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1.发明申请GOLD IMPLANTATION/DEPOSITION OF BIOLOGICAL SAMPLES FOR LASER DESORPTION TWO AND THREE DIMENSIONAL DEPTH PROFILING OF BIOLOGICAL TISSUES 审中-公开用于激光解吸的生物样品的金植入/沉积生物组织的两个和三维深度分布公开(公告)号：US20100090101A1
公开(公告)日：2010-04-15
申请号：US12630922
申请日：2009-12-04
申请人： J. Albert Schultz , Michael V. Ugarov , Thomas F. Egan , Agnes Tempez , Yvon Le Bayec , Serge Della-Negra
发明人： J. Albert Schultz , Michael V. Ugarov , Thomas F. Egan , Agnes Tempez , Yvon Le Bayec , Serge Della-Negra
IPC分类号： H01J49/04
CPC分类号： H01J49/0418 , H01J49/0481 , H01J49/142
摘要： The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.
摘要翻译： 本发明通过将低能离子簇（金，铝等）或化学衍生的簇离子注入到样品的近表面区域中，形成表面定位的MALDI粒子基质来增强生物分子离子从表面的激光解吸附。 然后可以通过激光解吸到质谱仪中或者在优选的实施方式中将离子迁移正交时间合并在离子迁移正交时间内的表面上或在由离子的注入范围限定的窄地下区域内的完整生物分子的MALDI分析 质谱仪
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2.发明授权Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues 有权金子植入/沉积生物样品用于激光解吸三维组织的深度剖析公开(公告)号：US06989528B2
公开(公告)日：2006-01-24
申请号：US10861962
申请日：2004-06-04
申请人： J. Albert Schultz , Michael V. Ugarov , Thomas F. Egan , Agnes Tempez , Yvon Le Beyec , Serge Della-Negra
发明人： J. Albert Schultz , Michael V. Ugarov , Thomas F. Egan , Agnes Tempez , Yvon Le Beyec , Serge Della-Negra
CPC分类号： H01J49/164 , H01J49/0031 , H01J49/0418
摘要： The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.
摘要翻译： 本发明通过将低能离子簇（金，铝等）或化学衍生的簇离子注入到样品的近表面区域中，形成表面定位的MALDI粒子基质来增强生物分子离子从表面的激光解吸附。 然后可以通过激光解吸到质谱仪中或者在优选的实施方式中将离子迁移正交时间合并在离子迁移正交时间内的表面上或在由离子的注入范围限定的窄地下区域内的完整生物分子的MALDI分析 质谱仪
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3.发明申请NEUTRAL/ION REACTOR IN ADIABATIC SUPERSONIC GAS FLOW FOR ION MOBILITY TIME-OF-FLIGHT MASS SPECTROMETRY 有权离子/离子反应器在惰性气体流动的离子流动时间飞行质谱公开(公告)号：US20090309015A1
公开(公告)日：2009-12-17
申请号：US12483831
申请日：2009-06-12
申请人： J. Albert Schultz , Valeriy V. Raznikov , Thomas F. Egan , Michael V. Ugarov , Agnes Tempez , Marina O. Raznikova , Vladislav V. Zelenov , Alexander R. Pikhtelev , Valerie E. Vaughn
发明人： J. Albert Schultz , Valeriy V. Raznikov , Thomas F. Egan , Michael V. Ugarov , Agnes Tempez , Marina O. Raznikova , Vladislav V. Zelenov , Alexander R. Pikhtelev , Valerie E. Vaughn
IPC分类号： H01J49/10
CPC分类号： H01J49/063 , G01N27/622 , H01J49/0404
摘要： The content of the invention comprises a concept of reactor for isolated ion transformations induced by collisions with neutral species. This reactor is also an interface between mobility cell and orthogonal injection TOFMS based on supersonic adiabatic gas flow with variable controlled composition directed along the axis of a multipole ion guide with sectioned rods for possibility of creating of controlled distributions of RF, DC and AC rotating fields.
摘要翻译： 本发明的内容包括用于与中性物质碰撞诱导的分离离子转化反应器的概念。 该反应器也是基于超音速绝热气体流动的移动电池和正交注入TOFMS之间的界面，其具有可变控制的组成，其沿着具有分段杆的多极离子导向器的轴线引导，以产生RF，DC和AC旋转场的受控分布 。
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4.发明授权Gold implantation/deposition of biological samples for laser desorption two and three dimensional depth profiling of biological tissues 有权用于激光解吸的生物样品的金植入/沉积生物组织的二维和三维深度剖析公开(公告)号：US07629576B2
公开(公告)日：2009-12-08
申请号：US11231448
申请日：2005-09-21
申请人： J. Albert Schultz , Michael V. Ugarov , Thomas F. Egan , Agnes Tempez , Yvon Le Beyec , Serge D. Negra
发明人： J. Albert Schultz , Michael V. Ugarov , Thomas F. Egan , Agnes Tempez , Yvon Le Beyec , Serge D. Negra
IPC分类号： H01J49/44
CPC分类号： H01J49/164 , H01J49/0031 , H01J49/0418
摘要： The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.
摘要翻译： 本发明通过将低能离子簇（金，铝等）或化学衍生的簇离子注入到样品的近表面区域中，形成表面定位的MALDI粒子基质来增强生物分子离子从表面的激光解吸附。 然后可以通过激光解吸到质谱仪中或者在优选的实施方式中将离子迁移正交时间合并在离子迁移正交时间内的表面上或在由离子的注入范围限定的窄地下区域内的完整生物分子的MALDI分析 质谱仪
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5.发明申请MULTI-BEAM ION MOBILITY TIME-OF-FLIGHT MASS SPECTROMETRY WITH MULTI-CHANNEL DATA RECORDING 有权具有多通道数据记录的多束离子移动时间飞行时间质谱公开(公告)号：US20090140140A1
公开(公告)日：2009-06-04
申请号：US12338529
申请日：2008-12-18
申请人： Valeri V. Raznikov , J. Albert Schultz , Thomas F. Egan , Michael V. Ugarov , Agnes Tempez , Gennadiy Savenkov , Vladislav Zelenov
发明人： Valeri V. Raznikov , J. Albert Schultz , Thomas F. Egan , Michael V. Ugarov , Agnes Tempez , Gennadiy Savenkov , Vladislav Zelenov
IPC分类号： H01J49/40
CPC分类号： H01J49/009 , G01N27/622 , H01J49/40
摘要： The content of the invention comprises a concept of multi-beam ion pre-selection from a single sample, coordinated mobility (against the gas flow) separation, cooling ions in supersonic gas flow and mass separation of thus low divergent ions by single or plural compact high-resolution orthogonal time-of-flight mass spectrometers both linear or reflectron type with controlled collision-induced dissociation (CID) and multi-channel data recording for the optimization of sample use in the analysis, and obtaining as much useful information about the sample as possible in a reasonably short time.
摘要翻译： 本发明的内容包括从单个样品的多光束离子预选择的概念，协调的移动性（相对于气体流）分离，超音速气流中的冷却离子以及因此低发散离子的质量分离通过单个或多个紧凑 具有受控碰撞诱导解离（CID）的线性或反射型的高分辨率正交飞行时间质谱仪和用于分析样品使用优化的多通道数据记录，并获得关于样品的有用信息 尽可能在短时间内。
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6.发明申请NEUTRAL/ION REACTOR IN ADIABATIC SUPERSONIC GAS FLOW FOR ION MOBILITY TIME-OF-FLIGHT MASS SPECTROMETRY 有权离子/离子反应器在惰性气体流动的离子流动时间飞行质谱公开(公告)号：US20080164409A1
公开(公告)日：2008-07-10
申请号：US11771711
申请日：2007-06-29
申请人： J. Albert Schultz , Valeriy V. Raznikov , Thomas F. Egan , Michael V. Ugarov , Agnes Tempez , Marina O. Raznikova , Vladislav V. Zelenov , Alexander R. Pikhtelev , Valerie E. Vaughn
发明人： J. Albert Schultz , Valeriy V. Raznikov , Thomas F. Egan , Michael V. Ugarov , Agnes Tempez , Marina O. Raznikova , Vladislav V. Zelenov , Alexander R. Pikhtelev , Valerie E. Vaughn
IPC分类号： H01J49/26
CPC分类号： H01J49/063 , G01N27/622 , H01J49/0404
摘要： The content of the invention comprises a concept of reactor for isolated ion transformations induced by collisions with neutral species. This reactor is also an interface between mobility cell and orthogonal injection TOFMS based on supersonic adiabatic gas flow with variable controlled composition directed along the axis of a multipole ion guide with sectioned rods for possibility of creating of controlled distributions of RF, DC and AC rotating fields.
摘要翻译： 本发明的内容包括用于与中性物质碰撞诱导的分离离子转化反应器的概念。 该反应器也是基于超音速绝热气体流动的移动电池和正交注入TOFMS之间的界面，其具有可变控制的组成，其沿着具有分段杆的多极离子导向器的轴线引导，以产生RF，DC和AC旋转场的受控分布 。
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7.发明授权Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions 有权离子迁移率TOF / MALDI / MS使用漂移电池交替高低电场区域公开(公告)号：US06992284B2
公开(公告)日：2006-01-31
申请号：US10969643
申请日：2004-10-20
IPC分类号： B01D59/44
CPC分类号： G01N27/622 , H01J49/0045
摘要： Improved ion focusing for an ion mobility drift cell allows for improved throughput for subsequent detection such as mass detection. Improved focusing is realized by the use of alternating regions of high and low electric fields in the ion mobility drift cell.
摘要翻译： 用于离子迁移率漂移池的改进的离子聚焦允许用于后续检测（例如质量检测）的提高的生产量。 通过在离子迁移率漂移池中使用高电场和低电场的交替区域来实现改进的聚焦。
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8.发明授权Neutral/ion reactor in adiabatic supersonic gas flow for ion mobility time-of-flight mass spectrometry 有权中性/离子反应器在绝热超音速气流中用于离子迁移时间飞行时质谱公开(公告)号：US08129675B2
公开(公告)日：2012-03-06
申请号：US12483831
申请日：2009-06-12
申请人： J. Albert Schultz , Valeriy V. Raznikov , Thomas F. Egan , Michael V. Ugarov , Agnès Tempez , Marina O. Raznikova , Vladislav V. Zelenov , Alexander R. Pikhtelev , Valerie E. Vaughn
发明人： J. Albert Schultz , Valeriy V. Raznikov , Thomas F. Egan , Michael V. Ugarov , Agnès Tempez , Marina O. Raznikova , Vladislav V. Zelenov , Alexander R. Pikhtelev , Valerie E. Vaughn
CPC分类号： H01J49/063 , G01N27/622 , H01J49/0404
摘要： The content of the invention comprises a concept of reactor for isolated ion transformations induced by collisions with neutral species. This reactor is also an interface between mobility cell and orthogonal injection TOFMS based on supersonic adiabatic gas flow with variable controlled composition directed along the axis of a multipole ion guide with sectioned rods for possibility of creating of controlled distributions of RF, DC and AC rotating fields.
摘要翻译： 本发明的内容包括用于与中性物质碰撞诱导的分离离子转化反应器的概念。 该反应器也是基于超音速绝热气体流动的移动电池和正交注入TOFMS之间的界面，其具有可变控制的组成，其沿着具有分段杆的多极离子导向器的轴线引导，以产生RF，DC和AC旋转场的受控分布 。
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9.发明授权Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions 有权离子迁移率TOF / MALDI / MS使用漂移电池交替高低电场区域公开(公告)号：US07223969B2
公开(公告)日：2007-05-29
申请号：US11342716
申请日：2006-01-30
IPC分类号： B01D59/44
CPC分类号： G01N27/622 , H01J49/0045
摘要： Improved ion focusing for an ion mobility drift cell allows for improved throughput for subsequent detection such as mass detection. Improved focusing is realized by the use of alternating regions of high and low electric fields in the ion mobility drift cell.
摘要翻译： 用于离子迁移率漂移池的改进的离子聚焦允许用于后续检测（例如质量检测）的提高的生产量。 通过在离子迁移率漂移池中使用高电场和低电场的交替区域来实现改进的聚焦。
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10.发明授权Neutral/Ion reactor in adiabatic supersonic gas flow for ion mobility time-of-flight mass spectrometry 有权中性/离子反应器在绝热超音速气流中用于离子迁移时间飞行时质谱公开(公告)号：US07547878B2
公开(公告)日：2009-06-16
申请号：US11771711
申请日：2007-06-29
申请人： J. Albert Schultz , Valeriy V. Raznikov , Thomas F. Egan , Michael V. Ugarov , Agnès Tempez , Marina O. Raznikova , Vladislav V. Zelenov , Alexander R. Pikhtelev , Valerie E. Vaughn
发明人： J. Albert Schultz , Valeriy V. Raznikov , Thomas F. Egan , Michael V. Ugarov , Agnès Tempez , Marina O. Raznikova , Vladislav V. Zelenov , Alexander R. Pikhtelev , Valerie E. Vaughn
CPC分类号： H01J49/063 , G01N27/622 , H01J49/0404
摘要： The content of the invention comprises a concept of reactor for isolated ion transformations induced by collisions with neutral species. This reactor is also an interface between mobility cell and orthogonal injection TOFMS based on supersonic adiabatic gas flow with variable controlled composition directed along the axis of a multipole ion guide with sectioned rods for possibility of creating of controlled distributions of RF, DC and AC rotating fields.
摘要翻译： 本发明的内容包括用于与中性物质碰撞诱导的分离离子转化反应器的概念。 该反应器也是基于超音速绝热气体流动的移动电池和正交注入TOFMS之间的界面，其具有可变控制的组成，其沿着具有分段杆的多极离子导向器的轴线引导，以产生RF，DC和AC旋转场的受控分布 。
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