Pro104 antibody compositions and methods of use
    1.
    发明授权
    Pro104 antibody compositions and methods of use 有权
    Pro104抗体组合物和使用方法

    公开(公告)号:US08080650B2

    公开(公告)日:2011-12-20

    申请号:US12354047

    申请日:2009-01-15

    IPC分类号: C07H21/04

    摘要: The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro104 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro104 antibodies. The invention encompasses a method of producing the anti-Pro104 antibodies. Other aspects of the invention are a method of killing a Pro104-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro104 antibody and a method of alleviating or treating a Pro104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro104 antibody to the mammal.

    摘要翻译: 本发明提供在体内在哺乳动物细胞上结合Pro104的分离的抗卵巢,胰腺,肺或乳腺癌抗原(Pro104)抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro104抗体的分离的核酸,以及包含分离的核酸的表达载体。 还提供产生抗Pro104抗体的细胞。 本发明包括产生抗Pro104抗体的方法。 本发明的其它方面是杀死表达Pro104的癌细胞的方法,包括使癌细胞与抗Pro104抗体接触,以及减轻或治疗哺乳动物中表达Pro104的癌症的方法,包括给予治疗有效量 的抗Pro104抗体。

    Pro104 antibody compositions and methods of use
    3.
    发明授权
    Pro104 antibody compositions and methods of use 失效
    Pro104抗体组合物和使用方法

    公开(公告)号:US07479546B2

    公开(公告)日:2009-01-20

    申请号:US10562259

    申请日:2004-06-28

    IPC分类号: C07K16/00

    摘要: The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro 104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro 104 antibody, as well as an expression vector comprising the isolated'l nucleic acid. Also provided are cells that produce the anti-Pro 104 antibodies. The invention encompasses a method of producing the anti-Pro 104 antibodies. Other aspects of the invention are a method of killing a Pro 104-expressing cancer cell, comprising contacting the cancer cell with an antiPro104 antibody and a method of alleviating or treating a Pro 104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro 104 antibody to the mammal.

    摘要翻译: 本发明提供在体内在哺乳动物细胞上结合Pro 104的分离的抗卵巢,胰腺,肺或乳腺癌抗原(Pro104)抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro 104抗体的分离的核酸,以及包含分离的核酸的表达载体。 还提供了产生抗Pro 104抗体的细胞。 本发明包括产生抗Pro 104抗体的方法。 本发明的其它方面是杀死表达Pro 104的癌细胞的方法,包括使癌细胞与抗Pro104抗体接触,以及减轻或治疗哺乳动物中Pro104表达的癌症的方法,包括给予治疗有效量 的抗Pro104抗体。