/10

CPC classification number: C07K14/705 ,  C07K14/47 ,  G01N33/564 ,  G01N2800/042 ,  G01N2800/52

Abstract: Described is the identification of ZnT8 as an autoantigen target in type I autoimmune diabetes (T1D), other autoimmune disease, and other diabetes-linked diseases and conditions. Also described are a variety of therapeutic, diagnostic, and prognostic tools and methods based on this discovery. The identification of genetic variation in ZnT8 as an important player in the initiation of the disease process and the progression of autoimmunity to clinical diabetes is disclosed.

Abstract translation: 描述了在I型自身免疫性糖尿病（T1D），其他自身免疫疾病和其他与糖尿病相关的疾病和病症中鉴定ZnT8作为自身抗原靶标。 还描述了基于该发现的各种治疗，诊断和预后工具和方法。 本发明公开了ZnT8中作为起始疾病过程中的重要参与者和临床糖尿病的自身免疫进展的遗传变异的鉴定。

公开(公告)号：US20070115004A1

公开(公告)日：2007-05-24

申请号：US11284354

申请日：2005-11-21

Applicant: Russell Mirov ,  Howard Davidson

Inventor： Russell Mirov ,  Howard Davidson

IPC: G01R31/04

CPC classification number: G01R31/312 ,  G01R31/046 ,  G01R31/2812 ,  G01R31/2853

Abstract: A system configured to detect faults in signal lines. A system includes a first component configured to communicate with a second component via a signal path including one or more signal traces. Sense signal lines are manufactured such that at some point they are in close proximity to a signal trace which is to be monitored. The sense signal lines are configured to use parasitic coupling to redirect a portion of a signal conveyed via a signal trace to a monitoring component. The first component is configured to convey a test signal indicative of a type of test via the signal path, and a reference signal to the monitoring component. The monitoring component is configured to utilize the reference signal to ascertain a presence or absence, or characteristics of a received redirected signal. The monitoring component may optionally utilize a locally generated reference signal.

Abstract translation: 被配置为检测信号线路中的故障的系统。 系统包括被配置为经由包括一个或多个信号迹线的信号路径与第二部件通信的第一部件。 感测信号线被制造成使得在某些点处它们处于要被监控的信号迹线附近。 感测信号线被配置为使用寄生耦合来将经由信号迹线传送的信号的一部分重定向到监视部件。 第一组件被配置为经由信号路径传送指示测试类型的测试信号，以及向监视组件传送参考信号。 监视组件被配置为利用参考信号来确定所接收的重定向信号的存在或不存在或特性。 监视组件可以可选地利用本地生成的参考信号。