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公开(公告)号：US07642057B2
公开(公告)日：2010-01-05
申请号：US12071268
申请日：2008-02-19
CPC分类号： C12Q1/6827 , C12Q1/6841 , C12Q1/6883 , C12Q2600/156 , C12Q2525/107 , C12Q2565/601
摘要： A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at least one set comprising one or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to a potential aberration in a chromosome, and at least one set comprising two or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to another potential aberration in a chromosome. In particular, the method may be used for detecting chromosome aberrations in the form of breakpoints.
摘要翻译： 公开了一种用于检测染色体畸变的新方法。 更具体地，使用至少两组杂交探针通过原位杂交检测染色体畸变，至少一组包含能够与染色体中的潜在像差相关的特定核酸序列杂交的一个或多个肽核酸探针，以及 至少一个包含两个或更多个肽核酸探针的组，所述肽核酸探针能够与与染色体中的另一个潜在像差相关的特定核酸序列杂交。 特别地，该方法可用于以断点的形式检测染色体畸变。
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公开(公告)号：US07105294B2
公开(公告)日：2006-09-12
申请号：US10229110
申请日：2002-08-27
CPC分类号： C12Q1/6827 , C12Q1/6841 , C12Q1/6883 , C12Q2600/156 , C12Q2525/107 , C12Q2565/601
摘要： A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at least one set comprising one or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to a potential aberration in a chromosome, and at least one set comprising two or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to another potential aberration in a chromosome. In particular, the method may be used for detecting chromosome aberrations in the form of breakpoints.
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公开(公告)号：US20080187934A1
公开(公告)日：2008-08-07
申请号：US12071268
申请日：2008-02-19
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6841 , C12Q1/6883 , C12Q2600/156 , C12Q2525/107 , C12Q2565/601
摘要： A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at least one set comprising one or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to a potential aberration in a chromosome, and at least one set comprising two or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to another potential aberration in a chromosome. In particular, the method may be used for detecting chromosome aberrations in the form of breakpoints.
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公开(公告)号：US07368245B2
公开(公告)日：2008-05-06
申请号：US11220718
申请日：2005-09-08
CPC分类号： C12Q1/6827 , C12Q1/6841 , C12Q1/6883 , C12Q2600/156 , C12Q2525/107 , C12Q2565/601
摘要： A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at least one set comprising one or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to a potential aberration in a chromosome, and at least one set comprising two or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to another potential aberration in a chromosome. In particular, the method may be used for detecting chromosome aberrations in the form of breakpoints.
摘要翻译： 公开了一种用于检测染色体畸变的新方法。 更具体地，使用至少两组杂交探针通过原位杂交检测染色体畸变，至少一组包含能够与染色体中的潜在像差相关的特定核酸序列杂交的一个或多个肽核酸探针，以及 至少一个包含两个或更多个肽核酸探针的组，所述肽核酸探针能够与与染色体中的另一个潜在像差相关的特定核酸序列杂交。 特别地，该方法可用于以断点的形式检测染色体畸变。
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公开(公告)号：US20060160106A1
公开(公告)日：2006-07-20
申请号：US11220718
申请日：2005-09-08
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6841 , C12Q1/6883 , C12Q2600/156 , C12Q2525/107 , C12Q2565/601
摘要： A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at least one set comprising one or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to a potential aberration in a chromosome, and at least one set comprising two or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to another potential aberration in a chromosome. In particular, the method may be used for detecting chromosome aberrations in the form of breakpoints.
摘要翻译： 公开了一种用于检测染色体畸变的新方法。 更具体地，使用至少两组杂交探针通过原位杂交检测染色体畸变，至少一组包含能够与染色体中的潜在像差相关的特定核酸序列杂交的一个或多个肽核酸探针，以及 至少一个包含两个或更多个肽核酸探针的组，所述肽核酸探针能够与与染色体中的另一个潜在像差相关的特定核酸序列杂交。 特别地，该方法可用于以断点的形式检测染色体畸变。
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6.发明授权Method of controlling the temperature of a specimen in or on a solid support member 有权控制固体支撑构件中或其上的样品的温度的方法公开(公告)号：US06930292B1
公开(公告)日：2005-08-16
申请号：US10031357
申请日：2000-07-21
申请人： Lars Winther , Kim Adelhorst
发明人： Lars Winther , Kim Adelhorst
CPC分类号： B01L3/50851 , B01L7/00 , G01N1/44 , G02B21/34
摘要： A method of controlling the temperature of a biological specimen by using induction heating. The specimen is either fixed to a carrier or is in liquid form in contact with a carrier with fixed capture probes. The carrier is removably placed in proximity to a solid support member with a conducting material, and the solid support is subjected to an oscillating magnetic field. The carrier and support member are preferably a microscope slide and a cartridge, respectively.
摘要翻译： 通过感应加热来控制生物样本的温度的方法。 样品或者固定在载体上，或者是与具有固定捕获探针的载体接触的液体形式。 载体可移除地放置在具有导电材料的固体支撑构件附近，并且固体支撑体经受振荡磁场。 载体和支撑构件优选分别是显微镜载玻片和暗盒。
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