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21 条记录 (耗时 0.026 秒)

    Polymeric Micelle Composition for Treatment of Resistant Cancer and Preparation Method of the Same
    2.
    发明申请
    Polymeric Micelle Composition for Treatment of Resistant Cancer and Preparation Method of the Same 审中-公开
    用于治疗耐药性的聚合物胶束组合物及其制备方法

    公开(公告)号：US20110224151A1

    公开(公告)日：2011-09-15

    申请号：US13130259

    申请日：2009-11-23

    申请人： Hye-Won Kang ,  Min Hyo Seo ,  Bong Oh Kim

    发明人： Hye-Won Kang ,  Min Hyo Seo ,  Bong Oh Kim

    IPC分类号： A61K38/13 ,  A61P35/00 ,  B01J13/02

    CPC分类号： A61K31/335 ,  A61K9/1075

    摘要： Disclosed are a polymer micelle composition for treatment of resistant cancer cells that contains an amphiphilic double block copolymer and taxane and a P-glycoprotein inhibitor of cyclosporin as its active ingredients, and a method of preparing the same. Said polymer micelle composition for treatment of cancer resistant cells is accumulated in cancer tissue at high concentrations, and has the advantages that it exhibits superior anti-cancer effects for the cancer cells that have exhibited resistance due to over-expression of P-glycoprotein by the taxane anticancer agent in said cancer tissue, and does not cause hypersensitive reactions due to the use of a solubilizer.

    摘要翻译： 公开了一种用于治疗含有两亲性双嵌段共聚物和紫杉烷和环孢菌素P-糖蛋白抑制剂作为其活性成分的抗性癌细胞的聚合物胶束组合物及其制备方法。 用于治疗耐癌细胞的所述聚合物胶束组合物以高浓度积聚在癌组织中，并且具有对由于P-糖蛋白过度表达而显示出抗性的癌细胞具有优异的抗癌作用的优点 所述癌组织中的紫杉烷抗癌剂，并且由于使用增溶剂而不引起过敏反应。

    SUBMICRON NANOPARTICLE OF POORLY WATER SOLUBLE CAMPTOTHECIN DERIVATIVES AND PROCESS FOR PREPARATION THEREOF
    3.
    发明申请
    SUBMICRON NANOPARTICLE OF POORLY WATER SOLUBLE CAMPTOTHECIN DERIVATIVES AND PROCESS FOR PREPARATION THEREOF 审中-公开
    不溶性水溶性衍生物的亚硝酸盐及其制备方法

    公开(公告)号：US20100008998A1

    公开(公告)日：2010-01-14

    申请号：US12442819

    申请日：2007-09-20

    申请人： Hye Won Kang ,  Eun Young Yim ,  Min Hyo Seo

    发明人： Hye Won Kang ,  Eun Young Yim ,  Min Hyo Seo

    IPC分类号： A61K31/4745 ,  A61P35/00 ,  A61K9/14

    CPC分类号： A61K9/14 ,  A61K9/0019 ,  A61K9/19

    摘要： The present invention relates to a nanoparticle composition comprising a camptothecin derivative, solid polyethyleneglycol and an anti-associative agent, and the process for preparing the same. Specifically, the present invention provides a composition comprising a nanoparticle of the camptothecin derivative, which is prepared by solid-dispersing the poorly water soluble camptothecin derivative in polyethyleneglycol and dissolving the solid dispersions in an aqueous solution containing an anti-associative agent. The composition of the present invention stabilizes the camptothecin derivative lactone form in body fluid for effective anticancer activity.

    摘要翻译： 本发明涉及包含喜树碱衍生物，固体聚乙二醇和抗结合剂的纳米颗粒组合物及其制备方法。 具体地说，本发明提供包含喜树碱衍生物的纳米颗粒的组合物，其通过将难溶于水的喜树碱衍生物固体分散在聚乙二醇中并将固体分散体溶解在含有抗关联剂的水溶液中制备。 本发明的组合物稳定了体液中的喜树碱衍生物内酯形式，有效的抗癌活性。

    Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
    4.
    发明授权
    Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery 有权
    两亲性嵌段共聚物和包含其用于药物递送的聚合物组合物

    公开(公告)号：US07311901B2

    公开(公告)日：2007-12-25

    申请号：US10962204

    申请日：2004-10-07

    申请人： Min Hyo Seo ,  Bong Oh Kim ,  In Ja Choi ,  Myung Seob Shim

    发明人： Min Hyo Seo ,  Bong Oh Kim ,  In Ja Choi ,  Myung Seob Shim

    IPC分类号： A61K31/74 ,  A61K47/48 ,  C08L39/04

    CPC分类号： A61K9/1075 ,  C08G63/08 ,  C08L53/00 ,  C08L2666/14 ,  C08L2666/02

    摘要： The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.

    摘要翻译： 本发明涉及亲水嵌段和具有末端羟基的疏水嵌段的两亲嵌段共聚物，其中疏水基团的末端羟基被生育酚或胆固醇基团取代。 它还涉及能够在水溶液中形成稳定的胶束的聚合物组合物，其包含两亲嵌段共聚物和聚乳酸衍生物，其中聚乳酸的一个或多个末端与至少一个羧基共价结合。

    HIGHLY PURE POLOXAMERS AND PURIFICATION METHOD THEREOF
    10.
    发明申请
    HIGHLY PURE POLOXAMERS AND PURIFICATION METHOD THEREOF 审中-公开
    高纯度POLOXAMERS及其纯化方法

    公开(公告)号：US20130274421A1

    公开(公告)日：2013-10-17

    申请号：US13976228

    申请日：2011-12-22

    申请人： Bong Oh Kim ,  Min Hyo Seo

    发明人： Bong Oh Kim ,  Min Hyo Seo

    IPC分类号： C08G65/30

    CPC分类号： C08G65/30 ,  B01D15/02 ,  C08G2650/58

    摘要： Disclosed are a method for purifying poloxamers, comprising dissolving poloxamers in an organic solvent to prepare a polymer solution, and removing organometals or water from the polymer solution by at least one physical method selected from mixing of activated carbon with the polymer solution and centrifugation of the polymer solution, and poloxamers purified by the method.

    摘要翻译： 公开了一种用于纯化泊洛沙姆的方法，包括将泊洛沙姆溶解在有机溶剂中以制备聚合物溶液，并通过至少一种选自活性炭与聚合物溶液的混合的物理方法从聚合物溶液中除去有机金属或水，并将 聚合物溶液和通过该方法纯化的泊洛沙姆。