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公开(公告)号:US08080650B2
公开(公告)日:2011-12-20
申请号:US12354047
申请日:2009-01-15
申请人: Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
发明人: Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
IPC分类号: C07H21/04
CPC分类号: G01N33/57415 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0032 , A61K49/0058 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/77 , G01N33/57449 , G01N2500/00
摘要: The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro104 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro104 antibodies. The invention encompasses a method of producing the anti-Pro104 antibodies. Other aspects of the invention are a method of killing a Pro104-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro104 antibody and a method of alleviating or treating a Pro104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro104 antibody to the mammal.
摘要翻译: 本发明提供在体内在哺乳动物细胞上结合Pro104的分离的抗卵巢,胰腺,肺或乳腺癌抗原(Pro104)抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro104抗体的分离的核酸,以及包含分离的核酸的表达载体。 还提供产生抗Pro104抗体的细胞。 本发明包括产生抗Pro104抗体的方法。 本发明的其它方面是杀死表达Pro104的癌细胞的方法,包括使癌细胞与抗Pro104抗体接触,以及减轻或治疗哺乳动物中表达Pro104的癌症的方法,包括给予治疗有效量 的抗Pro104抗体。
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公开(公告)号:US20120263647A1
公开(公告)日:2012-10-18
申请号:US13328458
申请日:2011-12-16
申请人: Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
发明人: Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
IPC分类号: A61K39/395 , G01N33/577 , A61P35/00 , C07H21/02 , C12N5/16 , C07K16/40 , A61K49/00
CPC分类号: G01N33/57415 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0032 , A61K49/0058 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/77 , G01N33/57449 , G01N2500/00
摘要: The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro104 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro104 antibodies. The invention encompasses a method of producing the anti-Pro104 antibodies. Other aspects of the invention are a method of killing a Pro104-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro104 antibody and a method of alleviating or treating a Pro104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro104 antibody to the mammal.
摘要翻译: 本发明提供在体内在哺乳动物细胞上结合Pro104的分离的抗卵巢,胰腺,肺或乳腺癌抗原(Pro104)抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro104抗体的分离的核酸,以及包含分离的核酸的表达载体。 还提供产生抗Pro104抗体的细胞。 本发明包括产生抗Pro104抗体的方法。 本发明的其它方面是杀死表达Pro104的癌细胞的方法,包括使癌细胞与抗Pro104抗体接触,以及减轻或治疗哺乳动物中表达Pro104的癌症的方法,包括给予治疗有效量 的抗Pro104抗体。
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公开(公告)号:US07479546B2
公开(公告)日:2009-01-20
申请号:US10562259
申请日:2004-06-28
申请人: Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
发明人: Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
IPC分类号: C07K16/00
CPC分类号: G01N33/57415 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0032 , A61K49/0058 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/77 , G01N33/57449 , G01N2500/00
摘要: The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro 104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro 104 antibody, as well as an expression vector comprising the isolated'l nucleic acid. Also provided are cells that produce the anti-Pro 104 antibodies. The invention encompasses a method of producing the anti-Pro 104 antibodies. Other aspects of the invention are a method of killing a Pro 104-expressing cancer cell, comprising contacting the cancer cell with an antiPro104 antibody and a method of alleviating or treating a Pro 104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro 104 antibody to the mammal.
摘要翻译: 本发明提供在体内在哺乳动物细胞上结合Pro 104的分离的抗卵巢,胰腺,肺或乳腺癌抗原(Pro104)抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro 104抗体的分离的核酸,以及包含分离的核酸的表达载体。 还提供了产生抗Pro 104抗体的细胞。 本发明包括产生抗Pro 104抗体的方法。 本发明的其它方面是杀死表达Pro 104的癌细胞的方法,包括使癌细胞与抗Pro104抗体接触,以及减轻或治疗哺乳动物中Pro104表达的癌症的方法,包括给予治疗有效量 的抗Pro104抗体。
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公开(公告)号:US20090220424A1
公开(公告)日:2009-09-03
申请号:US12354047
申请日:2009-01-15
申请人: Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Weniu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
发明人: Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Weniu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
IPC分类号: A61K49/00 , C07K16/00 , C12N5/00 , C12N5/02 , G01N33/567 , A61K39/395 , C07H21/02
CPC分类号: G01N33/57415 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0032 , A61K49/0058 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/77 , G01N33/57449 , G01N2500/00
摘要: The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro104 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro104 antibodies. The invention encompasses a method of producing the anti-Pro104 antibodies. Other aspects of the invention are a method of killing a Pro104-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro104 antibody and a method of alleviating or treating a Pro104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro104 antibody to the mammal.
摘要翻译: 本发明提供在体内在哺乳动物细胞上结合Pro104的分离的抗卵巢,胰腺,肺或乳腺癌抗原(Pro104)抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro104抗体的分离的核酸,以及包含分离的核酸的表达载体。 还提供产生抗Pro104抗体的细胞。 本发明包括产生抗Pro104抗体的方法。 本发明的其它方面是杀死表达Pro104的癌细胞的方法,包括使癌细胞与抗Pro104抗体接触,以及减轻或治疗哺乳动物中表达Pro104的癌症的方法,包括给予治疗有效量 的抗Pro104抗体。
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