公开(公告)号：US09662047B2

公开(公告)日：2017-05-30

申请号：US13167445

申请日：2011-06-23

申请人： Ishan Barman ,  Narahara Chari Dingari ,  Ramachandra Dasari ,  Michael Feld ,  Jonathan Feld ,  David Feld ,  Alison Hearn ,  Chae-Ryon Kong ,  Jeon Woong Kang

发明人： Ishan Barman ,  Narahara Chari Dingari ,  Ramachandra Dasari ,  Michael Feld ,  Chae-Ryon Kong ,  Jeon Woong Kang

IPC分类号： A61B5/1455 ,  A61B5/145 ,  G01J3/02 ,  G01J3/44 ,  G01N21/65 ,  A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/4312 ,  A61B5/444 ,  A61B2560/0223 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/44 ,  G01N21/65 ,  G01N2201/129

摘要： The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.

公开(公告)号：US20120035442A1

公开(公告)日：2012-02-09

申请号：US13167445

申请日：2011-06-23

申请人： Ishan Barman ,  Narahara Chari Dingari ,  Ramachandra Dasari ,  Michael Feld ,  Chae-Ryon Kong ,  David Feld ,  Alison Hearn ,  Jonathan Feld

发明人： Ishan Barman ,  Narahara Chari Dingari ,  Ramachandra Dasari ,  Michael Feld ,  Chae-Ryon Kong ,  David Feld ,  Alison Hearn ,  Jonathan Feld

IPC分类号： A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/4312 ,  A61B5/444 ,  A61B2560/0223 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/44 ,  G01N21/65 ,  G01N2201/129

摘要： The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.

摘要翻译： 本发明还涉及特定过滤器组合的选择，其可以提供足够的信息用于多变量校准以提取复杂生物系统中的精确分析物浓度。 本发明还描述了引起小型化设计的波长间隔选择方法。 最后，本发明提出了多种波长选择方法和小型化分光设备设计以及从一个域（波长选择）到另一个域（设计参数）映射的必要工具。 信息谱带的这种选择在使得特别采用拉曼光谱和其他光谱技术的任何临床诊断仪器的小型化方面具有广泛的范围。

公开(公告)号：US20120302892A1

公开(公告)日：2012-11-29

申请号：US13338920

申请日：2011-12-28

申请人： Niyom Lue ,  Michael Feld ,  Ishan Barman ,  Narahara Chari Dingari ,  Ramachandra Dasari ,  David Feld ,  Alison Hearn ,  Jonathan Feld

发明人： Niyom Lue ,  Michael Feld ,  Ishan Barman ,  Narahara Chari Dingari ,  Ramachandra Dasari ,  David Feld ,  Alison Hearn ,  Jonathan Feld

IPC分类号： A61B6/00

CPC分类号： A61B5/0091 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/42 ,  A61B5/4312 ,  G01N21/64 ,  G01N2021/4742 ,  G01N2021/656 ,  G01N2201/0639

摘要： A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.

摘要翻译： 用于疾病诊断的组织光谱扫描的多模式探针系统。 该系统可以使用漫反射光谱，荧光光谱和拉曼光谱法检测癌组织，如组织边缘评估。