公开(公告)号：US20100228149A1

公开(公告)日：2010-09-09

申请号：US12528660

申请日：2008-02-25

申请人： Tsuyoshi Fujimura ,  Hideaki Nakamura ,  Tomoko Ishikawa ,  Masao Gotoh ,  Isao Karube ,  Shingo Kaimori ,  Takahiko Kitamura ,  Hiroto Nakajima ,  Hiroshi Hayami ,  Toshifumi Hosoya

发明人： Tsuyoshi Fujimura ,  Hideaki Nakamura ,  Tomoko Ishikawa ,  Masao Gotoh ,  Isao Karube ,  Shingo Kaimori ,  Takahiko Kitamura ,  Hiroto Nakajima ,  Hiroshi Hayami ,  Toshifumi Hosoya

IPC分类号： A61B5/151

CPC分类号： A61B5/15194 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150519 ,  A61B5/150633 ,  A61B5/150702 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1513 ,  A61B5/1519 ,  A61B5/157 ,  A61B2562/0295

摘要： A sensor device has a needle-integrated type sensor element which is detachably mounted therein and which has a sensor chip, a lancet needle fixed to an end portion of the sensor chip, and a flow path forming element provided compressibly and restorably at the end portion of the sensor chip, to which the lancet needle is fixed. The sensor device includes a puncture mechanism (a drive spring) configured to cause the sensor element to puncture a target, and a pressing mechanism (a pressure spring) configured to urge the sensor element to the extent that the sensor element is prevented from being detached from the target by a restoring force of the flow path forming element after the target is punctured.

摘要翻译： 传感器装置具有可拆卸地安装在其中的针式集成型传感器元件，其具有传感器芯片，固定到传感器芯片的端部的刺血针，以及可流动地且可修复地设置在端部处的流路形成元件 传感器芯片，刺针针固定到该传感器芯片上。 传感器装置包括构造成使传感器元件刺穿目标的穿刺机构（驱动弹簧）以及构造成将传感器元件推压到防止传感器元件脱离的程度的按压机构（压力弹簧） 在目标被刺破之后，通过流路形成元件的恢复力从目标射出。

公开(公告)号：US20100069792A1

公开(公告)日：2010-03-18

申请号：US12513458

申请日：2007-11-01

申请人： Tsuyoshi Fujimura ,  Hideaki Nakamura ,  Tomoko Ishikawa ,  Masao Gotoh ,  Isao Karube ,  Takahiko Kitamura ,  Shingo Kaimori ,  Akira Harada ,  Hiroto Nakajima ,  Hiroshi Hayami ,  Toshifumi Hosoya

发明人： Tsuyoshi Fujimura ,  Hideaki Nakamura ,  Tomoko Ishikawa ,  Masao Gotoh ,  Isao Karube ,  Takahiko Kitamura ,  Shingo Kaimori ,  Akira Harada ,  Hiroto Nakajima ,  Hiroshi Hayami ,  Toshifumi Hosoya

IPC分类号： A61B5/151 ,  H01R43/00

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150549 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519 ,  A61B2562/0295 ,  Y10T29/49002

摘要： A biosensor cartridge capable of performing puncturing in an exact position, and easily collecting and measuring a sample of a puncture hole without requiring the operation of bringing a sample collection opening close to the puncture hole is provided. When tip portion 11a of biosensor chip body 11 is pushed against a subject M, elastic body 20 protruding from a tip portion 11a of biosensor chip body 11 is compressed, and puncturing tool 12 for puncturing protrudes. Thus, the subject M can be punctured. Additionally, if a pushing force is weakened, puncturing tool 12 is extracted from the subject M by the restoring force of elastic body 20, and the sample R flows out of the puncture hole. Additionally, cover member 19 is provided around biosensor chip body 11. Thus, when puncturing is performed by thin plate-shaped biosensor cartridge 10, biosensor chip body 11 can be prevented from deforming, and puncturing can be accurately performed in a desired puncturing position.

摘要翻译： 本发明提供一种生物传感器盒，其能够在精确位置进行穿刺，并且容易地收集和测量穿刺孔的样本，而不需要使样本收集开口靠近穿刺孔的操作。 当生物传感器芯体11的尖端部分11a被压靠在被检体M上时，从生物传感器芯体11的尖端部分11a突出的弹性体20被压缩，并且用于穿刺的穿刺工具12突出。 因此，可以对被检体M进行穿刺。 此外，如果推力减弱，则通过弹性体20的恢复力从被检体M取出穿刺工具12，并且样本R流出穿刺孔。 另外，盖体19设置在生物传感器芯体11周围。因此，当通过薄板状生物传感器盒10进行穿刺时，可以防止生物传感器芯体11变形，并且可以在期望的穿刺位置精确地进行穿刺。

公开(公告)号：US20090257917A1

公开(公告)日：2009-10-15

申请号：US12083694

申请日：2006-10-16

申请人： Hideaki Nakamura ,  Masao Gotoh ,  Tomoko Ishikawa ,  Isao Karube ,  Toshifumi Hosoya ,  Shingo Kaimori ,  Moriyasu Ichino

发明人： Hideaki Nakamura ,  Masao Gotoh ,  Tomoko Ishikawa ,  Isao Karube ,  Toshifumi Hosoya ,  Shingo Kaimori ,  Moriyasu Ichino

IPC分类号： B01J19/00 ,  B32B37/00

CPC分类号： G01N27/3271 ,  Y10T156/1051

摘要： It is intended to provide a sensor chip which has a small size and is easily produced and capable of determining quantities of at least two components of multiple samples rapidly, conveniently, and correctly as well as to provide a production method capable of producing the sensor chip easily and with high productivity.A sensor chip includes a substrate, a cover layer, a spacer layer sandwiched between the substrate and the cover layer, multiple reaction portions disposed between the substrate and the cover layer, multiple detection units exposed in the hollow reaction portions, and a sample inlet communicated with the hollow reaction portions and a method for producing the sensor chip.A sensor chip includes two substrates opposed to each other, a spacer layer sandwiched between the substrates, and multiple measurement units disposed between the substrates and including two or more hollow reaction portions that share one sample inlet opened on outer surfaces of the substrates and detection electrode units respectively exposed in the hollow reaction portions and a method for producing the sensor chip.

摘要翻译： 本发明旨在提供一种具有体积小且容易制造且能够快速，方便和正确地确定多个样品的至少两个组分的量的传感器芯片，以及提供能够生产传感器芯片的制造方法 容易和高生产力。 传感器芯片包括衬底，覆盖层，夹在衬底和覆盖层之间的间隔层，设置在衬底和覆盖层之间的多个反应部分，暴露在中空反应部分中的多个检测单元和连通的样品入口 中空反应部分和传感器芯片的制造方法。 传感器芯片包括彼此相对的两个基板，夹在基板之间的间隔层和设置在基板之间的多个测量单元，并且包括两个或更多个中空反应部分，其共享在基板的外表面上开放的一个样品入口和检测电极 分别暴露在中空反应部分中的单元和传感器芯片的制造方法。

公开(公告)号：US20090152127A1

公开(公告)日：2009-06-18

申请号：US11992102

申请日：2006-09-08

申请人： Shingo Kaimori ,  Toshifumi Hosoya ,  Moriyasu Ichino ,  Takahiko Kitamura ,  Isao Karube ,  Masao Gotoh ,  Hideaki Nakamura ,  Tomoko Ishikawa

发明人： Shingo Kaimori ,  Toshifumi Hosoya ,  Moriyasu Ichino ,  Takahiko Kitamura ,  Isao Karube ,  Masao Gotoh ,  Hideaki Nakamura ,  Tomoko Ishikawa

IPC分类号： G01N27/327 ,  G01N27/26 ,  G01N27/04 ,  G01N27/416

CPC分类号： G01N27/3273

摘要： Provided are a biosensor chip measurement machine that can obtain accurate measurement results within a short period of time by employing only a tiny amount as a sample, and a measurement method therefor.A biosensor measurement machine 20 includes a power source 21, which is connected to a voltage regulator 22, a measurement instrument 23, and a controller 24 for supplying power. When a biosensor chip 1 is connected to the biosensor measurement machine 20 and a voltage is applied, the measurement instrument begins the measurement of a current value for a biosensor. When a measured current value or a measured charge value is greater than a reference value, the measurement is ended in accordance with an instruction issued by the controller 24, and when the value is smaller than the reference value, the measurement is continued in accordance with a controller instruction.

摘要翻译： 提供一种生物传感器芯片测量机，其可以通过仅使用微量作为样品而在短时间内获得准确的测量结果及其测量方法。 生物传感器测量机20包括连接到电压调节器22的电源21，测量仪器23和用于供电的控制器24。 当生物传感器芯片1连接到生物传感器测量机20并施加电压时，测量仪器开始测量生物传感器的当前值。 当测量的电流值或测量的电荷值大于参考值时，根据控制器24发出的指令结束测量，并且当该值小于参考值时，根据 控制器指令。

公开(公告)号：US20090124876A1

公开(公告)日：2009-05-14

申请号：US11994010

申请日：2006-06-27

申请人： Hideaki Nakamura ,  Masao Gotoh ,  Isao Karube

发明人： Hideaki Nakamura ,  Masao Gotoh ,  Isao Karube

IPC分类号： A61B5/157 ,  A61B5/055

CPC分类号： A61B10/0045 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157 ,  A61B2562/0295

摘要： There is a needle integrated biosensor, including: a biosensor including at least two electrodes, and a puncture needle to collect a body fluid by piercing a skin of a person to be tested, the biosensor and the puncture needle being integrated, wherein the puncture needle is able to be kept hygienic without the need of a protective cover or the like for the puncture needle.There is a needle integrated biosensor, including: a biosensor including at least two electrodes, and a puncture needle to collect a body fluid by piercing a skin of a person to be tested, the biosensor and the puncture needle being integrated, wherein a soft material is attached to the front end of the puncture needle so that the front end of the puncture needle is protected.

摘要翻译： 针组合生物传感器包括：生物传感器，包括至少两个电极;以及穿刺针，用于通过刺穿待测试人员的皮肤来收集体液，所述生物传感器和穿刺针是一体的，其中所述穿刺针 能够保持卫生，而不需要用于穿刺针的保护罩等。 针组合式生物传感器包括：生物传感器，包括至少两个电极;以及穿刺针，用于通过刺穿待测试人的皮肤，生物传感器和穿刺针一体地收集体液，其中柔软材料 附着在穿刺针的前端，使得穿刺针的前端受到保护。

公开(公告)号：US20090053105A1

公开(公告)日：2009-02-26

申请号：US11795893

申请日：2006-01-23

申请人： Toshifumi Hosoya ,  Shingo Kaimori ,  Moriyasu Ichino ,  Hideaki Nakamura ,  Masao Gotoh ,  Fumiyo Kurusu ,  Tomoko Ishikawa ,  Isao Karube

发明人： Toshifumi Hosoya ,  Shingo Kaimori ,  Moriyasu Ichino ,  Hideaki Nakamura ,  Masao Gotoh ,  Fumiyo Kurusu ,  Tomoko Ishikawa ,  Isao Karube

IPC分类号： B01J19/00

CPC分类号： G01N33/54373 ,  B01L3/502707 ,  B01L2300/0645 ,  B01L2300/0822 ,  B01L2300/168

摘要： There is provided a sensor chip including: a base plate; a cover layer; a hollow reaction portion provided between the base plate and the cover layer, in which a reaction is performed between a sample and a reagent applied thereinto; a sensing member constructed of an electrode which is exposed to the hollow reaction portion; and a sample inlet for conducting the sample to the hollow reaction portion, wherein entire portions of the base plate and the cover layer, which are located opposite to the sensing member provided with the hollow reaction portion, are made transparent. Otherwise, in the above-described sensor chip, a plate A having a groove A to which a reagent has been applied and a plate B having a groove B are stacked on each other in such a manner that the groove A is coupled with the groove B, so that the hollow reaction portion is formed; and an opening width of the groove B is larger than an opening width of the groove A at a portion of the groove B which is located opposite to a portion with the groove A, to which the reagent has been applied.

摘要翻译： 提供了一种传感器芯片，包括：基板; 覆盖层; 设置在基板和覆盖层之间的中空反应部分，其中在样品和施加于其之间的试剂之间进行反应; 由暴露于中空反应部分的电极构成的传感部件; 以及用于将样品导引到中空反应部分的样品入口，其中与设置有中空反应部分的感测构件相对的基板和覆盖层的整个部分被制成透明的。 另外，在上述传感器芯片中，将具有涂敷有试剂的槽A的板A和具有槽B的板B彼此堆叠，使得槽A与槽 B，形成中空反应部分; 并且槽B的开口宽度大于槽B的与已经施加有试剂的部分的与槽A相对的部分处的槽A的开口宽度。

公开(公告)号：US20090020420A1

公开(公告)日：2009-01-22

申请号：US11921166

申请日：2006-10-16

申请人： Takahiko Kitamura ,  Toshifumi Hosoya ,  Shingo Kaimori ,  Moriyasu Ichino ,  Hideaki Nakamura ,  Isao Karube ,  Masao Gotoh ,  Tomoko Ishikawa

发明人： Takahiko Kitamura ,  Toshifumi Hosoya ,  Shingo Kaimori ,  Moriyasu Ichino ,  Hideaki Nakamura ,  Isao Karube ,  Masao Gotoh ,  Tomoko Ishikawa

IPC分类号： G01N27/327 ,  B05D5/00

CPC分类号： C12Q1/002

摘要： It is intended to provide a biosensor chip capable of rapid and correct measurement, including a reaction chamber that enables a measurement of a very small amount of a measurement sample and has a small capacity and potassium ferricyanide having a very small crystal particle size disposed in the reaction chamber.In a biosensor chip 1, electrodes 3 and 4 are disposed on the lower substrate 2, and lower spacer 5 (7 and 8) is adhered on the electrodes 3 and 4. An upper spacer 11 (12 and 13) is adhered to an upper substrate 15, and a lower spacer 5 is attached to the upper spacer 11 by and adhesive agent 10. A lower groove 9 is formed between long and short lower spacers 7 and 8, and an upper groove 14 is formed between long and short spacers 12 and 13, so that a reaction chamber 17 is formed by the upper and lower grooves 9 and 14. A capacity of the reaction chamber is 0.3 μL, and an enzyme 18 and potassium ferricyanide are disposed in the reaction chamber 17 in such a fashion as to oppose to each other with a gap being defined therebetween. A crystal particle diameter of the potassium ferricyanide is 100 μm or less, and amount of the potassium ferricyanide is V×0.1 mg or more when the capacity of the reaction chamber 17 is V.

摘要翻译： 旨在提供能够快速且正确测量的生物传感器芯片，其包括能够测量非常少量的测量样品并且具有小容量的反应室和具有非常小的晶粒度的铁氰化钾 反应室。 在生物传感器芯片1中，电极3和4设置在下基板2上，下隔片5（7和8）粘附在电极3和4上。上间隔件11（12和13） 基板15和下隔板5通过粘合剂10附接到上间隔件11.下槽9形成在长和短下隔板7和8之间，并且上槽14形成在长间隔件12和短间隔件12之间 和13，使得反应室17由上下槽9和14形成。反应室的容量为0.3微米，酶18和铁氰化钾以如下方式设置在反应室17中： 彼此相对，在其间限定间隙。 当反应室17的容量为V时，铁氰化钾的晶粒直径为100μm以下，铁氰化钾的量为Vx0.1mg以上。

公开(公告)号：US20070000776A1

公开(公告)日：2007-01-04

申请号：US10565830

申请日：2004-04-15

申请人： Isao Karube ,  Masao Gotoh ,  Hideaki Nakamura

发明人： Isao Karube ,  Masao Gotoh ,  Hideaki Nakamura

IPC分类号： G01N33/487

CPC分类号： G01N27/3272

摘要： A downsized biosensor in which an electrode is formed on one sheet of electrically-insulated substrate, and a sheet of flat substrate is worked three-dimensionally so as to dispose the electrode on the inner side of the substrate to provide a two-dimensional or three-dimensional electrode disposition, whereby a sample introduced by capillary phenomenon can be measured quantitatively in a small space. A production method of a biosensor comprising the steps of bending a plate member so as to position an electrode formed on the surface of the electrically-insulated plane member on the inner side, and disposing the electrode in a space surrounded by a substrate and a cover to thereby form the substrate and the cover from one sheet of plate member.

摘要翻译： 在一片电绝缘基板上形成电极的小型生物传感器，三维地加工一层平面基板，以将电极设置在基板的内侧，以提供二维或三维 通过毛细管现象引入的样品可以在很小的空间内定量测量。 一种生物传感器的生产方法，包括以下步骤：弯曲板构件，以将形成在电绝缘平面构件的表面上的电极定位在内侧，并将电极设置在由基板和盖子 从而从一片板构件形成基板和盖。

公开(公告)号：US20100004559A1

公开(公告)日：2010-01-07

申请号：US12519916

申请日：2007-12-17

申请人： Tsuyoshi Fujimura ,  Hideaki Nakamura ,  Masao Gotoh ,  Isao Karube ,  Tomoko Ishikawa ,  Takahiko Kitamura ,  Shingo Kaimori ,  Hiroto Nakajima ,  Hiroshi Hayami ,  Toshifumi Hosoya

发明人： Tsuyoshi Fujimura ,  Hideaki Nakamura ,  Masao Gotoh ,  Isao Karube ,  Tomoko Ishikawa ,  Takahiko Kitamura ,  Shingo Kaimori ,  Hiroto Nakajima ,  Hiroshi Hayami ,  Toshifumi Hosoya

IPC分类号： A61B5/151

CPC分类号： A61B5/1519 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150549 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15113 ,  A61B5/15117

摘要： A biosensor cartridge capable of making the collected amount of a sample required for measurement into a small quantity to reduce a user's burden, and easily collecting and measuring a sample of a puncture hole without requiring the operation of bringing a sample collection opening close to the puncture hole is provided. When one end portion of biosensor chip is pushed against subject, elastic body is compressed, and puncturing tool can protrude and perform puncturing. Additionally, if a pushing force is weakened, puncturing tool is extracted from subject by the restoring force of elastic body, and blood (sample) flows out of the puncture hole. In this case, since the puncture hole, and sample collection opening provided at biosensor chip are contained in enclosed half-open space formed by elastic body, even a small amount of blood (sample) can also be easily collected. Additionally, elastic body is formed with a groove which forms a ventilation passage, so that enclosed half-open space can be opened to the atmosphere.

摘要翻译： 一种生物传感器盒，其能够将少量测量所需的样本的收集量减少到用户的负担，并且容易地收集和测量穿孔的样本，而不需要使样本收集开口靠近穿刺的操作 提供孔。 当生物传感器芯片的一个端部被压住物体时，弹性体被压缩，并且穿刺工具可以伸出并进行穿刺。 此外，如果推力减弱，则通过弹性体的恢复力从被检体取出穿刺工具，血液（样品）从穿刺孔流出。 在这种情况下，由于设置在生物传感器芯片上的穿刺孔和样本收集开口包含在由弹性体形成的封闭半开放空间中，所以即使少量的血液（样品）也可以容易地收集。 此外，弹性体形成有形成通风通道的槽，使得封闭的半开放空间可以打开到大气。

公开(公告)号：US20090299225A1

公开(公告)日：2009-12-03

申请号：US12297387

申请日：2007-04-17

申请人： Takahiko Kitamura ,  Shingo Kaimori ,  Akira Harada ,  Toshifumi Hosoya ,  Tsuyoshi Fujimura ,  Isao Karube ,  Masao Gotoh ,  Hideaki Nakamura ,  Tomoko Ishikawa

发明人： Takahiko Kitamura ,  Shingo Kaimori ,  Akira Harada ,  Toshifumi Hosoya ,  Tsuyoshi Fujimura ,  Isao Karube ,  Masao Gotoh ,  Hideaki Nakamura ,  Tomoko Ishikawa

IPC分类号： A61B5/151

CPC分类号： A61B5/157 ,  A61B5/150022 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150442 ,  A61B5/150503 ,  A61B5/150511 ,  A61B5/150549 ,  A61B5/150717 ,  A61B5/15186

摘要： There is provided a biosensor chip where the collecting amount necessary for the measurement is made small whereby burden of a user is reduced and, at the same time, a sample at a puncture opening is able to be easily collected and measured without an operation of making the sample collection opening nearer the puncture opening. When an end of a main body chip is pushed onto a test body, an elastic body installed at an end of the main body chip is compressed and a device for puncture is produced whereby the test body is able to be punctured. When the pushing force is made weak, the device for puncture is pulled out from the test body due to resilience of the elastic body and a sample is flown out from the puncture opening. At that time, since the puncture opening and the sample collection opening installed in the main body chip are enclosed in a tightly-closed space formed by the elastic body, even small amount of the sample is able to be easily collected by the sample collection opening without conducting the positioning of the sample collection opening.

摘要翻译： 提供了一种生物传感器芯片，其中使得测量所需的收集量变小，从而减少了使用者的负担，并且同时，能够容易地收集和测量穿刺开口处的样本而不进行操作 样品收集开口更靠近穿刺孔。 当主体芯片的一端被推到测试体上时，安装在主体芯片的端部的弹性体被压缩，并且产生用于穿刺的装置，由此能够刺破测试体。 当推力变弱时，由于弹性体的弹性，用于穿刺的装置从测试体被拉出，并且样品从穿刺孔流出。 此时，由于安装在主体芯片上的穿刺开口和样本收集开口被包围在由弹性体形成的紧密封闭的空间中，所以即使少量的样本能够容易地被样本收集开口收集 而不进行样品收集开口的定位。