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公开(公告)号：US08858957B2
公开(公告)日：2014-10-14
申请号：US13830774
申请日：2013-03-14
IPC分类号： A61K39/09 , A61K39/02 , A61K39/00 , A61K38/00 , C07K1/00 , C07K14/315 , C07K16/12 , C07K16/40
CPC分类号： C07K14/315 , A61K38/164 , A61K38/18 , A61K38/19 , A61K38/22 , A61K39/092 , A61K45/06 , A61K2039/522 , A61K2039/6037 , A61K2039/6043 , A61K2039/6068 , C07K14/22 , C07K14/235 , C07K14/285 , C07K14/33 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/1275 , C07K16/40 , C07K2319/00 , C07K2319/55 , Y02A50/466 , Y02A50/478 , Y10S530/825
摘要： The invention provides mutants of GAS57 (Spy0416) which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
摘要翻译： 本发明提供的GAS57突变体（Spy0416）不能切割IL-8和类似的底物，但仍保持对化脓性链球菌的保护的能力。 本发明还提供了特异性结合GAS57并且抑制其分裂IL-8和类似底物的能力的抗体。 突变体尤其可用于诱导保护成脓性葡萄球菌的疫苗组合物。 抗体是有用的，例如用作治疗化脓性链球菌感染的治疗剂。
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公开(公告)号：US20130005030A1
公开(公告)日：2013-01-03
申请号：US13607990
申请日：2012-09-10
CPC分类号： C07K14/315 , A61K38/164 , A61K38/18 , A61K38/19 , A61K38/22 , A61K39/092 , A61K45/06 , A61K2039/522 , A61K2039/6037 , A61K2039/6043 , A61K2039/6068 , C07K14/22 , C07K14/235 , C07K14/285 , C07K14/33 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/1275 , C07K16/40 , C07K2319/00 , C07K2319/55 , Y02A50/466 , Y02A50/478 , Y10S530/825
摘要： The invention provides mutants of GAS57 (Spy0416) which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
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公开(公告)号：US20130202609A1
公开(公告)日：2013-08-08
申请号：US13830774
申请日：2013-03-14
IPC分类号： C07K14/315
CPC分类号： C07K14/315 , A61K38/164 , A61K38/18 , A61K38/19 , A61K38/22 , A61K39/092 , A61K45/06 , A61K2039/522 , A61K2039/6037 , A61K2039/6043 , A61K2039/6068 , C07K14/22 , C07K14/235 , C07K14/285 , C07K14/33 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/1275 , C07K16/40 , C07K2319/00 , C07K2319/55 , Y02A50/466 , Y02A50/478 , Y10S530/825
摘要： The invention provides mutants of GAS57 (Spy0416) which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
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公开(公告)号：US08399651B2
公开(公告)日：2013-03-19
申请号：US13607990
申请日：2012-09-10
CPC分类号： C07K14/315 , A61K38/164 , A61K38/18 , A61K38/19 , A61K38/22 , A61K39/092 , A61K45/06 , A61K2039/522 , A61K2039/6037 , A61K2039/6043 , A61K2039/6068 , C07K14/22 , C07K14/235 , C07K14/285 , C07K14/33 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/1275 , C07K16/40 , C07K2319/00 , C07K2319/55 , Y02A50/466 , Y02A50/478 , Y10S530/825
摘要： The invention provides mutants of GAS57 (Spy0416) which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
摘要翻译： 本发明提供的GAS57突变体（Spy0416）不能切割IL-8和类似的底物，但仍保持对化脓性链球菌的保护的能力。 本发明还提供了特异性结合GAS57并且抑制其分裂IL-8和类似底物的能力的抗体。 突变体尤其可用于诱导保护成脓性葡萄球菌的疫苗组合物。 抗体是有用的，例如用作治疗化脓性链球菌感染的治疗剂。
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公开(公告)号：US08287885B2
公开(公告)日：2012-10-16
申请号：US12676192
申请日：2008-09-12
CPC分类号： C07K14/315 , A61K38/164 , A61K38/18 , A61K38/19 , A61K38/22 , A61K39/092 , A61K45/06 , A61K2039/522 , A61K2039/6037 , A61K2039/6043 , A61K2039/6068 , C07K14/22 , C07K14/235 , C07K14/285 , C07K14/33 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/1275 , C07K16/40 , C07K2319/00 , C07K2319/55 , Y02A50/466 , Y02A50/478 , Y10S530/825
摘要： The invention provides mutants of GAS57 which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
摘要翻译： 本发明提供的GAS57突变体不能切割IL-8和类似的底物，但仍然保持对化脓性葡萄球菌的保护的能力。 本发明还提供了特异性结合GAS57并且抑制其分裂IL-8和类似底物的能力的抗体。 突变体尤其可用于诱导保护成脓性葡萄球菌的疫苗组合物。 抗体是有用的，例如用作治疗化脓性链球菌感染的治疗剂。
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公开(公告)号：US20110110967A1
公开(公告)日：2011-05-12
申请号：US12676192
申请日：2008-09-12
CPC分类号： C07K14/315 , A61K38/164 , A61K38/18 , A61K38/19 , A61K38/22 , A61K39/092 , A61K45/06 , A61K2039/522 , A61K2039/6037 , A61K2039/6043 , A61K2039/6068 , C07K14/22 , C07K14/235 , C07K14/285 , C07K14/33 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/1275 , C07K16/40 , C07K2319/00 , C07K2319/55 , Y02A50/466 , Y02A50/478 , Y10S530/825
摘要： The invention provides mutants of GAS57 which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
摘要翻译： 本发明提供的GAS57突变体不能切割IL-8和类似的底物，但仍然保持对化脓性葡萄球菌的保护的能力。 本发明还提供了特异性结合GAS57并且抑制其分裂IL-8和类似底物的能力的抗体。 突变体尤其可用于诱导保护成脓性葡萄球菌的疫苗组合物。 抗体是有用的，例如用作治疗化脓性链球菌感染的治疗剂。
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公开(公告)号：US20110195409A1
公开(公告)日：2011-08-11
申请号：US12741514
申请日：2008-11-06
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： The difference Lancefield T-serotypes correlate with the sequence of the pilus backbone protein (Pbp) in Streptococcus pyogenes (GAS). We have sequenced Pbp for over 50 GAS strains, representing the major disease-associated serotypes, and have identified 15 Pbp variants. These 15 variants have been shown to determine the specificity of the T-serotyping, such that sequencing of the Pbp from a given GAS strain reliably predicts that strain's T-serotype. thus the invention permits the t-serotype of a GAS strain to be determined based on genotype.
摘要翻译： 不同的Lancefield T型血清型与化脓链球菌（GAS）中的菌毛骨架蛋白（Pbp）的序列相关。 我们已经为超过50种GAS菌株测序了Pbp，代表了主要的疾病相关血清型，并确定了15种Pbp变体。 已经显示了这15种变体来确定T血清型的特异性，使得来自给定GAS菌株的Pbp的测序可靠地预测该菌株的T血清型。 因此本发明允许基于基因型确定GAS株的t-血清型。
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