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公开(公告)号：US20130189287A1
公开(公告)日：2013-07-25
申请号：US13725382
申请日：2012-12-21
发明人： Delphine Bregeon , Patrick Dennler , Christian Belmant , Eliane Fischer , Laurent Gauthier , Francois Romagné , Roger Schibli
IPC分类号： C07K19/00 , C12P21/00 , C12N9/10 , C07C323/60 , C07C323/12 , C07C247/04 , C07D225/08 , C07C217/08 , C07C229/26 , C07C233/62 , C07D277/06 , C07F9/50 , C07D257/08 , C07C223/02 , G01N33/68
CPC分类号： A61K47/6803 , A61K47/60 , A61K47/68 , A61K47/6807 , A61K47/6813 , A61K47/6817 , A61K47/6865 , A61K47/6871 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07C323/12 , C07C323/60 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/5022 , C07K16/00 , C07K19/00 , C07K2317/40 , C12N9/1044 , C12P21/005 , G01N33/6854
摘要： The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions
摘要翻译： 本申请涉及用于免疫球蛋白功能化的方法，特别是与药物。 本文还公开了连接试剂，官能化抗体，药物组合物和治疗疾病和/或病症的方法
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公开(公告)号：US09717803B2
公开(公告)日：2017-08-01
申请号：US13725382
申请日：2012-12-21
发明人： Delphine Bregeon , Patrick Dennler , Christian Belmant , Eliane Fischer , Laurent Gauthier , Francois Romagné , Roger Schibli
IPC分类号： A61K47/48 , C07K16/00 , C07K16/30 , C07K19/00 , A61K31/5517 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07C323/12 , C07C323/60 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/50 , C12N9/10 , C12P21/00 , G01N33/68
CPC分类号： A61K47/6803 , A61K47/60 , A61K47/68 , A61K47/6807 , A61K47/6813 , A61K47/6817 , A61K47/6865 , A61K47/6871 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07C323/12 , C07C323/60 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/5022 , C07K16/00 , C07K19/00 , C07K2317/40 , C12N9/1044 , C12P21/005 , G01N33/6854
摘要： The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
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公开(公告)号：US20160331842A1
公开(公告)日：2016-11-17
申请号：US15214331
申请日：2016-07-19
发明人： Delphine Bregeon , Patrick Dennler , Christian Belmant , Laurent Gauthier , François Romagne , Eliane Fischer , Roger Schibli
IPC分类号： A61K47/48 , C07K16/30 , A61K31/5517
CPC分类号： A61K47/48569 , A61K31/5517 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/24 , C07K2317/40
摘要： The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
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公开(公告)号：US20150346195A1
公开(公告)日：2015-12-03
申请号：US14414432
申请日：2013-07-10
发明人： Christian Belmant , Delphine Bregeon , Patrick Dennler , Eliane Fischer , François Romagne , Roger Schibli
IPC分类号： G01N33/532 , C07K16/00 , A61K47/48 , G01N33/50
CPC分类号： G01N33/532 , A61K47/68 , C07K16/00 , C07K2317/24 , G01N33/5014 , G01N33/6854
摘要： Provided is a method for the functionalization of immunoglobulins through the use of transglutaminase, including methods for screening functionalized antibodies for characteristics of interest, antibody compositions comprising a plurality of functionalized antibodies, and functionalized antibodies with rodent constant regions.
摘要翻译： 提供了通过使用转谷氨酰胺酶来功能化免疫球蛋白的方法，包括筛选用于感兴趣特征的功能化抗体的方法，包含多个官能化抗体的抗体组合物和具有啮齿动物恒定区的功能化抗体。
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公开(公告)号：US10675359B2
公开(公告)日：2020-06-09
申请号：US15702586
申请日：2017-09-12
发明人： Patrick Dennler , Delphine Bregeon , Laurent Gauthier , François Romagné , Christian Belmant , Eliane Fischer , Roger Schibli
IPC分类号： A61K47/68 , C07K16/00 , A61K47/60 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07C323/12 , C07C323/60 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/50 , C07K19/00 , C12N9/10 , C12P21/00 , G01N33/68
摘要： The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
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公开(公告)号：US20180193476A1
公开(公告)日：2018-07-12
申请号：US15702586
申请日：2017-09-12
发明人： Patrick Dennler , Delphine Bregeon , Laurent Gauthier , François Romagné , Christian Belmant , Eliane Fischer , Roger Schibli
IPC分类号： A61K47/68 , G01N33/68 , C12N9/10 , C12P21/00 , C07K19/00 , C07K16/00 , C07F9/50 , C07D277/06 , C07D257/08 , C07D225/08 , C07C323/60 , C07C323/12 , C07C247/04 , C07C233/62 , C07C229/26 , C07C223/02 , C07C217/08
摘要： The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
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公开(公告)号：US20180071402A1
公开(公告)日：2018-03-15
申请号：US15654585
申请日：2017-07-19
发明人： Delphine Bregeon , Patrick Dennler , Christian Belmant , Eliane Fischer , Laurent Gauthier , Francois Romagné , Roger Schibli
IPC分类号： G01N33/68 , C12N9/10 , C12P21/00 , C07K19/00 , C07K16/00 , C07F9/50 , C07D277/06 , C07D257/08 , C07D225/08 , C07C323/60 , C07C323/12 , C07C247/04 , C07C233/62 , C07C229/26 , C07C223/02 , C07C217/08
CPC分类号： A61K47/6803 , A61K47/60 , A61K47/68 , A61K47/6807 , A61K47/6813 , A61K47/6817 , A61K47/6865 , A61K47/6871 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07C323/12 , C07C323/60 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/5022 , C07K16/00 , C07K19/00 , C07K2317/40 , C12N9/1044 , C12P21/005 , G01N33/6854
摘要： The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
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公开(公告)号：US20140356385A1
公开(公告)日：2014-12-04
申请号：US14367840
申请日：2012-12-21
发明人： Patrick Dennler , Delphine Bregeon , Laurent Gauthier , François Romagné , Christian Belmant , Eliane Fischer , Roger Schibli
CPC分类号： A61K47/6803 , A61K47/60 , A61K47/68 , A61K47/6807 , A61K47/6813 , A61K47/6817 , A61K47/6865 , A61K47/6871 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07C323/12 , C07C323/60 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/5022 , C07K16/00 , C07K19/00 , C07K2317/40 , C12N9/1044 , C12P21/005 , G01N33/6854
摘要： The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
摘要翻译： 本申请涉及用于免疫球蛋白功能化的方法，特别是与药物。 本文还公开了连接试剂，官能化抗体，药物组合物和治疗疾病和/或病症的方法。
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公开(公告)号：US10434180B2
公开(公告)日：2019-10-08
申请号：US15214331
申请日：2016-07-19
发明人： Delphine Bregeon , Patrick Dennler , Christian Belmant , Laurent Gauthier , François Romagne , Eliane Fischer , Roger Schibli
IPC分类号： A61K31/5517 , C07K16/00 , C07K16/30 , C07K19/00 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/50 , C12N9/10 , C12P21/00 , G01N33/68 , A61K47/48 , A61K47/68
摘要： The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
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公开(公告)号：US10132799B2
公开(公告)日：2018-11-20
申请号：US14414432
申请日：2013-07-10
发明人： Christian Belmant , Delphine Bregeon , Patrick Dennler , Eliane Fischer , François Romagne , Roger Schibli , Laurent Gauthier
IPC分类号： A61K47/48 , C07K16/00 , C07K16/30 , C07K19/00 , A61K31/5517 , C07C217/08 , C07C223/02 , C07C229/26 , C07C233/62 , C07C247/04 , C07C323/12 , C07C323/60 , C07D225/08 , C07D257/08 , C07D277/06 , C07F9/50 , C12N9/10 , C12P21/00 , G01N33/68 , G01N33/532 , G01N33/50 , A61K47/68
摘要： Provided is a method for the functionalization of immunoglobulins through the use of transglutaminase, including methods for screening functionalized antibodies for characteristics of interest, antibody compositions comprising a plurality of functionalized antibodies, and functionalized antibodies with rodent constant regions.
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