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36 条记录 (耗时 0.031 秒)

    Antiviral alpha, alpha-dialkyl adamantylethylamines
    5.
    发明授权
    Antiviral alpha, alpha-dialkyl adamantylethylamines 失效
    抗病毒α，α-二烷基金刚烷乙胺

    公开(公告)号：US4351847A

    公开(公告)日：1982-09-28

    申请号：US277777

    申请日：1981-06-26

    申请人： Ronald C. Griffith ,  Clyde R. Kinsolving

    发明人： Ronald C. Griffith ,  Clyde R. Kinsolving

    IPC分类号： A61K31/13 ,  A61P31/12 ,  A61P31/22

    CPC分类号： A61K31/13 ,  Y10S514/934

    摘要： Warm-blooded animals are treated by administering to the animal a dosage, effective to prevent or to alleviate the symptoms of herpes virus, type II, of a compound of the formula I or its acid salt: ##STR1## wherein R.sub.1 and R.sub.2 are selected from the class consisting of H and --CH.sub.3 ; and at least one pharmaceutically acceptable carrier, wherein the compound is 0.01 to 95% by weight of the composition.

    摘要翻译： 通过向动物施用有效预防或减轻II型化合物或其酸式盐的疱疹病毒II型症状的剂量来治疗温血动物：其中R1和 R2选自H和-CH 3; 和至少一种药学上可接受的载体，其中所述化合物为所述组合物的0.01至95重量％。

    Spirofurane derivatives
    6.
    发明授权
    Spirofurane derivatives 失效
    螺旋体衍生物

    公开(公告)号：US5075317A

    公开(公告)日：1991-12-24

    申请号：US369324

    申请日：1989-06-21

    申请人： Edwin S. Wu ,  Ronald C. Griffith

    发明人： Edwin S. Wu ,  Ronald C. Griffith

    IPC分类号： A61K31/44 ,  A61P25/18 ,  A61P25/28 ,  C07D491/10 ,  C07D491/107

    CPC分类号： C07D491/10

    摘要： Compounds of general formula I, ##STR1## wherein R.sup.1 represents hydrogen or alkyl C.sub.1-3,R.sup.2 represents hydrogen or alkyl C.sub.1-6,n and m are integers from 1 to 3, provided that n+m=4, andone of X and Y represents CH.sub.2 and the other represents CHR.sup.3, C.dbd.O, C.dbd.CHR.sup.4 or C.dbd.NR.sup.5, in whichR.sup.3, R.sup.4 and R.sup.5 are as defined in the specification,and their saltsare useful as pharmaceuticals, in particular as central muscarinic acetylcholine receptors. The compounds are therefore useful in the treatment of diseases such as presenile and senile dementia, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania and Tourette Syndrome, and also as analgesic agents for use in the treatment of severe painful conditions such as rheumatism, arthritis, and terminal illness.

    摘要翻译： 通式I的化合物，其中R 1表示氢或烷基C 1-3，R 2表示氢或烷基C 1-6，n和m是1至3的整数，条件是n + m = 4，并且其中之一 X和Y表示CH 2，另一个表示CHR 3，C = O，C = CHR 4或C = NR 5，其中R 3，R 4和R 5如说明书中所定义，并且它们的盐可用作药物，特别是作为中毒毒蕈碱 乙酰胆碱受体。 因此，这些化合物可用于治疗诸如老年痴呆和老年痴呆，亨廷顿舞蹈病，迟发性运动障碍，运动过度，躁狂症和图雷特综合征等疾病，也可用作治疗严重疼痛病症如镇痛，关节炎， 和末期疾病。

    2-amino-N-(2-phenylindan-2-yl)acetamides useful as anti-epileptics
    7.
    发明授权
    2-amino-N-(2-phenylindan-2-yl)acetamides useful as anti-epileptics 失效
    可用作抗癫痫药的2-氨基-N-（2-苯基茚满-2-基）乙酰胺

    公开(公告)号：US4873241A

    公开(公告)日：1989-10-10

    申请号：US265087

    申请日：1988-10-31

    申请人： James J. Napier ,  Ronald C. Griffith

    发明人： James J. Napier ,  Ronald C. Griffith

    IPC分类号： C07C237/04 ,  C07D295/15

    CPC分类号： C07D295/15 ,  C07C237/04 ,  C07C2102/08

    摘要： 2-Amino-N-(2-phenylindan-2-yl)acetamides of the following formula are provided ##STR1## wherein, a=0 to 3,R.sub.1, R.sub.2 and R.sub.3 are independently selected from hydrogen and methyl,R.sub.4 is hydrogen or C.sub.1 -C.sub.4 alkyl,R.sub.5 is selected from hydrogen, C.sub.1 -C.sub.4 alkyl, cyclopropyl and (aminomethyl)carbonyl, orR.sub.4 and R.sub.5 taken together with the nitrogen atom to which they are attached from a heterocyclic ring selected from pyrrolidinyl, piperidinyl and morpholinyl, orR.sub.3 and R.sub.4 taken together with the carbon atom and nitrogen atom to which they are respectively attached form a heterocyclic ring selected from pyrrolidinyl and piperidinyl, andR.sub.6 is selected from hydrogen, halogen, C.sub.1 -C.sub.4 alkoxy, trifluoromethyl, C.sub.1 -C.sub.4 alkyl and combinations thereof.The compounds have antiepileptic or antihypoxia activity.

    摘要翻译： 提供下式的2-氨基-N-（2-苯基茚基-2-基）乙酰胺：其中a = 0至3，R 1，R 2和R 3独立地选自氢和甲基，R 4 是氢或C 1 -C 4烷基，R 5选自氢，C 1 -C 4烷基，环丙基和（氨基甲基）羰基，或者R 4和R 5与它们所连接的氮原子一起选自吡咯烷基，哌啶基 和吗啉基，或者R 3和R 4与它们分别连接的碳原子和氮原子一起形成选自吡咯烷基和哌啶基的杂环，R 6选自氢，卤素，C 1 -C 4烷氧基，三氟甲基， C4烷基及其组合。 该化合物具有抗癫痫或抗低氧活性。

    2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics
    9.
    发明授权
    2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics 失效
    2-氨基（或羟基）苯乙基-1,2,3,4-四氢异喹啉作为止痛剂

    公开(公告)号：US4766131A

    公开(公告)日：1988-08-23

    申请号：US948449

    申请日：1986-12-30

    申请人： Thomas A. Davidson ,  Ronald C. Griffith

    发明人： Thomas A. Davidson ,  Ronald C. Griffith

    IPC分类号： C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  A61K31/47 ,  C07D217/18

    CPC分类号： C07D217/04 ,  C07D217/02 ,  C07D217/06

    摘要： Analgesic 1,2,3,4-tetrahydroisoquinolines of the formula (1) ##STR1## wherein R.sub.1 and R.sub.2 respectively are hydrogen, hydroxy or alkoxy of 1 to 4 carbon atoms, R.sub.3 and R.sub.4 respectively are hydrogen or alkyl of 1 to 4 carbon atoms, and R.sub.5 is hydroxy, nitro or ##STR2## wherein R.sub.6 and R.sub.7 respectively are hydrogen, alkyl of 1 to 4 carbon atoms or RCO-- wherein R is hydrogen or alkyl of 1 to 4 carbon atoms; pharmaceutically acceptable addition salts thereof with non-toxic acids; analgesic compositions thereof in an inert, pharmaceutical carrier; and methods of preparation from corresponding R.sub.1, R.sub.2, R.sub.3 and R.sub.4 -substituted tetrahydroisoquinolines.

    摘要翻译： 式（1）的镇痛性1,2,3,4-四氢异喹啉其中R1和R2分别是氢，1-4个碳原子的羟基或烷氧基，R3和R4分别是氢或1的烷基 4个碳原子，R5是羟基，硝基或者其中R6和R7分别是氢，1-4个碳原子的烷基或RCO-，其中R是氢或1-4个碳原子的烷基; 其药学上可接受的加成盐与无毒酸; 其镇痛组合物在惰性药物载体中; 和由相应的R1，R2，R3和R4取代的四氢异喹啉制备的方法。