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公开(公告)号：US20190062374A1
公开(公告)日：2019-02-28
申请号：US16186879
申请日：2018-11-12
申请人： Ipsen Pharma S.A.S.
摘要： The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction.
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公开(公告)号：US09409948B2
公开(公告)日：2016-08-09
申请号：US14510188
申请日：2014-10-09
申请人： Ipsen Pharma S.A.S.
发明人： Zheng Xin Dong
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0205 , C07K5/06034 , C07K5/1016 , C07K5/1024 , C07K7/02 , C07K14/60
摘要： Disclosed are peptide and peptidomimetic compounds generally according to formula (I) that are useful as GHRP analogs: R1-A1-A2-A3-A4-A5-R2 (I) wherein: A1 is Aib, Apc or Inp; A2 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A3 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A4 is 2Fua, Orn, 2Pal, 3Pal, 4Pal, Pff, Phe, Pim, Taz, 2Thi, 3Thi, Thr(Bzl); A5 is Apc, Dab, Dap, Lys, Orn, or deleted; R1 is hydrogen, (C1-6)alkyl, (C5-14)aryl, (C1-6)alkyl(C5-14)aryl, (C3-8)cycloakyl, or (C2-10)acyl; and R2 is OH or NH2; and pharmaceutical compositions and methods of use thereof.
摘要翻译： 公开了通常根据式（I）的肽和拟肽化合物，其可用作GHRP类似物：R1-A1-A2-A3-A4-A5-R2（I）其中：A1是Aib，Apc或Inp; A2是D-Bal，D-Bip，D-Bpa，D-Dip，D-1Nal，D-2Nal，D-Ser（Bzl）或D-Trp; A3是D-Bal，D-Bip，D-Bpa，D-Dip，D-1Nal，D-2Nal，D-Ser（Bzl）或D-Trp; A4是2Fua，Orn，2Pal，3Pal，4Pal，Pff，Phe，Pim，Taz，2Thi，3Thi，Thr（Bzl）; A5是Apc，Dab，Dap，Lys，Orn或缺失; R1是氢，（C1-6）烷基，（C5-14）芳基，（C1-6）烷基（C5-14）芳基，（C3-8）环烷基或（C2-10）酰基; R2为OH或NH2; 和药物组合物及其使用方法。
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公开(公告)号：US09133261B2
公开(公告)日：2015-09-15
申请号：US14157770
申请日：2014-01-17
申请人： Ipsen Pharma S.A.S.
发明人： Zheng Xin Dong , Yeelana Shen
IPC分类号： A61K38/22 , C07K14/61 , C07K14/575 , C07K14/60 , A61K38/00
CPC分类号： C07K14/61 , A61K38/00 , A61K38/22 , C07K14/575 , C07K14/60
摘要： The invention comprises peptidyl analogs that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof.
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公开(公告)号：US08952128B2
公开(公告)日：2015-02-10
申请号：US14068286
申请日：2013-10-31
申请人： Ipsen Pharma S.A.S.
发明人： Zheng Xin Dong , Yeelana Shen , Sun Hyuk Kim
IPC分类号： A61K38/00 , C07K14/655 , A61K38/31 , C07K7/56 , C07K7/06 , C07K7/08 , A61K39/00 , C07K7/23 , C07C243/00 , C07K5/02 , A61K38/08 , C07K7/64 , C07K11/00 , C07C215/52 , C07K19/00
CPC分类号： A61K47/64 , A61K38/00 , A61K38/31 , A61K47/55 , C07C215/52 , C07K14/655 , C07K19/00
摘要： The present invention relates to novel somatostatin-dopamine chimeric analogs and their therapeutic uses for the inhibition, prevention, and/or treatment of neoplasia, neuroendocrine tumors, Cushing's disease/syndrome, and other conditions.
摘要翻译： 本发明涉及新的生长抑素 - 多巴胺嵌合类似物及其治疗用途，用于抑制，预防和/或治疗瘤形成，神经内分泌肿瘤，库兴氏病/综合征和其他病症。
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公开(公告)号：US20220127305A1
公开(公告)日：2022-04-28
申请号：US17572115
申请日：2022-01-10
申请人： IPSEN PHARMA S.A.S.
IPC分类号： C07K7/06 , C07K7/08 , C07K14/665
摘要： The present invention is directed to compounds according to formula, (R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1, and pharmaceutically-acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.
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公开(公告)号：US09850280B2
公开(公告)日：2017-12-26
申请号：US15587426
申请日：2017-05-05
申请人： Ipsen Pharma S.A.S.
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/665
摘要： The present invention is directed to compounds according to formula, (R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1, and pharmaceutically-acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.
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公开(公告)号：US09603942B2
公开(公告)日：2017-03-28
申请号：US14614458
申请日：2015-02-05
申请人： Ipsen Pharma S.A.S.
发明人： Zheng Xin Dong , Yeelana Shen
IPC分类号： A61K38/00 , A61P35/00 , A61K38/12 , A61K38/08 , A61K38/31 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/04 , A61K47/48 , C07K14/655 , C07K19/00 , C07C215/52
CPC分类号： A61K47/64 , A61K38/00 , A61K38/31 , A61K47/55 , C07C215/52 , C07K14/655 , C07K19/00
摘要： The present invention relates to novel somatostatin-dopamine chimeric analogs and their therapeutic uses for the inhibition, prevention, and/or treatment of neoplasia, neuroendocrine tumors, Cushing's disease/syndrome, and other conditions.
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8.发明申请公开(公告)号：US20160206700A1
公开(公告)日：2016-07-21
申请号：US14997678
申请日：2016-01-18
申请人： Ipsen Pharma S.A.S.
CPC分类号： A61K38/22 , A61K38/05 , A61K38/06 , A61K38/25 , C07K7/06 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/463 , Y02A50/475 , Y02A50/484
摘要： The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogues of native hGhrelin.
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公开(公告)号：US09296783B2
公开(公告)日：2016-03-29
申请号：US14024961
申请日：2013-09-12
申请人： Ipsen Pharma S.A.S.
摘要： The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction.
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公开(公告)号：US20190248861A1
公开(公告)日：2019-08-15
申请号：US16168870
申请日：2018-10-24
申请人： Ipsen Pharma S.A.S.
发明人： Rakesh Datta , Zheng Xin Dong
IPC分类号： C07K14/575 , C07K14/60 , A61K38/25
CPC分类号： C07K14/575 , A61K38/00 , A61K38/25 , C07K14/60
摘要： The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a peptidyl analog of ghrelin to said patient.
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