公开(公告)号：US11555486B2

公开(公告)日：2023-01-17

申请号：US17529059

申请日：2021-11-17

Applicant: ILLUMINA, INC.

Inventor： Reto Schoch ,  Xuance Zhou ,  Tarun Khurana ,  Chetanya Jain ,  Gregory Suematsu

IPC: F03G7/06

Abstract: Actuation systems and methods are disclosed. An apparatus includes a system including a flow cell receptacle and a valve drive assembly including a shape memory alloy actuator including a pair of shape memory alloy wires and a flow cell disposable within the flow cell receptacle and having a membrane valve. The system actuates the membrane valve, via the shape memory alloy actuator, by causing a voltage to be applied to a first one of the shape memory alloy wires and the system not applying the voltage to a second one of the shape memory alloy wires.

公开(公告)号：US20210080479A1

公开(公告)日：2021-03-18

申请号：US17021653

申请日：2020-09-15

Applicant: ILLUMINA, INC.

Inventor： Bradley Drews ,  Reto Schoch ,  Tarun Khurana ,  Minsoung Rhee

IPC: G01N35/10 ,  B01L3/00

Abstract: An apparatus includes a flow cell interface adapted to be coupled to a flow cell having a plurality of channels and a pump manifold assembly carrying pump valves and pumps and including pump-channel fluidic lines, pump fluidic lines, and a shared fluidic line. The pump valves and the pumps are operable to individually control fluid flow through each channel of the plurality of channels of the flow cell via the corresponding pump-channel fluidic lines. Each pump valve being coupled to a corresponding pump-channel fluidic line, a corresponding pump fluidic line, and the shared fluidic line and being movable between a first position fluidically coupling a corresponding channel, a corresponding pump-channel fluidic line, and a corresponding pump fluidic line and a second position fluidically coupling a corresponding pump fluidic line, the shared fluidic line, and a waste reservoir. Each pump coupled to a corresponding pump fluidic line.

公开(公告)号：US20230285963A1

公开(公告)日：2023-09-14

申请号：US18201054

申请日：2023-05-23

Applicant: ILLUMINA, INC.

Inventor： Bradley Drews ,  Reto Schoch ,  Tarun Kumar Khurana ,  Minsoung Rhee

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L2200/16 ,  B01L2300/0867

Abstract: An apparatus includes one or more valves adapted to be coupled to corresponding reagent reservoirs and a flow cell interface adapted to be coupled to a flow cell. The apparatus includes a sample cartridge interface having one or more ports and adapted to be coupled to a sample cartridge carrying a sample of interest. The sample cartridge interface positioned downstream of the flow cell interface. The apparatus includes a pump adapted to load a channel of the flow cell with the sample of interest via the flow cell interface associated with an outlet of the flow cell and a corresponding port of the sample cartridge interface.

公开(公告)号：US20230280364A1

公开(公告)日：2023-09-07

申请号：US18177946

申请日：2023-03-03

Applicant: ILLUMINA, INC.

Inventor： Xuance Zhou ,  Reto Schoch

IPC: G01N35/10

CPC classification number: G01N35/1002 ,  G01N35/1016

Abstract: Non-contact dispensers and related methods are disclosed. In an implementation, an apparatus includes a plate receptacle, a reagent reservoir receptacle, and a non-contact dispenser. The reagent reservoir receptacle receives a reagent reservoir containing reagent and the non-contact dispenser includes an inlet, an upstream valve, a syringe pump, a downstream valve, and an outlet. The syringe pump has a barrel and a hollow plunger movably disposed within the barrel. A flow path is defined between the inlet and the outlet and through the upstream valve, the barrel, the hollow plunger, and the downstream valve. The barrel is fluidically between the upstream valve and the downstream valve. The plate receptacle is to receive a well plate having a well and the non-contact dispenser is to dispense the reagent from the reagent reservoir into the well of the plate.

公开(公告)号：US12226767B2

公开(公告)日：2025-02-18

申请号：US17022611

申请日：2020-09-16

Applicant: ILLUMINA, INC.

Inventor： Bradley Drews ,  Reto Schoch ,  Tarun Khurana ,  Minsoung Rhee

IPC: B01L3/00

Abstract: An apparatus includes one or more valves adapted to be coupled to corresponding reagent reservoirs and a flow cell interface adapted to be coupled to a flow cell. The apparatus includes a sample cartridge interface having one or more ports and adapted to be coupled to a sample cartridge carrying a sample of interest. The sample cartridge interface positioned downstream of the flow cell interface. The apparatus includes a pump adapted to load a channel of the flow cell with the sample of interest via the flow cell interface associated with an outlet of the flow cell and a corresponding port of the sample cartridge interface.

公开(公告)号：US12209575B2

公开(公告)日：2025-01-28

申请号：US18382208

申请日：2023-10-20

Applicant: ILLUMINA, INC.

Inventor： Reto Schoch ,  Xuance Zhou ,  Tarun Khurana ,  Chetanya Jain ,  Gregory Suematsu

IPC: F03G7/06

Abstract: Actuation systems and methods are disclosed. An apparatus includes a system including a flow cell receptacle and a valve drive assembly including a shape memory alloy actuator including a pair of shape memory alloy wires and a flow cell disposable within the flow cell receptacle and having a membrane valve. The system actuates the membrane valve, via the shape memory alloy actuator, by causing a voltage to be applied to a first one of the shape memory alloy wires and the system not applying the voltage to a second one of the shape memory alloy wires.

公开(公告)号：US11821411B2

公开(公告)日：2023-11-21

申请号：US18087274

申请日：2022-12-22

Applicant: ILLUMINA, INC.

Inventor： Reto Schoch ,  Xuance Zhou ,  Tarun Khurana ,  Chetanya Jain ,  Gregory Suematsu

IPC: F03G7/06

CPC classification number: F03G7/06143 ,  F03G7/066

Abstract: Actuation systems and methods are disclosed. An apparatus includes a system including a flow cell receptacle and a valve drive assembly including a shape memory alloy actuator including a pair of shape memory alloy wires and a flow cell disposable within the flow cell receptacle and having a membrane valve. The system actuates the membrane valve, via the shape memory alloy actuator, by causing a voltage to be applied to a first one of the shape memory alloy wires and the system not applying the voltage to a second one of the shape memory alloy wires.

公开(公告)号：US20230038505A1

公开(公告)日：2023-02-09

申请号：US17790077

申请日：2020-12-21

Applicant: ILLUMINA, INC.

Inventor： Bradley Drews ,  Reto Schoch ,  Tarun Khurana ,  Rajagopal Panchapakesan

IPC: B01L3/00

Abstract: Flow cell assemblies and related reagent selector valves. In accordance with an implementation, an apparatus includes a system including a reagent cartridge receptacle. The apparatus includes a flow cell assembly. The apparatus includes a reagent cartridge receivable within the reagent cartridge receptacle. The reagent cartridge including a plurality of reagent reservoirs. The apparatus includes a manifold assembly. The manifold assembly including a reagent selector valve adapted to be fluidically coupled to the reagent reservoirs and to selectively flow reagent from a corresponding reagent reservoir to the flow cell assembly. At least a surface of the manifold assembly associated with the reagent selector valve is coupled to a portion of the flow cell assembly.

公开(公告)号：US20220163020A1

公开(公告)日：2022-05-26

申请号：US17529059

申请日：2021-11-17

Applicant: ILLUMINA, INC.

Inventor： Reto Schoch ,  Xuance Zhou ,  Tarun Khurana ,  Chetanya Jain ,  Gregory Suematsu

IPC: F03G7/06

Abstract: Actuation systems and methods are disclosed. An apparatus includes a system including a flow cell receptacle and a valve drive assembly including a shape memory alloy actuator including a pair of shape memory alloy wires and a flow cell disposable within the flow cell receptacle and having a membrane valve. The system actuates the membrane valve, via the shape memory alloy actuator, by causing a voltage to be applied to a first one of the shape memory alloy wires and the system not applying the voltage to a second one of the shape memory alloy wires.

公开(公告)号：US20240165627A1

公开(公告)日：2024-05-23

申请号：US18281018

申请日：2022-03-17

Applicant: ILLUMINA, INC.

Inventor： Mikko Ponkala ,  Paul Limb ,  Reto Schoch ,  Sonny Pham ,  Maulik Patel ,  Paul Crivelli

IPC: B01L3/00

CPC classification number: B01L3/527 ,  B01L2200/16 ,  B01L2300/0829 ,  B01L2300/18 ,  B01L2400/0487 ,  B01L2400/0638

Abstract: Non-contact dispenser assemblies and related systems and methods are disclosed. An implementation of an apparatus is disclosed that includes a reagent cartridge including a body defining a plurality of reservoirs. Each reservoir has an outlet and a distal end defining an opening, a manifold assembly including an outlet, a common fluidic line fluidly coupled to the outlet, a plurality of reagent fluidic lines coupled to the corresponding outlet of the reservoirs, and a plurality of membrane valves selectively fluidly coupling the common fluidic line and a corresponding one of the plurality of reagent fluidic lines.