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公开(公告)号：US11815458B2
公开(公告)日：2023-11-14
申请号：US17247777
申请日：2020-12-22
Applicant: Illumina, Inc.
Inventor： Simon Prince , Danilo Condello , Vincent Hsieh , Krysada Phounsiri , John O'Shaughnessy
CPC classification number: G01N21/6458 , G01N2021/058 , G01N2021/6463 , G01N2021/6482
Abstract: A method comprises: directing, using an objective and a first reflective surface, first autofocus light toward a sensor, the first autofocus light reflected from a first surface of a substrate; preventing second autofocus light from reaching the sensor, the second autofocus light reflected from a second surface of the substrate; and directing, using the objective and a second reflective surface, emission light toward the sensor, the emission light originating from a sample at the substrate.
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公开(公告)号：US20210199587A1
公开(公告)日：2021-07-01
申请号：US17247777
申请日：2020-12-22
Applicant: Illumina, Inc.
Inventor： Simon Prince , Danilo Condello , Vincent Hsieh , Krysada Phounsiri , John O'Shaughnessy
IPC: G01N21/64
Abstract: A method comprises: directing, using an objective and a first reflective surface, first autofocus light toward a sensor, the first autofocus light reflected from a first surface of a substrate; preventing second autofocus light from reaching the sensor, the second autofocus light reflected from a second surface of the substrate; and directing, using the objective and a second reflective surface, emission light toward the sensor, the emission light originating from a sample at the substrate.
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Patent Agency Ranking
公开(公告)号：US11143856B2
公开(公告)日：2021-10-12
申请号：US16542640
申请日：2019-08-16
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Simon Prince , John O'Shaughnessy , Christophe Sigel , Ashkan Arianpour
Abstract: An imaging system including a light source; a first focusing lens positioned to focus a beam from the light source to a beam waist at a predetermined location along an optical path of the beam in the imaging system; a beam splitter positioned relative to the first focusing lens to receive the beam from the first focusing lens and to create first and second beams; a second focusing lens positioned to receive the first and second beams output by the beam splitter, to focus the received first and second beams to a spot sized dimensioned to fall within a sample to be image, and further positioned to receive first and second beams reflected from the sample; an image sensor positioned to receive the light beams reflected from the sample; and a roof prism positioned in the optical path between the second focusing lens and the image sensor.
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公开(公告)号：US10416428B2
公开(公告)日：2019-09-17
申请号：US15913903
申请日：2018-03-06
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Simon Prince , John O'Shaughnessy , Christophe Sigel , Ashkan Arianpour
Abstract: An imaging system including a light source; a first focusing lens positioned to focus a beam from the light source to a beam waist at a predetermined location along an optical path of the beam in the imaging system; a beam splitter positioned relative to the first focusing lens to receive the beam from the first focusing lens and to create first and second beams; a second focusing lens positioned to receive the first and second beams output by the beam splitter, to focus the received first and second beams to a spot sized dimensioned to fall within a sample to be image, and further positioned to receive first and second beams reflected from the sample; an image sensor positioned to receive the light beams reflected from the sample; and a roof prism positioned in the optical path between the second focusing lens and the image sensor.
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公开(公告)号：US11125988B2
公开(公告)日：2021-09-21
申请号：US15913892
申请日：2018-03-06
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Simon Prince , David Hargis , John O'Shaughnessy , William Butterfield , Jeffrey Bendick , Peter Clarke Newman
Abstract: Systems and methods disclosed herein include an optical blocking structure that may include a frame defining an aperture, first and second elongate structural members each comprising first and second ends such that the first and second elongate structural members may be connected at their first ends to opposite sides of the aperture, and further such that the first and second elongate structural members may extend from the frame parallel to and in the same direction as one another; and an optically opaque blocking member positioned to extend between the respective second ends of the first and second blocking members.
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公开(公告)号：US20180259760A1
公开(公告)日：2018-09-13
申请号：US15913903
申请日：2018-03-06
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Simon Prince , John O'Shaughnessy , Christophe Sigel , Ashkan Arianpour
Abstract: Provided herein is an imaging system including a light source; a first focusing lens positioned to focus a beam from the light source to a beam waist at a predetermined location along an optical path of the beam in the imaging system; a beam splitter positioned relative to the first focusing lens to receive the beam from the first focusing lens and to create first and second beams; a second focusing lens positioned to receive the first and second beams output by the beam splitter, to focus the received first and second beams to a spot sized dimensioned to fall within a sample to be image, and further positioned to receive first and second beams reflected from the sample; an image sensor positioned to receive the light beams reflected from the sample; and a roof prism positioned in the optical path between the second focusing lens and the image sensor.
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公开(公告)号：US20180259758A1
公开(公告)日：2018-09-13
申请号：US15913892
申请日：2018-03-06
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Simon Prince , David Hargis , John O'Shaughnessy , William Butterfield , Jeffrey Bendick , Peter Clarke Newman
CPC classification number: G02B21/002 , G02B21/06 , G02B21/18 , G02B21/245 , G02B21/36 , G02B21/361
Abstract: Systems and methods disclosed herein include an optical blocking structure that may include a frame defining an aperture, first and second elongate structural members each comprising first and second ends such that the first and second elongate structural members may be connected at their first ends to opposite sides of the aperture, and further such that the first and second elongate structural members may extend from the frame parallel to and in the same direction as one another; and an optically opaque blocking member positioned to extend between the respective second ends of the first and second blocking members.
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