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公开(公告)号：US08772711B1
公开(公告)日：2014-07-08
申请号：US14011529
申请日：2013-08-27
CPC分类号： H01J49/063 , H01J49/0063
摘要： A method of dissociating ions in a multipole ion guide is disclosed. A stream of charged ions is supplied to the ion guide. A main RF field is applied to the ion guide to confine the ions through the ion guide. An excitation RF field is applied to one pair of rods of the ion guide. The ions undergo dissociation when the applied excitation RF field is resonant with a secular frequency of the ions. The multipole ion guide is, but not limited to, a quadrupole, a hexapole, and an octopole.
摘要翻译： 公开了一种在多极离子导向器中离解离子的方法。 将带电离子流供给到离子导向器。 将主RF场施加到离子导向器以将离子限制在离子导向器上。 激发RF场施加到离子导向器的一对杆上。 当所施加的激发RF场与离子的长期频率谐振时，离子发生解离。 多极离子导向器是但不限于四极，六极和八极。
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公开(公告)号：US08907273B1
公开(公告)日：2014-12-09
申请号：US14292437
申请日：2014-05-30
申请人： Tsung-Chi Chen , Keqi Tang , Yehia M. Ibrahim , Richard D. Smith , Gordon A. Anderson , Erin M. Baker
发明人： Tsung-Chi Chen , Keqi Tang , Yehia M. Ibrahim , Richard D. Smith , Gordon A. Anderson , Erin M. Baker
IPC分类号： H01J49/06
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area. A predetermined number of pairs of surfaces are disposed in one or more chambers, forming a multiple-layer ion mobility cyclotron device.
摘要翻译： 公开了一种离子操作方法和装置。 该装置包括一对基本平行的表面。 内部电极的阵列包含在每个平行表面内并且基本上沿着每个平行表面的长度延伸。 该装置包括电极的第一外部阵列和第二外部电极阵列。 每个外部电极阵列位于内部电极的任一侧上，并且基本上沿着每个平行表面的长度容纳并延伸。 DC电压施加到第一和第二外部电极阵列。 通过向每个电极施加直流电压，将具有叠加电场的RF电压施加到内部电极。 离子在离子限制区域内的平行表面之间或沿着电场方向的路径移动，或者可以被捕获在离子限制区域中。 预定数量的一对表面设置在一个或多个室中，形成多层离子迁移回旋加速器装置。
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公开(公告)号：US08901490B1
公开(公告)日：2014-12-02
申请号：US14292448
申请日：2014-05-30
申请人： Tsung-Chi Chen , Keqi Tang , Yehia M. Ibrahim , Richard D. Smith , Gordon A. Anderson , Erin M. Baker
发明人： Tsung-Chi Chen , Keqi Tang , Yehia M. Ibrahim , Richard D. Smith , Gordon A. Anderson , Erin M. Baker
IPC分类号： H01J49/42
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area. The surfaces are housed in a chamber, and at least one electrically insulative shield is coupled to an inner surface of the chamber for increasing a mean-free-path between two adjacent electrodes in the chamber.
摘要翻译： 公开了一种离子操作方法和装置。 该装置包括一对基本平行的表面。 内部电极的阵列包含在每个平行表面内并且基本上沿着每个平行表面的长度延伸。 该装置包括电极的第一外部阵列和第二外部电极阵列。 每个外部电极阵列位于内部电极的任一侧上，并且基本上沿着每个平行表面的长度容纳并延伸。 DC电压施加到第一和第二外部电极阵列。 通过向每个电极施加直流电压，将具有叠加电场的RF电压施加到内部电极。 离子在离子限制区域内的平行表面之间或沿着电场方向的路径移动，或者可以被捕获在离子限制区域中。 表面容纳在腔室中，并且至少一个电绝缘屏蔽件联接到腔室的内表面，以增加腔室中两个相邻电极之间的平均自由程。
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公开(公告)号：US20150357174A1
公开(公告)日：2015-12-10
申请号：US14733517
申请日：2015-06-08
IPC分类号： H01J49/06
CPC分类号： H01J49/066
摘要： An ion funnel device is disclosed. A first pair of electrodes is positioned in a first direction. A second pair of electrodes is positioned in a second direction. The device includes an RF voltage source and a DC voltage source. A RF voltage with a superimposed DC voltage gradient is applied to the first pair of electrodes, and a DC voltage gradient is applied to the second pair of electrodes.
摘要翻译： 公开了一种离子漏斗装置。 第一对电极位于第一方向。 第二对电极位于第二方向。 该器件包括一个RF电压源和一个直流电压源。 将具有叠加的DC电压梯度的RF电压施加到第一对电极，并且将直流电压梯度施加到第二对电极。
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公开(公告)号：US07491930B2
公开(公告)日：2009-02-17
申请号：US11617889
申请日：2006-12-29
CPC分类号： H01J49/004 , G01N27/624
摘要： Disclosed are a device and method for improved interfacing of differential mobility spectrometry (DMS) or field asymmetric waveform ion mobility spectrometry (FAIMS) analyzers of substantially planar geometry to subsequent or preceding instrument stages. Interfacing is achieved using curved DMS elements, where a thick ion beam emitted by planar DMS analyzers or injected into them for ion filtering is compressed to the gap median by DMS ion focusing effect in a spatially inhomogeneous electric field. Resulting thinner beams are more effectively transmitted through necessarily constrained conductance limit apertures to subsequent instrument stages operated at a pressure lower than DMS, and/or more effectively injected into planar DMS analyzers. The technology is synergetic with slit apertures, slit aperture/ion funnels, and high-pressure ion funnel interfaces known in the art which allow for increasing cross-sectional area of MS inlets. The invention may be used in integrated analytical platforms, including, e.g., DMS/MS, LC/DMS/MS, and DMS/IMS/MS that could replace and/or enhance current LC/MS methods, e.g., for proteomics research.
摘要翻译： 公开了一种用于改进基本平面几何形状的差分迁移率谱（DMS）或场非对称波形离子迁移谱（FAIMS）分析仪与随后或之前仪器级的接口的装置和方法。 使用弯曲的DMS元件实现接合，其中通过平面DMS分析仪发射或注入其中以进行离子过滤的厚离子束通过在空间不均匀电场中的DMS离子聚焦效应被压缩到间隙中间值。 所产生的较薄的梁更有效地通过必须约束的电导极限孔传输到在低于DMS的压力下操作的后续仪器级，和/或更有效地注入到平面DMS分析仪中。 该技术与本领域已知的狭缝孔，狭缝孔/离子漏斗和高压离子漏斗接口协同，允许增加MS入口的横截面面积。 本发明可以用于综合分析平台，包括例如DMS / MS，LC / DMS / MS和DMS / IMS / MS，其可以替代和/或增强当前的LC / MS方法，例如蛋白质组学研究。
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公开(公告)号：US20080156978A1
公开(公告)日：2008-07-03
申请号：US11617889
申请日：2006-12-29
IPC分类号： H01J49/06
CPC分类号： H01J49/004 , G01N27/624
摘要： Disclosed are a device and method for improved interfacing of differential mobility spectrometry (DMS) or field asymmetric waveform ion mobility spectrometry (FAIMS) analyzers of substantially planar geometry to subsequent or preceding instrument stages. Interfacing is achieved using curved DMS elements, where a thick ion beam emitted by planar DMS analyzers or injected into them for ion filtering is compressed to the gap median by DMS ion focusing effect in a spatially inhomogeneous electric field. Resulting thinner beams are more effectively transmitted through necessarily constrained conductance limit apertures to subsequent instrument stages operated at a pressure lower than DMS, and/or more effectively injected into planar DMS analyzers. The technology is synergetic with slit apertures, slit aperture/ion funnels, and high-pressure ion funnel interfaces known in the art which allow for increasing cross-sectional area of MS inlets. The invention may be used in integrated analytical platforms, including, e.g., DMS/MS, LC/DMS/MS, and DMS/IMS/MS that could replace and/or enhance current LC/MS methods, e.g., for proteomics research.
摘要翻译： 公开了一种用于改进基本平面几何形状的差分迁移率谱（DMS）或场非对称波形离子迁移谱（FAIMS）分析仪与随后或之前仪器级的接口的装置和方法。 使用弯曲的DMS元件实现接合，其中通过平面DMS分析仪发射或注入其中以进行离子过滤的厚离子束通过在空间不均匀电场中的DMS离子聚焦效应被压缩到间隙中间值。 所产生的较薄的梁更有效地通过必须约束的电导极限孔传输到在低于DMS的压力下操作的后续仪器级，和/或更有效地注入到平面DMS分析仪中。 该技术与本领域已知的狭缝孔，狭缝孔/离子漏斗和高压离子漏斗接口协同，允许增加MS入口的横截面面积。 本发明可以用于综合分析平台，包括例如DMS / MS，LC / DMS / MS和DMS / IMS / MS，其可以替代和/或增强当前的LC / MS方法，例如蛋白质组学研究。
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公开(公告)号：US20150076343A1
公开(公告)日：2015-03-19
申请号：US14528917
申请日：2014-10-30
IPC分类号： H01J49/06
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device to prevent loss of ions is disclosed. The device includes a pair of surfaces. An inner array of electrodes is coupled to the surfaces. A RF voltage and a DC voltage are alternately applied to the inner array of electrodes. The applied RF voltage is alternately positive and negative so that immediately adjacent or nearest neighbor RF applied electrodes are supplied with RF signals that are approximately 180 degrees out of phase.
摘要翻译： 公开了一种用于防止离子损失的离子操作方法和装置。 该装置包括一对表面。 电极的内部阵列耦合到表面。 RF电压和DC电压交替施加到电极的内部阵列。 施加的RF电压交替地是正的和负的，使得紧邻或最近邻RF施加的电极被提供有大约相差180度的RF信号。
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公开(公告)号：US09063086B1
公开(公告)日：2015-06-23
申请号：US14179329
申请日：2014-02-12
CPC分类号： G01N27/622
摘要： A method and apparatus for compressing ions inside an ion mobility device is disclosed. Ions are introduced into the mobility device. The ions are subjected to a non-constant electric field to form a potential gradient along a portion of the device so that ions with similar mobilities bunch together into sharper peaks while maintaining separation between other ions. The potential gradient progressively increases or decreases along the length of the device.
摘要翻译： 公开了一种用于在离子迁移率装置内压缩离子的方法和装置。 离子被引入到移动设备中。 离子受到非恒定电场以沿器件的一部分形成电位梯度，使得具有相似迁移率的离子聚集在一起成为更尖锐的峰，同时保持其他离子之间的分离。 电位梯度沿器件的长度逐渐增加或减小。
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公开(公告)号：US08969800B1
公开(公告)日：2015-03-03
申请号：US14528917
申请日：2014-10-30
IPC分类号： H01J49/26
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device to prevent loss of ions is disclosed. The device includes a pair of surfaces. An inner array of electrodes is coupled to the surfaces. A RF voltage and a DC voltage are alternately applied to the inner array of electrodes. The applied RF voltage is alternately positive and negative so that immediately adjacent or nearest neighbor RF applied electrodes are supplied with RF signals that are approximately 180 degrees out of phase.
摘要翻译： 公开了一种用于防止离子损失的离子操作方法和装置。 该装置包括一对表面。 电极的内部阵列耦合到表面。 RF电压和DC电压交替施加到电极的内部阵列。 施加的RF电压交替地是正的和负的，使得紧邻或最近邻RF施加的电极被提供有大约相差180度的RF信号。
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公开(公告)号：US08835839B1
公开(公告)日：2014-09-16
申请号：US14146922
申请日：2014-01-03
IPC分类号： H01J49/06
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area.
摘要翻译： 公开了一种离子操作方法和装置。 该装置包括一对基本上平行的表面。 内部电极的阵列包含在每个平行表面内并且基本上沿着每个平行表面的长度延伸。 该装置包括电极的第一外部阵列和第二外部电极阵列。 每个外部电极阵列位于内部电极的任一侧上，并且基本上沿着每个平行表面的长度容纳并延伸。 DC电压施加到第一和第二外部电极阵列。 通过向每个电极施加直流电压，将具有叠加电场的RF电压施加到内部电极。 离子在离子限制区域内的平行表面之间或沿着电场方向的路径移动，或者可以被捕获在离子限制区域中。
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