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公开(公告)号：US11911762B2
公开(公告)日：2024-02-27
申请号：US17314496
申请日：2021-05-07
CPC分类号： B01L3/502753 , G06T7/0012 , B01L2300/0654
摘要： Techniques regarding integrated purification-detection devices for detecting one or more biomarkers are provided. For example, one or more embodiments described herein are directed to an apparatus, comprising a housing and a microfluidic chip contained within the housing. The microfluidic chip comprises a separation unit that separates, using one or more nano deterministic lateral displacement (nanoDLD) arrays, target biological entities having a defined size range from other biological entities included in a biological fluid sample. The microfluidic chip further comprises a detection unit that facilitates detecting presence of one or more biomarkers associated with the target biological entities using one or more detection molecules or macromolecules that chemically reacts with the one or more biomarkers.
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公开(公告)号：US11186480B2
公开(公告)日：2021-11-30
申请号：US16276342
申请日：2019-02-14
摘要： An exemplary method includes forming a sacrificial layer along sidewalls of an array of trenches that are indented into a substrate, depositing a fill layer over the sacrificial layer, and then creating an array of gaps between the fill layer and the substrate by removing the sacrificial layer along the sidewalls of the trenches, while maintaining a structural connection between the substrate and the fill layer at the floors of the trenches. The method further includes covering the substrate, the fill layer, and the gaps with a cap layer that seal fluid-tight against the substrate and the fill layer. The method further includes indenting a first reservoir and a second reservoir through the cap layer, and into the substrate and the fill layer, across the lengths of the array of gaps, so that the array of gaps connects the first reservoir in fluid communication with the second reservoir.
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公开(公告)号：US20200166468A1
公开(公告)日：2020-05-28
申请号：US16203195
申请日：2018-11-28
摘要： Techniques regarding one or more structures for checking the via formation are provided. For example, one or more embodiments described herein can comprise an apparatus, which can comprise a microfluidic channel positioned on a silicon substrate. The apparatus can also comprise a pattern of material comprised within the microfluidic channel and positioned on a surface of the silicon substrate. Further, the pattern of material can define a future location of a through-silicon via. An advantage of such an apparatus can be that the pattern of material can facilitate checking whether the through-silicon via is fully or partially formed.
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公开(公告)号：US20190381505A1
公开(公告)日：2019-12-19
申请号：US16007107
申请日：2018-06-13
摘要： Multistage deterministic lateral displacement devices, methods of forming the devices, and methods of separating a fluid mixture including particles having three or more particle sizes generally include a first module and at least one additional module. Each module includes a condenser portion and a separate portion. The condenser portion is generally configured to focus a streamline of all particles to a center of a channel whereas the separator separates the streamline of all particles into two different streamlines. One of the streamlines focuses the largest particles in the fluid mixture along a sidewall of the channel and the other streamline of smaller particles is between opposing sidewalls that define the channel. Each additional module can be used to further separate the largest particles remaining in the fluid mixture from the smaller particles.
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公开(公告)号：US20240329021A1
公开(公告)日：2024-10-03
申请号：US18190228
申请日：2023-03-27
CPC分类号： G01N33/0027 , B01L3/502723 , B01L7/52 , G01N1/42 , G01N1/44 , G01N11/00 , B01L2200/16 , B01L2300/18 , B01L2400/0622
摘要： A system may comprise a heat spreader with a sample holder, an amine solution in the sample holder; a temperature sensor configured to measure a temperature of the amine solution; a heating and cooling device in the spreader, a gas flow valve connected to a gas inlet tube, wherein an end of the gas inlet tube sits below a surface level of the amine solution; and a CO2 (carbon dioxide) sensor connected to a gas outlet tube.
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公开(公告)号：US12042770B2
公开(公告)日：2024-07-23
申请号：US17520713
申请日：2021-11-07
CPC分类号： B01D71/0213 , B01D29/0093 , B01D29/44 , B01L3/502707 , B01L3/502753 , B01L3/502761 , B01L3/565 , B81C1/00119 , B01L2300/0861 , B01L2300/0896 , B01L2300/12 , B01L2400/0487 , B81C2201/0109 , B81C2201/0132 , B81C2201/0133
摘要： An exemplary method includes forming a sacrificial layer along sidewalls of an array of trenches that are indented into a substrate, depositing a fill layer over the sacrificial layer, and then creating an array of gaps between the fill layer and the substrate by removing the sacrificial layer along the sidewalls of the trenches, while maintaining a structural connection between the substrate and the fill layer at the floors of the trenches. The method further includes covering the substrate, the fill layer, and the gaps with a cap layer that seal fluid-tight against the substrate and the fill layer. The method further includes indenting a first reservoir and a second reservoir through the cap layer, and into the substrate and the fill layer, across the lengths of the array of gaps, so that the array of gaps connects the first reservoir in fluid communication with the second reservoir.
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公开(公告)号：US20220055893A1
公开(公告)日：2022-02-24
申请号：US17520713
申请日：2021-11-07
摘要： An exemplary method includes forming a sacrificial layer along sidewalls of an array of trenches that are indented into a substrate, depositing a fill layer over the sacrificial layer, and then creating an array of gaps between the fill layer and the substrate by removing the sacrificial layer along the sidewalls of the trenches, while maintaining a structural connection between the substrate and the fill layer at the floors of the trenches. The method further includes covering the substrate, the fill layer, and the gaps with a cap layer that seal fluid-tight against the substrate and the fill layer. The method further includes indenting a first reservoir and a second reservoir through the cap layer, and into the substrate and the fill layer, across the lengths of the array of gaps, so that the array of gaps connects the first reservoir in fluid communication with the second reservoir.
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公开(公告)号：US20210283611A1
公开(公告)日：2021-09-16
申请号：US16814947
申请日：2020-03-10
摘要： A microfluidic device comprising a channel within a substrate and a condenser or a hydrodynamic focusing chamber along the channel, configured to focus a fluid containing particles of a plurality of sizes. A negative angle deterministic lateral displacement (DLD) array is configured to receive the focused fluid and separate the particles in the focused fluid into three sizes ranges. The negative angle DLD array comprises a plurality of rows of pillars, wherein the rows of pillars are positioned to repeat a pattern every N rows with a shift of M columns, N and M are relatively coprime, and N is greater than 1.
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公开(公告)号：US20190382828A1
公开(公告)日：2019-12-19
申请号：US16007347
申请日：2018-06-13
IPC分类号： C12Q1/6813 , C12Q1/6825 , C12Q1/6806
摘要： Techniques regarding detecting one or more defined nucleic acid sequences are provided. For example, one or more embodiments described herein can comprise a method, which can comprise adding a molecular probe to a sample fluid comprising a first deoxyribonucleic acid segment and a second deoxyribonucleic acid segment. The molecular probe can have an affinity to bond to a defined nucleic acid sequence. The method can also comprise separating, via a nanoscale deterministic lateral displacement array, the first deoxyribonucleic acid segment from the second deoxyribonucleic acid segment based on a size of the first deoxyribonucleic acid segment.
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10.发明申请公开(公告)号：US20190382821A1
公开(公告)日：2019-12-19
申请号：US16007389
申请日：2018-06-13
IPC分类号： C12Q1/683 , C12Q1/6816
摘要： Techniques regarding screening for mutations using nanoscale deterministic arrays are provided. For example, one or more embodiments described herein can comprise a method, which can comprise cleaving a deoxyribonucleic acid segment hybridized with a molecular probe to form a sample fluid. The cleaving can occur at a first end and a second end of the molecular probe. Also, the cleaving can comprise a cleaving agent that targets base pair mismatches. The method can also comprise supplying the sample fluid to a nanoscale deterministic lateral displacement array to screen for a single nucleotide polymorphism.
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