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公开(公告)号：US09480712B2
公开(公告)日：2016-11-01
申请号：US14514137
申请日：2014-10-14
发明人： Ya-Chin Lo , Hsiang-Fa Liang , Ming-Cheng Wei , Maggie J. M. Lu , Min-Ying Lin , Chih-Peng Liu , Chun-Min Liu , Hsiang-Wen Tseng , Tse-Min Teng , Jui-Hsiang Chen , Yi-Man Chou , Yi-Ting Hsieh , Chia-Mu Tu
IPC分类号： C08B37/08 , A61K47/48 , A61K31/704 , A61K31/4745 , A61K31/7036 , A61K33/24 , A61K45/06 , A61K31/4172 , A61K31/555 , A61K31/728
CPC分类号： A61K33/24 , A61K31/4172 , A61K31/4745 , A61K31/555 , A61K31/7036 , A61K31/704 , A61K31/728 , A61K45/06 , A61K47/542 , A61K47/61 , A61K47/6921 , A61K2300/00
摘要： The disclosure provides a biomedical composition, including: a hyaluronic acid; a modified histidine; and a polymer or C4-C20 alkane, wherein the modified histidine and the polymer or C4-C20 alkane are grafted to at least one primary hydroxyl group of the hyaluronic acid to allow the hyaluronic acid to form a hyaluronic acid derivative, wherein a graft ratio of the modified histidine is about 1-100%, and a graft ratio of the polymer or C4-C20 alkane is about 0-40%.
摘要翻译： 本公开提供了一种生物医学组合物，其包括：透明质酸; 修饰的组氨酸 和聚合物或C 4 -C 20烷烃，其中将经修饰的组氨酸和聚合物或C 4 -C 20烷烃接枝至透明质酸的至少一个伯羟基，以使透明质酸形成透明质酸衍生物，其中接枝率 的改性组氨酸约为1-100％，聚合物或C4-C20烷烃的接枝率约为0-40％。
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公开(公告)号：US20160113905A1
公开(公告)日：2016-04-28
申请号：US14757364
申请日：2015-12-22
发明人： Ting-Yu Shih , Tse-Min Teng , Chia-Chun Wang , Yu-Hua Chen , Jui-Hsiang Chen , Mei-Ju Yang , Shu-Fang Chiang , Yen-Chun Chen , Chia-Ni Chang
IPC分类号： A61K31/4172 , A61L31/04 , A61K31/728 , A61L31/16 , A61K31/765 , A61K31/717
CPC分类号： A61K31/4172 , A61K31/715 , A61K31/717 , A61K31/728 , A61K31/765 , A61K47/58 , A61K47/61 , A61L15/24 , A61L15/28 , A61L15/44 , A61L27/16 , A61L27/20 , A61L27/54 , A61L29/041 , A61L29/043 , A61L29/16 , A61L31/042 , A61L31/048 , A61L31/16 , A61L2300/204 , A61L2300/434 , C08B11/04 , C08B11/08 , C08B11/20 , C08B15/06 , C08B37/0072 , C08L1/08 , C08L1/26 , C08L1/284 , C08L5/08
摘要： A polymer composition including a polymer having a hydroxyl group and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group. A polymer material is also provided, including a polymer composition which includes a polymer having a hydroxyl group, and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group.
摘要翻译： 包括具有羟基的聚合物和接枝到具有羟基的聚合物上的组氨酸或组氨酸衍生物的聚合物组合物。 还提供了聚合物材料，包括包含具有羟基的聚合物的聚合物组合物和接枝到具有羟基的聚合物上的组氨酸或组氨酸衍生物。
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公开(公告)号：US09737607B2
公开(公告)日：2017-08-22
申请号：US14757563
申请日：2015-12-24
发明人： Jui-Hsiang Chen , Yu-Hua Chen , Chia-Chen Tsai , Tse-Min Teng , Ting-Yu Shih , Chia-Chun Wang , Chia-wei Hong , Jennline Sheu , Hui-Ling Cheng , Shu-Feng Chen , Hung-Jui Huang , Shu-Ling Wang
IPC分类号： A61K47/32 , C08G81/02 , A61K9/107 , A61K31/18 , A61K31/235 , A61K31/437 , A61K31/44 , A61K31/5377 , A61K31/551 , A61K38/07 , C08G18/62 , C08G18/71 , C08G18/73 , C08G18/75 , C08G18/76 , C08G18/80 , C08G18/28 , A61K9/14 , A61K9/20
CPC分类号： A61K47/32 , A61K9/1075 , A61K9/146 , A61K9/2027 , A61K31/18 , A61K31/235 , A61K31/437 , A61K31/44 , A61K31/5377 , A61K31/551 , A61K38/07 , C08G18/283 , C08G18/6212 , C08G18/711 , C08G18/73 , C08G18/755 , C08G18/7671 , C08G18/8064 , C08G81/021 , C08G81/025 , C08G81/027
摘要： A polymer and a pharmaceutical composition employing the same are disclosed. The polymer includes a first repeating unit, a second repeating unit, and a third repeating unit. In particular, the first repeating unit is the second repeating unit is wherein R1 is C1-6 alkyl group; and the third repeating unit is wherein X is and Y is a hydrophilic polymeric moiety.
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公开(公告)号：US20160184437A1
公开(公告)日：2016-06-30
申请号：US14757563
申请日：2015-12-24
发明人： Jui-Hsiang Chen , Yu-Hua Chen , Chia-Chen Tsai , Tse-Min Teng , Ting-Yu Shih , Chia-Chun Wang , Chia-wei Hong , Jennline Sheu , Hui-Ling Cheng , Shu-Feng Chen , Hung-Jui Huang , Shu-Ling Wang
IPC分类号： A61K47/32 , A61K31/235 , A61K31/5377 , A61K9/107 , A61K31/18 , A61K31/44 , A61K31/437 , A61K38/07 , C08G81/02 , A61K31/551
CPC分类号： A61K47/32 , A61K9/1075 , A61K9/146 , A61K9/2027 , A61K31/18 , A61K31/235 , A61K31/437 , A61K31/44 , A61K31/5377 , A61K31/551 , A61K38/07 , C08G18/283 , C08G18/6212 , C08G18/711 , C08G18/73 , C08G18/755 , C08G18/7671 , C08G18/8064 , C08G81/021 , C08G81/025 , C08G81/027
摘要： A polymer and a pharmaceutical composition employing the same are disclosed. The polymer includes a first repeating unit, a second repeating unit, and a third repeating unit. In particular, the first repeating unit is the second repeating unit is wherein R1 is C1-6 alkyl group; and the third repeating unit is wherein X is and Y is a hydrophilic polymeric moiety.
摘要翻译： 公开了一种聚合物和使用其的药物组合物。 聚合物包括第一重复单元，第二重复单元和第三重复单元。 特别地，第一重复单元是第二重复单元，其中R 1是C 1-6烷基; 并且第三重复单元是其中X是和Y是亲水性聚合物部分。
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