SYSTEM AND METHOD FOR HILBERT PHASE IMAGING
    3.
    发明申请
    SYSTEM AND METHOD FOR HILBERT PHASE IMAGING 审中-公开
    用于HILBERT相位成像的系统和方法

    公开(公告)号:US20140361148A1

    公开(公告)日:2014-12-11

    申请号:US14301187

    申请日:2014-06-10

    摘要: Hilbert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron-size water droplets.

    摘要翻译: 希尔伯特相位显微镜(HPM)作为用于测量与光学透明物体相关的高横向分辨率定量相位图像的光学技术。 由于其单次性质,HPM适用于调查在诸如生物细胞的透明结构中发生的快速现象。 优选的实施例用于测量生物系统,包括对红血细胞的测量,而其量化毫秒级别的动态过程的能力可以用蒸发微米级水滴的测量来说明。

    TOMOGRAPHIC PHASE MICROSCOPY
    7.
    发明申请
    TOMOGRAPHIC PHASE MICROSCOPY 有权
    TOMOGRAPHIC相显微镜

    公开(公告)号:US20150177133A1

    公开(公告)日:2015-06-25

    申请号:US14490242

    申请日:2014-09-18

    IPC分类号: G01N21/45 G01N21/64

    摘要: The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.

    摘要翻译: 本发明涉及使用具有可变照明角度的移相激光干涉显微镜在生活或非活细胞,组织或生物体中定量三维映射折射率的系统和方法。 优选的实施方案提供细胞和多细胞生物的层析成像,以及在组织光散射中具有多种应用的高分辨率显微镜中细胞结构的时间依赖性变化和样品诱导的像差的定量表征。

    SYSTEMS AND METHODS FOR PHASE MEASUREMENTS
    8.
    发明申请
    SYSTEMS AND METHODS FOR PHASE MEASUREMENTS 有权
    用于相位测量的系统和方法

    公开(公告)号:US20130265585A1

    公开(公告)日:2013-10-10

    申请号:US13715475

    申请日:2012-12-14

    IPC分类号: G01B9/02

    摘要: Preferred embodiments of the present invention are directed to systems for phase measurement such as for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. Light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.

    摘要翻译: 本发明的优选实施例涉及用于相位测量的系统,例如用于利用光成像小生物物体。 这些实施方案可以应用于例如细胞生理学和神经科学领域。 这些优选实施例基于相位测量和成像技术的原理。 使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学,其可以包括但不限于成像发育异常起源,细胞通讯,神经元传播和遗传密码的实现。 具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。 因此,本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统,并且用于研究细胞生理学。 这些系统包括使用光学干涉仪来测量相位的低相干干涉测量(LCI)原理,或使用其中使用细胞部件本身内部的干扰的光散射光谱(LSS),或者替代地,LCI和LSS的原理可以组合以产生 在本发明的系统中。