公开(公告)号：US5342527A

公开(公告)日：1994-08-30

申请号：US82928

申请日：1993-06-29

申请人： Jacques Chevallet ,  Bernard Bene

发明人： Jacques Chevallet ,  Bernard Bene

IPC分类号： A61M1/14 ,  A61M1/16 ,  G01F25/00 ,  B01D61/32

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/165 ,  G01F25/0007

摘要： Disclosed is a method for the calibration of a pair of sensors placed in a dialysis circuit. The method includes performing at least one step for determining an auxiliary calibration coefficient for the intake sensor, performing at least one step for determining an auxiliary calibration coefficient for the outlet sensor, and in determining on the basis of at least one auxiliary calibration coefficient, a new calibration coefficient for the two sensors.

摘要翻译： 公开了一种用于校准放置在透析电路中的一对传感器的方法。 该方法包括执行用于确定进气传感器的辅助校准系数的至少一个步骤，执行用于确定出口传感器的辅助校准系数的至少一个步骤，以及基于至少一个辅助校准系数， 两个传感器的新校准系数。

公开(公告)号：US5725775A

公开(公告)日：1998-03-10

申请号：US493969

申请日：1995-06-23

申请人： Bernard Bene ,  Jacques Chevallet

发明人： Bernard Bene ,  Jacques Chevallet

IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/34 ,  B01D61/22 ,  B01D61/32

CPC分类号： A61M1/3441 ,  A61M1/16 ,  A61M1/1643 ,  A61M1/3437 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3413 ,  Y10S210/929

摘要： An artificial kidney dosing method includes the steps of connecting a patient to an exchanger having first and second compartments separated by a semipermeable membrane. The first compartment is connected to a circuit for extracorporeal blood circulation, and the second compartment has an outlet for draining a waste liquid. After the patient is connected to the exchanger, a perfusion liquid containing a substance (A) is perfused to the patient. The concentration of substance (A) in the blood of the patient is adjusted to a desired concentration {A}.sub.DES, by controlling a flow rate (Q.sub.A) of the perfusion liquid as a function of (1) a flow rate (Q.sub.OUT) of the waste liquid; (2) the desired concentration {A}.sub.DES ; and (3) a concentration {A}.sub.SOL of substance (A) in the perfusion liquid, whereby during this adjustment, a transfer of substance {A} through the semipermeable membrane is taken into account.

摘要翻译： 人造肾剂量方法包括将患者连接到具有由半透膜隔开的第一和第二隔室的交换器的步骤。 第一隔室连接到用于体外血液循环的回路，第二隔室具有用于排出废液的出口。 患者连接到交换器后，将含有物质（A）的灌注液灌注到患者身上。 通过控制灌注液的流量（QA）作为（1）的流量（QOUT）的函数，将患者血液中物质（A）的浓度调节至所需浓度{A} DES 废液; （2）所需浓度{A} DES; 和（3）灌注液中物质（A）的浓度{A} SOL，由此在该调整期间，考虑到物质{A}通过半透膜的转移。

公开(公告)号：US5698090A

公开(公告)日：1997-12-16

申请号：US738829

申请日：1996-10-28

申请人： Bernard Bene ,  Jacques Chevallet

发明人： Bernard Bene ,  Jacques Chevallet

IPC分类号： A61M1/16 ,  A61M1/34 ,  B01D61/00 ,  A61M1/14 ,  B01D61/22 ,  B01D61/32

CPC分类号： A61M1/3441 ,  A61M1/16 ,  A61M1/1643 ,  A61M1/3437 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3413 ,  Y10S210/929

摘要： An artificial kidney comprises an exchanger (1) having two compartments (2, 3) separated by a semipermeable membrane (4), a first compartment (2) being connected to a circuit (5, 7) for extracorporeal blood circulation, the second compartment (3) having an outlet for draining waste liquid. Means (22, 25) are provided for controlling the flow rate (Q.sub.A) of a sterile solution containing a substance (A) to be perfused into the circuit (5, 7) for conveying a flow of blood outside the body, which flow rate is controlled as a function of the flow rate (Q.sub.OUT) of waste liquid. This kidney makes it possible to dose a substance such as a medicine, glucose or bicarbonate, accurately into the blood of a patient undergoing treatment by hemofiltration, hemodialysis, or hemodiafiltration.

摘要翻译： 人造肾包括具有由半透膜隔开的两个隔室（2,3）的交换器（1），与用于体外血液循环的回路（5,7）连接的第一隔室（2），第二隔室 （3）具有用于排出废液的出口。 提供装置（22,25），用于控制含有要灌注到用于输送身体外部的血液的电路（5,7）中的物质（A）的无菌溶液的流量（QA），该流量 作为废液流量（QOUT）的函数进行控制。 该肾使得可以将药物，葡萄糖或碳酸氢盐等物质准确地注入通过血液透析，血液透析或血液透析滤过治疗的患者的血液中。

公开(公告)号：US5578223A

公开(公告)日：1996-11-26

申请号：US383208

申请日：1995-02-03

申请人： Bernard Bene ,  Jacques Chevallet

发明人： Bernard Bene ,  Jacques Chevallet

IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/34 ,  B01D61/00 ,  B01D61/22 ,  B01D61/32 ,  B01D61/34

CPC分类号： A61M1/3441 ,  A61M1/16 ,  A61M1/1643 ,  A61M1/3437 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3413 ,  Y10S210/929

摘要： An artificial kidney comprises an exchanger (1) having two compartments (2, 3) separated by a semipermeable membrane (4), a first compartment (2) being connected to a circuit (5, 7) for extracorporeal blood circulation, the second compartment (3) having an outlet for draining waste liquid. Means (22, 25) are provided for controlling the flow rate (Q.sub.A) of a sterile solution containing a substance (A) to be perfused into the circuit (5, 7) for conveying a flow of blood outside the body, which flow rate is controlled as a function of the flow rate (Q.sub.OUT) of waste liquid. This kidney makes it possible to dose a substance such as a medicine, glucose or bicarbonate, accurately into the blood of a patient undergoing treatment by hemofiltration, hemodialysis, or hemodiafiltration.

摘要翻译： 人造肾包括具有由半透膜隔开的两个隔室（2,3）的交换器（1），与用于体外血液循环的回路（5,7）连接的第一隔室（2），第二隔室 （3）具有用于排出废液的出口。 提供装置（22,25），用于控制含有要灌注到用于输送身体外部的血液的电路（5,7）中的物质（A）的无菌溶液的流量（QA），该流量 作为废液流量（QOUT）的函数进行控制。 该肾使得可以将药物，葡萄糖或碳酸氢盐等物质准确地注入通过血液透析，血液透析或血液透析滤过治疗的患者的血液中。

公开(公告)号：US06325774B1

公开(公告)日：2001-12-04

申请号：US09137410

申请日：1998-08-20

申请人： Bernard Bene ,  Jacques Burtin

发明人： Bernard Bene ,  Jacques Burtin

IPC分类号： A61M3700

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/165 ,  A61M1/3437 ,  A61M1/3458 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3393 ,  G06F19/00

摘要： A dialysis apparatus includes a dialysis liquid circuit for circulating sodium chloride and sodium bicarbonate through a haemodialyser and a circuit for infusing a patient with at least one solution containing at least one ionic substance “A” absent from the dialysis liquid. The substance “A” has a determined concentration (A)sol in the infusion solution. A dialysance detector determines the actual dialysance “D” of the haemodialyser for sodium, and a flow rate detector determines the flow rate Qinf of infusion solution such that the concentration of the substance “A” inside the patient's body tends towards a desired concentration (A)des, as a function of the dialysance “D”, the concentration (A)sol of the substance “A” in the infusion solution and the desired concentration (A)des, A regulator regulates the flow rate of infusion solution, and a controller drives the regulator to control the flow rate of the infusion solution such that this flow rate is substantially equal to the determined flow rate Qinf.

摘要翻译： 透析装置包括用于通过血液透析器循环氯化钠和碳酸氢钠的透析液回路，以及用于向患者注入至少一种含有至少一种离子物质“A”的透析液的回路。 物质“A”在输液中具有确定的浓度（A）溶胶。 透析检测器确定用于钠的血液透析器的实际透析度“D”，流量检测器确定输注溶液的流速Qinf，使得患者体内物质“A”的浓度趋向于期望的浓度（A ）des，作为透析“D”的函数，输液中物质“A”的浓度（A）溶液和所需浓度（A）des，A调节剂调节输液的流速， 控制器驱动调节器以控制输注溶液的流速，使得该流量基本上等于所确定的流量Qinf。

公开(公告)号：US08741147B2

公开(公告)日：2014-06-03

申请号：US12780301

申请日：2010-05-14

申请人： Bernard Bene ,  Georges Vantard ,  Carl W. Reitz

发明人： Bernard Bene ,  Georges Vantard ,  Carl W. Reitz

IPC分类号： B01D11/00 ,  B01D61/00 ,  C02F1/44

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/1617 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/52 ,  A61M2230/65

摘要： A controller for blood treatment equipment comprising a treatment unit including a semipermeable membrane separating the treatment unit into a first compartment for the circulation of blood and a second compartment for the circulation of a treatment liquid is enclosed. The controller is adapted to receive one or more entries of information measured during the course of a treatment procedure, to calculate from said measured information a value of a significant parameter indicative of the progress of an extracorporeal blood treatment carried out by the equipment. The controller is also adapted to compare the calculated significant parameter to a prescribed reference value for the same parameter and to generate at least one output control signal responsive to said comparison for automatically controlling one or more operations performed by the equipment. Equipment comprising the controller and a control method the controller can be programmed to carry out are also disclosed.

摘要翻译： 一种用于血液处理设备的控制器，其包括处理单元，该处理单元包括将处理单元分离成用于血液循环的第一隔室和用于处理液循环的第二隔室的半透膜。 控制器适于接收在治疗过程中测量的信息的一个或多个条目，从所述测量信息中计算指示由设备进行的体外血液处理进展的显着参数的值。 控制器还适于将所计算的有效参数与相同参数的规定参考值进行比较，并且响应于所述比较生成至少一个输出控制信号，以自动控制由设备执行的一个或多个操作。 还公开了包括控制器的设备和控制器可编程执行的控制方法。

公开(公告)号：US09162020B2

公开(公告)日：2015-10-20

申请号：US13175131

申请日：2011-07-01

申请人： Georges Vantard ,  Bernard Bene

发明人： Georges Vantard ,  Bernard Bene

IPC分类号： A61M1/16 ,  A61M1/36

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/3609 ,  A61M2205/33 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/52 ,  A61M2205/60

摘要： Apparatus for controlling an extra-corporeal blood treatment in a medical device, comprising a blood treatment device (7), an extra-corporeal blood transport line (4), a fluid transport line (3) for a treatment fluid for the blood, at least a sensor adapted to provide a measure (M) correlated to at least a treatment parameter of the extra-corporeal blood treatment and/or of the treatment device (7) in the medical device (1), at least one storage memory (29), and at least a control device (28), operatively connected at least with the storage memory (29) and with the sensor, and configured for receiving the measure (M) from the sensor, correlating the measure (M) with referential data (R) of the treatment device for the treatment parameter provided by the at least one storage memory (29), and correlating the measure (M) with patient historical data (H) for the treatment parameter for obtaining an information representative of the quality of the extra-corporeal blood treatment.

摘要翻译： 用于控制医疗装置中的体外血液处理的装置，包括血液处理装置（7），体外血液输送管线（4），用于血液的处理流体的流体输送管线（3） 至少一个传感器，适于提供与所述医疗器械（1）中至少一个外部血液处理和/或治疗设备（7）的治疗参数相关的测量（M），至少一个存储存储器（29） ）和至少一个至少与存储存储器（29）和传感器连接的控制设备（28），并且被配置为从传感器接收测量（M），将测量（M）与参考数据相关联 （29）的治疗参数的治疗装置（R），并且将所述措施（M）与所述治疗参数的患者历史数据（H）相关联，以获得表示所述治疗参数的质量的信息 额外的血液治疗。

公开(公告)号：US20130116650A1

公开(公告)日：2013-05-09

申请号：US13642404

申请日：2011-04-14

申请人： Georges Vantard ,  Bernard Bene

发明人： Georges Vantard ,  Bernard Bene

IPC分类号： A61M1/16

CPC分类号： A61M1/1656 ,  A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/1617 ,  A61M1/1647 ,  A61M1/1666 ,  A61M1/3403 ,  A61M5/168 ,  A61M5/16831 ,  A61M5/172 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/33 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3327 ,  A61M2210/12 ,  A61M2230/20 ,  A61M2230/65

摘要： Dialysis apparatus including a blood treatment unit having a dialysate chamber and a blood chamber separated by a semipermeable membrane, a dialysate circuit presenting a supply line and a discharge line connected to the blood treatment unit, a preparation device for preparing a dialysate containing a substance present in the blood too and a regulator regulating the concentration of the substance in the dialysate. A blood circuit to circulate extracorporeal blood through the blood chamber; a controller that determines a value representative of the concentration of the substance in the blood and are programmed for driving the regulator as a function of the determined value representative of the substance concentration in the blood such that the substance concentration in the dialysate tends towards the substance concentration in the blood.

摘要翻译： 包括具有透析液室的血液处理单元和由半透膜隔开的血液室的透析装置，具有与血液处理单元连接的供给管线和排出管线的透析液回路，制备含有物质的透析液的制备装置 在血液中也是调节调节透析液中物质浓度的调节剂。 通过血液室循环体外血液的血液回路; 控制器，其确定表示血液中物质浓度的值，并且被编程为用于驱动调节器作为代表血液中物质浓度的确定值的函数，使得透析液中的物质浓度倾向于物质 血液中的浓度

公开(公告)号：US20120305090A1

公开(公告)日：2012-12-06

申请号：US13518588

申请日：2010-11-29

申请人： Bernard Bene

发明人： Bernard Bene

IPC分类号： F17D3/00

CPC分类号： A61M1/342 ,  A61M1/1601 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M2205/3396 ,  A61M2205/702 ,  F17D3/00 ,  Y10T137/0324 ,  Y10T137/85986

摘要： An apparatus for controlling a fluid flow rate in a fluid transport line of a medical device, including at least a first pump, at least a chamber for collecting the fluid, at least a sensor for providing a first value correlated to the amount of fluid in the chamber, and a control device configured for receiving a second value representative of the fluid flow rate through the first pump and for correlating the second value with the first value to obtain an accuracy check of the second value. A method for controlling a fluid flow rate in a fluid transport line of a medical device including pumping a fluid, collecting the fluid in a chamber, sensing a first value correlated to the amount of fluid in the chamber, and detecting and sending a second value representative of the fluid flow rate through the first pump to a control device, sending the first value to the control device and correlating the second value with the first value to obtain an accuracy check.

摘要翻译： 一种用于控制医疗装置的流体输送管线中的流体流速的装置，包括至少第一泵，至少一个用于收集流体的室，至少一个传感器，用于提供与流体的量相关的第一值 所述腔室和控制装置构造成用于接收代表通过所述第一泵的流体流速的第二值，并且将所述第二值与所述第一值相关以获得所述第二值的精度检查。 一种用于控制医疗装置的流体输送管线中的流体流速的方法，包括泵送流体，在腔室中收集流体，感测与腔室中的流体量相关的第一值，以及检测和发送第二值 将通过第一泵的流体流量代表到控制装置，将第一值发送到控制装置，并将第二值与第一值相关联以获得精确度检查。

公开(公告)号：US20100219129A1

公开(公告)日：2010-09-02

申请号：US12780301

申请日：2010-05-14

申请人： Bernard Bene ,  Georges Vantard ,  Carl W. Reitz

发明人： Bernard Bene ,  Georges Vantard ,  Carl W. Reitz

IPC分类号： B01D61/32 ,  B01D61/24 ,  B01D61/34

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/1617 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/52 ,  A61M2230/65

摘要： A controller for blood treatment equipment comprising a treatment unit including a semipermeable membrane separating the treatment unit into a first compartment for the circulation of blood and a second compartment for the circulation of a treatment liquid is enclosed. The controller is adapted to receive one or more entries of information measured during the course of a treatment procedure, to calculate from said measured information a value of a significant parameter indicative of the progress of an extracorporeal blood treatment carried out by the equipment. The controller is also adapted to compare the calculated significant parameter to a prescribed reference value for the same parameter and to generate at least one output control signal responsive to said comparison for automatically controlling one or more operations performed by the equipment. Equipment comprising the controller and a control method the controller can be programmed to carry out are also disclosed.

摘要翻译： 一种用于血液处理设备的控制器，其包括处理单元，该处理单元包括将处理单元分离成用于血液循环的第一隔室和用于处理液循环的第二隔室的半透膜。 控制器适于接收在治疗过程中测量的信息的一个或多个条目，从所述测量信息中计算指示由设备进行的体外血液处理进展的显着参数的值。 控制器还适于将所计算的有效参数与相同参数的规定参考值进行比较，并且响应于所述比较生成至少一个输出控制信号，以自动控制由设备执行的一个或多个操作。 还公开了包括控制器的设备和控制器可编程执行的控制方法。