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公开(公告)号：US20090259026A1
公开(公告)日：2009-10-15
申请号：US11704832
申请日：2007-02-08
申请人： Ian Tomlinson , Laurent Jespers , Jasper Clube , Lucy J. Holt , Oliver Schon
发明人： Ian Tomlinson , Laurent Jespers , Jasper Clube , Lucy J. Holt , Oliver Schon
CPC分类号： C07K16/18 , A61K47/6843 , C07K16/241 , C07K16/2878 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/53 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/624 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/00 , C07K2319/01 , C07K2319/31
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.
摘要翻译： 本发明提供了包含具有第一结合特异性的第一免疫球蛋白可变结构域和具有第二结合特异性的互补或非互补免疫球蛋白可变结构域的双重特异性配体。
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公开(公告)号：US09321832B2
公开(公告)日：2016-04-26
申请号：US11704832
申请日：2007-02-08
申请人： Ian Tomlinson , Laurent Jespers , Jasper Clube , Lucy J. Holt , Oliver Schon
发明人： Ian Tomlinson , Laurent Jespers , Jasper Clube , Lucy J. Holt , Oliver Schon
CPC分类号： C07K16/18 , A61K47/6843 , C07K16/241 , C07K16/2878 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/53 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/624 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/00 , C07K2319/01 , C07K2319/31
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.
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3.发明申请公开(公告)号：US20100168393A1
公开(公告)日：2010-07-01
申请号：US12083368
申请日：2006-10-11
申请人： Jasper Clube , Laurent Jespers
发明人： Jasper Clube , Laurent Jespers
CPC分类号： C07K16/005 , C07K2317/569
摘要： The present invention provides further developments in the screening of antibody polypeptide libraries. The invention also provides novel isolated antibody polypeptides obtainable by the methods of the invention.
摘要翻译： 本发明提供了抗体多肽文库筛选的进一步发展。 本发明还提供可通过本发明的方法获得的新型分离的抗体多肽。
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公开(公告)号：US20110020345A1
公开(公告)日：2011-01-27
申请号：US12935591
申请日：2009-03-27
IPC分类号： A61K39/395 , C07K16/46 , C07H21/00 , C12N15/63 , C12N5/10 , C12P21/02 , A61P3/00 , A61P3/10 , A61P5/50
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6843 , C07K14/435 , C07K14/57563 , C07K14/605 , C07K2317/569 , C07K2319/30 , C07K2319/31 , C12N15/62
摘要： The present invention relates to drug fusions that have improved serum half lives. These fusions and conjugates comprise polypeptides, immunoglobulin (antibody) single variable domains and GLP and/or exendin molecules. The invention further relates to uses, formulations, compositions and devices comprising such drug fusions and conjugates.
摘要翻译： 本发明涉及具有改善的血清半衰期的药物融合物。 这些融合物和缀合物包含多肽，免疫球蛋白（抗体）单可变结构域和GLP和/或毒蜥外泌肽分子。 本发明还涉及包含这种药物融合物和缀合物的用途，制剂，组合物和装置。
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公开(公告)号：US20100266616A1
公开(公告)日：2010-10-21
申请号：US12663502
申请日：2008-06-04
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C07K14/00 , A61P35/00 , A61P29/00
CPC分类号： C07K16/005 , A61K9/0078 , A61K2039/544 , C07K16/22 , C07K16/2866 , C07K16/2878 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
摘要翻译： 本发明涉及抗TNFR1多肽和抗蛋白酶降解的抗体单可变结构域（dAb），以及包含它们的拮抗剂。 多肽，dAb和拮抗剂可用作当被施用于患者时可能遇到蛋白酶的治疗剂和/或预防剂，例如用于肺部给药，口服给药，递送至肺部并递送至患者的胃肠道， 以及用于治疗炎性疾病，例如关节炎或COPD。
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公开(公告)号：US20100254972A1
公开(公告)日：2010-10-07
申请号：US12663491
申请日：2008-06-03
CPC分类号： C07K16/2878 , A61K9/007 , A61K9/0078 , A61K9/1623 , A61K9/1641 , A61K39/3955 , A61K2039/544 , A61M11/005 , A61M15/08 , A61M16/14 , C07K16/00 , C07K16/005 , C07K16/22 , C07K16/2866 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The invention relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the GI tract or pulmonary tissue of a human. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, combining the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, eg for treating disease or conditions of GI tract or pulmonary tissue in humans.
摘要翻译： 本发明涉及一种用于从文库或肽和多肽（例如显示系统）的文库或组合库中选择，分离和/或回收肽或多肽的方法，所述多肽和多肽（例如，显示系统）可通过蛋白酶如蛋白酶 胃肠道或人体的肺组织。 通常，该方法包括提供肽或多肽的文库或库，在适用于蛋白酶活性的条件下将文库或库与蛋白酶组合，以及选择，分离和/或回收抗蛋白酶降解的肽或多肽 并具有所需的生物活性。 所选择的肽和多肽可用作治疗剂，例如用于治疗人类胃肠道或肺组织的疾病或病症。
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公开(公告)号：US08877186B2
公开(公告)日：2014-11-04
申请号：US12663505
申请日：2008-06-03
申请人： Michael Steward , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever , Laurent Jespers , Thil Dinuk Batuwangala
发明人： Michael Steward , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever , Laurent Jespers , Thil Dinuk Batuwangala
IPC分类号： C07K16/22 , C07K14/435 , A61K39/395 , C07K14/475 , C07K16/24 , C07K16/28
CPC分类号： C07K16/2878 , C07K16/22 , C07K16/244 , C07K16/2866 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The invention relates to anti-VEGF polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.
摘要翻译： 本发明涉及抗蛋白酶降解的抗VEGF多肽和抗体单可变结构域（dAb），以及包含它们的拮抗剂。 多肽，dAb和拮抗剂可用于肺部给药，口服给药，递送至肺部并递送至患者胃肠道，以及治疗癌症和炎性疾病如关节炎。
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公开(公告)号：US20110086019A1
公开(公告)日：2011-04-14
申请号：US12663509
申请日：2008-06-03
IPC分类号： A61K39/395 , C07K16/18 , C07K14/00 , A61P43/00
CPC分类号： C07K16/2878 , A61K9/007 , A61K9/0078 , A61K9/1623 , A61K9/1641 , A61K39/3955 , A61K2039/544 , A61M11/005 , A61M15/08 , A61M16/14 , C07K16/00 , C07K16/005 , C07K16/22 , C07K16/2866 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
摘要翻译： 本发明涉及抗TNFR1多肽和抗蛋白酶降解的抗体单可变结构域（dAb），以及包含它们的拮抗剂。 多肽，dAb和拮抗剂可用作当被施用于患者时可能遇到蛋白酶的治疗剂和/或预防剂，例如用于肺部给药，口服给药，递送至肺部并递送至患者的胃肠道， 以及用于治疗炎性疾病，例如关节炎或COPD。
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公开(公告)号：US08398979B2
公开(公告)日：2013-03-19
申请号：US12663502
申请日：2008-06-04
IPC分类号： A61K39/395
CPC分类号： C07K16/005 , A61K9/0078 , A61K2039/544 , C07K16/22 , C07K16/2866 , C07K16/2878 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
摘要翻译： 本发明涉及抗TNFR1多肽和抗蛋白酶降解的抗体单可变结构域（dAb），以及包含它们的拮抗剂。 多肽，dAb和拮抗剂可用作当被施用于患者时可能遇到蛋白酶的治疗剂和/或预防剂，例如用于肺部给药，口服给药，递送至肺部并递送至患者的胃肠道， 以及用于治疗炎性疾病，例如关节炎或COPD。
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公开(公告)号：US08357780B2
公开(公告)日：2013-01-22
申请号：US12663498
申请日：2008-06-03
IPC分类号： C07K16/00
CPC分类号： C07K16/2878 , A61K9/007 , A61K9/0078 , A61K9/1623 , A61K9/1641 , A61K39/3955 , A61K2039/544 , A61M11/005 , A61M15/08 , A61M16/14 , C07K16/00 , C07K16/005 , C07K16/22 , C07K16/2866 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The invention relates to anti-IL-1R1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
摘要翻译： 本发明涉及抗蛋白酶降解抗体的抗IL-1R1多肽和抗体单可变结构域（dAb），以及包含它们的拮抗剂。 多肽，dAb和拮抗剂可用作当被施用于患者时可能遇到蛋白酶的治疗剂和/或预防剂，例如用于肺部给药，口服给药，递送至肺部并递送至患者的胃肠道， 以及用于治疗炎性疾病，例如关节炎或COPD。
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