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公开(公告)号:US5773476A
公开(公告)日:1998-06-30
申请号:US486775
申请日:1995-06-07
申请人: Hui Chen , Aviv Gazit , Alexander Levitzki , Klaus Peter Hirth , Elaina Mann , Laura K. Shawver , Jianming Tsai , Peng Cho Tang
发明人: Hui Chen , Aviv Gazit , Alexander Levitzki , Klaus Peter Hirth , Elaina Mann , Laura K. Shawver , Jianming Tsai , Peng Cho Tang
IPC分类号: A61K31/245 , A61K31/277 , A61K31/415 , A61K31/4184 , A61K31/4402 , A61K31/498 , A61K31/517 , C07C229/60 , C07C255/36 , C07C255/37 , C07C255/41 , C07C255/42 , C07C255/66 , C07C311/27 , C07C317/46 , C07C327/44 , C07D241/52 , A01N37/18
CPC分类号: C07D241/52 , A61K31/245 , A61K31/277 , A61K31/415 , A61K31/4184 , A61K31/4402 , A61K31/498 , A61K31/517 , C07C229/60 , C07C255/36 , C07C255/37 , C07C255/41 , C07C255/42 , C07C255/66 , C07C311/27 , C07C317/46 , C07C327/44
摘要: The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers charcterized by over-activity or inappropriate activity HER2 or EGFR.
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2.
公开(公告)号:US07217737B2
公开(公告)日:2007-05-15
申请号:US10602617
申请日:2003-06-25
申请人: Hui Chen , Aviv Gazit , Alexander Levitzki , Klaus Peter Hirth , Elaina Mann , Peng Cho Tang , Laura K. Shawver , Jianming Tsai
发明人: Hui Chen , Aviv Gazit , Alexander Levitzki , Klaus Peter Hirth , Elaina Mann , Peng Cho Tang , Laura K. Shawver , Jianming Tsai
IPC分类号: A61K31/275
CPC分类号: C07D241/52 , A61K31/245 , A61K31/277 , A61K31/415 , A61K31/4184 , A61K31/4402 , A61K31/498 , A61K31/517 , C07C229/60 , C07C255/36 , C07C255/37 , C07C255/41 , C07C255/42 , C07C255/66 , C07C311/27 , C07C317/46 , C07C327/44
摘要: The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers characterized by over-activity or inappropriate activity HER2 or EGFR.
摘要翻译: 本发明涉及化合物及其抑制受体酪氨酸激酶活性的用途。 本发明优选用于治疗细胞增殖性疾病,例如以过度活动或不适当活性HER2或EGFR为特征的癌症。
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3.
公开(公告)号:US06596878B2
公开(公告)日:2003-07-22
申请号:US09953933
申请日:2001-09-18
申请人: Hui Chen , Aviv Gazit , Alexander Levitzki , Klaus Peter Hirth , Elaina Mann , Laura K. Shawver , Jianming Tsai , Peng Cho Tang
发明人: Hui Chen , Aviv Gazit , Alexander Levitzki , Klaus Peter Hirth , Elaina Mann , Laura K. Shawver , Jianming Tsai , Peng Cho Tang
IPC分类号: C07D23138
CPC分类号: C07D241/52 , A61K31/245 , A61K31/277 , A61K31/415 , A61K31/4184 , A61K31/4402 , A61K31/498 , A61K31/517 , C07C229/60 , C07C255/36 , C07C255/37 , C07C255/41 , C07C255/42 , C07C255/66 , C07C311/27 , C07C317/46 , C07C327/44
摘要: The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers characterized by over-activity or inappropriate activity HER2 or EGFR.
摘要翻译: 本发明涉及化合物及其抑制受体酪氨酸激酶活性的用途。 本发明优选用于治疗细胞增殖性疾病,例如以过度活动或不适当活性HER2或EGFR为特征的癌症。
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公开(公告)号:US5789427A
公开(公告)日:1998-08-04
申请号:US399967
申请日:1995-03-07
申请人: Hui Chen , Aviv Gazit , Klaus Peter Hirth , Elaina Mann , Laura K. Shawver , Jianming Tsai , Peng Cho Tang
发明人: Hui Chen , Aviv Gazit , Klaus Peter Hirth , Elaina Mann , Laura K. Shawver , Jianming Tsai , Peng Cho Tang
IPC分类号: A61K31/245 , A61K31/277 , A61K31/415 , A61K31/4184 , A61K31/4402 , A61K31/498 , A61K31/517 , C07C229/60 , C07C255/36 , C07C255/37 , C07C255/41 , C07C255/42 , C07C255/66 , C07C311/27 , C07C317/46 , C07C327/44 , C07D241/52 , A01N43/40 , C07D211/72
CPC分类号: C07D241/52 , A61K31/245 , A61K31/277 , A61K31/415 , A61K31/4184 , A61K31/4402 , A61K31/498 , A61K31/517 , C07C229/60 , C07C255/36 , C07C255/37 , C07C255/41 , C07C255/42 , C07C255/66 , C07C311/27 , C07C317/46 , C07C327/44
摘要: The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers characterized by over-activity or inappropriate activity HER2 or EGFR.
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公开(公告)号:US20160147526A1
公开(公告)日:2016-05-26
申请号:US14950012
申请日:2015-11-24
CPC分类号: G06F8/65 , G06F8/60 , G06F9/44505 , H04L67/34 , H04W4/50
摘要: Systems and methods for centralized client application management are provided. In an example embodiment, device data is received from a user device. The user device is identified according to an identification rule. A client state is received from the user device. A match between the client state and a specified state is determined. Based on the client state matching the specified state, an instruction to be performed on the user device is generated. The instruction is caused to be performed on the user device. The instruction causes a change to the client state stored on the user device.
摘要翻译: 提供了集中式客户端应用程序管理的系统和方法。 在示例实施例中,从用户设备接收设备数据。 根据识别规则识别用户设备。 从用户设备接收到客户端状态。 确定客户端状态和指定状态之间的匹配。 基于与指定状态匹配的客户端状态,生成在用户装置上执行的指令。 导致在用户设备上执行指令。 该指令改变存储在用户设备上的客户端状态。
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公开(公告)号:US08871999B2
公开(公告)日:2014-10-28
申请号:US11666714
申请日:2005-10-31
申请人: Gregg A. Howe , Hui Chen
发明人: Gregg A. Howe , Hui Chen
IPC分类号: A01H1/00 , C12N15/00 , C12N15/29 , C12N15/52 , C12N9/78 , C12N15/82 , C12N9/88 , C07H21/04 , C07K14/415
CPC分类号: C12N15/8286 , C12N9/78 , C12N9/88 , C12N15/8251 , Y02A40/162
摘要: The present invention relates to genes, proteins and methods comprising molecules that alter amino acid levels. In one embodiment, the present invention relates to altering guanidino substrate hydrolysis activities in plants, arthropods and microorganisms using molecules within the arginase family and other molecules that alter an amino acid levels. In ones embodiment, the present invention relates to altering threonine substrate deamination and dehydration activities in plants, arthropods and microorganisms using molecules within the threonine deaminase family and other molecules that alter amino acid levels. In one embodiment, the present invention relates to using genes, proteins and methods comprising arginase or threonine deaminase for altering the pathophysiology of plants, arthropods and microorganisms. In a preferred embodiment, the present invention relates to altering guanidino substrate hydrolysis activity in plants, arthropods, and microorganisms using arginase. In another preferred embodiment, the invention relates to altering threonine substrated deamination and dehydration activity in plants, arthropods, and microorganisms using threonine deaminase. In some embodiments, the invention related to overexpression and increased activity of arginase, threonine deaminase and a proteinase inhibitor.
摘要翻译: 本发明涉及包含改变氨基酸水平的分子的基因,蛋白质和方法。 在一个实施方案中,本发明涉及使用精氨酸酶家族内的分子和改变氨基酸水平的其它分子改变植物,节肢动物和微生物中胍基底物水解活性。 在一个实施方案中,本发明涉及使用苏氨酸脱氨酶家族内的分子和改变氨基酸水平的其它分子改变植物,节肢动物和微生物中的苏氨酸底物脱氨和脱水活性。 在一个实施方案中,本发明涉及使用包含精氨酸酶或苏氨酸脱氨酶的基因,蛋白质和方法来改变植物,节肢动物和微生物的病理生理学。 在优选的实施方案中,本发明涉及使用精氨酸酶改变植物,节肢动物和微生物中的胍基底物水解活性。 在另一个优选的实施方案中,本发明涉及使用苏氨酸脱氨酶改变植物,节肢动物和微生物中的苏氨酸降解脱水活性和脱水活性。 在一些实施方案中,本发明涉及精氨酸酶,苏氨酸脱氨酶和蛋白酶抑制剂的过表达和增加的活性。
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公开(公告)号:US08829081B2
公开(公告)日:2014-09-09
申请号:US13427361
申请日:2012-03-22
申请人: Hui Chen , Ming-Yu Lo , Yu-Cheng Kuo
发明人: Hui Chen , Ming-Yu Lo , Yu-Cheng Kuo
IPC分类号: C08F265/06 , C09D183/04 , C08G77/20
CPC分类号: C08F265/06 , B01J13/18 , C08F257/02 , C08G77/20 , C08L2207/53 , C09D183/04 , Y10S525/902 , C08F2/22
摘要: A method of preparing core-shell submicron spheres is disclosed. The method comprises steps hereafter. An emulsion containing a core monomer is heated to a temperature of 10° C. below its boiling point to the boiling point. A core forming step is performed by adding an initiator solution to the heated emulsion to form cores by polymerizing the core monomer. When the conversion of the above polymerization is 10% to 95%, a shell forming step is performed by adding a shell monomer into the emulsion, at a temperature of 50° C. below the emulsion's boiling point to the boiling point thereof, to form shells, respectively surrounding the cores, by polymerizing the shell monomer.
摘要翻译: 公开了制备核 - 壳亚微米球的方法。 该方法包括以下步骤。 将含有核心单体的乳液加热至低于沸点至10℃的温度。 通过将引发剂溶液加入到加热的乳液中以通过聚合核心单体形成核来进行核心形成步骤。 当上述聚合的转化率为10%至95%时,通过在低于乳液沸点至其沸点的50℃的温度下将壳单体加入到乳液中进行壳形成步骤,以形成 壳,分别围绕芯,通过聚合壳单体。
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