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    FLOW CELL ASSEMBLIES AND RELATED REAGENT SELECTOR VALVES
    1.
    发明申请
    FLOW CELL ASSEMBLIES AND RELATED REAGENT SELECTOR VALVES 有权

    公开(公告)号：US20230038505A1

    公开(公告)日：2023-02-09

    申请号：US17790077

    申请日：2020-12-21

    Applicant: ILLUMINA, INC.

    Inventor： Bradley Drews ,  Reto Schoch ,  Tarun Khurana ,  Rajagopal Panchapakesan

    IPC: B01L3/00

    Abstract: Flow cell assemblies and related reagent selector valves. In accordance with an implementation, an apparatus includes a system including a reagent cartridge receptacle. The apparatus includes a flow cell assembly. The apparatus includes a reagent cartridge receivable within the reagent cartridge receptacle. The reagent cartridge including a plurality of reagent reservoirs. The apparatus includes a manifold assembly. The manifold assembly including a reagent selector valve adapted to be fluidically coupled to the reagent reservoirs and to selectively flow reagent from a corresponding reagent reservoir to the flow cell assembly. At least a surface of the manifold assembly associated with the reagent selector valve is coupled to a portion of the flow cell assembly.

    Reagent exchange in an instrument
    2.
    发明授权
    Reagent exchange in an instrument 有权

    公开(公告)号：US11911765B2

    公开(公告)日：2024-02-27

    申请号：US16902826

    申请日：2020-06-16

    Applicant: ILLUMINA, INC.

    Inventor： Tony Yen ,  Eric Stava ,  Rajagopal Panchapakesan

    IPC: B01L3/00 ,  C12Q1/6869 ,  G06T7/00

    CPC classification number: B01L3/527 ,  C12Q1/6869 ,  G06T7/0012 ,  B01L2300/0861 ,  B01L2300/0877 ,  G06T2207/30024

    Abstract: A method includes flowing an incorporation reagent through a reagent management system and a flow cell of an instrument. The flow cell having a first polynucleotide positioned therein. The incorporation reagent adding a first base onto a sequence of bases. The sequence of bases includes a second polynucleotide complementary to the first polynucleotide. An image of an identification signal emanating from the first base is captured after the first base has been added onto the second polynucleotide. A cleavage reagent is flowed through the reagent management system and flow cell to remove a first terminator from the first base in order to enable a subsequent base in the sequence of bases to be added to the second polynucleotide. A buffer reagent is flowed through the reagent management system and flow cell in a plurality of cycles of consecutive forward and reverse flow directions.

    IN-SITU FLUIDIC INSPECTION
    6.
    发明申请
    IN-SITU FLUIDIC INSPECTION 有权

    公开(公告)号：US20220280940A1

    公开(公告)日：2022-09-08

    申请号：US17750610

    申请日：2022-05-23

    Applicant: ILLUMINA, INC.

    Inventor： Sz-Chin Steven Lin ,  Richard Lemoine ,  Rajagopal Panchapakesan ,  Wesley A. Cox-Muranami ,  Darren Segale

    IPC: B01L3/00 ,  F16K99/00 ,  G01M3/28 ,  G01M3/26

    Abstract: A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.

    In-situ fluidic inspection
    7.
    发明授权
    In-situ fluidic inspection 有权

    公开(公告)号：US11351541B2

    公开(公告)日：2022-06-07

    申请号：US16500787

    申请日：2018-04-02

    Applicant: ILLUMINA, INC.

    Inventor： Sz-Chin Steven Lin ,  Richard Lemoine ,  Rajagopal Panchapakesan ,  Wesley A. Cox-Muranami ,  Darren Segale

    IPC: B01L3/00 ,  F16K99/00 ,  G01M3/28 ,  G01M3/26

    Abstract: A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.

    VALVE ASSEMBLIES AND RELATED SYSTEMS
    8.
    发明申请
    VALVE ASSEMBLIES AND RELATED SYSTEMS 有权

    公开(公告)号：US20240390887A1

    公开(公告)日：2024-11-28

    申请号：US18795995

    申请日：2024-08-06

    Applicant: ILLUMINA, INC.

    Inventor： Ahmadreza Rashedi ,  Gregory Holst ,  Rajagopal Panchapakesan

    IPC: B01L3/00 ,  G01N35/10

    Abstract: Valve assemblies and related systems are disclosed. A method includes imaging a flow cell of a flow cell assembly carried by a flow cell interface using an imaging system of an apparatus and moving the flow cell assembly relative to the imaging system using a stage assembly based on a command from an associated controller. The method also includes driving a motor of the apparatus using shaped input signals to reduce vibration imposed on at least one of the stage assembly or another component of the apparatus based on movement of the motor.

    VALVE ASSEMBLIES AND RELATED SYSTEMS
    10.
    发明申请
    VALVE ASSEMBLIES AND RELATED SYSTEMS 有权

    公开(公告)号：US20220339621A1

    公开(公告)日：2022-10-27

    申请号：US17526943

    申请日：2021-11-15

    Applicant: ILLUMINA, INC.

    Inventor： Ahmadreza Rashedi ,  Gregory Holst ,  Rajagopal Panchapakesan

    IPC: B01L3/00 ,  G01N35/10

    Abstract: Valve assemblies and related systems are disclosed. An apparatus includes or comprises a system including or comprising an imaging system, a flow cell interface having a corresponding flow cell receptacle, a stage assembly, and a valve assembly including or comprising a valve and a valve drive assembly. The stage assembly moves the flow cell interface relative to the imaging system and the valve drive assembly is to drive the valve using shaped input signals to reduce vibration imposed on at least one of the stage assembly or another component of the apparatus based on movement of the valve.

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