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公开(公告)号：US20080220010A1
公开(公告)日：2008-09-11
申请号：US10568422
申请日：2004-09-15
CPC分类号： A61K39/09 , Y10S530/825
摘要： This application relates to Group B Streptococcus (“GBS”) vaccines comprising combinations of GBS polypeptide antigens where the polypeptides contribute to the immunological response in a recipient. Preferably, the compositions of the invention comprise a combination of two or more GBS antigens, wherein said combination includes GBS 80 or a fragment thereof. In one embodiment, the combination may consist of two to thirteen GBS antigens selected from an antigen group consisting of GBS 80, GBS 91, GBS 104, GBS 184, GBS 276, GBS 305, GBS 322, GBS 330, GBS 338, GBS 361, GBS 404, GBS 690, and GBS 691.
摘要翻译： 本申请涉及包含GBS多肽抗原组合的B组链球菌（“GBS”）疫苗，其中多肽有助于接受者的免疫应答。 优选地，本发明的组合物包含两种或更多种GBS抗原的组合，其中所述组合包括GBS 80或其片段。 在一个实施方案中，该组合可以由选自GBS 80，GBS 91，GBS 104，GBS 184，GBS 276，GBS 305，GBS 322，GBS 330，GBS 338，GBS 361的抗原组中的两至十三个GBS抗原组成 ，GBS 404，GBS 690和GBS 691。
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2.发明申请HYBRID POLYPEPTIDES COMPRISING GBS-80 AND SPB1 PROTEINS OF STREPTOCOCCUS 审中-公开包含GBS-80和SPB1蛋白质的杂交多肽公开(公告)号：US20110052620A1
公开(公告)日：2011-03-03
申请号：US12866845
申请日：2009-02-11
IPC分类号： A61K39/09 , C07K14/315 , C07H21/04 , A61P31/04
CPC分类号： A61K39/092 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C07K14/315
摘要： GBS antigens GBS-80 and Spb1 are expressed in a single polypeptide chain, preferably with Spb1 upstream of GBS-80. Thus the invention provides a polypeptide comprising an amino acid sequence NH2—W—X-L-Y—Z—CO2H wherein: X is a Spb 1 sequence; L is an optional linker; Y is a GBS-80 sequence; W is an optional N-terminal sequence; and Z is an optional C-terminal sequence.
摘要翻译： GBS抗原GBS-80和Spb1在单个多肽链中表达，优选用GBS-80上游的Spb1表达。 因此，本发明提供了包含氨基酸序列NH 2 -W-X-L-Y-Z-CO 2 H的多肽，其中：X是Spb 1序列; L是可选的接头; Y是GBS-80序列; W是可选的N-末端序列; Z是可选的C-末端序列。
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公开(公告)号：US08945589B2
公开(公告)日：2015-02-03
申请号：US10568422
申请日：2004-09-15
CPC分类号： A61K39/09 , Y10S530/825
摘要： This application relates to Group B Streptococcus (“GBS”) vaccines comprising combinations of GBS polypeptide antigens where the polypeptides contribute to the immunological response in a recipient. Preferably, the compositions of the invention comprise a combination of two or more GBS antigens, wherein said combination includes GBS 80 or a fragment thereof. In one embodiment, the combination may consist of two to thirteen GBS antigens selected from an antigen group consisting of GBS 80, GBS 91, GBS 104, GBS 184, GBS 276, GBS 305, GBS 322, GBS 330, GBS 338, GBS 361, GBS 404, GBS 690, and GBS 691.
摘要翻译： 本申请涉及包含GBS多肽抗原组合的B组链球菌（“GBS”）疫苗，其中多肽有助于接受者的免疫应答。 优选地，本发明的组合物包含两种或更多种GBS抗原的组合，其中所述组合包括GBS 80或其片段。 在一个实施方案中，该组合可以由选自GBS 80，GBS 91，GBS 104，GBS 184，GBS 276，GBS 305，GBS 322，GBS 330，GBS 338，GBS 361的抗原组中的两至十三个GBS抗原组成 ，GBS 404，GBS 690和GBS 691。
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4.发明授权Immunogenic compositions for gram positive bacteria such as Streptococcus agalactiae 失效革兰氏阳性菌如无乳链球菌的免疫原性组合物公开(公告)号：US08778358B2
公开(公告)日：2014-07-15
申请号：US12906510
申请日：2010-10-18
申请人： John Telford , Guido Grandi , Immaculada Margarit Y Ros , Cira Daniela Rinaudo , Domenico Maione
发明人： John Telford , Guido Grandi , Immaculada Margarit Y Ros , Cira Daniela Rinaudo , Domenico Maione
IPC分类号： A61K39/09 , C07K14/195 , C12P21/04 , C07H21/04
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/09 , A61K39/095 , A61K2039/523 , C07K16/1267 , Y02A50/396
摘要： The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B Streptococcus serotypes and isolates. The adhesin islands are thought to encode surface proteins which are important in the bacteria's virulence. Thus, the adhesin island proteins of the invention may be used in immunogenic compositions for prophylactic or therapeutic immunization against GAS or GBS infection. For example, the invention may include an immunogenic composition comprising one or more of the discovered adhesin island proteins.
摘要翻译： 本发明涉及鉴定几组A组和B组链球菌血清型和分离株的基因组中的新粘附素岛。 粘附素岛被认为编码在细菌的毒力中重要的表面蛋白质。 因此，本发明的粘附素岛蛋白可用于免疫原性组合物，用于针对GAS或GBS感染的预防性或治疗性免疫。 例如，本发明可以包括包含一种或多种所发现的粘附素岛蛋白的免疫原性组合物。
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5.发明申请DIAGNOSTIC AND THERAPEUTIC METHODS FOR RHEUMATIC HEART DISEASE BASED UPON GROUP A STREPTOCOCCUS MARKERS 审中-公开基于组织标记的病因性心脏病的诊断和治疗方法公开(公告)号：US20120276130A1
公开(公告)日：2012-11-01
申请号：US13502825
申请日：2010-10-20
IPC分类号： C40B40/10 , G01N33/566 , A61P37/04 , G01N21/64 , A61P9/00 , A61P31/04 , A61K39/09 , C40B30/04
CPC分类号： G01N33/56944 , G01N33/564 , G01N2800/24 , G01N2800/32
摘要： This invention is in the field of identifying patients having rheumatic heart disease (RHD) associated with Streptococcus pyogenes (Group A Streptococcus; GAS) infection and identifying patients at risk of developing RHD associated with GAS infection. The invention also provides methods and compositions for preventing and treating RHD associated with GAS infection.
摘要翻译： 本发明涉及鉴定与化脓性链球菌（A型链球菌; GAS）感染相关的风湿性心脏病（RHD）的患者，并鉴定患有与GAS感染有关的RHD风险的患者。 本发明还提供了用于预防和治疗与GAS感染相关的RHD的方法和组合物。
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公开(公告)号：US08858957B2
公开(公告)日：2014-10-14
申请号：US13830774
申请日：2013-03-14
IPC分类号： A61K39/09 , A61K39/02 , A61K39/00 , A61K38/00 , C07K1/00 , C07K14/315 , C07K16/12 , C07K16/40
CPC分类号： C07K14/315 , A61K38/164 , A61K38/18 , A61K38/19 , A61K38/22 , A61K39/092 , A61K45/06 , A61K2039/522 , A61K2039/6037 , A61K2039/6043 , A61K2039/6068 , C07K14/22 , C07K14/235 , C07K14/285 , C07K14/33 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/1275 , C07K16/40 , C07K2319/00 , C07K2319/55 , Y02A50/466 , Y02A50/478 , Y10S530/825
摘要： The invention provides mutants of GAS57 (Spy0416) which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
摘要翻译： 本发明提供的GAS57突变体（Spy0416）不能切割IL-8和类似的底物，但仍保持对化脓性链球菌的保护的能力。 本发明还提供了特异性结合GAS57并且抑制其分裂IL-8和类似底物的能力的抗体。 突变体尤其可用于诱导保护成脓性葡萄球菌的疫苗组合物。 抗体是有用的，例如用作治疗化脓性链球菌感染的治疗剂。
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7.发明申请公开(公告)号：US20120207778A1
公开(公告)日：2012-08-16
申请号：US13398079
申请日：2012-02-16
申请人： John Telford , Vega Masignani , Immaculada Margarit Y Ros , Guido Grandi , Claire Fraser , Hervé Tettelin
发明人： John Telford , Vega Masignani , Immaculada Margarit Y Ros , Guido Grandi , Claire Fraser , Hervé Tettelin
IPC分类号： A61K39/09 , C07K16/12 , C07K7/08 , A61K38/16 , A61P31/04 , C07K7/06 , C07K14/315 , C07H21/04
CPC分类号： C07K14/315 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K2319/00 , Y02A50/464 , Y02A50/466 , Y02A90/22 , Y02A90/26
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences.
摘要翻译： 本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。
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公开(公告)号：US20130005030A1
公开(公告)日：2013-01-03
申请号：US13607990
申请日：2012-09-10
CPC分类号： C07K14/315 , A61K38/164 , A61K38/18 , A61K38/19 , A61K38/22 , A61K39/092 , A61K45/06 , A61K2039/522 , A61K2039/6037 , A61K2039/6043 , A61K2039/6068 , C07K14/22 , C07K14/235 , C07K14/285 , C07K14/33 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/1275 , C07K16/40 , C07K2319/00 , C07K2319/55 , Y02A50/466 , Y02A50/478 , Y10S530/825
摘要： The invention provides mutants of GAS57 (Spy0416) which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
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公开(公告)号：US20120034230A1
公开(公告)日：2012-02-09
申请号：US13144149
申请日：2010-01-12
IPC分类号： A61K39/40 , C07K19/00 , C07K14/31 , C07K17/02 , C12N15/31 , C12N15/63 , C12P21/02 , C07K16/12 , C12N1/21 , C12N1/19 , C12N5/10 , A61K39/09 , A61K39/085 , A61K39/116 , A61P37/04 , A61P31/04 , C07K14/315
CPC分类号： C07K14/315 , A61K39/085 , A61K39/092 , A61K2039/55566 , C07K16/44 , C12N15/03 , C12N15/63
摘要： The invention provides protective antigens which are useful in vaccine compositions to induce protection against gram positive bacteria, particularly against S. agalactiae, S. pyogenes, S. pneumoniae, S. aureus, S. suis, and S. equi.
摘要翻译： 本发明提供了可用于疫苗组合物中的保护性抗原，以诱导针对革兰氏阳性细菌的保护，特别是针对无乳链球菌，化脓性链球菌，肺炎链球菌，金黄色葡萄球菌，猪链球菌和马赛克氏菌。
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10.发明授权公开(公告)号：US09102740B2
公开(公告)日：2015-08-11
申请号：US13912472
申请日：2013-06-07
IPC分类号： C12N15/03 , C12P21/04 , C07H21/04 , C07K14/315 , C12N15/63 , A61K39/085 , A61K39/09 , C07K16/44 , A61K39/00
CPC分类号： C07K14/315 , A61K39/085 , A61K39/092 , A61K2039/55566 , C07K16/44 , C12N15/03 , C12N15/63
摘要： The invention provides protective antigens which are useful in vaccine compositions to induce protection against gram positive bacteria, particularly against S. agalactiae, S. pyogenes, S. pneumoniae, S. aureus, S. suis, and S. equi.
摘要翻译： 本发明提供了可用于疫苗组合物中的保护性抗原，以诱导针对革兰氏阳性细菌的保护，特别是针对无乳链球菌，化脓性链球菌，肺炎链球菌，金黄色葡萄球菌，猪链球菌和马赛克氏菌。
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