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公开(公告)号:US06187587B1
公开(公告)日:2001-02-13
申请号:US09517584
申请日:2000-03-02
IPC分类号: C07H2104
CPC分类号: C12N15/113 , A61K38/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of E2F transcription factor 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding E2F transcription factor 1. Methods of using these compounds for modulation of E2F transcription factor 1 expression and for treatment of diseases associated with expression of E2F transcription factor 1 are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节E2F转录因子1的表达。该组合物包含靶向编码E2F转录因子1的核酸的反义化合物,特别是反义寡核苷酸。使用这些化合物调节E2F转录因子1的方法 提供了表达和治疗与E2F转录因子1表达相关的疾病。
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公开(公告)号:US06451602B1
公开(公告)日:2002-09-17
申请号:US09517467
申请日:2000-03-02
申请人: Ian Popoff , Lex M. Cowsert
发明人: Ian Popoff , Lex M. Cowsert
IPC分类号: C12Q168
CPC分类号: C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y204/0203 , Y02P20/582 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of human PARP. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding human PARP. Methods of using these compounds for modulation of human PARP expression and for treatment of diseases associated with expression of human PARP are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节人PARP的表达。 组合物包含靶向编码人PARP的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节人PARP表达和治疗与人PARP表达相关的疾病的方法。
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公开(公告)号:US08916531B2
公开(公告)日:2014-12-23
申请号:US12743797
申请日:2008-11-20
IPC分类号: C12N15/113
CPC分类号: C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要: Disclosed herein are antisense compounds and methods for decreasing CD40. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to CD40 include hyperproliferative disorders, graft versus host disease (GVHD), graft rejection, asthma, airway hyperresponsiveness, chronic obstructive pulmonary disease (COPD), multiple sclerosis (MS), systemic lupus erythematosus (SLE), and certain forms of arthritis.
摘要翻译: 本文公开了用于减少CD40的反义化合物和方法。 通过施用靶向CD40的反义化合物可以改善的疾病状况的实例包括过度增殖性疾病,移植物抗宿主病(GVHD),移植物排斥反应,哮喘,气道高反应性,慢性阻塞性肺疾病(COPD),多发性硬化(MS) ,系统性红斑狼疮(SLE)和某些形式的关节炎。
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公开(公告)号:US20120077862A1
公开(公告)日:2012-03-29
申请号:US13177462
申请日:2011-07-06
申请人: Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madelline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
发明人: Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madelline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
CPC分类号: C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
摘要翻译: 提供化合物,组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。
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公开(公告)号:US06784290B1
公开(公告)日:2004-08-31
申请号:US09575554
申请日:2000-05-22
IPC分类号: C07H2102
CPC分类号: C12N15/1135 , A61K38/00 , C07K14/82 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/3521 , C12N2310/3527 , C12N2310/3533 , C12Q2525/125 , C12N2310/3525
摘要: Compositions and methods are provided for the modulation of ras expression. Oligonucleotides are provided which are targeted to nucleic acids encoding human ras. Oligonucleotides specifically hybridizable with mRNA encoding human H-ras, Ki-ras and N-ras are provided. Such oligonucleotides can be used for therapeutics and diagnostics as well as for research purposes. Methods are also disclosed for modulating ras gene expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of activated ras. Methods for diagnosis, detection and treatment of conditions, or particular cancers, associated with ras are also disclosed.
摘要翻译: 提供了ras表达调控的组成和方法。 提供了靶向编码人ras的核酸的寡核苷酸。 提供与编码人H-ras,Ki-ras和N-ras的mRNA特异性杂交的寡核苷酸。 这样的寡核苷酸可用于治疗和诊断以及用于研究目的。 还公开了使用所提供的寡核苷酸调节细胞和组织中的ras基因表达以及用于特异性调节活化的ras表达的方法。 还公开了与ras有关的病症或特定癌症的诊断,检测和治疗方法。
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公开(公告)号:US06372492B1
公开(公告)日:2002-04-16
申请号:US09702251
申请日:2000-10-30
申请人: C. Frank Bennett , Lex M. Cowsert
发明人: C. Frank Bennett , Lex M. Cowsert
IPC分类号: C12N1500
CPC分类号: C12N15/113 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of Talin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Talin. Methods of using these compounds for modulation of Talin expression and for treatment of diseases associated with expression of Talin are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节Talin的表达。 组合物包含靶向编码Talin的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节Talin表达和治疗与Talin表达相关的疾病的方法。
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公开(公告)号:US06352858B1
公开(公告)日:2002-03-05
申请号:US09660925
申请日:2000-09-11
申请人: Lex M. Cowsert , Susan M. Freier
发明人: Lex M. Cowsert , Susan M. Freier
IPC分类号: C12N1511
CPC分类号: C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/01037 , Y02P20/582 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of BTAK. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding BTAK. Methods of using these compounds for modulation of BTAK expression and for treatment of diseases associated with expression of BTAK are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节BTAK的表达。 组合物包含靶向编码BTAK的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节BTAK表达和治疗与BTAK表达相关的疾病的方法。
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公开(公告)号:US06277640B1
公开(公告)日:2001-08-21
申请号:US09630706
申请日:2000-07-31
申请人: C. Frank Bennett , Lex M. Cowsert
发明人: C. Frank Bennett , Lex M. Cowsert
IPC分类号: C12N1563
CPC分类号: C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3521 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for inhibiting the expression of Her-3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Her-3. Methods of using these compounds for inhibition of Her-3 expression and for treatment of diseases associated with expression of Her-3 are provided.
摘要翻译: 提供反义化合物,组合物和方法用于抑制Her-3的表达。 组合物包含靶向编码Her-3的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物抑制Her-3表达和治疗与Her-3表达相关的疾病的方法。
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公开(公告)号:US06277636B1
公开(公告)日:2001-08-21
申请号:US09662249
申请日:2000-09-14
申请人: Brett P. Monia , Lex M. Cowsert
发明人: Brett P. Monia , Lex M. Cowsert
IPC分类号: C07H2104
CPC分类号: C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of MADH6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MADH6. Methods of using these compounds for modulation of MADH6 expression and for treatment of diseases associated with expression of MADH6 are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节MADH6的表达。 该组合物包含靶向编码MADH6的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节MADH6表达和治疗与MADH6表达相关的疾病的方法。
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公开(公告)号:US06271029B1
公开(公告)日:2001-08-07
申请号:US09428583
申请日:1999-10-27
申请人: C. Frank Bennett , Lex M. Cowsert
发明人: C. Frank Bennett , Lex M. Cowsert
IPC分类号: A61K317088
CPC分类号: C12N15/113 , A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of cytohesin-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding cytohesin-2. Methods of using these compounds for modulation of cytohesin-2 expression and for treatment of diseases associated with expression of cytohesin-2 are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节细胞色素-2的表达。 组合物包含靶向编码细胞色素-2的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节细胞凋亡蛋白-2表达和治疗与细胞色素-2表达相关疾病的方法。
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