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公开(公告)号：US08080650B2
公开(公告)日：2011-12-20
申请号：US12354047
申请日：2009-01-15
申请人： Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
发明人： Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
IPC分类号： C07H21/04
CPC分类号： G01N33/57415 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0032 , A61K49/0058 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/77 , G01N33/57449 , G01N2500/00
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro104 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro104 antibodies. The invention encompasses a method of producing the anti-Pro104 antibodies. Other aspects of the invention are a method of killing a Pro104-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro104 antibody and a method of alleviating or treating a Pro104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro104 antibody to the mammal.
摘要翻译： 本发明提供在体内在哺乳动物细胞上结合Pro104的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Pro104）抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro104抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Pro104抗体的细胞。 本发明包括产生抗Pro104抗体的方法。 本发明的其它方面是杀死表达Pro104的癌细胞的方法，包括使癌细胞与抗Pro104抗体接触，以及减轻或治疗哺乳动物中表达Pro104的癌症的方法，包括给予治疗有效量 的抗Pro104抗体。
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公开(公告)号：US20120263647A1
公开(公告)日：2012-10-18
申请号：US13328458
申请日：2011-12-16
申请人： Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
发明人： Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
IPC分类号： A61K39/395 , G01N33/577 , A61P35/00 , C07H21/02 , C12N5/16 , C07K16/40 , A61K49/00
CPC分类号： G01N33/57415 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0032 , A61K49/0058 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/77 , G01N33/57449 , G01N2500/00
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro104 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro104 antibodies. The invention encompasses a method of producing the anti-Pro104 antibodies. Other aspects of the invention are a method of killing a Pro104-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro104 antibody and a method of alleviating or treating a Pro104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro104 antibody to the mammal.
摘要翻译： 本发明提供在体内在哺乳动物细胞上结合Pro104的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Pro104）抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro104抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Pro104抗体的细胞。 本发明包括产生抗Pro104抗体的方法。 本发明的其它方面是杀死表达Pro104的癌细胞的方法，包括使癌细胞与抗Pro104抗体接触，以及减轻或治疗哺乳动物中表达Pro104的癌症的方法，包括给予治疗有效量 的抗Pro104抗体。
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公开(公告)号：US07479546B2
公开(公告)日：2009-01-20
申请号：US10562259
申请日：2004-06-28
申请人： Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
发明人： Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
IPC分类号： C07K16/00
CPC分类号： G01N33/57415 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0032 , A61K49/0058 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/77 , G01N33/57449 , G01N2500/00
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro 104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro 104 antibody, as well as an expression vector comprising the isolated'l nucleic acid. Also provided are cells that produce the anti-Pro 104 antibodies. The invention encompasses a method of producing the anti-Pro 104 antibodies. Other aspects of the invention are a method of killing a Pro 104-expressing cancer cell, comprising contacting the cancer cell with an antiPro104 antibody and a method of alleviating or treating a Pro 104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro 104 antibody to the mammal.
摘要翻译： 本发明提供在体内在哺乳动物细胞上结合Pro 104的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Pro104）抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro 104抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供了产生抗Pro 104抗体的细胞。 本发明包括产生抗Pro 104抗体的方法。 本发明的其它方面是杀死表达Pro 104的癌细胞的方法，包括使癌细胞与抗Pro104抗体接触，以及减轻或治疗哺乳动物中Pro104表达的癌症的方法，包括给予治疗有效量 的抗Pro104抗体。
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公开(公告)号：US20090220424A1
公开(公告)日：2009-09-03
申请号：US12354047
申请日：2009-01-15
申请人： Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Weniu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
发明人： Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Weniu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
IPC分类号： A61K49/00 , C07K16/00 , C12N5/00 , C12N5/02 , G01N33/567 , A61K39/395 , C07H21/02
CPC分类号： G01N33/57415 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0032 , A61K49/0058 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/77 , G01N33/57449 , G01N2500/00
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro104 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro104 antibodies. The invention encompasses a method of producing the anti-Pro104 antibodies. Other aspects of the invention are a method of killing a Pro104-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro104 antibody and a method of alleviating or treating a Pro104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro104 antibody to the mammal.
摘要翻译： 本发明提供在体内在哺乳动物细胞上结合Pro104的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Pro104）抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro104抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Pro104抗体的细胞。 本发明包括产生抗Pro104抗体的方法。 本发明的其它方面是杀死表达Pro104的癌细胞的方法，包括使癌细胞与抗Pro104抗体接触，以及减轻或治疗哺乳动物中表达Pro104的癌症的方法，包括给予治疗有效量 的抗Pro104抗体。
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公开(公告)号：US20100209438A1
公开(公告)日：2010-08-19
申请号：US12576313
申请日：2009-10-09
申请人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Jackie Papkoff
发明人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Jackie Papkoff
IPC分类号： A61K39/395 , C07K16/30 , A61P35/00 , G01N33/53
CPC分类号： C07K16/3069 , A61K47/6855 , A61K47/6869 , C07K16/3015 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.
摘要翻译： 本发明提供了在哺乳动物体内与Ovr110结合时内化的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Ovr110）抗体。 本发明还包括包含抗Ovr110抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Ovr110抗体的细胞。 本发明包括产生抗Ovr110抗体的方法。 本发明的其它方面是杀死表达Ovr110的癌细胞的方法，包括使癌细胞与抗Ovr110抗体接触，以及减轻或治疗哺乳动物中表达Ovr110的癌症的方法，包括给予治疗有效量 的抗Ovr110抗体。
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公开(公告)号：US20070178101A1
公开(公告)日：2007-08-02
申请号：US10557331
申请日：2004-05-10
申请人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Jackie Papkoff
发明人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Jackie Papkoff
IPC分类号： A61K39/395 , C12N5/06 , C12N1/21 , C07K16/30 , C07K16/46
CPC分类号： C07K16/3069 , A61K47/6855 , A61K47/6869 , C07K16/3015 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.
摘要翻译： 本发明提供了在哺乳动物体内与Ovr110结合时内化的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Ovr110）抗体。 本发明还包括包含抗Ovr110抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Ovr110抗体的细胞。 本发明包括产生抗Ovr110抗体的方法。 本发明的其它方面是杀死表达Ovr110的癌细胞的方法，包括使癌细胞与抗Ovr110抗体接触，以及减轻或治疗哺乳动物中表达Ovr110的癌症的方法，包括给予治疗有效量 的抗Ovr110抗体。
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公开(公告)号：US07619068B2
公开(公告)日：2009-11-17
申请号：US10557331
申请日：2004-05-10
申请人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Jackie Papkoff
发明人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Jackie Papkoff
IPC分类号： C07K16/00 , C12P21/08 , C07K17/00 , C07K17/14 , A61K39/395 , A61K39/00 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： C07K16/3069 , A61K47/6855 , A61K47/6869 , C07K16/3015 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.
摘要翻译： 本发明提供了在哺乳动物体内与Ovr110结合时内化的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Ovr110）抗体。 本发明还包括包含抗Ovr110抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Ovr110抗体的细胞。 本发明包括产生抗Ovr110抗体的方法。 本发明的其它方面是杀死表达Ovr110的癌细胞的方法，包括使癌细胞与抗Ovr110抗体接触，以及减轻或治疗哺乳动物中表达Ovr110的癌症的方法，包括给予治疗有效量 的抗Ovr110抗体。
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公开(公告)号：US20090136490A1
公开(公告)日：2009-05-28
申请号：US11719003
申请日：2005-11-10
申请人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Timothy S. Burcham , Laura Corral , Iris Simon , Jackie Papkoff
发明人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Timothy S. Burcham , Laura Corral , Iris Simon , Jackie Papkoff
IPC分类号： A61K39/395 , C07K16/18 , C12N9/96 , G01N33/574 , C12N5/06
CPC分类号： C07K16/3069 , A61K2039/505 , C07K16/2827 , C07K16/3015 , C07K2317/34 , C07K2317/732 , C07K2317/77
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110 expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.
摘要翻译： 本发明提供了在哺乳动物体内与Ovr110结合时内化的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Ovr110）抗体。 本发明还包括包含抗Ovr110抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Ovr110抗体的细胞。 本发明包括产生抗Ovr110抗体的方法。 本发明的其它方面是杀死表达Ovr110的癌细胞的方法，包括使癌细胞与抗Ovr110抗体接触，以及减轻或治疗哺乳动物中表达Ovr110的癌症的方法，包括给予治疗有效量的 抗Ovr110抗体。
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公开(公告)号：US20070087004A1
公开(公告)日：2007-04-19
申请号：US10562259
申请日：2004-06-28
CPC分类号： G01N33/57415 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0032 , A61K49/0058 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/77 , G01N33/57449 , G01N2500/00
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro 104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro 104 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro 104 antibodies. The invention encompasses a method of producing the anti-Pro 104 antibodies. Other aspects of the invention are a method of killing a Pro 104-expressing cancer cell, comprising contacting the cancer cell with an antiPro104 antibody and a method of alleviating or treating a Pro 104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pr 104 antibody to the mammal.
摘要翻译： 本发明提供在体内在哺乳动物细胞上结合Pro 104的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Pro104）抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。本发明的另一方面是编码抗Pro 104抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供了产生抗Pro 104抗体的细胞。 本发明包括产生抗Pro 104抗体的方法。 本发明的其它方面是杀死表达Pro 104的癌细胞的方法，包括使癌细胞与抗Pro104抗体接触，以及减轻或治疗哺乳动物中Pro104表达的癌症的方法，包括给予治疗有效量 的抗Pr 104抗体。
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公开(公告)号：US20130022539A1
公开(公告)日：2013-01-24
申请号：US13523393
申请日：2012-06-14
申请人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon
发明人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon
IPC分类号： A61K39/395 , A61P35/00 , A61P35/04 , A61K51/10 , G01N21/64 , C12N5/10 , C12N5/20 , C12N1/21 , C12N1/15 , C12N1/19 , C07K16/40 , G01N33/577
CPC分类号： C07K16/3069 , A61K47/6825 , A61K47/6851 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/1072 , A61K2039/505 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K2317/73 , C07K2317/77
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr115) antibodies that bind to Ovr115 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Ovr115 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr115 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr115 antibodies. The invention encompasses a method of producing the anti-Ovr115 antibodies. Other aspects of the invention are a method of killing an Ovr115-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr115 antibody and a method of alleviating or treating an Ovr115-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr115 antibody to the mammal.
摘要翻译： 本发明提供在体内在哺乳动物细胞上结合Ovr115的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Ovr115）抗体。 本发明还包括包含抗Ovr115抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Ovr115抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Ovr115抗体的细胞。 本发明包括产生抗Ovr115抗体的方法。 本发明的其它方面是杀死表达Ovr115的癌细胞的方法，包括使癌细胞与抗Ovr115抗体接触，以及减轻或治疗哺乳动物中表达Ovr115的癌症的方法，包括给予治疗有效量 的抗Ovr115抗体。
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