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公开(公告)号：US07994302B2
公开(公告)日：2011-08-09
申请号：US12535639
申请日：2009-08-04
申请人： Ian Foltz , Raffaella Faggioni , Giorgio Senaldi , Kathy Manchulenko , Jaspal S. Kang , Palaniswami Rathanaswami , Kiran Ahluwalia , Orit Foord , Scott Klakamp
发明人： Ian Foltz , Raffaella Faggioni , Giorgio Senaldi , Kathy Manchulenko , Jaspal S. Kang , Palaniswami Rathanaswami , Kiran Ahluwalia , Orit Foord , Scott Klakamp
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies directed to IL-13. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Additionally, methods of using these antibodies to treat patients are also provided. Additionally, IL-13 dependent biomarkers and methods of their identification and use are also provided.
摘要翻译： 本发明涉及针对IL-13的抗体和这种抗体的用途。 例如，根据本发明，提供了针对IL-13的人单克隆抗体。 提供了分离的多核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列。 此外，还提供了使用这些抗体治疗患者的方法。 此外，还提供IL-13依赖性生物标志物及其鉴定和使用方法。
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公开(公告)号：US20100047253A1
公开(公告)日：2010-02-25
申请号：US12535639
申请日：2009-08-04
申请人： Ian Foltz , Raffaella Faggioni , Giorgio Senaldi , Kathy Manchulenko , Jaspal S. Kang , Palaniswami Rathanaswami , Kiran Ahluwalia , Orit Foord , Scott Klakamp
发明人： Ian Foltz , Raffaella Faggioni , Giorgio Senaldi , Kathy Manchulenko , Jaspal S. Kang , Palaniswami Rathanaswami , Kiran Ahluwalia , Orit Foord , Scott Klakamp
IPC分类号： A61K39/395 , C07H21/04 , C12N5/00 , C12N15/63 , C12P21/04
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies directed to IL-13. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Additionally, methods of using these antibodies to treat patients are also provided. Additionally, IL-13 dependent biomarkers and methods of their identification and use are also provided.
摘要翻译： 本发明涉及针对IL-13的抗体和这种抗体的用途。 例如，根据本发明，提供了针对IL-13的人单克隆抗体。 提供了分离的多核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列。 此外，还提供了使用这些抗体治疗患者的方法。 此外，还提供IL-13依赖性生物标志物及其鉴定和使用方法。
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公开(公告)号：US07585500B2
公开(公告)日：2009-09-08
申请号：US11281266
申请日：2005-11-16
申请人： Ian Foltz , Raffaella Faggioni , Giorgio Senaldi , Kathy Manchulenko , Jaspal S. Kang , Palaniswami Rathanaswami , Kiran Ahluwalia , Orit Foord , Scott Klakamp
发明人： Ian Foltz , Raffaella Faggioni , Giorgio Senaldi , Kathy Manchulenko , Jaspal S. Kang , Palaniswami Rathanaswami , Kiran Ahluwalia , Orit Foord , Scott Klakamp
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies directed to IL-13. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Additionally, methods of using these antibodies to treat patients are also provided. Additionally, IL-13 dependent biomarkers and methods of their identification and use are also provided.
摘要翻译： 本发明涉及针对IL-13的抗体和这种抗体的用途。 例如，根据本发明，提供了针对IL-13的人单克隆抗体。 提供了分离的多核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列。 此外，还提供了使用这些抗体治疗患者的方法。 此外，还提供IL-13依赖性生物标志物及其鉴定和使用方法。
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公开(公告)号：US20060140948A1
公开(公告)日：2006-06-29
申请号：US11281266
申请日：2005-11-16
申请人： Ian Foltz , Raffaella Faggioni , Giorgio Senaldi , Kathy Manchulenko , Jaspal Kang , Palaniswami Rathanaswami , Kiran Ahluwalia , Orit Foord , Scott Klakamp
发明人： Ian Foltz , Raffaella Faggioni , Giorgio Senaldi , Kathy Manchulenko , Jaspal Kang , Palaniswami Rathanaswami , Kiran Ahluwalia , Orit Foord , Scott Klakamp
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies directed to IL-13. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Additionally, methods of using these antibodies to treat patients are also provided. Additionally, IL-13 dependent biomarkers and methods of their identification and use are also provided.
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公开(公告)号：US20080187531A1
公开(公告)日：2008-08-07
申请号：US11876669
申请日：2007-10-22
申请人： John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah "Rozanne" Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
发明人： John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah "Rozanne" Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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公开(公告)号：US08101178B2
公开(公告)日：2012-01-24
申请号：US11876669
申请日：2007-10-22
申请人： John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
发明人： John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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公开(公告)号：US07285269B2
公开(公告)日：2007-10-23
申请号：US10727155
申请日：2003-12-02
申请人： John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
发明人： John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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公开(公告)号：US20050049402A1
公开(公告)日：2005-03-03
申请号：US10727155
申请日：2003-12-02
申请人： John Babcook , Jaspal Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah Lee , Kathy Manchulencko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Su
发明人： John Babcook , Jaspal Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah Lee , Kathy Manchulencko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Su
IPC分类号： C07K16/24
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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9.发明授权公开(公告)号：US09062113B2
公开(公告)日：2015-06-23
申请号：US12268363
申请日：2008-11-10
申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
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10.发明授权公开(公告)号：US09096672B2
公开(公告)日：2015-08-04
申请号：US12396313
申请日：2009-03-02
申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395 , A61K47/48 , B82Y5/00
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
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