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1.发明授权
公开(公告)号：US4382151A
公开(公告)日：1983-05-03
申请号：US296728
申请日：1981-08-27
申请人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Toshiharu Ohgoh , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki
发明人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Toshiharu Ohgoh , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki
IPC分类号： A61K31/045 , A61P1/04 , A61P35/00 , C07C27/00 , C07C29/143 , C07C33/02 , C07C67/00
CPC分类号： C07C33/02
摘要： 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraene-2-ols of the general formula: ##STR1##
摘要翻译： 6,10,14,18-四甲基-5,9,13,17-十九四烯-2-醇，其通式如下：
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2.发明授权Polyprenyl compounds, process for the production thereof and medicines containing same 失效聚丙烯基化合物，其制备方法和含有它们的药物
公开(公告)号：US4576963A
公开(公告)日：1986-03-18
申请号：US609664
申请日：1984-05-14
申请人： Isao Yamatsu , Shinya Abe , Yuichi Inai , Takeshi Suzuki , Kensaku Kinoshita , Mannen Mishima , Yoshinori Katoh , Seiichi Kobayashi , Manabu Murakami , Kouzi Yamada
发明人： Isao Yamatsu , Shinya Abe , Yuichi Inai , Takeshi Suzuki , Kensaku Kinoshita , Mannen Mishima , Yoshinori Katoh , Seiichi Kobayashi , Manabu Murakami , Kouzi Yamada
IPC分类号： C07C69/612 , A61K31/215 , A61K31/22 , A61K31/403 , A61K31/404 , A61K31/405 , A61P29/00 , C07C67/00 , C07C69/767 , C07C69/88 , C07C227/00 , C07C227/18 , C07C229/42 , C07C229/58 , C07D209/26 , C07D209/28 , A61K31/235
CPC分类号： C07D209/28 , C07C67/11 , C07C67/14 , C07C69/612 , C07C69/86
摘要： Non-steroidal, anti-inflammatory drugs are disclosed which are polyprenyl alcohol esters of indolyl lower carboxylic acids, phenyl lower carboxylic acids, acetyl salicylic acid, anthranilic acid and derivatives thereof.
摘要翻译： 公开了非吲哚基低级羧酸的聚异戊醇酯，苯基低级羧酸，乙酰水杨酸，邻氨基苯甲酸及其衍生物的非甾体抗炎药。
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3.发明授权
公开(公告)号：US4455316A
公开(公告)日：1984-06-19
申请号：US396184
申请日：1982-07-08
申请人： Isao Yamatsu , Shinya Abe , Yuichi Inai , Takeshi Suzuki , Kensaku Kinoshita , Mannen Mishima , Yoshinori Katoh , Seiichi Kobayashi , Manabu Murakami , Kouzi Yamada
发明人： Isao Yamatsu , Shinya Abe , Yuichi Inai , Takeshi Suzuki , Kensaku Kinoshita , Mannen Mishima , Yoshinori Katoh , Seiichi Kobayashi , Manabu Murakami , Kouzi Yamada
IPC分类号： C07C69/612 , A61K31/215 , A61K31/22 , A61K31/403 , A61K31/404 , A61K31/405 , A61P29/00 , C07C67/00 , C07C69/767 , C07C69/88 , C07C227/00 , C07C227/18 , C07C229/42 , C07C229/58 , C07D209/26 , C07D209/28
CPC分类号： C07D209/28 , C07C67/11 , C07C67/14 , C07C69/612 , C07C69/86
摘要： Non-steroidal, anti-inflammatory drugs are disclosed which are polyprenyl alcohol esters of indolyl lower carboxylic acids, phenyl lower carboxylic acids, acetyl salicylic acid, anthranilic acid and derivatives thereof.
摘要翻译： 公开了非吲哚基低级羧酸的聚异戊醇酯，苯基低级羧酸，乙酰水杨酸，邻氨基苯甲酸及其衍生物的非甾体抗炎药。
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4.发明授权Polyprenyl compounds, process for the production thereof and medicines containing same 失效聚丙烯基化合物，其制备方法和含有它们的药物
公开(公告)号：US4709079A
公开(公告)日：1987-11-24
申请号：US820488
申请日：1986-01-17
申请人： Isao Yamatsu , Shinya Abe , Yuichi Inai , Takeshi Suzuki , Kensaku Kinoshita , Mannen Mishima , Yoshinori Katoh , Seiichi Kobayashi , Manabu Murakami , Kouzi Yamada
发明人： Isao Yamatsu , Shinya Abe , Yuichi Inai , Takeshi Suzuki , Kensaku Kinoshita , Mannen Mishima , Yoshinori Katoh , Seiichi Kobayashi , Manabu Murakami , Kouzi Yamada
IPC分类号： C07C69/612 , A61K31/215 , A61K31/22 , A61K31/403 , A61K31/404 , A61K31/405 , A61P29/00 , C07C67/00 , C07C69/767 , C07C69/88 , C07C227/00 , C07C227/18 , C07C229/42 , C07C229/58 , C07D209/26 , C07D209/28 , C07C69/76
CPC分类号： C07D209/28 , C07C67/11 , C07C67/14 , C07C69/612 , C07C69/86
摘要： Non-steroidal, anti-inflammatory drugs are disclosed which are polyprenyl alcohol esters of indolyl lower carboxylic acids, phenyl lower carboxylic acids, acetyl salicyclic acid, anthranilic acid and derivatives thereof.
摘要翻译： 公开了非吲哚基低级羧酸的聚异戊醇酯，苯基低级羧酸，乙酰水杨酸，邻氨基苯甲酸及其衍生物的非甾体抗炎药。
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5.发明授权Therapeutic preparations for peptic ulcers comprising aliphatic ketone derivative 失效包含脂肪族酮衍生物的消化性溃疡的治疗剂
公开(公告)号：US4169157A
公开(公告)日：1979-09-25
申请号：US908634
申请日：1978-05-23
IPC分类号： A61K31/12 , A61P1/04 , C07C45/00 , C07C45/62 , C07C45/67 , C07C45/68 , C07C49/04 , C07C49/203 , C07C67/00 , A61K31/11
CPC分类号： A61K31/12 , C07C45/62 , C07C45/676
摘要： A therapeutic preparation having excellent effect for peptic ulcers with low toxicity which comprises aliphatic ketone derivative of the general formula: ##STR1## wherein represents a saturated or unsaturated bond, R.sub.1 is hydrogen or a lower alkyl group, R.sub.2 is hydrogen atom, a lower alkyl group or a lower alkylcarbonyl group, R.sub.3 is an aliphatic hydrocarbon group of the general formula: ##STR2## WHEREIN L, M AND N ARE 0 OR 1, PROVIDED THAT L+M+N.gtoreq.2; AND A, B, C, D, E AND F ARE HYDROGEN ATOM, OR THEY MAY FORM A BOND OF A--B, C--D OR E--F, PROVIDED THAT IF THE BOND IS A SATURATED BOND, THE A, B, C, D, E AND F REPRESENT ALL HYDROGEN ATOM.
摘要翻译： 一种具有低毒性的消化性溃疡具有优异效果的治疗剂，其包含以下通式的脂肪族酮衍生物：其中表示饱和或不饱和键，R 1为氢或低级烷基，R 2为氢原子，低级烷基 基团或低级烷基羰基，R 3是以下通式的脂族烃基：其中L，M和N为0或1，提供L + M + N> / = 2; A，B，C，D，E和F是氢原子，或者他们可以形成AB，CD或EF的债券，如果债券是饱和债券，A，B，C，D，E和 代表所有氢原子。
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公开(公告)号：US4482734A
公开(公告)日：1984-11-13
申请号：US504769
申请日：1983-06-16
申请人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Yuichi Inai , Yoshikazu Suzuki , Osamu Tagaya
发明人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Yuichi Inai , Yoshikazu Suzuki , Osamu Tagaya
IPC分类号： C07C69/612 , A61K31/235 , A61P17/00 , A61P35/00 , C07C27/02 , C07C51/00 , C07C51/353 , C07C53/42 , C07C57/42 , C07C61/00 , C07C63/64 , C07C67/00 , C07C69/618 , C07C69/76
CPC分类号： C07C63/64 , C07C57/42 , Y10S514/863 , Y10S514/96
摘要： The polyprenyl compound having the formula: ##STR1## wherein X represents a group of the formula: --CH.dbd.CH--, a group of the formula: ##STR2## or a group of the formula: ##STR3## and Y represents a group of the formula: --COOR.sup.1 in which R.sup.1 represents a hydrogen atom or a lower alkyl group or a group of the formula: ##STR4## in which R.sup.2 represents a hydrogen atom or a lower alkyl group, is new and useful as a medicine.
摘要翻译： 具有下式的聚异戊二烯基化合物：其中X表示下式的基团：-CH = CH-，下式的基团：
或下式的基团： ，Y表示 其中R 1表示氢原子或低级烷基的-COOR 1基团或其中R 2表示氢原子或低级烷基的下式的基团：新的和有用的药物 。 -
公开(公告)号：US4454126A
公开(公告)日：1984-06-12
申请号：US434454
申请日：1982-10-15
申请人： Isao Yamatsu , Yuichi Inai , Takeshi Suzuki , Shinya Abe , Masaru Satoh , Naosuke Seto
发明人： Isao Yamatsu , Yuichi Inai , Takeshi Suzuki , Shinya Abe , Masaru Satoh , Naosuke Seto
CPC分类号： C07F9/222
摘要： Phosphoramide derivatives of the general formula: ##STR1## are disclosed wherein X and Y each represents a hydrogen atom or X and Y are removed to form a double bond between the respective adjoining carbon atoms, and n represents an integer of 0 to 2. A process for the preparation of these compounds and pharmaceutical compositions containing these phosphoramide derivatives are also disclosed. The phosphoramide derivatives of the invention are used to treat urethral calculosis and pyelonephritis.
摘要翻译： 公开了下列通式：的磷酰胺衍生物，其中X和Y各自表示氢原子，除去X和Y以形成相邻的碳原子之间的双键，n表示0-2的整数。 还公开了制备这些化合物的方法和含有这些磷酰胺衍生物的药物组合物。 本发明的磷酰胺衍生物用于治疗尿道结石和肾盂肾炎。
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公开(公告)号：US4954525A
公开(公告)日：1990-09-04
申请号：US260870
申请日：1981-05-06
申请人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Yoshikazu Suzuki , Osamu Tagaya , Kouichi Suzuki , Kouichi Abe , Kouji Yamada
发明人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Yoshikazu Suzuki , Osamu Tagaya , Kouichi Suzuki , Kouichi Abe , Kouji Yamada
IPC分类号： A61K31/165 , A61K31/12 , A61K31/16 , A61K31/20 , A61K31/23 , A61P35/00 , C07C49/203 , C07C57/03
CPC分类号： A61K31/16 , A61K31/12 , A61K31/23 , C07C49/203 , C07C57/03 , Y10S514/886
摘要： Skin diseases with keratinization and allergic or inflammatory skin diseases are treated by orally or parenterally administering to an adult human patient from 40 mg to 4 g/day of a polyprenyl compound having the formula (I): ##STR1## in which each of n and m is 0, 1, or 2, n+m is 0, 1 or 2, A is ##STR2## and B is ##STR3## [in which R represents the hydroxyl group, a lower alkoxy group, or ##STR4## (wherein each of R.sub.1 and R.sub.2 is the hydrogen atom, a lower alkyl group or an aryl group)]; provided that R is a lower alkoxy or ##STR5## if n is 1, m is 0, a is ##STR6## and B is ##STR7##
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公开(公告)号：US4346109A
公开(公告)日：1982-08-24
申请号：US249290
申请日：1981-03-30
申请人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Yoshikazu Suzuki , Osamu Tagaya , Nozomu Koyanagi
发明人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Yoshikazu Suzuki , Osamu Tagaya , Nozomu Koyanagi
IPC分类号： A61K31/20 , A61K8/36 , A61K31/19 , A61P17/00 , A61Q19/00 , C07C51/00 , C07C51/087 , C07C57/02 , C07C57/03 , C07C67/00 , C07C69/587 , C07C317/44
CPC分类号： A61Q19/00 , A61K31/202 , A61K8/361 , A61K9/1652 , C07C317/44 , C07C57/03 , C07C69/587 , Y10S514/859 , Y10S514/863 , Y10S514/886 , Y10S514/887
摘要： A compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed as a therapeutic agent for treatment of skin diseases with keratinization.
摘要翻译： 公开了化合物3,7,11,15-四甲基-2,4,6,10,14-十六碳五烯酸及其盐作为用角质化治疗皮肤病的治疗剂。
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10.发明授权
公开(公告)号：US4917829A
公开(公告)日：1990-04-17
申请号：US865934
申请日：1986-05-16
申请人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Yoshikazu Suzuki , Osamu Tagaya , Kouichi Suzuki , Koichi Abe , Kouji Yamada
发明人： Isao Yamatsu , Yuichi Inai , Shinya Abe , Takeshi Suzuki , Yoshikazu Suzuki , Osamu Tagaya , Kouichi Suzuki , Koichi Abe , Kouji Yamada
IPC分类号： A61K8/36 , A61K31/19 , A61K31/20 , A61P35/00 , A61Q19/00 , C07C27/00 , C07C27/02 , C07C51/00 , C07C51/347 , C07C57/03 , C07C67/00 , C07C69/587 , C07C317/44
CPC分类号： A61Q19/00 , A61K31/19 , A61K8/361 , C07C317/44 , C07C57/03 , C07C69/587
摘要： A novel compound, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid, and a salt thereof are disclosed together with a number of different processes for the preparation of the compound. The uses of the novel compound as an anticancer agent are also disclosed.
摘要翻译： 公开了一种新的化合物3,7,11,15-四甲基-2,4,6,10,14-十六碳五烯酸及其盐以及许多制备该化合物的不同方法。 还公开了新化合物作为抗癌剂的用途。
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