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公开(公告)号：US11054624B2
公开(公告)日：2021-07-06
申请号：US15852699
申请日：2017-12-22
Applicant: Illumina, Inc.
Inventor： Ashkan Arianpour , John Bailey , Dustin Blair , Xiangling (Steve) Chen , Stanley S. Hong , Simon Prince , Merek C. Siu , Chunhong (Allen) Zhou , Danilo Condello
Abstract: An imaging system may include a sample stage comprising a surface to support a sample container, the sample container having a plurality of sample locations; an optical stage having an objective lens, the optical stage being positionable relative to the sample stage to image samples at the sample locations; an actuator physically coupled to at least one of the sample stage and the optical stage to move the sample stage relative to the optical stage to focus the optical stage onto a current sample location; and a drive circuit to determine a focus setting for a next sample location and to provide a drive signal to the actuator before the optical stage is positioned to image a sample at the next sample location, wherein at least one parameter of the drive signal is determined using a difference between a focus setting for the current sample location and the determined focus setting for the next sample location.
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公开(公告)号：US20180259760A1
公开(公告)日：2018-09-13
申请号：US15913903
申请日：2018-03-06
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Simon Prince , John O'Shaughnessy , Christophe Sigel , Ashkan Arianpour
Abstract: Provided herein is an imaging system including a light source; a first focusing lens positioned to focus a beam from the light source to a beam waist at a predetermined location along an optical path of the beam in the imaging system; a beam splitter positioned relative to the first focusing lens to receive the beam from the first focusing lens and to create first and second beams; a second focusing lens positioned to receive the first and second beams output by the beam splitter, to focus the received first and second beams to a spot sized dimensioned to fall within a sample to be image, and further positioned to receive first and second beams reflected from the sample; an image sensor positioned to receive the light beams reflected from the sample; and a roof prism positioned in the optical path between the second focusing lens and the image sensor.
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Patent Agency Ranking
公开(公告)号：US11977213B2
公开(公告)日：2024-05-07
申请号：US17339587
申请日：2021-06-04
Applicant: ILLUMINA, INC.
Inventor： Ashkan Arianpour , John Bailey , Dustin Blair , Xiangling (Steve) Chen , Stanley S. Hong , Simon Prince , Merek C. Siu , Chunhong (Allen) Zhou , Danilo Condello
CPC classification number: G02B21/002 , G02B7/09 , G02B7/102 , G02B21/006 , G02B21/245 , G02B27/16
Abstract: An imaging system may include a sample stage comprising a surface to support a sample container, the sample container including a sample having a plurality of sample locations; an optical stage to image the sample at the plurality of sample locations; one or more actuators physically coupled to at least one of the sample stage and the optical stage to move the sample stage relative to the optical stage to focus the optical stage onto a current sample location of the plurality of sample locations; a first light source to illuminate the current sample location; a second light source to project a pair of spots on a next sample location of the plurality of sample locations; and a controller to determine, based on an image of the pair of spots projected on the next sample location, a focus setting for the next sample location.
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公开(公告)号：US11143856B2
公开(公告)日：2021-10-12
申请号：US16542640
申请日：2019-08-16
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Simon Prince , John O'Shaughnessy , Christophe Sigel , Ashkan Arianpour
Abstract: An imaging system including a light source; a first focusing lens positioned to focus a beam from the light source to a beam waist at a predetermined location along an optical path of the beam in the imaging system; a beam splitter positioned relative to the first focusing lens to receive the beam from the first focusing lens and to create first and second beams; a second focusing lens positioned to receive the first and second beams output by the beam splitter, to focus the received first and second beams to a spot sized dimensioned to fall within a sample to be image, and further positioned to receive first and second beams reflected from the sample; an image sensor positioned to receive the light beams reflected from the sample; and a roof prism positioned in the optical path between the second focusing lens and the image sensor.
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公开(公告)号：US20210294083A1
公开(公告)日：2021-09-23
申请号：US17339587
申请日：2021-06-04
Applicant: ILLUMINA, INC.
Inventor： Ashkan Arianpour , John Bailey , Dustin Blair , Xiangling (Steve) Chen , Stanley S. Hong , Simon Prince , Merek C. Siu , Chunhong (Allen) Zhou , Danilo Condello
Abstract: An imaging system may include a sample stage comprising a surface to support a sample container, the sample container including a sample having a plurality of sample locations; an optical stage to image the sample at the plurality of sample locations; one or more actuators physically coupled to at least one of the sample stage and the optical stage to move the sample stage relative to the optical stage to focus the optical stage onto a current sample location of the plurality of sample locations; a first light source to illuminate the current sample location; a second light source to project a pair of spots on a next sample location of the plurality of sample locations; and a controller to determine, based on an image of the pair of spots projected on the next sample location, a focus setting for the next sample location.
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公开(公告)号：US10416428B2
公开(公告)日：2019-09-17
申请号：US15913903
申请日：2018-03-06
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Simon Prince , John O'Shaughnessy , Christophe Sigel , Ashkan Arianpour
Abstract: An imaging system including a light source; a first focusing lens positioned to focus a beam from the light source to a beam waist at a predetermined location along an optical path of the beam in the imaging system; a beam splitter positioned relative to the first focusing lens to receive the beam from the first focusing lens and to create first and second beams; a second focusing lens positioned to receive the first and second beams output by the beam splitter, to focus the received first and second beams to a spot sized dimensioned to fall within a sample to be image, and further positioned to receive first and second beams reflected from the sample; an image sensor positioned to receive the light beams reflected from the sample; and a roof prism positioned in the optical path between the second focusing lens and the image sensor.
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公开(公告)号：US20180188514A1
公开(公告)日：2018-07-05
申请号：US15852699
申请日：2017-12-22
Applicant: Illumina, Inc.
Inventor： Ashkan Arianpour , John Bailey , Dustin Blair , Xiangling (Steve) Chen , Stanley S. Hong , Simon Prince , Merek C. Siu , Chunhong (Allen) Zhou , Danilo Condello
CPC classification number: G02B21/002 , G02B7/09 , G02B7/102 , G02B21/006 , G02B27/16
Abstract: An imaging system may include a sample stage comprising a surface to support a sample container, the sample container having a plurality of sample locations; an optical stage having an objective lens, the optical stage being positionable relative to the sample stage to image samples at the sample locations; an actuator physically coupled to at least one of the sample stage and the optical stage to move the sample stage relative to the optical stage to focus the optical stage onto a current sample location; and a drive circuit to determine a focus setting for a next sample location and to provide a drive signal to the actuator before the optical stage is positioned to image a sample at the next sample location, wherein at least one parameter of the drive signal is determined using a difference between a focus setting for the current sample location and the determined focus setting for the next sample location.
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