公开(公告)号：US20180142214A1

公开(公告)日：2018-05-24

申请号：US15861625

申请日：2018-01-03

Applicant: Industrial Technology Research Institute

Inventor： Mei-Wei Lin ,  Dian-Kun Li ,  Ling-Mei Wang ,  Ching-Huai Ko ,  Chin-Pen Lai ,  Chun-Min Liu ,  Hsiang-Wen Tseng

IPC: C12N5/09 ,  G01N33/50 ,  C12N5/071

CPC classification number: C12N5/0693 ,  C12N5/067 ,  G01N33/5011 ,  G01N33/5067

Abstract: An in vitro method for screening a testing compound to evaluate its potential as a liver drug of the disclosure is provided. The method includes applying the testing compound to cells of an isolated human liver tumor cell line, named as ITRI-H28, measuring a cell viability of the cells and determining the effect of the testing compound on the cells by calculating a half maximal inhibitory concentration (IC50) of the testing compound.

公开(公告)号：US20180169262A1

公开(公告)日：2018-06-21

申请号：US15830272

申请日：2017-12-04

Applicant: Industrial Technology Research Institute

Inventor： Maggie Lu ,  May-Hua Chang ,  Jenn-Tsang Hwang ,  Ping-Fu Cheng ,  Li-Wen Chang ,  Yi-Ju Ko ,  Chi-Y Hung ,  Chun-Min Liu ,  Chia-Yu Fan

IPC: A61K47/68 ,  A61K31/4745 ,  A61K47/64 ,  C07K16/30

CPC classification number: A61K47/6889 ,  A61K31/4745 ,  A61K47/64 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6851 ,  A61K47/6855 ,  A61P35/00 ,  C07K16/30

Abstract: A linker-drug represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), C is a conjugator, L is a linker unit, D is a toxin unit, and n is an integer ranging from 1 to 4. The structure of the conjugator is represented by formula (II). In formula (II), X is a leaving group, each of R1 and R2 is independently a single bond or —NH—, and Z is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or a combination thereof. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. An antibody-drug conjugate (ADC) employing the above linker-drug is also provided.

公开(公告)号：US09480712B2

公开(公告)日：2016-11-01

申请号：US14514137

申请日：2014-10-14

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Ya-Chin Lo ,  Hsiang-Fa Liang ,  Ming-Cheng Wei ,  Maggie J. M. Lu ,  Min-Ying Lin ,  Chih-Peng Liu ,  Chun-Min Liu ,  Hsiang-Wen Tseng ,  Tse-Min Teng ,  Jui-Hsiang Chen ,  Yi-Man Chou ,  Yi-Ting Hsieh ,  Chia-Mu Tu

IPC: C08B37/08 ,  A61K47/48 ,  A61K31/704 ,  A61K31/4745 ,  A61K31/7036 ,  A61K33/24 ,  A61K45/06 ,  A61K31/4172 ,  A61K31/555 ,  A61K31/728

CPC classification number: A61K33/24 ,  A61K31/4172 ,  A61K31/4745 ,  A61K31/555 ,  A61K31/7036 ,  A61K31/704 ,  A61K31/728 ,  A61K45/06 ,  A61K47/542 ,  A61K47/61 ,  A61K47/6921 ,  A61K2300/00

Abstract: The disclosure provides a biomedical composition, including: a hyaluronic acid; a modified histidine; and a polymer or C4-C20 alkane, wherein the modified histidine and the polymer or C4-C20 alkane are grafted to at least one primary hydroxyl group of the hyaluronic acid to allow the hyaluronic acid to form a hyaluronic acid derivative, wherein a graft ratio of the modified histidine is about 1-100%, and a graft ratio of the polymer or C4-C20 alkane is about 0-40%.

Abstract translation: 本公开提供了一种生物医学组合物，其包括：透明质酸; 修饰的组氨酸 和聚合物或C 4 -C 20烷烃，其中将经修饰的组氨酸和聚合物或C 4 -C 20烷烃接枝至透明质酸的至少一个伯羟基，以使透明质酸形成透明质酸衍生物，其中接枝率 的改性组氨酸约为1-100％，聚合物或C4-C20烷烃的接枝率约为0-40％。

公开(公告)号：US20150159141A1

公开(公告)日：2015-06-11

申请号：US14510136

申请日：2014-10-09

Applicant: Industrial Technology Research Institute

Inventor： Mei-Wei Lin ,  Dian-Kun Li ,  Ling-Mei Wang ,  Ching-Huai Ko ,  Chin-Pen Lai ,  Chun-Min Liu ,  Hsiang-Wen Tseng

IPC: C12N5/09 ,  G01N33/50

CPC classification number: C12N5/0693 ,  C12N5/067 ,  G01N33/5011 ,  G01N33/5067

Abstract: An isolated human liver tumor cell line is provided, which was named as ITRI-H28 and deposited in the Food Industry Research and Development Institute with the accession number BCRC960457 on Dec. 14, 2012. A method of an agent screening is also provided. The method includes providing the isolated human liver tumor cell line ITRI-H28 and adding an interest compound into the ITRI-H28 cell line to determine an effect on the ITRI-H28 cell line.

Abstract translation: 提供了一种分离的人肝肿瘤细胞系，被命名为ITRI-H28，并于2012年12月14日保藏于食品工业研究开发研究所，登记号为BCRC960457。还提供了一种试剂筛选方法。 该方法包括提供分离的人肝肿瘤细胞系ITRI-H28并将兴趣化合物加入到ITRI-H28细胞系中以确定对ITRI-H28细胞系的影响。