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公开(公告)号：US20230314405A1
公开(公告)日：2023-10-05
申请号：US18086873
申请日：2022-12-22
Applicant: Instrumentation Laboratory Company
Inventor： Benjamin Horev , Ethan Schonbrun , Gert Blankenstein , Luisa Andruzzi , Anne Winkler , Jacqueline Scott
CPC classification number: G01N33/4905 , G01N33/86 , C12Q1/56 , G16H50/20 , G01N2800/226
Abstract: An example method includes: analyzing a clot curve for a test sample that is based on an assay performed on the test sample in order to obtain two or more parameters associated with the clot curve; analyzing the two or more parameters to determine at least one of (i) whether a fibrinogen concentration in the test sample is below a threshold, or (ii) whether there is a therapeutic or pharmaceutical anticoagulant present in the test sample; and outputting, to a user interface, information based on the determination.
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公开(公告)号：US10288600B2
公开(公告)日：2019-05-14
申请号：US15594827
申请日：2017-05-15
Applicant: Instrumentation Laboratory Company
Inventor： Ethan Schonbrun , Gert Blankenstein , Josef Kerimo , Hansong Zeng
Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.
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公开(公告)号：US10648907B2
公开(公告)日：2020-05-12
申请号：US16403180
申请日：2019-05-03
Applicant: Instrumentation Laboratory Company
Inventor： Ethan Schonbrun , Lara Adib , Gert Blankenstein
Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.
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公开(公告)号：US10302559B2
公开(公告)日：2019-05-28
申请号：US16211581
申请日：2018-12-06
Applicant: Instrumentation Laboratory Company
Inventor： Ethan Schonbrun , Lara Adib , Gert Blankenstein
Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.
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公开(公告)号：US20170336385A1
公开(公告)日：2017-11-23
申请号：US15594827
申请日：2017-05-15
Applicant: Instrumentation Laboratory Company
Inventor： Ethan Schonbrun , Gert Blankenstein , Josef Kerimo , Hansong Zeng
CPC classification number: G01N33/49 , B01L3/502 , B01L2300/0654 , B01L2300/168 , G01N21/0303 , G01N21/05 , G01N21/25 , G01N21/552 , G01N2201/0612
Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.
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Patent Agency Ranking
公开(公告)号：US20190257750A1
公开(公告)日：2019-08-22
申请号：US16403180
申请日：2019-05-03
Applicant: Instrumentation Laboratory Company
Inventor： Ethan Schonbrun , Lara Adib , Gert Blankenstein
Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.
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公开(公告)号：US20190107486A1
公开(公告)日：2019-04-11
申请号：US16211581
申请日：2018-12-06
Applicant: Instrumentation Laboratory Company
Inventor： Ethan Schonbrun , Lara Adib , Gert Blankenstein
Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.
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公开(公告)号：US20180106720A1
公开(公告)日：2018-04-19
申请号：US15725504
申请日：2017-10-05
Applicant: Instrumentation Laboratory Company
Inventor： Ethan Schonbrun , Lara Adib , Gert Blankenstein
CPC classification number: G01N21/4133 , G01N21/27 , G01N33/4915 , G01N33/6803
Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.
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公开(公告)号：US11478796B2
公开(公告)日：2022-10-25
申请号：US16336832
申请日：2017-10-09
Applicant: ACOUSORT AB , INSTRUMENTATION LABORATORY COMPANY
Inventor： Per Augustsson , Pelle Daniel Ohlsson , Ola Jakobsson , Klara Andersson , Gert Blankenstein , Josef Kerimo , Ethan Schonbrun
Abstract: The invention relates to a method of performing an optical or electrical measurement in a sample of a disperse fluid, the sample comprising particles and a fluid. The method comprises the steps of: a) positioning the sample in a microfluidic cavity having a resonance frequency, b) subjecting the sample, in the cavity, to an acoustic standing wave configured for causing the particles to congregate in at least one first region of the cavity, thereby causing the fluid to occupy at least one second region of the cavity, wherein the frequency of the acoustic standing wave is varied between a frequency below the resonance frequency and a frequency above the resonance frequency, and c) performing an optical or electrical measurement in the fluid in at least one of the at least one second region of the cavity. Varying the frequency ensures reproducible results. The invention also relates to a system therefore and a method and system for measuring hematocrit.
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公开(公告)号：US10852295B2
公开(公告)日：2020-12-01
申请号：US16383427
申请日：2019-04-12
Applicant: Instrumentation Laboratory Company
Inventor： Ethan Schonbrun , Gert Blankenstein , Josef Kerimo , Hansong Zeng
Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.
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