公开(公告)号：US4090791A

公开(公告)日：1978-05-23

申请号：US733719

申请日：1976-10-18

申请人： Iqbal Siddiqi ,  Tito Suva ,  Christian Roehrich

发明人： Iqbal Siddiqi ,  Tito Suva ,  Christian Roehrich

IPC分类号： G01N21/25 ,  G01J3/50

CPC分类号： G01N21/253

摘要： A device for colorimetric analysis of samples comprises a plurality of groups of receptacles, means for bringing these groups successively to a testing station, and means for automatically performing a cycle of analysis on the receptacles of the group at that station. The analysis means includes a light source, a photodetector aligned therewith, and a plurality of filters. The receptacles of each group and respective filters are moved successively into alignment with the source and detector so that the contents of each receptacle are analyzed with the aid of the correct corresponding filter.

摘要翻译： 用于样品的比色分析的装置包括多组容器，用于将这些组连续地带到测试台的装置，以及用于在该工位上对组的容器自动执行分析循环的装置。 分析装置包括光源，与其对准的光电检测器和多个滤光器。 每个组的容器和相应的过滤器被连续地移动到与源和检测器对准，使得每个容器的内容物借助于正确的对应的过滤器被分析。

公开(公告)号：US4438067A

公开(公告)日：1984-03-20

申请号：US372796

申请日：1982-04-28

申请人： Iqbal Siddiqi

发明人： Iqbal Siddiqi

IPC分类号： G01N33/50 ,  C12Q1/00 ,  G01N21/78 ,  G01N31/22 ,  G01N33/52 ,  G01N33/66 ,  C12Q1/54 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/30 ,  C12N11/04

CPC分类号： G01N33/521 ,  Y10S435/805 ,  Y10S435/81 ,  Y10T436/144444

摘要： Test strip for the dip and read colorimetric determination of substances dissolved in liquids. Such strips are composed of an inert supporting base covered with a layer of polymer beads in which the reagents are incorporated. The color reaction takes place within the beads themselves which improves sensitivity and reproducibility of the testing.

摘要翻译： 测试条用于倾析和读取比色测定溶解在液体中的物质。 这样的条由惰性支撑基底组成，该基底覆盖有一层聚合物珠，其中掺入试剂。 颜色反应发生在珠子本身内，从而提高了测试的灵敏度和再现性。

公开(公告)号：US4353983A

公开(公告)日：1982-10-12

申请号：US205325

申请日：1980-07-15

申请人： Iqbal Siddiqi

发明人： Iqbal Siddiqi

IPC分类号： G01N33/50 ,  C12Q1/28 ,  C12Q1/60 ,  C12Q1/54

CPC分类号： C12Q1/28 ,  Y10S435/817 ,  Y10T436/206664

摘要： The present invention relates to the quantitative determination of hydrogen peroxide in water media and of substrates capable of being oxidized enzymatically with the formation of H.sub.2 O.sub.2 as well as the enzymes which are involved in such reaction and also the peroxidase which catalyzes the oxidation by H.sub.2 O.sub.2 of other substrates.

摘要翻译： PCT No.PCT / EP79 / 00089 Sec。 371日期1980年7月15日 102（e）日期1980年7月10日PCT提交1979年11月13日PCT公布。 出版物WO80 / 01081 日期：1980年5月29日。本发明涉及水介质中的过氧化氢的定量测定，以及能够在形成H 2 O 2时酶促氧化的底物以及与该反应有关的酶以及催化的过氧化物酶 其他底物的H2O2氧化。

公开(公告)号：US4960693A

公开(公告)日：1990-10-02

申请号：US151279

申请日：1988-01-06

申请人： Iqbal Siddiqi ,  Ciaron Mangan

发明人： Iqbal Siddiqi ,  Ciaron Mangan

IPC分类号： G01N33/542 ,  G01N33/573 ,  G01N33/535

CPC分类号： G01N33/573 ,  G01N33/542

摘要： A quick and simple immunoassay technique applicable to the determination of large molecules like proteins, polynucleotides and others involves labelling competitive immunospecies with an enzyme as signal generator. This enzyme can be converted to the corresponding apo-enzyme form and its regeneration, upon addition of a suitable co-factor, is inhibited by complexation when the labelled specie is reacted with its immunopartner. The degree of complexation is therefore ascertained by measuring the extent of regenerated activity.

公开(公告)号：US4867860A

公开(公告)日：1989-09-19

申请号：US942305

申请日：1986-12-16

申请人： Iqbal Siddiqi ,  Hans-Rudolf Wuhrmann

发明人： Iqbal Siddiqi ,  Hans-Rudolf Wuhrmann

IPC分类号： G01N27/28 ,  G01N27/27 ,  G01N27/30 ,  G01N27/333 ,  G01N27/416

CPC分类号： G01N27/3335

摘要： There is disclosed a process for producing a laminar electrode. The method comprises successive superposition of an insulating support, a conductive layer, a stable-potential internal reference element and an ion-selective diaphragm, all of which are protected by a mask which is impermeable to aqueous solutions. A completely tight seal between the mask and the ion-selective diaphragm is formed by casting the diaphragm in the form of a solution containing a binder which dissolves with and intimately mixes with the mask material.

摘要翻译： 公开了层叠电极的制造方法。 该方法包括绝缘支撑件，导电层，稳定电位的内部参考元件和离子选择性隔膜的连续叠加，所有这些都由不透水的掩模保护。 掩模和离子选择性隔膜之间的完全紧密的密封通过以包含粘合剂的溶液的形式浇铸隔膜而形成，所述粘合剂溶解并与掩模材料紧密地混合。

公开(公告)号：US20050155921A1

公开(公告)日：2005-07-21

申请号：US11079695

申请日：2005-03-15

申请人： Iqbal Siddiqi

发明人： Iqbal Siddiqi

IPC分类号： B03C1/01 ,  B03C1/24 ,  B03C1/28 ,  G01N35/00 ,  C02F1/48

CPC分类号： B03C1/12 ,  B01F13/0809 ,  B01F13/1013 ,  B01F13/1022 ,  B01L9/523 ,  B03C1/01 ,  B03C1/14 ,  B03C1/24 ,  B03C1/288 ,  G01N35/0098 ,  Y10T436/25 ,  Y10T436/25375

摘要： An apparatus and method for carrying out the affinity separation of a target substance from a liquid test medium by mixing magnetic particles having surface immobilized ligand or receptor within the test medium to promote an affinity binding reaction between the ligand and the target substance. The test medium with the magnetic particles in a suitable container is removably mounted in an apparatus that creates a magnetic field gradient in the test medium. This magnetic gradient is used to induce the magnetic particles to move, thereby effecting mixing. The mixing is achieved either by movement of a magnet relative to a stationary container or movement of the container relative to a stationary magnet. In either case, the magnetic particles experience a continuous angular position change with the magnet. Concurrently with the relative angular movement between the magnet and the magnetic particles, the magnet is also moved along the length of the container causing the magnetic field gradient to sweep the entire length of the container. After the desired time, sufficient for the affinity reaction to occur, movement of the magnetic gradient is ended, whereby the magnetic particles are immobilized on the inside wall of the container nearest to the magnetic source. The remaining test medium is removed while the magnetic particles are retained on the wall of the container. The test medium or the particles may then be subjected to further processing.

摘要翻译： 一种用于通过将具有表面固定的配体或受体的磁性颗粒混合在测试介质中以促进配体与目标物质之间的亲合力结合反应来进行目标物质与液体测试介质的亲和分离的装置和方法。 具有适当容器中的磁性颗粒的测试介质可移除地安装在在测试介质中产生磁场梯度的装置中。 该磁梯度用于诱导磁性颗粒移动，从而进行混合。 混合通过磁体相对于固定容器的运动或容器相对于固定磁体的运动来实现。 在任一情况下，磁性颗粒与磁体经历连续的角位置变化。 与磁体和磁性颗粒之间的相对角运动同时地，磁体也沿着容器的长度移动，导致磁场梯度扫掠容器的整个长度。 在期望的时间之后，足以发生亲和反应，结束磁梯度的移动，由此将磁性颗粒固定在最靠近磁源的容器的内壁上。 剩余的测试介质被移除，同时磁性颗粒保留在容器的壁上。 然后可以对测试介质或颗粒进行进一步处理。

公开(公告)号：US5110746A

公开(公告)日：1992-05-05

申请号：US299939

申请日：1988-12-22

申请人： Howard Grey ,  Ciaran Mangan ,  Jean Brochot ,  Iqbal Siddiqi

发明人： Howard Grey ,  Ciaran Mangan ,  Jean Brochot ,  Iqbal Siddiqi

IPC分类号： G01N33/68

CPC分类号： G01N33/6827

摘要： Serum is reacted with a dinitrohalobenzene compound and the rate of halogen formation is measured. This rate is in proportion to the amount of albumin in the sample. Other proteins like the globulins, as well as free aminoacids and urea, do not interfere with this reaction.

摘要翻译： PCT No.PCT / US88 / 01328 Sec。 371日期：1988年12月22日 102（e）日期1988年12月22日PCT提交1988年4月22日PCT公布。 第WO88 / 08533号公报 日期：1988年11月3日。与二硝基卤代苯化合物反应，测定卤素形成速率。 该比例与样品中白蛋白的量成比例。 其他蛋白质，如球蛋白，以及游离氨基酸和尿素，都不会干扰该反应。

公开(公告)号：US4859306A

公开(公告)日：1989-08-22

申请号：US203550

申请日：1988-05-31

申请人： Iqbal Siddiqi ,  Hans-Rudolf Wuhrmann

发明人： Iqbal Siddiqi ,  Hans-Rudolf Wuhrmann

IPC分类号： G01N27/30 ,  G01N27/333 ,  G01N27/416

CPC分类号： G01N27/3335

摘要： The electrode comprises an internal reference half-cell at stable potential comprising a conductive sheet, e.g. of metal of carbon, covered by a redox system. The redox system comprises a thin dehydrated layer of Prussian blue deposited by contact between the sheet and a mixture of alkaline ferrocyanide and a ferric salt.

摘要翻译： 电极包括稳定电势的内部参考半电池，包括导电片，例如 的金属，被氧化还原体系覆盖。 氧化还原体系包括通过片材与碱性亚铁氰化物和铁盐的混合物之间的接触而沉积的稀释的普鲁士蓝脱水层。

公开(公告)号：US20060207944A1

公开(公告)日：2006-09-21

申请号：US11435060

申请日：2006-05-17

申请人： Iqbal Siddiqi

发明人： Iqbal Siddiqi

IPC分类号： C02F1/48

CPC分类号： B03C1/12 ,  B01F13/0809 ,  B01F13/1013 ,  B01F13/1022 ,  B01L9/523 ,  B03C1/01 ,  B03C1/14 ,  B03C1/24 ,  B03C1/288 ,  G01N35/0098 ,  Y10T436/25 ,  Y10T436/25375

摘要： An apparatus and method for carrying out the affinity separation of a target substance from a liquid test medium by mixing magnetic particles having surface immobilized ligand or receptor within the test medium to promote an affinity binding reaction between the ligand and the target substance. The test medium with the magnetic particles in a suitable container is removably mounted in an apparatus that creates a magnetic field gradient in the test medium. This magnetic gradient is used to induce the magnetic particles to move, thereby effecting mixing. The mixing is achieved either by movement of a magnet relative to a stationary container or movement of the container relative to a stationary magnet. In either case, the magnetic particles experience a continuous angular position change with the magnet. Concurrently with the relative angular movement between the magnet and the magnetic particles, the magnet is also moved along the length of the container causing the magnetic field gradient to sweep the entire length of the container. After the desired time, sufficient for the affinity reaction to occur, movement of the magnetic gradient is ended, whereby the magnetic particles are immobilized on the inside wall of the container nearest to the magnetic source. The remaining test medium is removed while the magnetic particles are retained on the wall of the container. The test medium or the particles may then be subjected to further processing.

公开(公告)号：US20060201887A1

公开(公告)日：2006-09-14

申请号：US11433608

申请日：2006-05-15

申请人： Iqbal Siddiqi

发明人： Iqbal Siddiqi

IPC分类号： C02F1/48

CPC分类号： B03C1/12 ,  B01F13/0809 ,  B01F13/1013 ,  B01F13/1022 ,  B01L9/523 ,  B03C1/01 ,  B03C1/14 ,  B03C1/24 ,  B03C1/288 ,  G01N35/0098 ,  Y10T436/25 ,  Y10T436/25375

摘要： An apparatus and method for carrying out the affinity separation of a target substance from a liquid test medium by mixing magnetic particles having surface immobilized ligand or receptor within the test medium to promote an affinity binding reaction between the ligand and the target substance. The test medium with the magnetic particles in a suitable container is removably mounted in an apparatus that creates a magnetic field gradient in the test medium. This magnetic gradient is used to induce the magnetic particles to move, thereby effecting mixing. The mixing is achieved either by movement of a magnet relative to a stationary container or movement of the container relative to a stationary magnet. In either case, the magnetic particles experience a continuous angular position change with the magnet. Concurrently with the relative angular movement between the magnet and the magnetic particles, the magnet is also moved along the length of the container causing the magnetic field gradient to sweep the entire length of the container. After the desired time, sufficient for the affinity reaction to occur, movement of the magnetic gradient is ended, whereby the magnetic particles are immobilized on the inside wall of the container nearest to the magnetic source. The remaining test medium is removed while the magnetic particles are retained on the wall of the container. The test medium or the particles may then be subjected to further processing.