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公开(公告)号：US07015046B2
公开(公告)日：2006-03-21
申请号：US10693441
申请日：2003-10-24
申请人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
发明人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
IPC分类号： G01N21/76
CPC分类号： G01N21/76 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , B01L2300/0645 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N21/253 , G01N21/66 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/807
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
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公开(公告)号：US06673533B1
公开(公告)日：2004-01-06
申请号：US08932110
申请日：1997-09-17
申请人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
发明人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
IPC分类号： G01N33543
CPC分类号： G01N21/76 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , B01L2300/0645 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N21/253 , G01N21/66 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/807
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
摘要翻译： 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多重特定的测试程序。
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公开(公告)号：US06207369B1
公开(公告)日：2001-03-27
申请号：US08715163
申请日：1996-09-17
申请人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau
发明人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau
IPC分类号： G01N33543
CPC分类号： G01N21/66 , B82Y15/00 , B82Y30/00 , G01N21/76 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/81 , Y10S435/968 , Y10S435/975 , Y10S436/805
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
摘要翻译： 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多重特定的测试程序。
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公开(公告)号：US07824925B2
公开(公告)日：2010-11-02
申请号：US11264535
申请日：2005-10-31
申请人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
发明人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
IPC分类号： G01N33/551 , G01N33/553
CPC分类号： G01N21/76 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , B01L2300/0645 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N21/253 , G01N21/66 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/807
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
摘要翻译： 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多种具体的测试程序。
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公开(公告)号：US08722323B2
公开(公告)日：2014-05-13
申请号：US12917661
申请日：2010-11-02
申请人： Jacob N. Wohlstadter , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
发明人： Jacob N. Wohlstadter , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
IPC分类号： C12Q1/00
CPC分类号： G01N21/76 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , B01L2300/0645 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N21/253 , G01N21/66 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/807
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
摘要翻译： 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多重特定的测试程序。
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公开(公告)号：US20110124116A1
公开(公告)日：2011-05-26
申请号：US12917661
申请日：2010-11-02
申请人： Jacob N. WOHLSTADTER , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
发明人： Jacob N. WOHLSTADTER , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau , Larry R. Helms , Ramin Darvari
IPC分类号： G01N21/76
CPC分类号： G01N21/76 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , B01L2300/0645 , B82Y15/00 , B82Y30/00 , C12Q1/6825 , G01N21/253 , G01N21/66 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/807
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
摘要翻译： 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多重特定的测试程序。
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公开(公告)号：US08541174B2
公开(公告)日：2013-09-24
申请号：US11300808
申请日：2005-12-14
申请人： Jacob N. Wohlstadter , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau
发明人： Jacob N. Wohlstadter , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau
IPC分类号： G01N33/53
CPC分类号： G01N21/66 , B82Y15/00 , B82Y30/00 , G01N21/76 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/81 , Y10S435/968 , Y10S435/975 , Y10S436/805
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
摘要翻译： 提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。 本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。 它还提供用于ECL测定的新型电极。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多重特定的测试程序。
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8.发明授权Assay buffer, compositions containing the same, and methods of using the same 有权测定缓冲液，含有该组合物的组合物及其使用方法公开(公告)号：US08785201B2
公开(公告)日：2014-07-22
申请号：US12368742
申请日：2009-02-10
申请人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
发明人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
CPC分类号： G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
摘要： The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.
摘要翻译： 本发明涉及使用磷酸化特异性抗体和基本上不含无机磷酸盐的缓冲组合物的磷酸化肽或蛋白质的改进的电化学发光测定方法。
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9.发明申请ASSAY BUFFER, COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME 有权测定缓冲剂，含有该组合物的组合物及其使用方法公开(公告)号：US20090170121A1
公开(公告)日：2009-07-02
申请号：US12368742
申请日：2009-02-10
申请人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
发明人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
IPC分类号： G01N33/53 , G01N33/536
CPC分类号： G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
摘要： Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.
摘要翻译： 组合物，试剂，试剂盒，系统，系统组分和用于进行测定的方法。 更具体地说，本发明涉及使用新颖的试剂组合来提供改进的测定性能。
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10.发明授权Assay buffer, compositions containing the same, and methods of using the same 有权测定缓冲液，含有该组合物的组合物及其使用方法公开(公告)号：US07491540B2
公开(公告)日：2009-02-17
申请号：US11055472
申请日：2005-02-09
申请人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
发明人： Michael Tsionsky , Eli N. Glezer , Selen Altunata , George Sigal , Jonathan K. Leland , Mark A. Billadeau , Svetlana Leytner , Mark Martin , Larry Helms
CPC分类号： G01N33/573 , C12Q1/485 , G01N21/76 , G01N33/5306 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N2333/91205 , G01N2458/30 , G01N2458/40 , Y10S435/967 , Y10S435/968 , Y10T436/10 , Y10T436/108331
摘要： Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.
摘要翻译： 组合物，试剂，试剂盒，系统，系统组分和用于进行测定的方法。 更具体地说，本发明涉及使用新颖的试剂组合来提供改进的测定性能。
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