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    GENE EXPRESSED IN PROSTATE CANCER AND METHODS OF USE
    1.
    发明申请
    GENE EXPRESSED IN PROSTATE CANCER AND METHODS OF USE 审中-公开
    前列腺癌中表达的基因和使用方法

    公开(公告)号：US20090304702A1

    公开(公告)日：2009-12-10

    申请号：US12497382

    申请日：2009-07-02

    申请人： Ira Pastan ,  Tapan K. Bera ,  Byungkook Lee

    发明人： Ira Pastan ,  Tapan K. Bera ,  Byungkook Lee

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C12N5/02 ,  C07K16/00

    CPC分类号： A61K38/168 ,  A61K38/164 ,  A61K47/64 ,  C07K14/47 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/106 ,  G01N33/57434 ,  G01N2500/00

    摘要： A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugates are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.

    摘要翻译： 公开了在前列腺细胞中特异性检测到的多肽，称为前列腺中表达的剪接变体 - 新型基因（SV-NGEP）。 还公开了编码SV-NGEP的多核苷酸，以及包括这些多核苷酸的载体。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合SV-NGEP的抗体和免疫偶联物。 公开了使用NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的方法。 公开了检测前列腺癌的检测。 还公开了包含SV-NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。

    Gene expressed in prostate cancer, methods and use thereof
    2.
    发明授权
    Gene expressed in prostate cancer, methods and use thereof 失效
    在前列腺癌中表达的基因，其方法和用途

    公开(公告)号：US07572887B2

    公开(公告)日：2009-08-11

    申请号：US10552515

    申请日：2004-04-05

    申请人： Ira Pastan ,  Tapan K. Bera ,  Byungkook Lee

    发明人： Ira Pastan ,  Tapan K. Bera ,  Byungkook Lee

    IPC分类号： C07K14/00 ,  C07H21/04 ,  C12N15/00 ,  C12Q1/68

    CPC分类号： A61K38/168 ,  A61K38/164 ,  A61K47/64 ,  C07K14/47 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/106 ,  G01N33/57434 ,  G01N2500/00

    摘要： A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugages are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection of prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NEGP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.

    摘要翻译： 公开了在前列腺细胞中特异性检测到的多肽，称为前列腺中表达的剪接变体 - 新型基因（SV-NGEP）。 还公开了编码SV-NGEP的多核苷酸，以及包括这些多核苷酸的载体。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合SV-NGEP的抗体和免疫结合物。 公开了使用NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的方法。 公开了检测前列腺癌的测定。 还公开了包含SV-NGEP多肽，特异性结合SV-NEGP的抗体或编码SV-NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。

    Gene expressed in prostate cancer and methods of use
    3.
    发明授权
    Gene expressed in prostate cancer and methods of use 失效
    在前列腺癌中表达的基因和使用方法

    公开(公告)号：US07897355B2

    公开(公告)日：2011-03-01

    申请号：US12193604

    申请日：2008-08-18

    申请人： Ira H. Pastan ,  Tapan K. Bera ,  Curt Wolfgang ,  Byungkook Lee ,  James Vincent

    发明人： Ira H. Pastan ,  Tapan K. Bera ,  Curt Wolfgang ,  Byungkook Lee ,  James Vincent

    IPC分类号： G01N33/53

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K39/00

    摘要： A new polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Novel Gene Expressed in Prostate (NGEP). Polynucleotides encoding NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies are disclosed that specifically bind NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.

    摘要翻译： 公开了在前列腺细胞中被特异性检测到的新的多肽，称为前列腺中表达的新基因（NGEP）。 还公开了编码NGEP的多核苷酸，以及包括这些多核苷酸的载体也是公开的。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合NGEP的抗体。 公开了使用NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的方法。 公开了检测前列腺癌的检测。 还公开了包括NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。

    Gene expressed in prostate cancer and methods of use
    4.
    发明授权
    Gene expressed in prostate cancer and methods of use 失效
    在前列腺癌中表达的基因和使用方法

    公开(公告)号：US07816087B2

    公开(公告)日：2010-10-19

    申请号：US10495663

    申请日：2002-11-13

    申请人： Ira H. Pastan ,  Tapan K. Bera ,  Curt Wolfgang ,  Byungkook Lee ,  James Vincent

    发明人： Ira H. Pastan ,  Tapan K. Bera ,  Curt Wolfgang ,  Byungkook Lee ,  James Vincent

    IPC分类号： G01N33/53

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K39/00

    摘要： A new polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Novel Gene Expressed in Prostate (NGEP). Polynucleotides encoding NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies are disclosed that specfically bind NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP. Assays are disclosed for the detection prostate cancer. Pharamaceutical compositions including an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.

    摘要翻译： 公开了在前列腺细胞中被特异性检测到的新的多肽，称为前列腺中表达的新基因（NGEP）。 还公开了编码NGEP的多核苷酸，以及包括这些多核苷酸的载体也是公开的。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合NGEP的抗体。 公开了使用NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的方法。 公开了检测前列腺癌的检测。 还公开了包括NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。

    GENE EXPRESSED IN PROSTATE CANCER AND METHODS OF USE
    5.
    发明申请
    GENE EXPRESSED IN PROSTATE CANCER AND METHODS OF USE 失效
    前列腺癌中表达的基因和使用方法

    公开(公告)号：US20090202552A1

    公开(公告)日：2009-08-13

    申请号：US12193604

    申请日：2008-08-18

    申请人： Ira H. Pastan ,  Tapan K. Bera ,  Curt Wolfgang ,  Byungkook Lee ,  James Vincent

    发明人： Ira H. Pastan ,  Tapan K. Bera ,  Curt Wolfgang ,  Byungkook Lee ,  James Vincent

    IPC分类号： A61K39/395 ,  C07K14/00 ,  C07H21/00 ,  C12N15/63 ,  C12N5/00 ,  C07K16/30 ,  G01N33/53 ,  G01N33/574 ,  C12Q1/68 ,  A61K38/16 ,  A61K31/7052 ,  A61P35/00

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K39/00

    摘要： A new polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Novel Gene Expressed in Prostate (NGEP). Polynucleotides encoding NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies are disclosed that specifically bind NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.

    摘要翻译： 公开了在前列腺细胞中被特异性检测到的新的多肽，称为前列腺中表达的新基因（NGEP）。 还公开了编码NGEP的多核苷酸，以及包括这些多核苷酸的载体也是公开的。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合NGEP的抗体。 公开了使用NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的方法。 公开了检测前列腺癌的检测。 还公开了包括NGEP多肽，特异性结合NGEP的抗体或编码NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。

    Blocking mesothelin peptide fragments
    6.
    发明授权
    Blocking mesothelin peptide fragments 失效
    阻断间皮素肽片段

    公开(公告)号：US08623828B2

    公开(公告)日：2014-01-07

    申请号：US13133136

    申请日：2008-12-05

    申请人： Mitchell Ho ,  Ira Pastan ,  Osamu Kaneko ,  Byungkook Lee

    发明人： Mitchell Ho ,  Ira Pastan ,  Osamu Kaneko ,  Byungkook Lee

    IPC分类号： C07K5/00

    CPC分类号： C07K14/47 ,  C07K2319/30

    摘要： The present invention provides mesothelin peptide fragments corresponding to the CA125 binding site of mesothelin. The peptide fragments find use in disrupting the binding interaction between mesothelin and CA 125, for example, in the treatment and prevention of cancers that require the interaction of mesothelin and CA125 for growth, progression and/or metastasis.

    摘要翻译： 本发明提供对应于间皮素的CA125结合位点的间皮素肽片段。 肽片段用于破坏间皮素和CA125之间的结合相互作用，例如在治疗和预防需要间皮素和CA125与生长，进展和/或转移相互作用的癌症中。

    Gene expressed in prostate cancer, methods and use thereof
    7.
    发明申请
    Gene expressed in prostate cancer, methods and use thereof 失效
    在前列腺癌中表达的基因，其方法和用途

    公开(公告)号：US20060194204A1

    公开(公告)日：2006-08-31

    申请号：US10552515

    申请日：2004-04-05

    申请人： Ira Pastan ,  Tapan Bera ,  Byungkook Lee

    发明人： Ira Pastan ,  Tapan Bera ,  Byungkook Lee

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

    CPC分类号： A61K38/168 ,  A61K38/164 ,  A61K47/64 ,  C07K14/47 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/106 ,  G01N33/57434 ,  G01N2500/00

    摘要： A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these poynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugages are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection of prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NEGP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.

    摘要翻译： 公开了在前列腺细胞中特异性检测到的多肽，称为前列腺中表达的剪接变体 - 新型基因（SV-NGEP）。 还公开了编码SV-NGEP的多核苷酸，以及包括这些寡核苷酸的载体也是如此。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合SV-NGEP的抗体和免疫结合物。 公开了使用NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的方法。 公开了检测前列腺癌的测定。 还公开了包含SV-NGEP多肽，特异性结合SV-NEGP的抗体或编码SV-NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。

    T-cell receptorγ alternate reading frame protein, (TARP) and uses thereof
    8.
    发明授权
    T-cell receptorγ alternate reading frame protein, (TARP) and uses thereof 有权
    T细胞接受体交替阅读框蛋白（TARP）及其用途

    公开(公告)号：US07052703B1

    公开(公告)日：2006-05-30

    申请号：US10031158

    申请日：2000-07-12

    申请人： Ira Pastan ,  Magnus Essand ,  Byungkook Lee ,  George Vasmatzis ,  Curt Wolfgang ,  Ulrich Brinkmann

    发明人： Ira Pastan ,  Magnus Essand ,  Byungkook Lee ,  George Vasmatzis ,  Curt Wolfgang ,  Ulrich Brinkmann

    IPC分类号： A61K39/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

    摘要： This invention provides nucleic acids containing sequences from a TCRγ transcript from prostate epithelial cells and many breast cancer cells and a T-cell receptor gamma Alternate Reading frame Protein (“TARP”) expressed from the translation of those sequences. Vaccines made from TARP are useful in raising immune responses to cells in which the protein is expressed, including prostate cancer cells and cells of many breast cancers. The invention also provides methods for diagnosing the presence of prostate cancer and TARP-expressing breast cancers, as well as methods of administering TARP and nucleic acids encoding TARP to subjects.

    摘要翻译： 本发明提供了含有来自前列腺上皮细胞的TCRγ转录物和许多乳腺癌细胞的序列的核酸，以及从这些序列翻译表达的T细胞受体γ替代阅读框架蛋白（“TARP”）。 由TARP制成的疫苗可用于提高蛋白质表达细胞的免疫应答，包括前列腺癌细胞和许多乳腺癌细胞。 本发明还提供了用于诊断前列腺癌和TARP表达乳腺癌的存在的方法，以及将TARP和编码TARP的核酸给予受试者的方法。

    Page-4, an X-linked gage-like gene expressed in normal and neoplastic prostate, testis and uterus, and uses therefor
    10.
    发明申请
    Page-4, an X-linked gage-like gene expressed in normal and neoplastic prostate, testis and uterus, and uses therefor 审中-公开
    第4页，在正常和肿瘤前列腺，睾丸和子宫中表达的X连接的量规样基因，并用于其

    公开(公告)号：US20070248972A1

    公开(公告)日：2007-10-25

    申请号：US11704714

    申请日：2007-02-09

    申请人： Ira Pastan ,  Ulrich Brinkmann ,  George Vasmatzis ,  Byungkook Lee

    发明人： Ira Pastan ,  Ulrich Brinkmann ,  George Vasmatzis ,  Byungkook Lee

    IPC分类号： C12Q1/68 ,  C07H21/00 ,  C12N1/00 ,  C12N1/21 ,  C12N15/00 ,  C12N5/00

    CPC分类号： C07K14/4748 ,  A61K39/00

    摘要： PAGE-4 is a gene preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus and placenta, as well as in prostate cancer, testicular cancer and uterine cancer. This expression pattern makes it a target for diagnosis and for vaccine based therapy of neoplasms of prostate, testis and uterus. The invention provides immunogenic compositions comprising PAGE-4 protein or immunogenic peptides thereof, methods of inhibiting the growth of malignant cells expressing PAGE-4, and methods of inducing an enhanced immune response to PAGE-4-expressing cancers.

    摘要翻译： PAGE-4是在正常男性和女性生殖组织，前列腺，睾丸，输卵管，子宫和胎盘以及前列腺癌，睾丸癌和子宫癌中优先表达的基因。 这种表达模式使其成为诊断和基于疫苗的前列腺，睾丸和子宫肿瘤的治疗的目标。 本发明提供包含PAGE-4蛋白或其免疫原性肽的免疫原性组合物，抑制表达PAGE-4的恶性细胞生长的方法，以及诱导对表达PAGE-4的癌症增强的免疫应答的方法。