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1.发明授权Compounds pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia 失效化合物药物组合物和治疗菌血症和/或败血症的方法公开(公告)号：US07435716B2
公开(公告)日：2008-10-14
申请号：US10451795
申请日：2002-01-16
申请人： Itzhak Ofek , Matityahu Fridkin , Haim Tsubery
发明人： Itzhak Ofek , Matityahu Fridkin , Haim Tsubery
CPC分类号： C07K7/62 , A61K38/00 , C07K5/1016
摘要： Novel conjugates of bacterial outer membrane binding peptides, preferably having bacterial sensitization activity, and immune cells chemotactic peptides, and pharmaceutical compositions containing same useful in the treatment of bacteremia and/or septicemia following infection by gram negative bacteria administered alone or in combination with conventional antibiotics.
摘要翻译： 细菌外膜结合肽的新结合物，优选具有细菌致敏活性，和免疫细胞趋化肽，以及含有可用于单独施用或与常规抗生素组合的革兰氏阴性细菌感染后的菌血症和/或败血症的药物组合物 。
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公开(公告)号：US20100303841A1
公开(公告)日：2010-12-02
申请号：US12745090
申请日：2008-11-27
申请人： Nira Hochman , Jacob Hochman , Ervin Weiss , Itzhak Ofek
发明人： Nira Hochman , Jacob Hochman , Ervin Weiss , Itzhak Ofek
IPC分类号： A61K36/45 , A61K39/39 , A61P31/12 , A61P31/04 , A61P33/00 , A61P31/10 , A61P33/10 , A61P31/00 , A61P35/00
CPC分类号： A61K39/39 , A61K35/768 , A61K36/45 , A61K39/0011 , A61K39/0258 , A61K39/092 , A61K39/12 , A61K39/21 , A61K2039/55511 , A61K2039/55588 , A61K2039/70 , C12N2740/12034 , Y02A50/474
摘要： The subject invention provides new adjuvant therapy.
摘要翻译： 本发明提供了新的辅助治疗。
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公开(公告)号：US06843993B2
公开(公告)日：2005-01-18
申请号：US09916486
申请日：2001-07-27
申请人： Itzhak Ofek , Ervin Weiss , Yoel Kashman , Janina Goldhar , Nathan Sharon
发明人： Itzhak Ofek , Ervin Weiss , Yoel Kashman , Janina Goldhar , Nathan Sharon
IPC分类号： A01N25/02 , A23L1/30 , A23L2/02 , A23L2/56 , A61K20060101 , A61K8/97 , A61K31/00 , A61K36/45 , A61P31/04 , A61Q11/00 , A01N65/00 , A61K35/78
摘要： A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight ≧14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and Helicobacter pylori.
摘要翻译： 一种非食品抗微生物粘附和聚集组合物，其包含合适的载体和有效量的从牛痘植物属的浆果汁分离的粘附抑制级分。 在一个实施方案中，从蔓越莓汁分离抗聚集和粘附级分。 其特征在于是聚合物并且具有> = 14,000的分子量; 碳元素分析43-51％，氢4-5％，无氮，无硫，无氯; 如图1和2所示的核磁共振（NMR）线谱。 2A和2B; 和在碱溶液中不存在的中性或酸性pH溶液中在280nm具有吸收峰的紫外光谱。 该级分显示对P菌毛细菌，口腔细菌和幽门螺杆菌的粘附抑制活性。
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公开(公告)号：US07390515B2
公开(公告)日：2008-06-24
申请号：US11069041
申请日：2005-03-02
IPC分类号： A61K36/04
CPC分类号： A61K36/45 , A61K9/0043
摘要： The present invention concerns the use as anti-viral agents of isolated fractions from berry juice of the plant genus Vaccinium. Two specific fractions are provided: (a) polymeric material having a molecular weight≧12,000; and (b) proanthocyanidins-containing fraction.Thus, the invention provides methods of treating a subject against a viral infection; the method comprises providing said subject with at least one of the above isolated fractions in an amount effective to prevent production of a viral infection in said subject.A specific and preferred viral infection according to the invention is an influenza virus infection.
摘要翻译： 本发明涉及作为牛痘植物属植物来自浆果汁的分离级分的抗病毒剂的用途。 提供两个特定的部分：（a）分子量> = 12,000的聚合物材料; 和（b）含原花青素的级分。 因此，本发明提供了针对病毒感染治疗受试者的方法; 所述方法包括以有效防止所述受试者的病毒感染产生的量向所述受试者提供上述分离级分中的至少一种。 根据本发明的特定且优选的病毒感染是流感病毒感染。
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公开(公告)号：US5840322A
公开(公告)日：1998-11-24
申请号：US772021
申请日：1996-12-19
申请人： Ervin Weiss , Itzhak Ofek , Yoel Kashman , Janina Goldhar , Nathan Sharon
发明人： Ervin Weiss , Itzhak Ofek , Yoel Kashman , Janina Goldhar , Nathan Sharon
摘要： A non-food oral hygiene composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In a preferred embodiment the anti-aggregation fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight .gtoreq.14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; an NMR line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against both P fimbriated bacteria and oral bacteria.
摘要翻译： 一种非食物口腔卫生组合物，其包含合适的载体和有效量的从牛痘植物属的浆果汁中分离的粘附抑制级分。 在一个优选的实施方案中，从蔓越莓汁中分离出抗凝聚级分。 其特征在于是聚合物，分子量≥14,000; 碳元素分析43-51％，氢4-5％，无氮，无硫，无氯; 如图1和2所示的NMR线谱。 2A和2B; 和在碱溶液中不存在的中性或酸性pH溶液中在280nm具有吸收峰的紫外光谱。 该级分显示出对P菌毛细菌和口腔细菌的粘附抑制活性。
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6.发明申请公开(公告)号：US20050196472A1
公开(公告)日：2005-09-08
申请号：US11069041
申请日：2005-03-02
CPC分类号： A61K36/45 , A61K9/0043
摘要： The present invention concerns the use as anti-viral agents of isolated fractions from berry juice of the plant genus Vaccinium. Two specific fractions are provided: (a) polymeric material having a molecular weight ≧12,000; and (b) proanthocyanidins-containing fraction. Thus, the invention provides methods of treating a subject against a viral infection; the method comprises providing said subject with at least one of the above isolated fractions in an amount effective to prevent production of a viral infection in said subject. A specific and preferred viral infection according to the invention is an influenza virus infection.
摘要翻译： 本发明涉及作为牛痘植物属植物来自浆果汁的分离级分的抗病毒剂的用途。 提供两个特定的部分：（a）分子量> = 12,000的聚合物材料; 和（b）含原花青素的级分。 因此，本发明提供了针对病毒感染治疗受试者的方法; 所述方法包括以有效防止所述受试者的病毒感染产生的量向所述受试者提供上述分离级分中的至少一种。 根据本发明的特定且优选的病毒感染是流感病毒感染。
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公开(公告)号：US06303125B1
公开(公告)日：2001-10-16
申请号：US09159626
申请日：1998-09-24
申请人： Itzhak Ofek , Ervin Weiss , Yoel Kashman , Janina Goldhar , Nathan Sharon
发明人： Itzhak Ofek , Ervin Weiss , Yoel Kashman , Janina Goldhar , Nathan Sharon
IPC分类号： A01N6500
摘要： A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight ≧14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and Helicobacter pylori.
摘要翻译： 一种非食品抗微生物粘附和聚集组合物，其包含合适的载体和有效量的从牛痘植物属的浆果汁分离的粘附抑制级分。 在一个实施方案中，从蔓越莓汁分离抗聚集和粘附级分。 其特征在于是聚合物并且具有> = 14,000的分子量; 碳元素分析43-51％，氢4-5％，无氮，无硫，无氯; 如图1和2所示的核磁共振（NMR）线谱。 2A和2B; 和在碱溶液中不存在的中性或酸性pH溶液中在280nm具有吸收峰的紫外光谱。 该级分显示对P菌毛细菌，口腔细菌和幽门螺杆菌的粘附抑制活性。
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