公开(公告)号：US07572887B2

公开(公告)日：2009-08-11

申请号：US10552515

申请日：2004-04-05

申请人： Ira Pastan ,  Tapan K. Bera ,  Byungkook Lee

发明人： Ira Pastan ,  Tapan K. Bera ,  Byungkook Lee

IPC分类号： C07K14/00 ,  C07H21/04 ,  C12N15/00 ,  C12Q1/68

CPC分类号： A61K38/168 ,  A61K38/164 ,  A61K47/64 ,  C07K14/47 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/106 ,  G01N33/57434 ,  G01N2500/00

摘要： A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugages are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection of prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NEGP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.

摘要翻译： 公开了在前列腺细胞中特异性检测到的多肽，称为前列腺中表达的剪接变体 - 新型基因（SV-NGEP）。 还公开了编码SV-NGEP的多核苷酸，以及包括这些多核苷酸的载体。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合SV-NGEP的抗体和免疫结合物。 公开了使用NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的方法。 公开了检测前列腺癌的测定。 还公开了包含SV-NGEP多肽，特异性结合SV-NEGP的抗体或编码SV-NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。

公开(公告)号：US20090304702A1

公开(公告)日：2009-12-10

申请号：US12497382

申请日：2009-07-02

申请人： Ira Pastan ,  Tapan K. Bera ,  Byungkook Lee

发明人： Ira Pastan ,  Tapan K. Bera ,  Byungkook Lee

IPC分类号： A61K39/395 ,  G01N33/53 ,  C12N5/02 ,  C07K16/00

CPC分类号： A61K38/168 ,  A61K38/164 ,  A61K47/64 ,  C07K14/47 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/106 ,  G01N33/57434 ,  G01N2500/00

摘要： A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugates are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.

摘要翻译： 公开了在前列腺细胞中特异性检测到的多肽，称为前列腺中表达的剪接变体 - 新型基因（SV-NGEP）。 还公开了编码SV-NGEP的多核苷酸，以及包括这些多核苷酸的载体。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合SV-NGEP的抗体和免疫偶联物。 公开了使用NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的方法。 公开了检测前列腺癌的检测。 还公开了包含SV-NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。

公开(公告)号：US07816087B2

公开(公告)日：2010-10-19

申请号：US10495663

申请日：2002-11-13

申请人： Ira H. Pastan ,  Tapan K. Bera ,  Curt Wolfgang ,  Byungkook Lee ,  James Vincent

发明人： Ira H. Pastan ,  Tapan K. Bera ,  Curt Wolfgang ,  Byungkook Lee ,  James Vincent

IPC分类号： G01N33/53

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K39/00

摘要： A new polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Novel Gene Expressed in Prostate (NGEP). Polynucleotides encoding NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies are disclosed that specfically bind NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP. Assays are disclosed for the detection prostate cancer. Pharamaceutical compositions including an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.

摘要翻译： 公开了在前列腺细胞中被特异性检测到的新的多肽，称为前列腺中表达的新基因（NGEP）。 还公开了编码NGEP的多核苷酸，以及包括这些多核苷酸的载体也是公开的。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合NGEP的抗体。 公开了使用NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的方法。 公开了检测前列腺癌的检测。 还公开了包括NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。

公开(公告)号：US07897355B2

公开(公告)日：2011-03-01

申请号：US12193604

申请日：2008-08-18

申请人： Ira H. Pastan ,  Tapan K. Bera ,  Curt Wolfgang ,  Byungkook Lee ,  James Vincent

发明人： Ira H. Pastan ,  Tapan K. Bera ,  Curt Wolfgang ,  Byungkook Lee ,  James Vincent

IPC分类号： G01N33/53

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K39/00

摘要： A new polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Novel Gene Expressed in Prostate (NGEP). Polynucleotides encoding NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies are disclosed that specifically bind NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.

摘要翻译： 公开了在前列腺细胞中被特异性检测到的新的多肽，称为前列腺中表达的新基因（NGEP）。 还公开了编码NGEP的多核苷酸，以及包括这些多核苷酸的载体也是公开的。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合NGEP的抗体。 公开了使用NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的方法。 公开了检测前列腺癌的检测。 还公开了包括NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。

公开(公告)号：US20090202552A1

公开(公告)日：2009-08-13

申请号：US12193604

申请日：2008-08-18

申请人： Ira H. Pastan ,  Tapan K. Bera ,  Curt Wolfgang ,  Byungkook Lee ,  James Vincent

发明人： Ira H. Pastan ,  Tapan K. Bera ,  Curt Wolfgang ,  Byungkook Lee ,  James Vincent

IPC分类号： A61K39/395 ,  C07K14/00 ,  C07H21/00 ,  C12N15/63 ,  C12N5/00 ,  C07K16/30 ,  G01N33/53 ,  G01N33/574 ,  C12Q1/68 ,  A61K38/16 ,  A61K31/7052 ,  A61P35/00

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K39/00

摘要： A new polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Novel Gene Expressed in Prostate (NGEP). Polynucleotides encoding NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies are disclosed that specifically bind NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.

摘要翻译： 公开了在前列腺细胞中被特异性检测到的新的多肽，称为前列腺中表达的新基因（NGEP）。 还公开了编码NGEP的多核苷酸，以及包括这些多核苷酸的载体也是公开的。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合NGEP的抗体。 公开了使用NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的方法。 公开了检测前列腺癌的检测。 还公开了包括NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。