公开(公告)号：US20060140948A1

公开(公告)日：2006-06-29

申请号：US11281266

申请日：2005-11-16

申请人： Ian Foltz ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Kathy Manchulenko ,  Jaspal Kang ,  Palaniswami Rathanaswami ,  Kiran Ahluwalia ,  Orit Foord ,  Scott Klakamp

发明人： Ian Foltz ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Kathy Manchulenko ,  Jaspal Kang ,  Palaniswami Rathanaswami ,  Kiran Ahluwalia ,  Orit Foord ,  Scott Klakamp

IPC分类号： A61K39/395 ,  C07K16/24

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

摘要： The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies directed to IL-13. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Additionally, methods of using these antibodies to treat patients are also provided. Additionally, IL-13 dependent biomarkers and methods of their identification and use are also provided.

公开(公告)号：US07585500B2

公开(公告)日：2009-09-08

申请号：US11281266

申请日：2005-11-16

申请人： Ian Foltz ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Kathy Manchulenko ,  Jaspal S. Kang ,  Palaniswami Rathanaswami ,  Kiran Ahluwalia ,  Orit Foord ,  Scott Klakamp

发明人： Ian Foltz ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Kathy Manchulenko ,  Jaspal S. Kang ,  Palaniswami Rathanaswami ,  Kiran Ahluwalia ,  Orit Foord ,  Scott Klakamp

IPC分类号： A61K39/395 ,  C07K16/24

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

摘要： The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies directed to IL-13. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Additionally, methods of using these antibodies to treat patients are also provided. Additionally, IL-13 dependent biomarkers and methods of their identification and use are also provided.

摘要翻译： 本发明涉及针对IL-13的抗体和这种抗体的用途。 例如，根据本发明，提供了针对IL-13的人单克隆抗体。 提供了分离的多核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列。 此外，还提供了使用这些抗体治疗患者的方法。 此外，还提供IL-13依赖性生物标志物及其鉴定和使用方法。

公开(公告)号：US07994302B2

公开(公告)日：2011-08-09

申请号：US12535639

申请日：2009-08-04

申请人： Ian Foltz ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Kathy Manchulenko ,  Jaspal S. Kang ,  Palaniswami Rathanaswami ,  Kiran Ahluwalia ,  Orit Foord ,  Scott Klakamp

发明人： Ian Foltz ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Kathy Manchulenko ,  Jaspal S. Kang ,  Palaniswami Rathanaswami ,  Kiran Ahluwalia ,  Orit Foord ,  Scott Klakamp

IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N5/10 ,  C12N15/63

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

摘要： The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies directed to IL-13. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Additionally, methods of using these antibodies to treat patients are also provided. Additionally, IL-13 dependent biomarkers and methods of their identification and use are also provided.

摘要翻译： 本发明涉及针对IL-13的抗体和这种抗体的用途。 例如，根据本发明，提供了针对IL-13的人单克隆抗体。 提供了分离的多核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列。 此外，还提供了使用这些抗体治疗患者的方法。 此外，还提供IL-13依赖性生物标志物及其鉴定和使用方法。

公开(公告)号：US20100047253A1

公开(公告)日：2010-02-25

申请号：US12535639

申请日：2009-08-04

申请人： Ian Foltz ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Kathy Manchulenko ,  Jaspal S. Kang ,  Palaniswami Rathanaswami ,  Kiran Ahluwalia ,  Orit Foord ,  Scott Klakamp

发明人： Ian Foltz ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Kathy Manchulenko ,  Jaspal S. Kang ,  Palaniswami Rathanaswami ,  Kiran Ahluwalia ,  Orit Foord ,  Scott Klakamp

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N5/00 ,  C12N15/63 ,  C12P21/04

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

摘要： The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies directed to IL-13. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Additionally, methods of using these antibodies to treat patients are also provided. Additionally, IL-13 dependent biomarkers and methods of their identification and use are also provided.

摘要翻译： 本发明涉及针对IL-13的抗体和这种抗体的用途。 例如，根据本发明，提供了针对IL-13的人单克隆抗体。 提供了分离的多核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列。 此外，还提供了使用这些抗体治疗患者的方法。 此外，还提供IL-13依赖性生物标志物及其鉴定和使用方法。

公开(公告)号：US20080187531A1

公开(公告)日：2008-08-07

申请号：US11876669

申请日：2007-10-22

申请人： John S. Babcook ,  Jaspal S. Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah "Rozanne" Lee ,  Kathy Manchulenko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Jane Su

发明人： John S. Babcook ,  Jaspal S. Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah "Rozanne" Lee ,  Kathy Manchulenko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Jane Su

IPC分类号： A61K39/395 ,  C07K16/00

CPC分类号： C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

公开(公告)号：US08101178B2

公开(公告)日：2012-01-24

申请号：US11876669

申请日：2007-10-22

申请人： John S. Babcook ,  Jaspal S. Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah Lee ,  Kathy Manchulenko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Jane Su

发明人： John S. Babcook ,  Jaspal S. Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah Lee ,  Kathy Manchulenko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Jane Su

IPC分类号： A61K39/395

CPC分类号： C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

公开(公告)号：US07285269B2

公开(公告)日：2007-10-23

申请号：US10727155

申请日：2003-12-02

申请人： John S. Babcook ,  Jaspal S. Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah Lee ,  Kathy Manchulenko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Jane Su

发明人： John S. Babcook ,  Jaspal S. Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah Lee ,  Kathy Manchulenko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Jane Su

IPC分类号： A61K39/395 ,  C07K16/24

CPC分类号： C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

公开(公告)号：US20050049402A1

公开(公告)日：2005-03-03

申请号：US10727155

申请日：2003-12-02

申请人： John Babcook ,  Jaspal Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah Lee ,  Kathy Manchulencko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Su

发明人： John Babcook ,  Jaspal Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah Lee ,  Kathy Manchulencko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Su

IPC分类号： C07K16/24

CPC分类号： C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

公开(公告)号：US20050053608A1

公开(公告)日：2005-03-10

申请号：US10877773

申请日：2004-06-25

申请人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal Kang ,  Chadwick King ,  Scott Klakamp ,  Qiaojuan Su

发明人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal Kang ,  Chadwick King ,  Scott Klakamp ,  Qiaojuan Su

IPC分类号： A61K39/395 ,  A61K47/48 ,  C07K16/22 ,  C07K16/28 ,  C07K17/00 ,  C12N20060101 ,  C12N5/06 ,  G01N33/53

CPC分类号： C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

公开(公告)号：US20050059087A1

公开(公告)日：2005-03-17

申请号：US10877774

申请日：2004-06-25

申请人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal Kang ,  Chadwick King ,  Scott Klakamp ,  Qiaojuan Su

发明人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal Kang ,  Chadwick King ,  Scott Klakamp ,  Qiaojuan Su

IPC分类号： A61K39/395 ,  A61K47/48 ,  C07K16/22 ,  C07K16/28 ,  C07K17/00 ,  C12N20060101 ,  C12N5/06 ,  G01N33/53

CPC分类号： C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

摘要翻译： 本发明涉及新型抗体，特别是针对表皮生长因子受体的缺失突变体的抗体，特别涉及III型缺失突变体EGFRvIII的抗体。 本发明还涉及针对表皮生长因子受体，特别是EGFRvIII的缺失突变体的人单克隆抗体。 还提供了这种抗体的诊断和治疗制剂及其免疫偶联物。