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1.发明申请公开(公告)号：US20180320205A1
公开(公告)日：2018-11-08
申请号：US15885927
申请日：2018-02-01
CPC分类号： C12P7/46 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis.
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公开(公告)号：US20160159723A1
公开(公告)日：2016-06-09
申请号：US14842696
申请日：2015-09-01
CPC分类号： C07C51/42 , B01D15/02 , B01D15/185 , B01D15/1892 , B01D15/22 , C07C51/47 , C07C55/02 , C07C55/21 , C07C55/14
摘要： The present disclosure relates to methods for separating and purifying a long chain diacid from other long chain diacids, monocarboxylic acids, hydroxyl acids or alkanes by simulated or actual moving bed chromatography.
摘要翻译： 本公开涉及通过模拟或实际移动床层析从其它长链二酸，单羧酸，羟基酸或烷烃中分离和纯化长链二酸的方法。
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3.发明申请公开(公告)号：US20190382811A1
公开(公告)日：2019-12-19
申请号：US16199550
申请日：2018-11-26
IPC分类号： C12P13/00 , C12P7/42 , C12N15/52 , C12N9/02 , C12N9/10 , C12N9/88 , C12N9/04 , C12P7/44 , C12P7/18
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
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公开(公告)号：US20140193861A1
公开(公告)日：2014-07-10
申请号：US14138827
申请日：2013-12-23
CPC分类号： C12P7/44 , C12N9/0006 , C12N9/0008 , C12N9/1096 , C12N9/13 , C12N9/16 , C12N9/80 , C12N9/93 , C12N15/52 , C12P7/18 , C12P7/42 , C12P13/001 , C12P13/005 , C12Y101/01258 , C12Y102/01063 , C12Y206/01 , C12Y208/03012 , C12Y301/02 , C12Y305/01062 , C12Y602/01005
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.
摘要翻译： 本文件描述了通过在C7脂肪族主链基质中形成由羧基，胺或羟基组成的两个末端官能团，生成庚二酸，7-氨基庚酸酯，7-羟基庚酸酯，七亚甲基二胺或1,7-庚二醇的生化途径， 草酸盐或苯甲酸盐。 本文描述的这些途径，代谢工程和培养策略依赖于厌氧苯甲酰辅酶A降解途径酶。
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公开(公告)号：US20140141482A1
公开(公告)日：2014-05-22
申请号：US13916156
申请日：2013-06-12
IPC分类号： C12P5/02
CPC分类号： C12P5/026 , C12N9/001 , C12N9/0071 , C12N9/88 , C12N15/52 , C12P5/02 , C12P7/16 , C12P7/18 , C12Y103/01035 , C12Y103/08 , C12Y114/11022 , C12Y401/01033 , C12Y402/01 , C12Y402/01127 , C12Y402/03027 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as mevalonate diphosphate decarboxylase, isoprene synthase, and dehydratases for the final enzymatic step.
摘要翻译： 该文献描述了通过在丁二烯合成底物中形成两个乙烯基来生产丁二烯的生化途径。 本文描述的这些途径依赖于酶，例如甲羟戊酸二磷酸脱羧酶，异戊二烯合酶和用于最终酶促步骤的脱水酶。
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公开(公告)号：US10071947B2
公开(公告)日：2018-09-11
申请号：US14842696
申请日：2015-09-01
IPC分类号： C07C59/245 , C07C51/42 , B01D15/18 , C07C51/47 , B01D15/02 , B01D15/22 , C07C55/02 , C07C55/21
CPC分类号： C07C51/42 , B01D15/02 , B01D15/185 , B01D15/1892 , B01D15/22 , C07C51/47 , C07C55/02 , C07C55/21 , C07C55/14
摘要： The present disclosure relates to methods for separating and purifying a long chain diacid from other long chain diacids, monocarboxylic acids, hydroxyl acids or alkanes by simulated or actual moving bed chromatography.
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7.发明申请公开(公告)号：US20170191096A1
公开(公告)日：2017-07-06
申请号：US15459116
申请日：2017-03-15
CPC分类号： C12P13/001 , C12N9/0008 , C12N9/1096 , C12N9/16 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/002 , C12Y102/99006 , C12Y301/02002
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation enzymes or homologs thereof associated with the cyclohexane carboxylate biosynthesis from Syntrophus aciditrophicus or 2-aminoadipate lysine biosynthesis.
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