公开(公告)号：US20050038423A1

公开(公告)日：2005-02-17

申请号：US10881409

申请日：2004-06-30

申请人： Inder Makin ,  Conrad Klotz ,  Sarah Stephens ,  Robert Dunki-Jacobs

发明人： Inder Makin ,  Conrad Klotz ,  Sarah Stephens ,  Robert Dunki-Jacobs

IPC分类号： A61B19/00 ,  A61N7/02 ,  A61B18/04 ,  A61F7/00 ,  A61F7/12

CPC分类号： A61N7/02 ,  A61B8/14 ,  A61B2090/374 ,  A61B2090/378 ,  A61N2007/0078

摘要： A system, method and/or apparatus is provided for visualization or imaging of the transverse carpal ligament and surrounding structures/features of a hand of a patient, and treatment of the transverse carpal ligament, particularly, but not necessarily, for performing non-invasive carpal tunnel release. The subject invention utilizes ultrasound waves preferably, but not necessarily, in the high frequency range and cavitations to image the transverse carpal ligament (TCL), record its location in three-dimensional space, and perform precision treatment on the transverse carpal ligament. Treatment may range from stretching or lengthening the TCL to complete tissue ablation or dissection of a portion or portions of the TCL (as is performed in a standard carpal tunnel release procedure) in order to release pressure within the carpal tunnel. Particularly, high temperature conditions are generated at target tissue of the TCL resulting in elongation or necrosis/dissection. The subject system, apparatus and/or method provides the surgeon to relieve a patient of carpal tunnel syndrome symptoms in a bloodless, efficient, and accurate manner.

摘要翻译： 提供了一种系统，方法和/或装置，用于横向腕韧带和患者的手的周围结构/特征的可视化或成像，以及横向腕韧带的治疗，特别地但不一定用于执行非侵入性 腕管释放。 本发明优选但不一定在高频范围内使用超声波，并且对横向腕韧带（TCL）进行成像的空化，将其位置记录在三维空间中，并对横腕腕韧带进行精确的处理。 治疗可以从拉伸或延长TCL到完成组织消融或TCL的一部分或部分的解剖（如在标准腕管释放程序中执行的）以释放腕管内的压力。 特别地，在TCL的靶组织处产生高温条件，导致伸长或坏死/解剖。 受试者系统，装置和/或方法提供外科医生以无血型，有效率和准确的方式缓解患者腕管综合征症状。

公开(公告)号：US20130226040A1

公开(公告)日：2013-08-29

申请号：US13719172

申请日：2012-12-18

申请人： Slayton H. Michael ,  Inder Makin ,  Robert Dunki-Jacobs ,  Richard C. Pellegrino

发明人： Slayton H. Michael ,  Inder Makin ,  Robert Dunki-Jacobs ,  Richard C. Pellegrino

IPC分类号： A61N7/00

CPC分类号： A61N7/00 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4488 ,  A61B10/0233 ,  A61B17/22012 ,  A61B17/2202 ,  A61B17/29 ,  A61B17/320092 ,  A61B2090/378 ,  A61B2090/3784 ,  A61B2090/3929 ,  A61B2090/3975 ,  A61N7/022 ,  A61N2007/0078

摘要： An ultrasound medical treatment system includes an end effector insertable into a patient. The end effector includes a tissue-retaining device. The tissue-retaining device includes a first tissue-retaining member having an ultrasound medical-treatment transducer and includes a second tissue-retaining member. The first and second tissue-retaining members are operatively connected together to retain patient tissue between the first and second tissue-retaining members and to release patient tissue so retained. In one example, the second tissue-retaining member has an ultrasound reflector. In the same or a different example, the ultrasound medical-treatment transducer is an ultrasound imaging and medical-treatment transducer.

摘要翻译： 超声医疗系统包括可插入病人的末端执行器。 末端执行器包括组织保持装置。 组织保持装置包括具有超声波医疗换能器的第一组织保持构件，并且包括第二组织保持构件。 第一和第二组织保持构件可操作地连接在一起以将患者组织保持在第一和第二组织保持构件之间并且释放如此保留的患者组织。 在一个示例中，第二组织保持构件具有超声波反射器。 在相同或不同的示例中，超声医疗换能器是超声成像和医疗换能器。

公开(公告)号：US20060074355A1

公开(公告)日：2006-04-06

申请号：US10950112

申请日：2004-09-24

申请人： Michael Slayton ,  Inder Makin ,  Peter Barthe

发明人： Michael Slayton ,  Inder Makin ,  Peter Barthe

IPC分类号： A61H1/00

CPC分类号： A61H23/0245 ,  A61B8/4472 ,  A61B8/483 ,  A61H2201/5007 ,  A61N7/00 ,  A61N7/02 ,  A61N2007/0008 ,  A61N2007/0073 ,  A61N2007/0078

摘要： A non-invasive method and system for combined ultrasound treatment are provided. An exemplary combined ultrasound treatment system comprises a transducer configured to deliver ultrasound energy to provide two or more energy effects to a region of interest. The energy effects facilitate the initiation of one or more responses in the region of interest. In accordance with an exemplary embodiment of the present invention, a transducer is configured to deliver energy over varying temporal and/or spatial distributions in order to provide energy effects and initiate responses in a region of interest.

公开(公告)号：US20050261587A1

公开(公告)日：2005-11-24

申请号：US10850041

申请日：2004-05-20

申请人： Inder Makin ,  T. Mast ,  Michael Slayton ,  Peter Barthe ,  Jeffrey Messerly ,  Waseem Faidi

发明人： Inder Makin ,  T. Mast ,  Michael Slayton ,  Peter Barthe ,  Jeffrey Messerly ,  Waseem Faidi

IPC分类号： A61B8/00 ,  A61B8/12 ,  A61B8/14 ,  A61B17/22 ,  A61B17/34

CPC分类号： A61B17/2202 ,  A61B8/4281 ,  A61B17/22012 ,  A61B2017/3484 ,  A61B2017/3488

摘要： An ultrasound medical system includes an ultrasound end effector. The ultrasound end effector has an exterior surface, includes a medical ultrasound transducer assembly having at least one medical-treatment ultrasound transducer, and includes at least one tine. The at-least-one tine is deployable to extend away from the exterior surface into patient tissue to provide at least some stabilization of the ultrasound end effector with respect to patient tissue and is retrievable to retract back toward the exterior surface.

摘要翻译： 超声波医疗系统包括超声末端执行器。 超声末端执行器具有外表面，包括具有至少一个医疗超声换能器的医疗超声换能器组件，并且包括至少一个齿。 至少一个齿可展开以从外表面延伸到患者组织中，以相对于患者组织提供超声末端执行器的至少一些稳定性，并且可回收以向外表面缩回。

公开(公告)号：US20050240123A1

公开(公告)日：2005-10-27

申请号：US10824196

申请日：2004-04-14

申请人： T. Mast ,  Waseem Faidi ,  Inder Makin ,  Michael Slayton ,  Peter Barthe

发明人： T. Mast ,  Waseem Faidi ,  Inder Makin ,  Michael Slayton ,  Peter Barthe

IPC分类号： A61B8/00 ,  A61B17/00 ,  A61H1/00 ,  A61N7/02

CPC分类号： A61N7/022 ,  A61B2017/00274 ,  A61B2018/00547

摘要： An embodiment of an ultrasound medical treatment system includes an ultrasound medical-treatment transducer and a controller. The controller powers the transducer to deliver ultrasound to thermally ablate patient tissue in vivo. In a first expression of the embodiment and/or a first method for thermally ablating patient tissue in vivo which optionally can employ the embodiment, the transducer is powered to deliver ultrasound for or beyond an in vivo treatment time which is a function of an experimentally-determined in vitro treatment time for the same ultrasound acoustic power. In a second expression of the embodiment and/or a second method, the transducer is powered to deliver ultrasound at or above an in vivo ultrasound acoustic power which is a function of an experimentally-determined in vitro ultrasound acoustic power for the same treatment time. In a third expression of the embodiment and/or a third method, the transducer is powered to deliver ultrasound at or above an ultrasound acoustic power threshold which is calculated from an equation.

摘要翻译： 超声医疗系统的一个实施例包括超声医疗换能器和控制器。 控制器为传感器供电以输送超声波，以在体内热消融患者组织。 在本实施例的第一个表达方式和/或用于在体内热消融患者组织的第一种方法，其任选地可以采用本实施例，换能器被供电以输送超出体内治疗时间或超过体内治疗时间， 确定体外治疗时间为相同的超声波功率。 在实施例和/或第二方法的第二表达中，换能器被供电以在等于或高于体内超声声功率的情况下传送超声波，该功率在相同的治疗时间内是实验确定的体外超声声功率的函数。 在实施例和/或第三方法的第三表达式中，换能器被供电以将超声波输送到等于或高于根据等式计算的超声声功率阈值。

公开(公告)号：US20050240124A1

公开(公告)日：2005-10-27

申请号：US10825090

申请日：2004-04-15

申请人： T. Mast ,  Waseem Faidi ,  Inder Makin ,  Megan Runk ,  Michael Slayton ,  Peter Barthe

发明人： T. Mast ,  Waseem Faidi ,  Inder Makin ,  Megan Runk ,  Michael Slayton ,  Peter Barthe

IPC分类号： A61B8/00 ,  A61B17/00 ,  A61B17/22 ,  A61H1/00 ,  A61N7/02

CPC分类号： A61N7/022 ,  A61B2017/00274 ,  A61B2017/22028 ,  A61B2018/00547

摘要： An ultrasound medical treatment system includes an ultrasound medical treatment transducer and a controller. In one arrangement, the controller movingly controls the medical treatment transducer to emit ultrasound to thermally ablate patient tissue: 1) for a plurality of predetermined time intervals each associated with the medical treatment transducer movingly disposed at a different one of an equal number of predetermined positions, wherein a next-in-time time interval is associated with a position which is spatially non-adjacent to a position associated with a present-in-time time interval; or 2) for a predetermined time interval during which the transducer is continuously moved. Methods of the invention so control the medical treatment transducer using or not using the controller. In another arrangement, the transducer has an array of transducer elements and the controller activates different non-overlapping groups or different overlapping groups of transducer elements at different times.

摘要翻译： 超声医疗系统包括超声医疗换能器和控制器。 在一种布置中，控制器移动地控制医疗换能器发射超声波以热消融患者组织：1）多个预定时间间隔，每个预定的时间间隔与医疗治疗换能器相关联，移位地设置在相同数量的预定位置 其中，与时间上的时间间隔相关联的位置与空间上不相邻的位置相关联的时间时间间隔; 或2）在传感器连续移动的预定时间间隔内。 本发明的方法使用或不使用控制器来控制医疗换能器。 在另一种布置中，换能器具有换能器元件的阵列，并且控制器在不同时间激活不同的非重叠组或不同重叠的换能器元件组。

公开(公告)号：US20050131339A1

公开(公告)日：2005-06-16

申请号：US11050214

申请日：2005-02-03

申请人： Inder Makin ,  Jurgen Mensch ,  Marcus Noppe ,  Michael Slayton

发明人： Inder Makin ,  Jurgen Mensch ,  Marcus Noppe ,  Michael Slayton

IPC分类号： A61B18/00 ,  A61M37/00 ,  A61N7/00 ,  A61B17/20

CPC分类号： A61M37/0092 ,  A61N7/00

摘要： The present invention relates, in general, to ultrasonic surgical instruments and, more particularly, to an intracorporeal ultrasonic surgical instrument for sonodynamic therapy. Disclosed is an ultrasonic surgical system comprising: a generator and an instrument comprising: a housing; a transducer; a semi-permeable membrane; a pharmaceutical agent; and an agent delivery system. The transducer is adapted to convert the electrical energy of the generator into mechanical energy. The pharmaceutical agent, delivered into a chamber of the semi-permeable membrane, is driven through the semi-permeable membrane by the mechanical energy. A method in accordance with the present invention comprises the steps of: providing a surgical instrument comprising: a housing; a transducer connected to the housing; a semi-permeable membrane; a pharmaceutical agent; and an agent delivery system; inserting the surgical instrument into a patient; delivering a drug to the patient; and locally activating the drug with the surgical instrument.

摘要翻译： 本发明一般涉及超声外科器械，更具体地，涉及用于声波动力学治疗的体外超声外科器械。 公开了一种超声波手术系统，包括：发生器和器械，包括：壳体; 换能器 半透膜; 药剂; 和代理分发系统。 换能器适于将发电机的电能转换为机械能。 输送到半透膜的室中的药剂通过机械能驱动通过半透膜。 根据本发明的方法包括以下步骤：提供外科器械，包括：外壳; 连接到壳体的换能器; 半透膜; 药剂; 和代理交付系统; 将外科器械插入患者体内; 向患者运送药物; 并用手术器械局部活化药物。

公开(公告)号：US20130218013A1

公开(公告)日：2013-08-22

申请号：US13752151

申请日：2013-01-28

申请人： Peter Barthe ,  Michael Slayton ,  Paul Jaeger ,  Douglas Mast ,  Inder Makin ,  Brian OConner ,  Jeffery Messerly ,  Waseem Faidi ,  Megan Runk ,  Christopher Park

发明人： Peter Barthe ,  Michael Slayton ,  Paul Jaeger ,  Douglas Mast ,  Inder Makin ,  Brian OConner ,  Jeffery Messerly ,  Waseem Faidi ,  Megan Runk ,  Christopher Park

IPC分类号： A61B5/00 ,  A61B18/12 ,  A61B18/06 ,  A61B18/18 ,  A61B5/053 ,  A61B8/13 ,  A61N7/00 ,  A61B18/08

CPC分类号： A61B5/4836 ,  A61B5/053 ,  A61B8/13 ,  A61B8/4281 ,  A61B8/4483 ,  A61B17/2202 ,  A61B18/06 ,  A61B18/08 ,  A61B18/12 ,  A61B18/1815 ,  A61B2090/378 ,  A61N7/00

摘要： An ultrasound medical system includes an interstitial end effector. The interstitial end effector is interstitially insertable into patient tissue, includes at least one medical-treatment ultrasound transducer, and includes at least one end-effector-tissue-track ablation device. One method for ultrasonically treating a lesion in a patient includes the steps of obtaining the interstitial end effector and inserting it into the patient creating a tissue track which is surrounded by patient tissue and which ends at the distal end of the inserted interstitial end effector. Other steps include ultrasonically ablating the lesion using the at-least-one medical-treatment ultrasound transducer, using the at-least-one end-effector-tissue-track ablation device to ablate the patient tissue surrounding the tissue track along substantially the entire tissue track, and withdrawing the end effector from the patient.

摘要翻译： 超声波医疗系统包括间质末端执行器。 间质末端效应器在间质中可插入患者组织中，包括至少一个医疗超声换能器，并且包括至少一个末端效应器 - 组织 - 轨道消融装置。 用于超声治疗患者病变的一种方法包括以下步骤：获得间隙末端执行器并将其插入患者中，从而产生组织轨迹，所述组织轨道被患者组织包围，并且在组织轨迹的末端处被插入插入的末端执行器。 其他步骤包括使用至少一个医疗超声换能器超声波消融损伤，使用至少一个末端效应器 - 组织道消融装置沿着基本上整个组织消融围绕组织轨迹的患者组织 跟踪并从患者中取出末端执行器。

公开(公告)号：US20050261586A1

公开(公告)日：2005-11-24

申请号：US10848550

申请日：2004-05-18

申请人： Inder Makin ,  T. Mast ,  Michael Slayton ,  Peter Barthe ,  Jeffrey Messerly ,  Waseem Faidi ,  Megan Runk

发明人： Inder Makin ,  T. Mast ,  Michael Slayton ,  Peter Barthe ,  Jeffrey Messerly ,  Waseem Faidi ,  Megan Runk

IPC分类号： A61B17/22 ,  A61H1/00 ,  A61N7/02

CPC分类号： A61B8/4272 ,  A61B8/12 ,  A61B8/4281 ,  A61B8/4444 ,  A61B8/546 ,  A61B2017/2253 ,  A61N7/00 ,  A61N7/022 ,  A61N2007/0052

摘要： An ultrasound medical system has an end effector including a medical ultrasound transducer and an acoustic coupling medium. The acoustic coupling medium has a transducer-proximal surface and a transducer-distal surface. The medical ultrasound transducer is positioned to emit medical ultrasound through the acoustic coupling medium from the transducer-proximal surface to the transducer-distal surface. The end effector is adapted to change a property (such as the shape and/or the temperature) of the acoustic coupling medium during emission, and/or between emissions, of medical ultrasound from the medical ultrasound transducer during a medical procedure on a patient. In one example, such changes are used to change the focus and/or beam angle of the emitted ultrasound during the medical procedure.

摘要翻译： 超声波医疗系统具有包括医用超声波换能器和声耦合介质的末端执行器。 声耦合介质具有换能器近侧表面和换能器远侧表面。 医疗超声换能器被定位成通过声耦合介质从换能器近端表面到换能器远侧表面发射医用超声波。 端部执行器适于在医疗超声波换能器在患者的医疗过程期间改变声学耦合介质在发射期间和/或发射之间的医疗超声波的性质（例如形状和/或温度）。 在一个示例中，这样的改变用于在医疗过程期间改变发射的超声的焦点和/或束角。

公开(公告)号：US20050228286A1

公开(公告)日：2005-10-13

申请号：US10819726

申请日：2004-04-07

申请人： Jeffrey Messerly ,  Michael Slayton ,  Richard Nuchols ,  Inder Makin ,  Peter Barthe ,  T. Mast

发明人： Jeffrey Messerly ,  Michael Slayton ,  Richard Nuchols ,  Inder Makin ,  Peter Barthe ,  T. Mast

IPC分类号： A61B8/12 ,  A61B8/14 ,  A61B19/00 ,  A61N7/02

CPC分类号： A61B8/12 ,  A61B8/4281 ,  A61B8/445 ,  A61B8/4461 ,  A61B2090/378 ,  A61N7/02

摘要： An ultrasound medical system includes a handpiece and an end effector which is operatively connected to the handpiece and which is insertable into a patient. The end effector includes a shaft, a medical ultrasound transducer assembly, and a shaft head. The shaft has a longitudinal axis, has a distal end, and is rotatable about the longitudinal axis with respect to the handpiece. The transducer assembly is non-rotatably attached to the shaft and is adapted to emit medical ultrasound. The shaft head is attached to the distal end of the shaft and has a piercing tip which is insertable into patient tissue.

摘要翻译： 超声波医疗系统包括手持件和端部执行器，其可操作地连接到手持件并且可插入到患者体内。 末端执行器包括轴，医用超声换能器组件和轴头。 轴具有纵向轴线，具有远端，并且可相对于手持件围绕纵向轴线旋转。 换能器组件不可旋转地附接到轴并且适于发射医用超声波。 轴头连接到轴的远端并且具有可插入患者组织中的穿刺尖端。