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    KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE
    8.
    发明申请
    KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE 有权
    用于生产AZETIDINONE的KETOREDUCTASE POLYPEPTIDES

    公开(公告)号：US20110159567A1

    公开(公告)日：2011-06-30

    申请号：US12977825

    申请日：2010-12-23

    申请人： Onorato Campopiano ,  Emily Mundorff ,  Birthe Borup ,  Rama Voladri

    发明人： Onorato Campopiano ,  Emily Mundorff ,  Birthe Borup ,  Rama Voladri

    IPC分类号： C12N9/04

    CPC分类号： C12N9/0006 ,  C12P17/10 ,  C12Y101/01184 ,  Y02P20/52

    摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

    摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。

    Ketoreductase polypeptides and uses thereof
    9.
    发明授权
    Ketoreductase polypeptides and uses thereof 有权
    酮还原酶多肽及其用途

    公开(公告)号：US08288131B2

    公开(公告)日：2012-10-16

    申请号：US12545761

    申请日：2009-08-21

    申请人： Rama Voladri ,  Owen Gooding ,  Stephan Jenne ,  Emily Mundorff

    发明人： Rama Voladri ,  Owen Gooding ,  Stephan Jenne ,  Emily Mundorff

    IPC分类号： C12P17/14 ,  C12N9/02

    CPC分类号： C12P41/002 ,  C12N9/0006 ,  C12P7/04 ,  C12P7/24

    摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of stereo specifically reducing (R)-2-methylpentanal to (R)-2-methylpentanol. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to produce (R)-2-methylpentanol and related compounds.

    摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进的性质的工程化酮还原酶，其包括立体特异性还原（R）-2-甲基戊醛至（R）-2-甲基戊醇的能力。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶制备（R）-2-甲基戊醇和相关化合物的方法。