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1.发明申请HYBRID POLYPEPTIDES COMPRISING GBS-80 AND SPB1 PROTEINS OF STREPTOCOCCUS 审中-公开包含GBS-80和SPB1蛋白质的杂交多肽公开(公告)号：US20110052620A1
公开(公告)日：2011-03-03
申请号：US12866845
申请日：2009-02-11
IPC分类号： A61K39/09 , C07K14/315 , C07H21/04 , A61P31/04
CPC分类号： A61K39/092 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K14/315
摘要： GBS antigens GBS-80 and Spb1 are expressed in a single polypeptide chain, preferably with Spb1 upstream of GBS-80. Thus the invention provides a polypeptide comprising an amino acid sequence NH2—W—X-L-Y—Z—CO2H wherein: X is a Spb 1 sequence; L is an optional linker; Y is a GBS-80 sequence; W is an optional N-terminal sequence; and Z is an optional C-terminal sequence.
摘要翻译： GBS抗原GBS-80和Spb1在单个多肽链中表达，优选用GBS-80上游的Spb1表达。 因此，本发明提供了包含氨基酸序列NH 2 -W-X-L-Y-Z-CO 2 H的多肽，其中：X是Spb 1序列; L是可选的接头; Y是GBS-80序列; W是可选的N-末端序列; Z是可选的C-末端序列。
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公开(公告)号：US20080220010A1
公开(公告)日：2008-09-11
申请号：US10568422
申请日：2004-09-15
CPC分类号： A61K39/09 , Y10S530/825
摘要： This application relates to Group B Streptococcus (“GBS”) vaccines comprising combinations of GBS polypeptide antigens where the polypeptides contribute to the immunological response in a recipient. Preferably, the compositions of the invention comprise a combination of two or more GBS antigens, wherein said combination includes GBS 80 or a fragment thereof. In one embodiment, the combination may consist of two to thirteen GBS antigens selected from an antigen group consisting of GBS 80, GBS 91, GBS 104, GBS 184, GBS 276, GBS 305, GBS 322, GBS 330, GBS 338, GBS 361, GBS 404, GBS 690, and GBS 691.
摘要翻译： 本申请涉及包含GBS多肽抗原组合的B组链球菌（“GBS”）疫苗，其中多肽有助于接受者的免疫应答。 优选地，本发明的组合物包含两种或更多种GBS抗原的组合，其中所述组合包括GBS 80或其片段。 在一个实施方案中，该组合可以由选自GBS 80，GBS 91，GBS 104，GBS 184，GBS 276，GBS 305，GBS 322，GBS 330，GBS 338，GBS 361的抗原组中的两至十三个GBS抗原组成 ，GBS 404，GBS 690和GBS 691。
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3.发明申请IMMUNOGENIC COMPOSITIONS FOR GRAM POSITIVE BACTERIA SUCH AS STREPTOCOCCUS AGALACTIAE 失效AM AM E E E E E E E E E E E E E E E E E E E E E E E公开(公告)号：US20110110982A1
公开(公告)日：2011-05-12
申请号：US12906510
申请日：2010-10-18
申请人： John Telford , Guido Grandi , Immaculada Margarit Y. Ros , Cira Daniela Rinaudo , Domenico Maione
发明人： John Telford , Guido Grandi , Immaculada Margarit Y. Ros , Cira Daniela Rinaudo , Domenico Maione
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/09 , A61K39/095 , A61K2039/523 , C07K16/1267 , Y02A50/396
摘要： The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B Streptococcus serotypes and isolates. The adhesin islands are thought to encode surface proteins which are important in the bacteria's virulence. Thus, the adhesin island proteins of the invention may be used in immunogenic compositions for prophylactic or therapeutic immunization against GAS or GBS infection. For example, the invention may include an immunogenic composition comprising one or more of the discovered adhesin island proteins.
摘要翻译： 本发明涉及鉴定几组A组和B组链球菌血清型和分离株的基因组中的新粘附素岛。 粘附素岛被认为编码在细菌的毒力中重要的表面蛋白质。 因此，本发明的粘附素岛蛋白可用于免疫原性组合物，用于针对GAS或GBS感染的预防性或治疗性免疫。 例如，本发明可以包括包含一种或多种所发现的粘附素岛蛋白的免疫原性组合物。
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公开(公告)号：US08945589B2
公开(公告)日：2015-02-03
申请号：US10568422
申请日：2004-09-15
CPC分类号： A61K39/09 , Y10S530/825
摘要： This application relates to Group B Streptococcus (“GBS”) vaccines comprising combinations of GBS polypeptide antigens where the polypeptides contribute to the immunological response in a recipient. Preferably, the compositions of the invention comprise a combination of two or more GBS antigens, wherein said combination includes GBS 80 or a fragment thereof. In one embodiment, the combination may consist of two to thirteen GBS antigens selected from an antigen group consisting of GBS 80, GBS 91, GBS 104, GBS 184, GBS 276, GBS 305, GBS 322, GBS 330, GBS 338, GBS 361, GBS 404, GBS 690, and GBS 691.
摘要翻译： 本申请涉及包含GBS多肽抗原组合的B组链球菌（“GBS”）疫苗，其中多肽有助于接受者的免疫应答。 优选地，本发明的组合物包含两种或更多种GBS抗原的组合，其中所述组合包括GBS 80或其片段。 在一个实施方案中，该组合可以由选自GBS 80，GBS 91，GBS 104，GBS 184，GBS 276，GBS 305，GBS 322，GBS 330，GBS 338，GBS 361的抗原组中的两至十三个GBS抗原组成 ，GBS 404，GBS 690和GBS 691。
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5.发明授权Immunogenic compositions for gram positive bacteria such as Streptococcus agalactiae 失效革兰氏阳性菌如无乳链球菌的免疫原性组合物公开(公告)号：US08778358B2
公开(公告)日：2014-07-15
申请号：US12906510
申请日：2010-10-18
申请人： John Telford , Guido Grandi , Immaculada Margarit Y Ros , Cira Daniela Rinaudo , Domenico Maione
发明人： John Telford , Guido Grandi , Immaculada Margarit Y Ros , Cira Daniela Rinaudo , Domenico Maione
IPC分类号： A61K39/09 , C07K14/195 , C12P21/04 , C07H21/04
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/09 , A61K39/095 , A61K2039/523 , C07K16/1267 , Y02A50/396
摘要： The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B Streptococcus serotypes and isolates. The adhesin islands are thought to encode surface proteins which are important in the bacteria's virulence. Thus, the adhesin island proteins of the invention may be used in immunogenic compositions for prophylactic or therapeutic immunization against GAS or GBS infection. For example, the invention may include an immunogenic composition comprising one or more of the discovered adhesin island proteins.
摘要翻译： 本发明涉及鉴定几组A组和B组链球菌血清型和分离株的基因组中的新粘附素岛。 粘附素岛被认为编码在细菌的毒力中重要的表面蛋白质。 因此，本发明的粘附素岛蛋白可用于免疫原性组合物，用于针对GAS或GBS感染的预防性或治疗性免疫。 例如，本发明可以包括包含一种或多种所发现的粘附素岛蛋白的免疫原性组合物。
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公开(公告)号：US20110206692A1
公开(公告)日：2011-08-25
申请号：US12304018
申请日：2007-06-11
IPC分类号： A61K39/40 , C07K14/195 , C07K16/12 , C07K16/46 , A61K39/02 , C07K1/18 , C07K1/14 , A61P31/04 , B01D57/02
CPC分类号： A61K39/092 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/315 , G01N33/56944 , G01N2469/20
摘要： The invention relates to isolated or purified bacterial adhesin conformers, preferably with improved stability and/or immunogenicity. In a preferred aspect, the invention comprises an isolated bacterial adhesin conformer F. Also provided are methods of isolation and/or separation of such adhesin conformers. The compositions may include one or more of the immunogenic polypeptides either alone or with other antigenic components. For example, the immunogenic polypeptides may be combined with other bacterial antigens to provide therapeutic compositions with broader range.
摘要翻译： 本发明涉及分离或纯化的细菌粘附素构象异构体，优选具有改善的稳定性和/或免疫原性。 在优选的方面，本发明包括分离的细菌粘附素构象体F.还提供了这种粘附素构象异构体的分离和/或分离的方法。 组合物可以单独或与其它抗原成分一起包括一种或多种免疫原性多肽。 例如，免疫原性多肽可以与其他细菌抗原组合以提供更宽范围的治疗组合物。
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公开(公告)号：US20060165716A1
公开(公告)日：2006-07-27
申请号：US11192046
申请日：2005-07-29
申请人： John Telford , Guido Grandi , Peter Lauer , Marirosa Mora , Immaculada Y Ros , Domenico Maione , Guiliano Bensi , Daniela Rinaudo , Vega Masignani , Michelle Barocchi , Rino Rappuoli
发明人： John Telford , Guido Grandi , Peter Lauer , Marirosa Mora , Immaculada Y Ros , Domenico Maione , Guiliano Bensi , Daniela Rinaudo , Vega Masignani , Michelle Barocchi , Rino Rappuoli
IPC分类号： A61K39/02
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/09 , A61K39/095 , A61K2039/523 , C07K16/1267 , Y02A50/396
摘要： The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B Streptococcus serotypes and isolates. The adhesin islands are thought to encode surface proteins which are important in the bacteria's virulence. Thus, the adhesin island proteins of the invention may be used in immunogenic compositions for prophylactic or therapeutic immunization against GAS or GBS infection. For example, the invention may include an immunogenic composition comprising one or more of the discovered adhesin island proteins.
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8.发明授权Immunogenic proteins and compositions for the treatment and prevention of streptococcus agalactiae 有权用于治疗和预防无乳链球菌的免疫原性蛋白质和组合物公开(公告)号：US09079946B2
公开(公告)日：2015-07-14
申请号：US13637929
申请日：2011-04-01
IPC分类号： A61K39/09 , C07K16/12 , C07K14/315
CPC分类号： A61K39/092 , A61K2039/55 , A61K2039/57 , A61K2039/575 , C07K14/315 , C07K16/1275 , C07K2317/734 , C07K2319/40
摘要： The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS).
摘要翻译： 本发明提供了用于治疗和预防无乳链球菌（B族链球菌; GBS）的蛋白质和组合物。
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公开(公告)号：US20100015168A1
公开(公告)日：2010-01-21
申请号：US12303999
申请日：2007-06-11
申请人： Domenico Maione , Guido Grandi , Nathalie Norais
发明人： Domenico Maione , Guido Grandi , Nathalie Norais
CPC分类号： A61K39/092 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/315 , G01N33/56944 , G01N2469/20
摘要： The invention relates to immunogenic polypeptides derived from epitopes in a Streptococcus agalactiae (“GBS”) protein GBS 80 and their use as prophylactic, diagnostic and therapeutic compositions. The invention also provides nucleic acids encoding the immunogenic polypeptides. Also provided are vectors useful for making such immunogenic polypeptides and host cells transformed with such vectors. In particular, the invention relates to a group immunogenic polypeptides derived from GBS 80. The compositions may include one or more of the immunogenic polypeptides either alone or with other antigenic components. For example, the immunogenic polypeptides may be combined with other GBS antigens to provide therapeutic compositions with broader range. In addition, the immunogenic polypeptides may also include flanking portions of the GBS 80 protein.
摘要翻译： 本发明涉及源自无乳链球菌（GBS）蛋白GBS 80中的表位的免疫原性多肽及其作为预防，诊断和治疗组合物的用途。 本发明还提供编码免疫原性多肽的核酸。 还提供了可用于制备这种免疫原性多肽的载体和用这些载体转化的宿主细胞。 特别地，本发明涉及衍生自GBS80的组免疫原性多肽。组合物可以单独或与其它抗原成分一起包括一种或多种免疫原性多肽。 例如，免疫原性多肽可以与其他GBS抗原组合以提供更宽范围的治疗组合物。 此外，免疫原性多肽还可以包括GBS 80蛋白的侧翼部分。
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公开(公告)号：US20120141521A1
公开(公告)日：2012-06-07
申请号：US13339628
申请日：2011-12-29
申请人： Domenico Maione , Guido Grandi , Nathalie Norais
发明人： Domenico Maione , Guido Grandi , Nathalie Norais
IPC分类号： A61K39/09 , A61P37/04 , A61P31/04 , C07K14/315
CPC分类号： A61K39/092 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/315 , G01N33/56944 , G01N2469/20
摘要： The invention relates to immunogenic polypeptides derived from epitopes in a Streptococcus agalactiae (“GBS”) protein GBS 80 and their use as prophylactic, diagnostic and therapeutic compositions. The invention also provides nucleic acids encoding the immunogenic polypeptides. Also provided are vectors useful for making such immunogenic polypeptides and host cells transformed with such vectors. In particular, the invention relates to a group immunogenic polypeptides derived from GBS 80. The compositions may include one or more of the immunogenic polypeptides either alone or with other antigenic components. For example, the immunogenic polypeptides may be combined with other GBS antigens to provide therapeutic compositions with broader range. In addition, the immunogenic polypeptides may also include flanking portions of the GBS 80 protein
摘要翻译： 本发明涉及源自无乳链球菌（GBS）蛋白GBS 80中的表位的免疫原性多肽及其作为预防，诊断和治疗组合物的用途。 本发明还提供编码免疫原性多肽的核酸。 还提供了可用于制备这种免疫原性多肽的载体和用这些载体转化的宿主细胞。 特别地，本发明涉及衍生自GBS80的组免疫原性多肽。组合物可以单独或与其它抗原成分一起包括一种或多种免疫原性多肽。 例如，免疫原性多肽可以与其他GBS抗原组合以提供更宽范围的治疗组合物。 此外，免疫原性多肽还可以包括GBS 80蛋白的侧翼部分
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