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公开(公告)号：US09704701B2
公开(公告)日：2017-07-11
申请号：US14851935
申请日：2015-09-11
CPC分类号： H01J49/26 , G01N27/622 , H01J49/0013 , H01J49/022 , H01J49/40
摘要： Methods and devices for ion separations or manipulations in gas phase are disclosed. The device includes a single non-planar surface. Arrays of electrodes are coupled to the surface. A combination of RF and DC voltages are applied to the arrays of electrodes to create confining and driving fields that move ions through the device. The DC voltages are static DC voltages or time-dependent DC potentials or waveforms.
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公开(公告)号：US20150303046A1
公开(公告)日：2015-10-22
申请号：US14256555
申请日：2014-04-18
申请人： Yehia M. Ibrahim , Richard D. Smith
发明人： Yehia M. Ibrahim , Richard D. Smith
IPC分类号： H01J49/06
CPC分类号： H01J49/066 , H01J49/06 , H01J49/062 , H01J49/063 , H01J49/065
摘要： A device for separating non-ions from ions is disclosed. The device includes a plurality of electrodes positioned around a center axis of the device and having apertures therein through which the ions are transmitted. An inner diameter of the apertures varies in length. At least a portion of the center axis between the electrodes is non-linear.
摘要翻译： 公开了一种用于从离子离子分离的装置。 该装置包括围绕该装置的中心轴定位的多个电极，并且其中具有孔，离子通过该孔传输。 孔径的内径长度变化。 电极之间的中心轴的至少一部分是非线性的。
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公开(公告)号：US20150076343A1
公开(公告)日：2015-03-19
申请号：US14528917
申请日：2014-10-30
IPC分类号： H01J49/06
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device to prevent loss of ions is disclosed. The device includes a pair of surfaces. An inner array of electrodes is coupled to the surfaces. A RF voltage and a DC voltage are alternately applied to the inner array of electrodes. The applied RF voltage is alternately positive and negative so that immediately adjacent or nearest neighbor RF applied electrodes are supplied with RF signals that are approximately 180 degrees out of phase.
摘要翻译： 公开了一种用于防止离子损失的离子操作方法和装置。 该装置包括一对表面。 电极的内部阵列耦合到表面。 RF电压和DC电压交替施加到电极的内部阵列。 施加的RF电压交替地是正的和负的，使得紧邻或最近邻RF施加的电极被提供有大约相差180度的RF信号。
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公开(公告)号：US08907273B1
公开(公告)日：2014-12-09
申请号：US14292437
申请日：2014-05-30
申请人： Tsung-Chi Chen , Keqi Tang , Yehia M. Ibrahim , Richard D. Smith , Gordon A. Anderson , Erin M. Baker
发明人： Tsung-Chi Chen , Keqi Tang , Yehia M. Ibrahim , Richard D. Smith , Gordon A. Anderson , Erin M. Baker
IPC分类号： H01J49/06
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area. A predetermined number of pairs of surfaces are disposed in one or more chambers, forming a multiple-layer ion mobility cyclotron device.
摘要翻译： 公开了一种离子操作方法和装置。 该装置包括一对基本平行的表面。 内部电极的阵列包含在每个平行表面内并且基本上沿着每个平行表面的长度延伸。 该装置包括电极的第一外部阵列和第二外部电极阵列。 每个外部电极阵列位于内部电极的任一侧上，并且基本上沿着每个平行表面的长度容纳并延伸。 DC电压施加到第一和第二外部电极阵列。 通过向每个电极施加直流电压，将具有叠加电场的RF电压施加到内部电极。 离子在离子限制区域内的平行表面之间或沿着电场方向的路径移动，或者可以被捕获在离子限制区域中。 预定数量的一对表面设置在一个或多个室中，形成多层离子迁移回旋加速器装置。
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公开(公告)号：US07888635B2
公开(公告)日：2011-02-15
申请号：US12156360
申请日：2008-05-30
IPC分类号： H01J49/26
CPC分类号： H01J49/4235 , H01J49/066
摘要： An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of ˜1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of ˜10,000,000 elementary charges, 4) ion ejection time of 40 to 200 μs, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.
摘要翻译： 描述了一种离子漏斗阱，其包括入口部分，捕获部分和出口部分，其在正常操作中与离子漏斗相连。 离子阱在〜1乇的压力下有效地工作，并提供：1）去除低质量 - 电荷（m / z）离子物质，2）离子累积效率高达80％，3）充电容量 〜10万次基本电荷，4）离子喷射时间为40〜200μs，5）优化的可变离子积聚时间。 具有低浓度肽混合物的离子累积显示出30倍的分析物信噪比（SNR）的增加，以及多次充电分析物的SNR的提高大于10倍。
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公开(公告)号：US20150357174A1
公开(公告)日：2015-12-10
申请号：US14733517
申请日：2015-06-08
IPC分类号： H01J49/06
CPC分类号： H01J49/066
摘要： An ion funnel device is disclosed. A first pair of electrodes is positioned in a first direction. A second pair of electrodes is positioned in a second direction. The device includes an RF voltage source and a DC voltage source. A RF voltage with a superimposed DC voltage gradient is applied to the first pair of electrodes, and a DC voltage gradient is applied to the second pair of electrodes.
摘要翻译： 公开了一种离子漏斗装置。 第一对电极位于第一方向。 第二对电极位于第二方向。 该器件包括一个RF电压源和一个直流电压源。 将具有叠加的DC电压梯度的RF电压施加到第一对电极，并且将直流电压梯度施加到第二对电极。
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公开(公告)号：US09245725B2
公开(公告)日：2016-01-26
申请号：US14179008
申请日：2014-02-12
申请人： Yehia M. Ibrahim , Richard D. Smith
发明人： Yehia M. Ibrahim , Richard D. Smith
CPC分类号： H01J49/065
摘要： An ion trap device is disclosed. The device includes a series of electrodes that define an ion flow path. A radio frequency (RF) field is applied to the series of electrodes such that each electrode is phase shifted approximately 180 degrees from an adjacent electrode. A DC voltage is superimposed with the RF field to create a DC gradient to drive ions in the direction of the gradient. A second RF field or DC voltage is applied to selectively trap and release the ions from the device. Further, the device may be gridless and utilized at high pressure.
摘要翻译： 公开了一种离子阱装置。 该装置包括限定离子流动路径的一系列电极。 射频（RF）场被施加到一系列电极，使得每个电极与相邻电极相差大约180度。 直流电压与RF场叠加以产生沿梯度方向驱动离子的直流梯度。 施加第二RF场或DC电压以选择性地从装置中捕集和释放离子。 此外，该装置可以是无栅极的并且在高压下使用。
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公开(公告)号：US09063086B1
公开(公告)日：2015-06-23
申请号：US14179329
申请日：2014-02-12
CPC分类号： G01N27/622
摘要： A method and apparatus for compressing ions inside an ion mobility device is disclosed. Ions are introduced into the mobility device. The ions are subjected to a non-constant electric field to form a potential gradient along a portion of the device so that ions with similar mobilities bunch together into sharper peaks while maintaining separation between other ions. The potential gradient progressively increases or decreases along the length of the device.
摘要翻译： 公开了一种用于在离子迁移率装置内压缩离子的方法和装置。 离子被引入到移动设备中。 离子受到非恒定电场以沿器件的一部分形成电位梯度，使得具有相似迁移率的离子聚集在一起成为更尖锐的峰，同时保持其他离子之间的分离。 电位梯度沿器件的长度逐渐增加或减小。
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公开(公告)号：US08772711B1
公开(公告)日：2014-07-08
申请号：US14011529
申请日：2013-08-27
CPC分类号： H01J49/063 , H01J49/0063
摘要： A method of dissociating ions in a multipole ion guide is disclosed. A stream of charged ions is supplied to the ion guide. A main RF field is applied to the ion guide to confine the ions through the ion guide. An excitation RF field is applied to one pair of rods of the ion guide. The ions undergo dissociation when the applied excitation RF field is resonant with a secular frequency of the ions. The multipole ion guide is, but not limited to, a quadrupole, a hexapole, and an octopole.
摘要翻译： 公开了一种在多极离子导向器中离解离子的方法。 将带电离子流供给到离子导向器。 将主RF场施加到离子导向器以将离子限制在离子导向器上。 激发RF场施加到离子导向器的一对杆上。 当所施加的激发RF场与离子的长期频率谐振时，离子发生解离。 多极离子导向器是但不限于四极，六极和八极。
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公开(公告)号：US08541737B2
公开(公告)日：2013-09-24
申请号：US12769268
申请日：2010-04-28
IPC分类号： H01J49/00
CPC分类号： H01J49/004
摘要： A collision cell is disclosed that provides ion activation in various selective modes. Ion activation is performed inside selected segments of a segmented quadrupole that provides maximum optimum capture and collection of fragmentation products. The invention provides collisional cooling of precursor ions as well as product fragments and further allows effective transmission of ions through a high pressure interface into a coupled mass analysis instrument.
摘要翻译： 公开了一种以各种选择模式提供离子激活的碰撞池。 离子激活在分段四极杆的选定区段内进行，提供最大限度的捕获和收集碎裂产物。 本发明提供前体离子以及产物碎片的碰撞冷却，并进一步允许离子通过高压界面有效传输到耦合的质量分析仪器中。
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