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公开(公告)号:US09580554B2
公开(公告)日:2017-02-28
申请号:US14705451
申请日:2015-05-06
发明人: Gregory Breyta , Julian M. W. Chan , Daniel J. Coady , Amanda C. Engler , Jeannette M. Garcia , Wei Han , James L. Hedrick , Shaoqiong Liu , Alshakim Nelson , Robert J. Ono , Jye Yng Teo , Yi Yan Yang , Mu San Zhang
IPC分类号: C08L79/02 , C08G73/06 , C08G73/02 , A01N43/60 , A01N37/44 , A01N37/18 , A61K8/86 , A61K8/88 , A61K31/785 , A61K31/787 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q19/00 , C11D3/48 , D21H17/55 , C08L77/04
CPC分类号: C08G69/48 , A01N37/12 , A01N37/18 , A01N37/20 , A01N37/44 , A01N43/40 , A01N43/58 , A01N43/60 , A01N47/06 , A61K8/84 , A61K8/85 , A61K8/86 , A61K8/88 , A61K31/785 , A61K31/787 , A61K45/06 , A61K2800/10 , A61K2800/74 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/00 , A61Q17/005 , A61Q19/007 , C08G63/916 , C08G64/42 , C08G73/0206 , C08G73/024 , C08G73/0273 , C08G73/028 , C08G73/0293 , C08G73/0633 , C08G2650/02 , C08G2650/38 , C08G2650/58 , C08L77/04 , C08L79/02 , C11D3/3723 , C11D3/48 , D21H17/55 , D21H17/56 , D21H21/36 , A61K2300/00
摘要: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.
摘要翻译: 已经通过大量的缩聚合成了许多阳离子抗微生物聚合物。 形成的初始聚合物具有主链叔氮,随后使用合适的季铵化剂(例如烷基卤)季铵化。 阳离子聚合物包括具有阳离子重复单元的聚酰胺,聚碳酸酯,聚赖氨酸和聚胍,所述阳离子重复单元包含季铵氮作为主链氮。 阳离子聚合物可以对革兰氏阴性,革兰氏阳性微生物和/或真菌具有活性。
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公开(公告)号:US11045552B2
公开(公告)日:2021-06-29
申请号:US15479071
申请日:2017-04-04
申请人: International Business Machines Corporation , Agency for Science, Technology and Research (ASTAR)
发明人: Dylan J. Boday , Jeannette M. Garcia , James L. Hedrick , Nathaniel H. Park , Rudy J. Wojtecki , Yang Chuan , Ashlynn Lee , Zhen Chang Liang , Shaoqiong Liu , Yi Yan Yang
摘要: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.
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公开(公告)号:US11890342B2
公开(公告)日:2024-02-06
申请号:US17130415
申请日:2020-12-22
申请人: International Business Machines Corporation , Agency for Science, Technology, and Research (ASTAR)
发明人: Dylan J. Boday , Jeannette M. Garcia , James L. Hedrick , Nathaniel Park , Rudy J. Wojtecki , Yang Chuan , Ashlynn Lee , Zhen Chang Liang , Shaoqiong Liu , Yi Yan Yang
CPC分类号: A61K47/34 , A61K9/0019 , A61K9/107 , A61K31/7088 , A61K38/00 , A61K47/10 , C08G64/183
摘要: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.
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公开(公告)号:US20160326319A1
公开(公告)日:2016-11-10
申请号:US14705451
申请日:2015-05-06
发明人: Gregory Breyta , Julian M.W. Chan , Daniel J. Coady , Amanda C. Engler , Jeannette M. Garcia , Wei Han , James L. Hedrick , Shaoqiong Liu , Alshakim Nelson , Robert J. Ono , Jye Yng Teo , Yi Yan Yang , Mu San Zhang
IPC分类号: C08G73/06 , A01N43/60 , A01N37/44 , A01N37/18 , A61K8/86 , C11D3/48 , A61K31/785 , A61K31/787 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q19/00 , C08G73/02 , A61K8/88
CPC分类号: C08G69/48 , A01N37/12 , A01N37/18 , A01N37/20 , A01N37/44 , A01N43/40 , A01N43/58 , A01N43/60 , A01N47/06 , A61K8/84 , A61K8/85 , A61K8/86 , A61K8/88 , A61K31/785 , A61K31/787 , A61K45/06 , A61K2800/10 , A61K2800/74 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/00 , A61Q17/005 , A61Q19/007 , C08G63/916 , C08G64/42 , C08G73/0206 , C08G73/024 , C08G73/0273 , C08G73/028 , C08G73/0293 , C08G73/0633 , C08G2650/02 , C08G2650/38 , C08G2650/58 , C08L77/04 , C08L79/02 , C11D3/3723 , C11D3/48 , D21H17/55 , D21H17/56 , D21H21/36 , A61K2300/00
摘要: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.
摘要翻译: 已经通过大量的缩聚合成了许多阳离子抗微生物聚合物。 形成的初始聚合物具有主链叔氮,随后使用合适的季铵化剂(例如烷基卤)季铵化。 阳离子聚合物包括具有阳离子重复单元的聚酰胺,聚碳酸酯,聚赖氨酸和聚胍,所述阳离子重复单元包含季铵氮作为主链氮。 阳离子聚合物可以对革兰氏阴性,革兰氏阳性微生物和/或真菌具有活性。
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