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公开(公告)号：US20230201825A1
公开(公告)日：2023-06-29
申请号：US18086347
申请日：2022-12-21
Applicant: ILLUMINA, INC.
Inventor： Dustin Blair , Xiangxiong Chen , Gabriel Chan , Bindya Rani Dhanekula , John Earney , Damian Kelley
CPC classification number: B01L3/502715 , G01J5/80 , B01L2300/1894 , B01L2300/0877
Abstract: Systems and related temperature calibration methods. In accordance with a first implementation, an apparatus includes a flow cell interface, a temperature control device, an infrared sensor, and a controller. The flow cell interface includes a flow cell support and the temperature control device is for the flow cell support. The controller is to command the temperature control device to cause the flow cell support to achieve a temperature value, cause the infrared sensor to measure an actual temperature value of the flow cell support, and calibrate the temperature control device based on a difference between the commanded temperature value and the actual temperature value.
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公开(公告)号：US20230228984A1
公开(公告)日：2023-07-20
申请号：US18097947
申请日：2023-01-17
Applicant: ILLUMINA, INC.
Inventor： Dakota Watson , Merek Siu , Dustin Blair , Danilo Condello , John Earney , Paul Sangiorgio
CPC classification number: G02B21/245 , G02B21/26 , G02B21/0036 , G02B21/0032 , H04N23/56 , G02B21/0076 , G02B21/362
Abstract: Some implementations of the disclosure relate to an imaging system, including: a sample holder to support a sample container having multiple sample locations; an optical stage having; an assembly comprising one or more actuators physically coupled to the sample holder to tilt the sample holder relative to the optical stage during imaging of the multiple sample locations to focus the optical stage onto a current sample location; a first light source to project a first pair of spots on the sample container; and a controller to control, based on a sample tilt determined from a first separation measurement of the first pair of spots from one or more images taken by an image sensor at one or more of the sample locations, the one or more actuators to tilt the sample holder along a first direction of the imaging or a second direction substantially perpendicular to the first direction.
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公开(公告)号：US10834308B2
公开(公告)日：2020-11-10
申请号：US16245128
申请日：2019-01-10
Applicant: Illumina, Inc.
Inventor： Chunhong (Allen) Zhou , John Bailey , Dustin Blair
Abstract: An imaging system may include a sample stage having a surface to support a sample to be scanned by the imaging system; an optical stage having an objective lens, the optical stage being positionable relative to the sample stage; an actuator physically coupled to at least one of the sample stage and the optical stage to move the sample stage relative to the optical stage; a servo circuit to control the actuator; a first set of control parameters to control the servo circuit; a second set of control parameters to control the servo circuit; and a servo control circuit to apply the first set of control parameters to the servo circuit when the imaging system is operating in a first mode of operation and to apply the second set of control parameters to the servo circuit when the imaging system is operating in a second mode of operation.
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公开(公告)号：US20190222743A1
公开(公告)日：2019-07-18
申请号：US16245128
申请日：2019-01-10
Applicant: Illumina, Inc.
Inventor： Chunhong (Allen) Zhou , John Bailey , Dustin Blair
Abstract: An imaging system may include a sample stage having a surface to support a sample to be scanned by the imaging system; an optical stage having an objective lens, the optical stage being positionable relative to the sample stage; an actuator physically coupled to at least one of the sample stage and the optical stage to move the sample stage relative to the optical stage; a servo circuit to control the actuator; a first set of control parameters to control the servo circuit; a second set of control parameters to control the servo circuit; and a servo control circuit to apply the first set of control parameters to the servo circuit when the imaging system is operating in a first mode of operation and to apply the second set of control parameters to the servo circuit when the imaging system is operating in a second mode of operation.
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公开(公告)号：US11054624B2
公开(公告)日：2021-07-06
申请号：US15852699
申请日：2017-12-22
Applicant: Illumina, Inc.
Inventor： Ashkan Arianpour , John Bailey , Dustin Blair , Xiangling (Steve) Chen , Stanley S. Hong , Simon Prince , Merek C. Siu , Chunhong (Allen) Zhou , Danilo Condello
Abstract: An imaging system may include a sample stage comprising a surface to support a sample container, the sample container having a plurality of sample locations; an optical stage having an objective lens, the optical stage being positionable relative to the sample stage to image samples at the sample locations; an actuator physically coupled to at least one of the sample stage and the optical stage to move the sample stage relative to the optical stage to focus the optical stage onto a current sample location; and a drive circuit to determine a focus setting for a next sample location and to provide a drive signal to the actuator before the optical stage is positioned to image a sample at the next sample location, wherein at least one parameter of the drive signal is determined using a difference between a focus setting for the current sample location and the determined focus setting for the next sample location.
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Patent Agency Ranking
公开(公告)号：US20210029292A1
公开(公告)日：2021-01-28
申请号：US16949042
申请日：2020-10-09
Applicant: Illumina, Inc.
Inventor： Chunhong (Allen) Zhou , John Bailey , Dustin Blair
Abstract: An imaging system may include a sample stage having a surface to support a sample to be scanned by the imaging system; an optical stage having an objective lens, the optical stage being positionable relative to the sample stage; an actuator physically coupled to at least one of the sample stage and the optical stage to move the sample stage relative to the optical stage; a servo circuit to control the actuator; a first set of control parameters to control the servo circuit; a second set of control parameters to control the servo circuit; and a servo control circuit to apply the first set of control parameters to the servo circuit when the imaging system is operating in a first mode of operation and to apply the second set of control parameters to the servo circuit when the imaging system is operating in a second mode of operation.
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公开(公告)号：US20180341798A1
公开(公告)日：2018-11-29
申请号：US15557811
申请日：2016-03-11
Applicant: ILLUMINA, INC.
Inventor： Dustin Blair , Nitin Udpa , Linh Tran , Nicholas Scheidler
IPC: G06K7/14
CPC classification number: G06K7/1417 , G06K7/1413 , G06K19/06159
Abstract: A method for tracking an item that includes the steps of (a) providing an item having a solid polymer material; (b) irradiating the item to create a spatial pattern of optical modifications in the polymer material, wherein the spatial pattern of optical modifications includes a code that indicates information; and (c) detecting the pattern of optical modifications, thereby determining the information.
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公开(公告)号：US11977213B2
公开(公告)日：2024-05-07
申请号：US17339587
申请日：2021-06-04
Applicant: ILLUMINA, INC.
Inventor： Ashkan Arianpour , John Bailey , Dustin Blair , Xiangling (Steve) Chen , Stanley S. Hong , Simon Prince , Merek C. Siu , Chunhong (Allen) Zhou , Danilo Condello
CPC classification number: G02B21/002 , G02B7/09 , G02B7/102 , G02B21/006 , G02B21/245 , G02B27/16
Abstract: An imaging system may include a sample stage comprising a surface to support a sample container, the sample container including a sample having a plurality of sample locations; an optical stage to image the sample at the plurality of sample locations; one or more actuators physically coupled to at least one of the sample stage and the optical stage to move the sample stage relative to the optical stage to focus the optical stage onto a current sample location of the plurality of sample locations; a first light source to illuminate the current sample location; a second light source to project a pair of spots on a next sample location of the plurality of sample locations; and a controller to determine, based on an image of the pair of spots projected on the next sample location, a focus setting for the next sample location.
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公开(公告)号：US20240033738A1
公开(公告)日：2024-02-01
申请号：US18357006
申请日：2023-07-21
Applicant: ILLUMINA, INC.
Inventor： Michael Burek , Gregory Holst , Danilo Condello , Dustin Blair
IPC: B01L3/00
CPC classification number: B01L3/502761 , B01L2200/0652 , B01L2300/0654 , B01L2200/16 , B01L2200/12 , B01L2300/0893
Abstract: The presently described techniques relate generally to providing motion feedback (e.g., motion system calibration and/or sample alignment) in the context of an imaging system (such as a time delay and integration (TDI) based imaging system). The architecture and techniques discussed may achieve nanoscale control and calibration of a movement feedback system without a high-resolution encoder subsystem or, in the alternative embodiments, with a lower resolution (and correspondingly less expensive) encoder subsystem than might otherwise be employed. By way of example, certain embodiments described herein relate to ascertaining or calibrating linear motion of a sample holder surface using nanoscale features (e.g., sample sites or nanowells or lithographically patterned features) provided on a surface of the sample holder.
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公开(公告)号：US20230272837A1
公开(公告)日：2023-08-31
申请号：US18113815
申请日：2023-02-24
Applicant: ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED
Inventor： Gregory Holst , Dustin Blair , John Earney , Geraint Evans , Matthew Hage
IPC: F16F15/03
CPC classification number: F16F15/035 , F16F2230/0047
Abstract: An apparatus includes a chassis, a frame, a sample support member, an imaging assembly, an actuation assembly, and a vibration capture assembly. The frame is coupled with the chassis. The sample support member is supported by the frame. The actuation assembly is supported by the frame and is operable to drive movement of the imaging assembly relative to the sample support member. The vibration capture assembly is operable to selectively transition between a plurality of modes, including a damping mode and an isolation mode. In the damping mode, the vibration capture assembly is configured to resist movement of the frame relative to the chassis in response to operation of the actuation assembly. In the isolation mode, the vibration capture assembly is configured to prevent transmission of vibrational movement in the chassis to the frame.
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