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Patent Agency Ranking
公开(公告)号：US11885800B2
公开(公告)日：2024-01-30
申请号：US17037162
申请日：2020-09-29
Applicant: IMRA America, Inc.
Inventor： Bing Liu , Matthew L. Elani , Alison R. Garrett
IPC: G01N33/543 , G01N27/74 , G01N33/68 , G01N33/76 , G01N35/00
CPC classification number: G01N33/54333 , G01N27/745 , G01N33/54326 , G01N33/6887 , G01N33/76 , B01L2200/025 , G01N35/0098
Abstract: A system includes an apparatus having at least one permanent magnet and at least one magnetic field sensor at a pole of the at least one permanent magnet and configured to be positioned relative to a surface of a membrane containing immobilized magnetic particles selectively bound to an analyte such that the magnetic particles are magnetized by the at least one permanent magnet. The system further includes a stage configured to move at least one of the apparatus and the membrane relative to one another with an oscillatory movement parallel to the surface of the membrane, at least one controller configured to control the oscillatory movement, and a data acquisition unit configured to receive signals from the at least one magnetic field sensor and the at least one controller method.
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2.发明申请公开(公告)号：US20190317103A1
公开(公告)日：2019-10-17
申请号：US16314499
申请日：2017-07-26
Applicant: IMRA America, Inc.
Inventor： Andrew A. Mills , Kristin B. Cederquist , Bing Liu
Abstract: Disclosed is a method of pulsed laser ablation production of gold-platinum AuxPt1-x alloy nanoparticles in a colloidal solution. The colloidal solution of AuxPt1-x alloy nanoparticles is suitable for many biological applications including lateral flow immunoassays and other bio-detections based on optical scattering. The nanoparticles form by fragmentation of the bulk material without evaporation, minimizing oxidation of the nanoparticles. The nanoparticles conjugate with bio-molecules such as protein, antibodies, peptides, RNA oligomers, DNA oligomers, other oligomers, or polymers effectively by passive adsorption. Advantageously the AuxPt1-x alloy nanoparticles have a wide optical extinction spectrum in the visible region, appearing nearly black in both colloidal and dried form. The nanoparticles can be used for labeling bio-molecules and provide a high visual contrast in visual-based bioassays. A combination of the near black color of the AuxPt1-x alloy nanoparticles with the red color of pure Au nanoparticles makes multiplexing bio-detection assays possible.
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公开(公告)号：US20140093744A1
公开(公告)日：2014-04-03
申请号：US14097633
申请日：2013-12-05
Applicant: IMRA AMERICA, INC.
Inventor： ZHENDONG HU , Yong Che , Bing Liu
CPC classification number: C30B23/08 , C23C14/083 , C23C14/28 , C30B29/16
Abstract: A one-step and room-temperature process for depositing nanoparticles or nanocomposite (nanoparticle-assembled) films of metal oxides such as crystalline titanium dioxide (TiO2) onto a substrate surface using ultrafast pulsed laser ablation of Titania or metal titanium target. The system includes a pulsed laser with a pulse duration ranging from a few femtoseconds to a few tens of picoseconds, an optical setup for processing the laser beam such that the beam is focused onto the target surface with an appropriate average energy density and an appropriate energy density distribution, and a vacuum chamber in which the target and the substrate are installed and background gases and their pressures are appropriately adjusted.
Abstract translation: 使用二氧化钛或金属钛靶的超快速脉冲激光烧蚀将金属氧化物如结晶二氧化钛（TiO 2）的纳米颗粒或纳米复合材料（纳米颗粒组装的）膜沉积到基底表面上的一步和室温方法。 该系统包括脉冲激光，其脉冲持续时间范围从几飞秒到几十皮秒，用于处理激光束的光学设置，使得光束以适当的平均能量密度和适当的能量聚焦到目标表面上 密度分布，以及真空室，其中安装了目标物和基质，背景气体及其压力被适当调节。
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公开(公告)号：US20220178919A1
公开(公告)日：2022-06-09
申请号：US17037162
申请日：2020-09-29
Applicant: IMRA America, Inc.
Inventor： Bing Liu , Matthew L. Elani , Alison R. Garrett
IPC: G01N33/543 , G01N33/76 , G01N33/68 , G01N27/74
Abstract: A method, system, and apparatus for the rapid detection of analyte(s) of interest are disclosed which can provide high sensitivity quantification of the analyte concentration in a lateral follow assay. The method includes labeling detection molecules with magnetic particles and immobilizing the magnetic particles on a nitrocellulose membrane upon specific biochemical recognition and binding. An external magnetic field is applied to the magnetic particles to induce magnetic induction, and a magnetoresistance sensor is positioned close to the membrane and magnetic particles. A periodic signal in the sensor is produced when a mechanical oscillatory movement is provided to the membrane relative to the sensor (or vice versa). Triggered time averaging of signals in synchronization with the oscillatory motion enables noise reduction of less than 30 dB and significant improvement of assay sensitivity. An x-y motion program for scanning the test line and control line on the membrane can produce magnetic 2D mapping of the lines, further differentiating the bound particles at the lines from unbound particles in the background, rendering a more accurate assay.
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5.发明申请公开(公告)号：US20170226560A1
公开(公告)日：2017-08-10
申请号：US15356950
申请日：2016-11-21
Applicant: IMRA America, Inc.
Inventor： Wei Qian , Bing Liu , Kori Michael Fetters
CPC classification number: C12Q1/37 , G01N33/587 , G01N2333/81 , G01N2333/948
Abstract: In the present invention, a method and assay for the detection of proteases and protease inhibitors using colloidal gold nanoparticles and peptide substrates, which are selectively recognized and cleaved by proteases being assayed, is disclosed. In this assay, the mechanism of signal generation relies on peptide sequence induced aggregation of gold nanoparticles, which are used as signal reporters. The peptide sequences that induce aggregation are either the intact peptide substrates or proteolytic fragments of the intact peptide substrate wherein the proteolytic fragments are produced by the protease being assayed. The present invention provides a novel, simple, sensitive, and inexpensive colloidal gold nanoparticle-based colorimetric assay that allows both visual and quantitative detection of proteases and protease inhibitors.
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