公开(公告)号：US20230112623A1

公开(公告)日：2023-04-13

申请号：US17961020

申请日：2022-10-06

申请人： JEOL Ltd.

发明人： Seketsu Fukuzawa ,  Koji Takahashi ,  Yoshiyuki Itoh ,  Masaki Takiwaki ,  Shugo Tsuda ,  Masayoshi Mochizuki ,  Taku Yoshiya

IPC分类号： C07F9/54

摘要： Provided is a phosphonium compound represented by Formula (I): in Formula (I), R1, R2, and R3 are independently from each other, an alkyl group or an aryl group, the alkyl group is a substituted or unsubstituted, linear or branched alkyl group having 1 to 20 carbon atoms or a substituted or unsubstituted cyclic alkyl group having 5 to 20 carbon atoms, the aryl group is a substituted or unsubstituted aryl group having 6 to 20 carbon atoms; X is a reactive group having a hydrazide group, a halide group, a pseudohalide group, or a thioester group; and Y− is an anion having a total charge of −1, or Y− is absence.

公开(公告)号：US20220288558A1

公开(公告)日：2022-09-15

申请号：US17689389

申请日：2022-03-08

申请人： JEOL Ltd.

发明人： Seketsu Fukuzawa ,  Koji Takahashi

IPC分类号： B01J20/14 ,  G01N33/82 ,  B01J20/285 ,  B01J20/283 ,  B01J20/26 ,  B01J20/06 ,  B01J20/28 ,  B01D15/20

摘要： Provided is a solid phase mixture including an oxidizing agent and/or a salt of the oxidizing agent and solid phase particles. The oxidizing agent is a compound capable of selectively oxidizing 1,2-diol compounds. In addition, a packing material containing the solid phase mixture is provided. Further, a column packed with the packing material is provided.

公开(公告)号：US20230242480A1

公开(公告)日：2023-08-03

申请号：US18087881

申请日：2022-12-23

申请人： Tokyo University of Agriculture and Technology ,  JEOL Ltd.

发明人： Akiko Nagata ,  Yuka Mizumoto ,  Ryota Sakamoto ,  Kazuo Nagasawa ,  Masaki Takiwaki ,  Yoshikuni Kikutani ,  Koji Takahashi ,  Seketsu Fukuzawa

IPC分类号： C07C401/00 ,  G01N30/72 ,  C07F7/18

CPC分类号： C07C401/00 ,  G01N30/72 ,  C07F7/1804 ,  G01N2030/027

摘要： The present invention is intended to provide a compound useful to analyze a vitamin D compound. The present invention provides an alkyne compound represented by Formula (I):




where in Formula (I), A is a linear carbon chain having an alkynyl group at an end and having a vinyl group at another end; X1 is CH or 13CH; X2 is CHY, CDY, 13CHY, 13CDY, CO, 13CO, C18O, or 13C18O; m is an integer from 1 to 4; when m is 2 or more, X2s are identical or different; Y is H, D, NH2, 15NH2, OH, 18OH, SH, OR, O(CO)R, OSO3H, OSO3Na, or a sugar substituent; when Formula (I) contains two or more Ys, Ys are identical or different; R is an alcohol protective group, an alkyl group, an alkenyl group, or an aryl group; X3 is C or 13C; and at least one selected from the group consisting of X1, X2(s), and X3 is modified with a stable isotope D, 13C, 18O, or 15N.

公开(公告)号：US20240110922A1

公开(公告)日：2024-04-04

申请号：US18241473

申请日：2023-09-01

申请人： TOKYO UNIVERSITY OF SCIENCE FOUNDATION ,  JEOL Ltd.

发明人： Tatsuya Higashi ,  Masaki Takiwaki ,  Koji Takahashi ,  Seketsu Fukuzawa

IPC分类号： G01N33/68

CPC分类号： G01N33/6848

摘要： An estrogen derivatization method uses a quaternary cation-containing 5-fluoro-2,4-dinitrophenyl compound represented by Formula (1):






where in Formula (1), X is a quaternary cation. A mass spectrometry method includes derivatizing estrogen by the above estrogen derivatization method. A derivatization reagent derivatizing estrogen includes a quaternary cation-containing 5-fluoro-2,4-dinitrophenyl compound represented by Formula (1), where in Formula (1), X is a quaternary cation.