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    Cd25 Dna Vaccines for Treating and Preventing T-Cell Mediated Diseases
    1.
    发明申请
    Cd25 Dna Vaccines for Treating and Preventing T-Cell Mediated Diseases 审中-公开
    用于治疗和预防T细胞介导的疾病的Cd25 Dna疫苗

    公开(公告)号：US20070274949A1

    公开(公告)日：2007-11-29

    申请号：US10591558

    申请日：2007-06-08

    申请人： Irun Cohen ,  Avishai Mimran ,  Francisco Quintana ,  Felix Mor ,  Pnina Carmi

    发明人： Irun Cohen ,  Avishai Mimran ,  Francisco Quintana ,  Felix Mor ,  Pnina Carmi

    IPC分类号： A61K48/00 ,  A61K9/127

    CPC分类号： A61K39/0008 ,  A61K2039/53

    摘要： Compositions comprising nucleic acids encoding the α chain of IL-2 receptor (IL-2Ra, CD25), homologs and fragment thereof, are effective in the treatment and prevention of T cell mediated pathologies. Methods are provided for enhancing anti-ergotypic T cell activity in a subject in need thereof, and for treating or preventing T cell mediated pathologies, such as autoimmune disease, inflammatory diseases and graft rejection.

    摘要翻译： 包含编码IL-2受体α链（IL-2Rα，CD25）的核酸，同系物及其片段的组合物在治疗和预防T细胞介导的病理方面是有效的。 提供了用于在有需要的受试者中增强抗细胞型T细胞活性，以及​​用于治疗或预防T细胞介导的病症如自身免疫性疾病，炎性疾病和移植排斥反应的方法。

    Antigen Receptor Variable Region Typing
    2.
    发明申请
    Antigen Receptor Variable Region Typing 审中-公开
    抗原受体可变区域键入

    公开(公告)号：US20070238099A1

    公开(公告)日：2007-10-11

    申请号：US10581913

    申请日：2004-10-25

    申请人： Irun Cohen ,  Daniel Douek ,  Avishai Mimran ,  Pnina Carmi ,  Francisco Quintana

    发明人： Irun Cohen ,  Daniel Douek ,  Avishai Mimran ,  Pnina Carmi ,  Francisco Quintana

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12M1/00

    CPC分类号： C12Q1/6883 ,  C07K14/7051 ,  C12Q1/6876 ,  C12Q2600/156

    摘要： A method of typing a variable region of a specific variant of an antigen receptor chain is disclosed. The method comprises: (a) exposing a probe set to a sense or antisense strand of a polynucleotide encoding at least a portion of the variable region of the specific variant of the antigen receptor chain, wherein the probe set includes a plurality of probe molecules, wherein each probe molecule of the plurality of probe molecules is substantially complementary to a sense or antisense strand of a nucleic acid sequence region of a specific polynucleotide encoding a variant of the antigen receptor chain, the nucleic acid sequence region encoding a specific combination of at least two variable region segments of the antigen receptor chain; and (b) measuring a hybridization of each probe molecule of the plurality of probe molecules with the sense or antisense strand of the nucleic acid sequence region of the polynucleotide encoding at least a portion of the variable region of the specific variant of the antigen receptor chain, thereby typing the variable region of the specific variant of the antigen receptor chain.

    摘要翻译： 公开了一种对抗原受体链的特定变体的可变区进行分型的方法。 该方法包括：（a）将探针组暴露于编码抗原受体链特异性变体的至少一部分可变区的多核苷酸的有义或反义链，其中探针组包括多个探针分子， 其中所述多个探针分子中的每个探针分子基本上与编码抗原受体链变体的特异性多核苷酸的核酸序列区域的有义链或反义链互补，所述核酸序列区编码至少 抗原受体链的两个可变区片段; 和（b）测量多个探针分子的每个探针分子与编码抗原受体链特异变体的可变区的至少一部分的核酸序列区的有义链或反义链的杂交 ，从而键入抗原受体链的特定变体的可变区。

    DNA vaccines encoding heat shock proteins
    3.
    发明申请
    DNA vaccines encoding heat shock proteins 审中-公开
    编码热休克蛋白的DNA疫苗

    公开(公告)号：US20050197306A1

    公开(公告)日：2005-09-08

    申请号：US10994152

    申请日：2004-11-19

    申请人： Irun Cohen ,  Francisco Quintana ,  Pnina Carmi ,  Felix Mor

    发明人： Irun Cohen ,  Francisco Quintana ,  Pnina Carmi ,  Felix Mor

    IPC分类号： A61K20060101 ,  A61K38/17 ,  A61K39/00 ,  A61K48/00

    CPC分类号： A61K39/0008 ,  A61K31/7088 ,  A61K38/1709 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57

    摘要： The present invention is related to recombinant constructs encoding heat shock proteins or active fragments thereof that are effective in treating T cell mediated inflammatory autoimmune diseases by DNA vaccines. The treatment with the recombinant constructs of the present invention provides long-term expression of specific heat shock proteins for fragments thereof. In one embodiment, the present invention is related to a recombinant construct of a nucleic acid sequence encoding HSP60, HSP70 or HSP90. The present invention also is related to a recombinant construct of a nucleic acid sequence selected from amino acids 1-140 of HSP60, amino acids 130-260 of HSP60 and amino acids 31-50 of HSP60. Another aspect of the present invention is related to an active fragment of HSP60 corresponding to amino acids 31-50 of HSP60 effective in treating arthritis.

    摘要翻译： 本发明涉及编码热休克蛋白或其活性片段的重组构建体，其通过DNA疫苗有效治疗T细胞介导的炎性自身免疫疾病。 用本发明的重组构建体进行的治疗提供了对其片段的特异性热休克蛋白的长期表达。 在一个实施方案中，本发明涉及编码HSP60，HSP70或HSP90的核酸序列的重组构建体。 本发明还涉及选自HSP60的氨基酸1-140，HSP60的氨基酸130-260和HSP60的氨基酸31-50的核酸序列的重组构建体。 本发明的另一方面涉及对应于有效治疗关节炎的HSP60的氨基酸31-50的HSP60的活性片段。

    Antigen array and diagnostic uses thereof
    4.
    发明申请
    Antigen array and diagnostic uses thereof 审中-公开
    抗原阵列及其诊断用途

    公开(公告)号：US20050260770A1

    公开(公告)日：2005-11-24

    申请号：US11094142

    申请日：2005-03-31

    申请人： Irun Cohen ,  Francisco Quintana ,  Eytan Domany ,  Gad Elizur ,  Peter Hagedorn

    发明人： Irun Cohen ,  Francisco Quintana ,  Eytan Domany ,  Gad Elizur ,  Peter Hagedorn

    IPC分类号： G01N33/543 ,  G01N33/564

    CPC分类号： G01N33/564

    摘要： A method of diagnosing an immune disease, or a predisposition thereto, in a subject is disclosed. The method comprises determining a capacity of immunoglobulins of the subject to specifically bind each antigen probe of an antigen probe set, wherein the antigen probe set comprises a plurality of antigen probes selected from the group consisting of at least a portion of a cell/tissue structure molecule, at least a portion of a heat shock protein, at least a portion of an immune system molecule, at least a portion of a homopolymeric polypeptide, at least a portion of a hormone, at least a portion of a metabolic enzyme, at least a portion of a microbial antigen, at least a portion of a molluscan antigen, at least a portion of a nucleic acid, at least a portion of a plant antigen, at least a portion of plasma molecule, and at least a portion of a tissue antigen, wherein the capacity is indicative of the immune disease or the predisposition thereto, thereby diagnosing the immune disease, or the predisposition thereto, in the subject.

    摘要翻译： 公开了一种在受试者中诊断免疫疾病或其倾向的方法。 该方法包括确定受试者的免疫球蛋白的能力以特异性结合抗原探针组的每个抗原探针，其中所述抗原探针组包含多个选自下组的抗原探针：至少一部分细胞/组织结构 分子，至少一部分热休克蛋白，至少一部分免疫系统分子，至少一部分均聚多肽，至少一部分激素，代谢酶的至少一部分，至少 一部分微生物抗原，至少一部分软体动物素抗原，至少一部分核酸，至少一部分植物抗原，至少一部分血浆分子和至少一部分组织 抗原，其中所述能力指示免疫疾病或其易感性，从而诊断受试者的免疫疾病或其易感性。

    HSP60, HSP60 peptides and T cell vaccines for immunomodulation
    7.
    发明授权
    HSP60, HSP60 peptides and T cell vaccines for immunomodulation 失效
    HSP60，HSP60肽和用于免疫调节的T细胞疫苗

    公开(公告)号：US08691772B2

    公开(公告)日：2014-04-08

    申请号：US11813333

    申请日：2006-01-04

    申请人： Irun R. Cohen ,  Alexandra Zanin-Zhorov ,  Guy Tal ,  Francisco Quintana ,  Meirav Pevsner ,  Osnat Lider ,  Lihi Lider

    发明人： Irun R. Cohen ,  Alexandra Zanin-Zhorov ,  Guy Tal ,  Francisco Quintana ,  Meirav Pevsner ,  Ofer Lider

    IPC分类号： A61K38/00 ,  C07K7/08

    CPC分类号： A61K38/1709 ,  A61K35/17 ,  A61K39/0008 ,  A61K2035/124 ,  A61K2039/5158 ,  A61K2039/53 ,  C12N5/0636 ,  C12N2501/07

    摘要： The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention further provides novel uses for HSP60 and p277 in the treatment or prevention of hepatic disorders. The invention discloses methods for treating, preventing or ameliorating the symptoms of T cell mediated inflammatory and autoimmune disorders, including hepatic disorders, which comprise administering to a subject in need thereof a composition comprising as an active ingredient an effective quantity of a molecule selected from: HSP60, p277, fragments, analogs, homologs and derivatives thereof, and nucleic acids encoding same. Also disclosed are T cell vaccination methods for treating or preventing T cell mediated disorders.

    摘要翻译： 本发明提供了人类热休克蛋白60（HSP60）的肽p277-位置437-460在调节免疫应答和炎性疾病方面的新用途。 本发明进一步提供HSP60和p277在治疗或预防肝病中的新用途。 本发明公开了治疗，预防或改善T细胞介导的炎症和自身免疫性疾病（包括肝脏疾病）的症状的方法，其包括向有需要的受试者施用包含有效量的选自以下的分子的组合物： HSP60，p277，其片段，类似物，同源物及其衍生物，以及编码其的核酸。 还公开了用于治疗或预防T细胞介导的病症的T细胞疫苗接种方法。