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公开(公告)号：US10793825B2
公开(公告)日：2020-10-06
申请号：US16713737
申请日：2019-12-13
IPC分类号： C07K1/20 , A23L1/30 , C12N1/20 , C12N9/16 , C12N9/10 , C12P19/12 , C07K14/315 , A23K10/18 , A23C9/123 , A23L33/135 , C12N1/04 , C12R1/225 , C12R1/01 , A61K39/00
摘要： The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC) activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
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公开(公告)号：US10030234B2
公开(公告)日：2018-07-24
申请号：US15258433
申请日：2016-09-07
IPC分类号： A01N63/00 , A61K39/02 , A01N63/02 , C12N1/20 , C12N1/00 , C12N9/10 , A61K35/744 , C12N1/04 , C12N15/74 , A23L33/135 , C12P19/12 , A61K38/00 , A61K39/00 , C07K14/325 , C12N15/86
摘要： The present invention relates to a gram positive bacterium, preferably a lactic acid bacterium (LAB) or Bifidobacterium, with increased stress resistance and/or improved manufacturing, processing and/or storage characteristics. In particular, the invention relates to a gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further lack cellobiose-specific PTS system IIC component (ptcC) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
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公开(公告)号：US10988770B2
公开(公告)日：2021-04-27
申请号：US15897427
申请日：2018-02-15
IPC分类号： C12N15/74
摘要： The invention relates to polycistronic expression in gram-positive bacterium and in particular concerns polycistronic expression units comprising one or more gene endogenous to the gram-positive bacterium transcriptionally coupled to one or more genes exogenous to the bacterium.
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公开(公告)号：US20200165564A1
公开(公告)日：2020-05-28
申请号：US16713737
申请日：2019-12-13
IPC分类号： C12N1/20 , C12N1/04 , C12N9/16 , C12N9/10 , C12P19/12 , C07K14/315 , A23K10/18 , A23C9/123 , A23L33/135
摘要： The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC) activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
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公开(公告)号：US09982228B2
公开(公告)日：2018-05-29
申请号：US15003426
申请日：2016-01-21
IPC分类号： C12N1/04 , C12N1/20 , C12N9/10 , C07K14/315 , C12P19/12 , C12N9/16 , A23C9/123 , A23K10/18 , A23L33/135 , A61K39/00 , C12R1/01 , C12R1/225
CPC分类号： C12N1/20 , A23C9/1234 , A23K10/18 , A23L33/135 , A23Y2220/00 , A23Y2300/00 , A61K2039/523 , C07K14/315 , C12N1/04 , C12N9/1051 , C12N9/16 , C12P19/12 , C12R1/01 , C12R1/225 , C12Y204/01216 , Y02P20/52
摘要： The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC) activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
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公开(公告)号：US20160376574A1
公开(公告)日：2016-12-29
申请号：US15258433
申请日：2016-09-07
IPC分类号： C12N9/10 , A23L33/135 , C12P19/12 , A61K35/744 , C12N1/20 , C12N15/74
CPC分类号： C12N9/1051 , A23L33/135 , A23V2002/00 , A61K35/744 , A61K38/00 , A61K2039/522 , C07K14/325 , C12N1/04 , C12N1/20 , C12N15/746 , C12N15/86 , C12P19/12 , C12Y204/01216
摘要： The present invention relates to a gram positive bacterium, preferably a lactic acid bacterium (LAB) or Bifidobacterium, with increased stress resistance and/or improved manufacturing, processing and/or storage characteristics. In particular, the invention relates to a gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further lack cellobiose-specific PTS system IIC component (ptcC) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
摘要翻译： 本发明涉及革兰氏阳性菌，优选乳酸菌（LAB）或双歧杆菌，具有增加的抗逆性和/或改进的制造，加工和/或储存特性。 特别地，本发明涉及一种积累细胞内海藻糖的革兰氏阳性细菌。 根据本发明的革兰氏阳性细菌缺乏海藻糖-6-磷酸磷酸化酶（TrePP）活性。 革兰氏阳性细菌可能进一步缺乏纤维二糖特异性PTS系统IIC成分（ptcC）活性。 革兰氏阳性菌可能进一步过表达海藻糖转运蛋白。 本发明还涉及包含这种革兰氏阳性细菌的组合物及其方法和用途。
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公开(公告)号：US10519418B2
公开(公告)日：2019-12-31
申请号：US15959705
申请日：2018-04-23
IPC分类号： C12N1/04 , C12N1/20 , C12N9/10 , C07K14/315 , A23L33/135 , A23C9/123 , A23K10/18 , C12P19/12 , C12N9/16 , A61K39/00 , C12R1/01 , C12R1/225
摘要： The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC)activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP)activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
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公开(公告)号：US20180237739A1
公开(公告)日：2018-08-23
申请号：US15959705
申请日：2018-04-23
IPC分类号： C12N1/20 , A23C9/123 , C12N9/16 , C12N9/10 , A23K10/18 , C12N1/04 , C07K14/315 , A23L33/135 , C12P19/12 , C12R1/225 , C12R1/01 , A61K39/00
摘要： The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC)activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP)activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
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公开(公告)号：US09458467B2
公开(公告)日：2016-10-04
申请号：US14346504
申请日：2012-09-21
IPC分类号： A61K39/02 , A01N63/02 , A01N63/00 , C12N1/20 , C12N1/00 , C12N15/74 , C12N1/04 , C12N9/10 , A23L1/30 , A61K38/00 , A61K39/00 , C07K14/325 , C12N15/86 , A61K35/744
CPC分类号： C12N9/1051 , A23L33/135 , A23V2002/00 , A61K35/744 , A61K38/00 , A61K2039/522 , C07K14/325 , C12N1/04 , C12N1/20 , C12N15/746 , C12N15/86 , C12P19/12 , C12Y204/01216
摘要： The present invention relates to a gram positive bacterium, preferably a lactic acid bacterium (LAB) or Bifidobacterium, with increased stress resistance and/or improved manufacturing, processing and/or storage characteristics. In particular, the invention relates to a gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further lack cellobiose-specific PTS system IIC component (ptcC) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
摘要翻译： 本发明涉及革兰氏阳性菌，优选乳酸菌（LAB）或双歧杆菌，具有增加的抗逆性和/或改进的制造，加工和/或储存特性。 特别地，本发明涉及一种积累细胞内海藻糖的革兰氏阳性细菌。 根据本发明的革兰氏阳性细菌缺乏海藻糖-6-磷酸磷酸化酶（TrePP）活性。 革兰氏阳性细菌可能进一步缺乏纤维二糖特异性PTS系统IIC成分（ptcC）活性。 革兰氏阳性菌可能进一步过表达海藻糖转运蛋白。 本发明还涉及包含这种革兰氏阳性细菌的组合物及其方法和用途。
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公开(公告)号：US09347036B2
公开(公告)日：2016-05-24
申请号：US14346488
申请日：2012-09-21
IPC分类号： C07K1/20 , A23L1/30 , C12N1/20 , C12N1/04 , C07K14/315 , C12P19/12 , C12N9/10 , C12N9/16 , A23C9/123 , A23K1/00 , A61K39/00 , C12R1/01 , C12R1/225
CPC分类号： C12N1/20 , A23C9/1234 , A23K10/18 , A23L33/135 , A23Y2220/00 , A23Y2300/00 , A61K2039/523 , C07K14/315 , C12N1/04 , C12N9/1051 , C12N9/16 , C12P19/12 , C12R1/01 , C12R1/225 , C12Y204/01216 , Y02P20/52
摘要： The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC) activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
摘要翻译： 本发明涉及具有增加的耐应力和/或改善的储存特性的革兰氏阳性细菌。 特别地，本发明涉及积累胞内海藻糖的革兰氏阳性细菌。 根据本发明的革兰氏阳性细菌缺乏纤维二糖特异性PTS系统IIC组分（PtcC）活性。 革兰氏阳性菌可能进一步缺乏海藻糖-6-磷酸磷酸化酶（TrePP）活性。 革兰氏阳性菌可能进一步过表达海藻糖转运蛋白。 本发明还涉及包含这种革兰氏阳性细菌的组合物及其方法和用途。
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